There is growing interest in sex differences and RAS components. However, whether gender influences cardiac angiotensin I-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) activity ...is still unknown. In the present work, we determined the relationship between ACE and ACE2 activity, left ventricular function and gender in spontaneously hypertensive rats (SHRs).
Twelve-week-old female (F) and male (M) SHRs were divided into 2 experimental groups (n = 7 in each group): sham (S) and gonadectomized (G). Fifty days after gonadectomy, we measured positive and negative first derivatives (dP/dt maximum left ventricle (LV) and dP/dt minimum LV, respectively), hypertrophy (morphometric analysis) and ACE and ACE2 catalytic activity (fluorimetrically). Expression of calcium handling proteins was measured by western blot. Male rats exhibited higher cardiac ACE and ACE2 activity as well as hypertrophy compared to female rats. Orchiectomy decreased the activity of these enzymes and hypertrophy, while ovariectomy increased hypertrophy and ACE2, but did not change ACE activity. For cardiac function, the male sham group had a lower +dP/dt than the female sham group. After gonadectomy, the +dP/dt increased in males and reduced in females. The male sham group had a lower -dP/dt than the female group. After gonadectomy, the -dP/dt increased in the male and decreased in the female groups when compared to the sham group. No difference was observed among the groups in SERCA2a protein expression. Gonadectomy increased protein expression of PLB (phospholamban) and the PLB to SERCA2a ratio in female rats, but did not change in male rats.
Ovariectomy leads to increased cardiac hypertrophy, ACE2 activity, PLB expression and PLB to SERCA2a ratio, and worsening of hemodynamic variables, whereas in males the removal of testosterone has the opposite effects on RAS components.
(ProQuest: ... denotes formulae and/or non-USASCII text omitted; see image).Exclusive electroproduction of ... mesons on unpolarized hydrogen and deuterium targets is studied in the kinematic region ...of ... GeV..., 3.0 GeV ... 6.3 GeV, and ... GeV... Results on the angular distribution of the ... meson, including its decay products, are presented. The data were accumulated with the HERMES forward spectrometer during the 1996-2007 running period using the 27.6 GeV longitudinally polarized electron or positron beam of HERA. The determination of the virtual-photon longitudinal-to-transverse cross-section ratio reveals that a considerable part of the cross section arises from transversely polarized photons. Spin density matrix elements are presented in projections of ... or ... Violation of ...-channel helicity conservation is observed for some of these elements. A sizable contribution from unnatural-parity-exchange amplitudes is found and the phase shift between those amplitudes that describe transverse ... production by longitudinal and transverse virtual photons, ... and ..., is determined for the first time. A hierarchy of helicity amplitudes is established, which mainly means that the unnatural-parity-exchange amplitude describing the ... transition dominates over the two natural-parity-exchange amplitudes describing the ... and ... transitions, with the latter two being of similar magnitude. Good agreement is found between the HERMES proton data and results of a pQCD-inspired phenomenological model that includes pion-pole contributions, which are of unnatural parity.
The HERMES polarized atomic beam source Nass, A.; Baumgarten, C.; Braun, B. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
06/2003, Letnik:
505, Številka:
3
Journal Article
Recenzirano
Odprti dostop
The HERMES atomic beam source is used to provide nuclear polarized hydrogen or deuterium atoms for the HERMES target. The setup including the dissociator, the sextupole magnet system and the ...high-frequency transitions is described. Measurements of the hydrogen intensity of up to
6.4×10
16
atoms/
s
in two hyperfine substates and of the deuterium intensity of up to
5.8×10
16
atoms/
s
in three hyperfine substates are presented. A degree of dissociation of 92.8% for H (94.5% for D) at the entrance of the storage cell and a nuclear polarization of around 0.97 (H) and 0.92 (D) have been found constant within a couple of percent over the whole running period of the HERMES experiment.
Design of a Test Bench for MgB2 and HTS Wires STATERA, M; CIULLO, G; LENISA, P ...
IEEE transactions on applied superconductivity,
06/2013, Letnik:
23, Številka:
3
Conference Proceeding
The R&D activities performed in Ferrara regarding a test bench for low temperature field measurement are presented. The system will be built and tested in Ferrara
A high intensity Superconducting atomic beam source Statera, M.; Stancari, M.; Capiluppi, M. ...
IEEE transactions on applied superconductivity,
06/2005, Letnik:
15, Številka:
2
Journal Article, Conference Proceeding
Recenzirano
A high intensity atomic beam source design, based on superconducting technology, is presented. The design requires compact sextupole magnets with a tapered bore and pole tip fields of 6-9 T, using ...superfluid helium if necessary. The cryostat housing these magnets, in addition to maintaining a stable magnet temperature with a minimal thickness along the inner bore, must also function as a cryopump for the atoms that are not focused.
Exclusive electroproduction of
ω
mesons on unpolarized hydrogen and deuterium targets is studied in the kinematic region of
Q
2
>
1.0
GeV
2
, 3.0 GeV
<
W
<
6.3 GeV, and
-
t
′
<
0.2
GeV
2
. ...Results on the angular distribution of the
ω
meson, including its decay products, are presented. The data were accumulated with the HERMES forward spectrometer during the 1996–2007 running period using the 27.6 GeV longitudinally polarized electron or positron beam of HERA. The determination of the virtual-photon longitudinal-to-transverse cross-section ratio reveals that a considerable part of the cross section arises from transversely polarized photons. Spin density matrix elements are presented in projections of
Q
2
or
-
t
′
. Violation of
s
-channel helicity conservation is observed for some of these elements. A sizable contribution from unnatural-parity-exchange amplitudes is found and the phase shift between those amplitudes that describe transverse
ω
production by longitudinal and transverse virtual photons,
γ
L
∗
→
ω
T
and
γ
T
∗
→
ω
T
, is determined for the first time. A hierarchy of helicity amplitudes is established, which mainly means that the unnatural-parity-exchange amplitude describing the
γ
T
∗
→
ω
T
transition dominates over the two natural-parity-exchange amplitudes describing the
γ
L
∗
→
ω
L
and
γ
T
∗
→
ω
T
transitions, with the latter two being of similar magnitude. Good agreement is found between the HERMES proton data and results of a pQCD-inspired phenomenological model that includes pion-pole contributions, which are of unnatural parity.
The PAX Collaboration has successfully performed a spin-filtering experiment with protons at the COSY-ring. The measurement allowed the determination of the spin-dependent polarizing cross section, ...that compares well with the theoretical prediction from the nucleonanucleon potential. The test confirms that spin-filtering can be adopted as a method to polarize a stored beam and that the present interpretation of the mechanism in terms of the protonaproton interaction is correct. The outcome of the experiment is of utmost importance in view of the possible application of the method to polarize a beam of stored antiprotons.
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