In this work, a hybrid free-space optics (FSO)/ teraHertz (THz) based backhaul network is considered to provide high-data-rate reliable communication to the terrestrial mobile users (MUs) operating ...at millimeter-wave (mmWave) bands. The FSO link is affected by atmospheric turbulence and pointing error impairments. At the FSO receiver, both intensity-modulated direct detection and heterodyne detection techniques are considered. The multi-antenna THz link suffers from high path-loss, small-scale fading, and misalignment error. To minimize the effect of back-and-forth switching, soft switching method is introduced at the access point (AP) to select the signal coming through the hybrid FSO/THz link, and a comparison with hard switching method is presented. Selective decode-and-forward relaying is considered at the AP. In this context, we derive closed-form expressions of the individual link's outage probability, end-to-end (E2E) outage probability, asymptotic outage probability, ergodic capacity, and generalized average bit-error-rate. Finally, we study the effect of different parameters such as atmospheric turbulence, pointing/misalignment errors, link distance, atmospheric attenuation/path-loss, fading parameters of the THz and access links, and number of antennas on the network performance. Our results indicate that, with a proper switching method, the joint implementation of FSO/THz links improves the rate/reliability of the backhaul links with limited switching overhead.
We report the case of a 61-year-old male who had complications with a mitral valve (MV) bioprosthesis replacement by post-cardiotomy shock leading to VA ECMO implantation. The patient suffered early ...bioprosthetic valve failure owing to early thrombosis. The complication was successfully treated with a MV bioprosthesis transapical balloon valvuloplasty that restored normal leaflet mobility.
As traffic volumes carried by optical networks continue to grow by tens of percent year over year, we are rapidly approaching the capacity limit of the conventional communication band within a ...single-mode fiber. New measures such as elastic optical networking, spectral extension to multi-bands, and spatial expansion to additional fiber overlays or new fiber types are all being considered as potential solutions, whether near term or far. In this tutorial paper, we survey the photonic switching hardware solutions in support of evolving optical networking solutions enabling capacity expansion based on the proposed approaches. We also suggest how reconfigurable add/drop multiplexing nodes will evolve under these scenarios and gauge their properties and relative cost scalings. We identify that the switching technologies continue to evolve and offer network operators the required flexibility in routing information channels in both the spectral and spatial domains. New wavelength-selective switch designs can now support greater resolution, increased functionality and packing density, as well as operation with multiple input and output ports. Various switching constraints can be applied, such as routing of complete spatial superchannels, in an effort to reduce the network cost and simplify the routing protocols and managed pathway count. However, such constraints also reduce the transport efficiency when the network is only partially loaded, and may incur fragmentation. System tradeoffs between switching granularity and implementation complexity and cost will have to be carefully considered for future high-capacity SDM–WDM optical networks. In this work, we present the first cost comparisons, to our knowledge, of the different approaches in an effort to quantify such tradeoffs.
Alzheimer’s disease (AD) is the most common neurodegenerative pathology among progressive dementias, and it is characterized by the accumulation in the brain of extracellular aggregates of ...beta-amyloid proteins and neurofibrillary intracellular tangles consisting of τ-hyperphosphorylated proteins. Under normal conditions, beta-amyloid peptides exert important trophic and antioxidant roles, while their massive presence leads to a cascade of events culminating in the onset of AD. The fibrils of beta-amyloid proteins are formed by the process of fibrillogenesis that, starting from individual monomers of beta-amyloid, can generate polymers of this protein, constituting the hypothesis of the “amyloid cascade”. To date, due to the lack of pharmacological treatment for AD without toxic side effects, chemical research is directed towards the realization of hybrid compounds that can act as an adjuvant in the treatment of this neurodegenerative pathology. The hybrid compounds used in this work include moieties of a hydroxytyrosol, a nitrohydroxytyrosol, a tyrosol, and a homovanillyl alcohol bound to the N-benzylpiperidine moiety of donepezil, the main drug used in AD. Previous experiments have shown different properties of these hybrids, including low toxicity and antioxidant and chelating activities. The purpose of this work was to test the effects of hybrid compounds mixed with Aβ 1–40 to induce fibrillogenesis and mimic AD pathogenesis. This condition has been studied both in test tubes and by an in vitro model of neuronal differentiated human SH-SY5Y neuroblastoma cells. The results obtained from test tube experiments showed that some hybrids inhibit the activity of the enzymes AChE, BuChE, and BACE-1. Cell experiments suggested that hybrids could inhibit fibrillogenesis, negatively modulating caspase-3. They were also shown to exert antioxidant effects, and the acetylated hybrids were found to be more functional and efficient than nonacetylated forms.
Display omitted
•In an Italian birth cohort three indirect methods to assess pesticide exposure during pregnancy were used.•The association of each of the maternal exposure variables with infant ...wheezing occurrence was evaluated.•Self-reported pesticide use during pregnancy was weakly associated with infant wheezing.•Involvement in agricultural activities during pregnancy was not associated with infant wheezing.•In rural areas, living in proximity of crops, especially fruit trees, during pregnancy was associated with infant wheezing.
Pesticide exposure in pregnancy may have health effects in the offspring. We studied whether maternal pesticides exposure during pregnancy is associated with infant wheezing.
