A young woman presented with an acute ST-segment elevation myocardial infarction. Her clinical course was complicated by cardiogenic shock and acute renal failure. Work-up revealed thrombocytopenia ...and hemolytic anemia. A diagnosis of atypical hemolytic-uremic syndrome was made on the basis of clinical and pathological findings. (Level of Difficulty: Intermediate.)
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The prevalence of atrial fibrillation (AF) and heart failure increases with advancing age. It is estimated that the annual incidence of AF in the general heart failure population is approximately 5%, ...whereas as many as 40% of patients with advanced heart failure have AF. The goals of therapy in patients with heart failure and AF are symptom control and prevention of arterial thromboembolism. The adverse hemodynamic events of AF may lead to symptom deterioration and reduced exercise capacity. This review addresses the impact of AF on heart failure outcomes as they pertain to prognosis and management.
Heart failure (HF) and obesity are commonly seen in the USA. Although obesity is associated with traditional cardiovascular disease, its relationship with HF is complex. Obesity is an accepted risk ...factor for incident HF. However, in patients with established HF, there exists a paradoxical correlation, with escalating BMI incrementally protective against adverse outcomes. Despite this relationship, patients with HF may desire to lose weight to reduce comorbidities or to improve quality of life. Thus far, studies have shown that intentional weight loss in obese patients with HF does not increase risk, with strategies including dietary modification, physical activity, pharmacotherapy, and/or surgical intervention.
Multivariate Cox proportional hazard regression analysis was adjusted for sex, DM, race, ischemic time, dialysis, life support, VAD use, wait time & HLA mismatch.
Multivariate Cox proportional hazard regression analysis was adjusted for age, sex, DM, race, ischemic time, dialysis, life support, VAD use, wait time & HLA mismatch.
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