A modern aeronautical structure is made of a laminated composite in which plies are terminated at discrete position to provide taperness. Ply termination is called ply-drop. Thickness variation in ...laminated composite is achieved by changing the number of plies in proportion to the thickness change. It requires the termination of plies within the laminate. In the present study, two different ply-drop configurations are taken for the analysis under tensile loading: overlapped-grouped and overlapped-dispersed. Commercial finite-element software ANSYS 14.0 is used for the analysis. To construct the model geometry, layered 3-D finite element (SOLID 20 node 186) is considered which have six degrees of freedom at each node. The Tsai–Wu criterion is implemented to obtain the value of the failure factor for separate plies. Interlaminar stress variations along the interface of plies are determined to initialize possible delamination sites. For both configurations the value of the failure factor is found to be maximum at the position of the first resin pocket tip. In case of overlapped-grouped, delamination growth occurs at a position near the thin section but in case of overlapped-dispersed it is spread over discrete positions over the laminate.
The recent identification of germline and somatic mutations in BAP1 as well as in multiple members of the ASXL (additional sex combs-like) family of genes has highlighted the role of these proteins ...in a diverse array of biological functions. A diverse number of possible functions have previously been ascribed to ASXL1 in non-hematopoietic contexts, including physical co-operativity with HP1a and LSD1. Here we discuss new evidence for a BAP1-independent function of ASXL1 in regulating histone H3 lysine 27 methylation through interactions with the Polycomb-repressive complex 2 (PRC2). BAP1, a nuclear-localized deubiquitinase, has been shown to interact with a number of proteins, including ASXL1 and/or ASXL2, but the functional importance of this interaction has remained elusive. Here, we highlight recent work revealing the critical function of BAP1 in restricting myelopoiesis and in regulating hematopoietic stem cell function. These data provide evidence that BAP1 and ASXL1 function as a novel class of tumor suppressors in myeloid malignancies. BAP1 functions through effects on stability of host cell factor-1, and O-GlcNAcylation, and ASXL1 impacts histone post-translational modifications through interaction with PRC2. Future studies investigating the mechanism of transformation by loss of BAP1 and ASXL1 may result in new therapeutic approaches to treat hematological malignancies.
Abstract
We have conducted a search for new strong gravitational lensing systems in the Dark Energy Spectroscopic Instrument Legacy Imaging Surveys’ Data Release 8. We use deep residual neural ...networks, building on previous work presented by Huang et al. These surveys together cover approximately one-third of the sky visible from the Northern Hemisphere, reaching a
z
-band AB magnitude of ∼22.5. We compile a training sample that consists of known lensing systems as well as non-lenses in the Legacy Surveys and the Dark Energy Survey. After applying our trained neural networks to the survey data, we visually inspect and rank images with probabilities above a threshold. Here we present 1210 new strong lens candidates.
There are many circumstances where shallow footings are constructed near sloping ground. When a footing is placed near the crest of sloping surface, the bearing capacity of the soil and the stability ...of the slope have been decreased remarkably based on the position of the footing with reference to the slope and slope inclination. In this regard, a sequence of finite element analysis has been carried out using Plaxis 2D
v
2015.02 to investigate the ultimate bearing capacity of strip footings located near
c
–
φ
soil slope. The influence of different geo-parameters on the load carrying capacity of the footing has been investigated, and the outcomes are appropriately explained. Moreover, large database of numerically simulated ultimate bearing capacity has been considered for developing and verifying the ANN model to establish a predictive model equation and the relative importance of the input parameters. It has been professed that angle of internal friction is the most important input parameter for estimating the bearing capacity of strip footing located on crest of
c
–
φ
slope.
India, with its rapidly aging population, faces an alarming burden of dementia. We implemented DSM-5 criteria in large-scale, nationally representative survey data in India to characterize the ...prevalence of mild and major Neurocognitive disorder.
The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) (N = 4,096) is a nationally representative cohort study in India using multistage area probability sampling methods. Using neuropsychological testing and informant reports, we defined DSM-5 mild and major neurocognitive disorder, reported its prevalence, and evaluated criterion and construct validity of the algorithm using clinician-adjudicated Clinical Dementia Ratings (CDR)®.
The prevalence of mild and major neurocognitive disorder, weighted to the population, is 17.6% and 7.2%. Demographic gradients with respect to age and education conform to hypothesized patterns. Among N = 2,390 participants with a clinician-adjudicated CDR, CDR ratings and DSM-5 classification agreed for N = 2,139 (89.5%) participants.
The prevalence of dementia in India is higher than previously recognized. These findings, coupled with a growing number of older adults in the coming decades in India, have important implications for society, public health, and families. We are aware of no previous Indian population-representative estimates of mild cognitive impairment, a group which will be increasingly important in coming years to identify for potential therapeutic treatment.
We perform a semi-automated search for strong gravitational lensing systems in the 9000 deg2 Dark Energy Camera Legacy Survey (DECaLS), part of the Dark Energy Spectroscopic Instrument Legacy Imaging ...Surveys. The combination of the depth and breadth of these surveys are unparalleled at this time, making them particularly suitable for discovering new strong gravitational lensing systems. We adopt the deep residual neural network architecture developed by Lanusse et al. for the purpose of finding strong lenses in photometric surveys. We compile a training sample that consists of known lensing systems in the Legacy Surveys and the Dark Energy Survey as well as non-lenses in the footprint of DECaLS. In this paper we show the results of applying our trained neural network to the cutout images centered on galaxies typed as ellipticals in DECaLS. The images that receive the highest scores (probabilities) are visually inspected and ranked. Here we present 335 candidate strong lensing systems, identified for the first time.
Abstract
The Dark Energy Spectroscopic Instrument (DESI) is carrying out a five-year survey that aims to measure the redshifts of tens of millions of galaxies and quasars, including 8 million ...luminous red galaxies (LRGs) in the redshift range 0.4 <
z
≲ 1.0. Here we present the selection of the DESI LRG sample and assess its spectroscopic performance using data from Survey Validation (SV) and the first two months of the Main Survey. The DESI LRG sample, selected using
g
,
r
,
z
, and
W
1 photometry from the DESI Legacy Imaging Surveys, is highly robust against imaging systematics. The sample has a target density of 605 deg
−2
and a comoving number density of 5 × 10
−4
h
3
Mpc
−3
in 0.4 <
z
< 0.8; this is a significantly higher density than previous LRG surveys (such as SDSS, BOSS, and eBOSS) while also extending to
z
∼ 1. After applying a bright star veto mask developed for the sample, 98.9% of the observed LRG targets yield confident redshifts (with a catastrophic failure rate of 0.2% in the confident redshifts), and only 0.5% of the LRG targets are stellar contamination. The LRG redshift efficiency varies with source brightness and effective exposure time, and we present a simple model that accurately characterizes this dependence. In the appendices, we describe the extended LRG samples observed during SV.
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