The study involved 5997 children from the Italian NINFEA birth cohort, whose mothers were recruited during pregnancy between 2005 and 2016. We used questionnaires completed during pregnancy and 6 months after delivery to derive the following indirect measures of exposure: i) Self-reported pesticide use during the first and the third trimester of pregnancy; (ii) Agricultural activities during the same trimesters. We also evaluated the exposure to agricultural pesticides applied near home using the Corine Land Cover inventory to derive the proportion of a 200-metre buffer area around maternal home address covered by agricultural crops and specific crop types (arable land, fruit trees, heterogeneous cultivations). Questionnaires completed when the child turned 18 months reported information on wheezing between 6 and 18 months of age. We estimated the odds ratios of wheezing adjusting for the following maternal characteristics: age, education, parity, asthma, atopy, smoking in pregnancy, region and area of residence, pet ownership during pregnancy. Crops proximity analyses were restricted to residents in rural areas (N = 1674).
Agricultural activities during pregnancy were not associated with infant wheezing. Compared to no pesticide use, there was a weak positive association for self-reported use in the third trimester (POR: 1.30; 95 %CI 0.95–1.78) and a stronger association for use in both trimesters (POR: 1.72; 95 %CI 1.11–2.65). The relationship between the proportion of crops around the home address and the risk of infant wheezing, was J-shaped, in particular for fruit trees with the lowest risk for mid values and elevated risk for higher values.
We found some evidence of association for maternal pesticide use in pregnancy and residential proximity to fruit trees cultivations with infant wheezing.
The exposome drivers are less studied than its consequences but may be crucial in identifying population subgroups with unfavourable exposures.
We used three approaches to study the socioeconomic ...position (SEP) as a driver of the early-life exposome in Turin children of the NINFEA cohort (Italy).
Forty-two environmental exposures, collected at 18 months of age (N = 1989), were classified in 5 groups (lifestyle, diet, meteoclimatic, traffic-related, built environment).
We performed cluster analysis to identify subjects sharing similar exposures, and intra-exposome-group Principal Component Analysis (PCA) to reduce the dimensionality. SEP at childbirth was measured through the Equivalised Household Income Indicator.
SEP-exposome association was evaluated using: 1) an Exposome Wide Association Study (ExWAS), a one-exposure (SEP) one-outcome (exposome) approach; 2) multinomial regression of cluster membership on SEP; 3) regressions of each intra-exposome-group PC on SEP.
In the ExWAS, medium/low SEP children were more exposed to greenness, pet ownership, passive smoking, TV screen and sugar; less exposed to NO2, NOX, PM25abs, humidity, built environment, traffic load, unhealthy food facilities, fruit, vegetables, eggs, grain products, and childcare than high SEP children.
Medium/low SEP children were more likely to belong to a cluster with poor diet, less air pollution, and to live in the suburbs than high SEP children.
Medium/low SEP children were more exposed to lifestyle PC1 (unhealthy lifestyle) and diet PC2 (unhealthy diet), and less exposed to PC1s of the built environment (urbanization factors), diet (mixed diet), and traffic (air pollution) than high SEP children.
The three approaches provided consistent and complementary results, suggesting that children with lower SEP are less exposed to urbanization factors and more exposed to unhealthy lifestyles and diet. The simplest method, the ExWAS, conveys most of the information and is more replicable in other populations. Clustering and PCA may facilitate results interpretation and communication.
Alzheimer’s (AD) and Parkinson’s diseases (PD) are multifactorial neurogenerative disorders of the Central Nervous System causing severe cognitive and motor deficits in elderly people. Because ...treatment of AD and PD by synthetic drugs alleviates the symptoms often inducing side effects, many studies have aimed to find neuroprotective properties of diet polyphenols, compounds known to act on different cell signaling pathways. In this article, we analyzed the effect of polyphenols obtained from the agro-food industry waste of Citrus limon peel (LPE) on key enzymes of cholinergic and aminergic neurotransmission, such as butyryl cholinesterase (BuChE) and monoamine oxidases (MAO)-A/B, on Aβ1–40 aggregation and on superoxide dismutase (SOD) 1/2 that affect oxidative stress. In our in vitro assays, LPE acts as an enzyme inhibitor on BuChE (IC50 ~ 73 µM), MAO-A/B (IC50 ~ 80 µM), SOD 1/2 (IC50 ~ 10–20 µM) and interferes with Aβ1–40 peptide aggregation (IC50 ~ 170 µM). These results demonstrate that LPE behaves as a multitargeting agent against key factors of AD and PD by inhibiting to various extents BuChE, MAOs, and SODs and reducing Aβ-fibril aggregation. Therefore, LPE is a promising candidate for the prevention and management of AD and PD symptoms in combination with pharmacological therapies.
Abstract
Optoelectronics is a valuable solution to scale up wireless links frequency to sub-THz in the next generation antenna systems and networks. Here, we propose a low-power consumption, small ...footprint building block for 6 G and 5 G new radio wireless transmission allowing broadband capacity (e.g., 10–100 Gb/s per link and beyond). We demonstrate a wireless datalink based on graphene, reaching setup limited sub-THz carrier frequency and multi-Gbit/s data rate. Our device consists of a graphene-based integrated optoelectronic mixer capable of mixing an optically generated reference oscillator approaching 100 GHz, with a baseband electrical signal. We report >96 GHz optoelectronic bandwidth and −44 dB upconversion efficiency with a footprint significantly smaller than those of state-of-the-art photonic transmitters (i.e., <0.1 mm
2
). These results are enabled by an integrated-photonic technology based on wafer-scale high-mobility graphene and pave the way towards the development of optoelectronics-based arrayed-antennas for millimeter-wave technology.
PDF
