Background
GENetics of mOyaMoyA (GEN-O-MA) project is a multicenter observational study implemented in Italy aimed at creating a network of centers involved in moyamoya angiopathy (MA) care and ...research and at collecting a large series and bio-repository of MA patients, finally aimed at describing the disease phenotype and clinical course as well as at identifying biological or cellular markers for disease progression. The present paper resumes the most important study methodological issues and preliminary results.
Methods
Nineteen centers are participating to the study. Patients with both bilateral and unilateral radiologically defined MA are included in the study. For each patient, detailed demographic and clinical as well as neuroimaging data are being collected. When available, biological samples (blood, DNA, CSF, middle cerebral artery samples) are being also collected for biological and cellular studies.
Results
Ninety-eight patients (age of onset mean ± SD 35.5 ± 19.6 years; 68.4% females) have been collected so far. 65.3% of patients presented ischemic (50%) and haemorrhagic (15.3%) stroke. A higher female predominance concomitantly with a similar age of onset and clinical features to what was reported in previous studies on Western patients has been confirmed.
Conclusion
An accurate and detailed clinical and neuroimaging classification represents the best strategy to provide the characterization of the disease phenotype and clinical course. The collection of a large number of biological samples will permit the identification of biological markers and genetic factors associated with the disease susceptibility in Italy.
Staphylococcus aureus and Staphylococcus epidermidis associated with implantable medical devices, are often difficult to treat with conventional antimicrobials. Formation of a biofilm and subsequent ...production of toxins are two distinct mechanisms considered important in foreign body infections. Staphylococcal virulence is caused by a complex regulatory process, which involves cell-to-cell communication through the release and response to chemical signals in a process known as quorum sensing. We explored the possibility of preventing infections by interfering with biofilm formation and toxin production using the quorum sensing inhibitor ribonucleic-acid-III-inhibiting peptide. In our studies ribonucleic-acid-III-inhibiting peptide prevented graft-associated infections caused by all species of staphylococci tested so far, including methicillin resistant S. aureus and S. epidermidis. Ribonucleic-acid-III-inhibiting peptide also enhances the effects of antibiotics and cationic peptides in the clearance of normally recalcitrant biofilm infections. Ribonucleic-acid-III-inhibiting peptide is nontoxic, highly stable, and no resistant strains have been found so far, suggesting that ribonucleic-acid-III-inhibiting peptide may be used to coat medical devices or used systemically to prevent infections. When the target of ribonucleic-acid-III activating protein activity is disrupted, biofilm formation is reduced under flow and static conditions and genes important for toxin production or biofilm formation are down-regulated. These in vitro data help explain why ribonucleic-acid-III-inhibiting peptide seems to be effective in preventing staphylococcal infections.
The authors present a fuzzy approach to the analysis of airborne synthetic aperture radar (SAR) images of urban environments. In particular, they want to show how to implement structure extraction ...algorithms based on fuzzy clustering unsupervised approaches. To this aim, the idea is to segment first the sensed data and recognize very basic urban classes (vegetation, roads, and built areas). Then, from these classes, we extract structures and infrastructures of interest. The initial clustering step is obtained by means of fuzzy logic concepts and the successive analyses are able to exploit the corresponding fuzzy partition. As a possible complete procedure for urban SAR images, they focus on the street tracking and extraction problem. Three road extraction algorithms available in literature (namely, the connectivity weighted Hough transform (CWHT), the rotation Hough transform, and the shortest path extraction) have been modified to be consistent with the previously computed fuzzy clustering results. Their different capabilities are applied for the characterization of streets with different width and shape. The whole approach is validated by the analysis of AIRSAR images of Los Angeles, CA.
Very high resolution hyperspectral data should be very useful to provide detailed maps of urban land cover. In order to provide such maps, both accurate and precise classification tools need, ...however, to be developed. In this letter, new methods for classification of hyperspectral remote sensing data are investigated, with the primary focus on multiple classifications and spatial analysis to improve mapping accuracy in urban areas. In particular, we compare spatial reclassification and mathematical morphology approaches. We show results for classification of DAIS data over the town of Pavia, in northern Italy. Classification maps of two test areas are given, and the overall and individual class accuracies are analyzed with respect to the parameters of the proposed classification procedures.
