Liste des auteurs Aragon, Adeline; Aragon, Sandrine; Bak, Marcel ...
Lectrices d'Ancien Régime,
07/2016
Journal Article
Adeline AragonUniversité de Toulouse II-Le Mirail Sandrine AragonUniversité de Lille III Cathleen M. BauschatzUniversité du Maine, USA Marcel BakUniversité de Paris IV Catherine BeaudryDickinson ...College, Pennsylvania Jean-Philippe BeaulieuUniversité de Montréal Nadine BérenguierUniversité du New-Hampshire Marc-André BernierUniversité du Québec, Trois-Rivières Marie-Françoise BosquetUniversité de La Réunion Pollie BromilowUniversité Paris XII Isabelle Brouard-ArendsUniversité de Rennes 2 C...
Many calcium-mediated effects in mammalian cells may be activated by calcium-calmodulin stimulated enzymes. These effects are inhibited by various antidepressant drugs which bind to and inactivate ...calmodulin. In the current study, calmodulin was identified by affinity chromatography and gel electrophoresis in the cytoplasm of dispersed rat pancreatic acinar cells. Its role in enzyme secretion was assessed by evaluating the effects of various antidepressants drugs on the enzyme secretory process. Chlorpromazine, trifluoperazine, thioridazine, chlorprothixene and amitriptyline inhibited amylase secretion stimulated by carbachol, A-23187, and cholecystokinin-pancreozymin but not that elicited by dibutyryl cyclic AMP secretin or vasoactive intestinal peptide (VIP). Haloperidol, sulpiride, phenobarbital, and ethanol were without effect on secretagogue-stimulated enzyme release. Only those agents which blocked secretion also inhibited 45Ca release stimulated by carbachol from isotope preloaded cells. The data suggest that calmodulin may have a functional role in pancreatic enzyme secretion.