BackgroundMedical devices used in clinical practice are often associated with biofilm-associated staphylococcal infections MethodsAn in vitro antibiotic susceptibility assay of Staphylococcus aureus ...biofilms using 96-well polystyrene tissue-culture plates was performed to test the effects of RNAIII-inhibiting peptide (RIP), ciprofloxacin, imipenem, and vancomycin. Efficacy studies were performed using a rat model of central venous catheter (CVC)–associated infection. Twenty-four hours after implantation, the catheters were filled with RIP (1 mg/mL). Thirty minutes later, rats were challenged, via the CVC, with 1.0×106 cfu of S. aureus strain Smith diffuse. The antibiotic-lock technique was begun 24 h later ResultsMinimum inhibitory concentrations of antibiotics in biofilms were at least 4-fold higher than those against the freely growing planktonic cells. When they were first treated with RIP, the cells in biofilms became as susceptible to antibiotics as did planktonic cells. These data were confirmed by the in vivo studies. In particular, when CVCs were treated with both RIP and antibiotics, the biofilm bacterial load was further reduced to 1×101 cfu/mL, and bacteremia was not detected, suggesting that there was 100% elimination of bacteremia and a 6 log10 reduction in biofilm bacterial load ConclusionRIP significantly reduces bacterial load and enhances the effect of antibiotics in the treatment of CVC-associated S. aureus infections
Three experiments examined the effects of unconsciously presented picture primes on semantic categorization and naming responses to both word and picture targets. Picture naming and word ...categorization responses to targets were faster and more accurate when the picture primes belonged to the same semantic category as the targets, so called priming effect. No priming was found when subjects performed a word reading task. When priming was evident, no difference was found between responses to targets that were nominally identical to primes (e.g. the picture of a lion followed by either the word LION or the picture of a lion) compared with nominally different targets from the same semantic category as the primes (e.g. the picture of an ELEPHANT followed by either the word LION or the picture of a lion). Responding did not differ significantly from chance when subjects were asked to categorize the primes as natural objects vs. artifacts or as meaningful vs. meaningless objects in three distinct forced-choice unspeeded tasks.
Conference Calls and Stock Price Volatility in the Post-Reg FD Era Dell'Acqua, Alberto; Perrini, Francesco; Caselli, Stefano
European financial management : the journal of the European Financial Management Association,
03/2010, Letnik:
16, Številka:
2
Journal Article
Recenzirano
Past research has documented that the utilisation of conference calls is greater in the high tech sector than in other industries. Do high tech firms benefit from that? This study attempts to answer ...this question by examining the impact of ‘post‐Reg FD’ conference calls on the price volatility of high tech firms listed in the US market. We find evidence that more open conference calls results in lower idiosyncratic volatility.
We present some improvements to urban area characterization by means of synthetic aperture radar (SAR) images using multitemporal and multiangle datasets. The first aim of this research is to show ...that a temporal sequence of satellite SAR data may improve the classification accuracy and the discriminability of land cover classes in an urban area. Similarly, a second point worth discussing is to what extent multiangle SAR data allows extracting complementary urban features, exploiting different acquisition geometries. To these aims, in this paper, we show results on the same urban test site (Pavia, northern Italy), referring to a sequence of European Remote Sensing Satellite 1/2 (ERS-1/2) C-band images and to a set of simulated X-band data with a finer spatial resolution and different viewing angles. In particular, the multitemporal data is analyzed by means of a novel procedure based on a neuro-fuzzy classifier whose input is a subset of the ERS sequence chosen using the histogram distance index. Instead, the multiangle dataset is used to provide a better characterization of the road network in the area, overcoming effects due to the orientation of the SAR sensor.
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