Green infrastructure (GI) revitalizes vegetation and soil, restores hydro-ecological processes destroyed by traditional urbanization, and naturally manages stormwater on-site, offering numerous ...sustainability benefits. However, despite being sustainable and despite being the object of unrelenting expert advocacy for more than two decades, GI implementation remains slow. On the other hand, the practice of traditional gray infrastructure, which is known to have significant adverse impacts on the environment, is still ubiquitous in urban areas throughout the world. This relationship between knowledge and practice seems unaccountable, which has not yet received adequate attention from academia, policy makers, or research communities. We deal with this problem in this paper. The specific objective of the paper is to explore the barriers to GI, and suggest policies that can both overcome these barriers and expedite implementation. By surveying the status of implementation in 10 US cities and assessing the relevant city, state and federal policies, we identified 29 barriers and grouped them into 5 categories. The findings show that most of the barriers stem from cognitive limitations and socio-institutional arrangements. Accordingly, we suggest 33 policies, also grouped into 5 categories, which span from conducting public education and awareness programs to changing policies and governance structures.
•Green infrastructure manages urban stormwater on-site and offers numerous sustainability benefits.•Unfortunately, the pace of implementation of the technology is frustratingly slow.•We explore the barriers to implementation of the technology.•We suggest policies that can both overcome the barriers and expedite implementation.
Coronavirus disease (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The symptoms of the disease range from asymptomatic to mild respiratory ...symptoms and even potentially life-threatening cardiovascular and pulmonary complications. Cardiac complications include acute myocardial injury, arrhythmias, cardiogenic shock and even sudden death. Furthermore, drug interactions with COVID-19 therapies may place the patient at risk for arrhythmias, cardiomyopathy and sudden death. In this review, we summarise the cardiac manifestations of COVID-19 infection and propose a simplified algorithm for patient management during the COVID-19 pandemic.
•6.2% CZTS/CdS solar cell without AR coating.•QE modeling shows less than half the thickness of the CZTS layer contributes to photocurrent.•Detailed characterization of the CZTS cell properties.
We ...report the performance of Cu2ZnSnS4 (CZTS) thin film solar cell that showed efficiency in the range of 6.2% without an anti-reflection coating. Initially, the CZTS precursor film was co-sputtered using three different targets; copper (Cu), tin sulfide (SnS) and zinc sulfide (ZnS). The Cu target was subjected to DC power, and RF power was used for the SnS and ZnS targets. The as-grown CZTS film was sulfurized in a H2S/N2 environment at 525°C, which re-crystalized the film with grain sizes in the range of 1μm. Cadmium sulfide (CdS) was used as the n-type layer. Current–voltage (I–V), quantum efficiency (QE) and capacitance–voltage (C–V) measurements were used to characterize the cell device. The modeling and analysis of QE and CV data showed that a significant portion of the CZTS layer did not contribute to the photo-generation. Optimizing CZTS phase purity, improving QE in the broader wavelength region, and increasing minority carrier lifetime are necessary steps to further improve CZTS device performance.
S-net is a large-scale ocean bottom (OB) network in the Japan Trench area, consisting of inline-type 150 observatories equipped with seismometers and pressure gauges. Among them, 41 observatories ...have been buried about one meter beneath the seafloors in the shallow water regions (water depth <1500 m). We analyzed the strong-motion data recorded at the S-net sites from earthquakes with magnitudes 3.5 <
M
w
≤ 7 and focal depths < 70 km to understand the site amplification effect on the recorded motions. We used the spectral inversion technique and obtained some fundamental properties of the earthquake source spectra, path attenuation, and site factors from the horizontal-component S-wave portions of the recordings. We obtained that the source spectra followed the
ω
-
2
source model generally well, and the estimated magnitudes were mostly within ± 0.3 magnitude units of the catalog magnitudes. The stress drops increased systematically with the focal depths, and the values for the shallow earthquakes in the Pacific Plate were higher than those for the interplate earthquakes with comparable focal depths. The path-averaged quality factors were generally frequency-dependent and were somewhat larger than those in the past studies. The peak site frequencies ranged between about 0.2 and 10 Hz, while the peak amplification factors ranged between 10 and 50. Even though the peak frequencies and amplification factors differed from site to site, the peak frequencies were mostly higher than 2 Hz at the outer trench stations, while they were lower than 2 Hz at many inner trench stations. The amplification factors at a few OB sites in the shallow water regions were comparable with the theoretical ones computed from the 1-D subsea model. The amplification factors at intermediate frequencies (~ 0.3 to 2 Hz) generally increased with P-wave travel time in the sediments estimated from the multi-channel seismic survey. At about 20% of the sites (mainly at the unburied stations), spurious site spectra were recognized at frequencies higher than about 4 Hz. If the site spectra between 4 and 10 Hz are required, using only the X-component records is recommended.
Graphical Abstract
Diagnosis and management of hematopoietic cell transplant-associated thrombotic microangiopathy (TA-TMA) are very complex and controversial, given multiple ongoing issues and comorbidities in sick ...transplant recipients. Complement activation via classic and alternative pathways is emerging as a potential pathogenetic mechanism in the development of TA-TMA. Complement-centric diagnostic strategy using functional and genetic tests may possibly support diagnosis, enhance molecular understanding and direct drug development. Complement blockade using eculizumab has shown some promising rates of hematologic responses, however, survival may still be poor. Early discontinuation of calcineurin inhibitor where feasible, use of eculizumab, aggressive infection prophylaxis, close monitoring and early treatment of potential complications including GvHD and organ failure may improve outcomes. A number of complement inhibitors are in the development and may change treatment paradigm. Future studies are important to better understand TA-TMA as a disease process and may aim to confirm the role of complement activation in TA-TMA, enhance diagnostic strategy, determine therapeutic approaches and strategies to reduce the risk of other complications particularly infection and GvHD.
Published information on snakebite is rare in Bhutan although remarkably higher number of snakebites and associated deaths are reported from other South Asian countries.
Structured questionnaire was ...used to collect knowledge of health workers in snakebite management and health seeking behavior of snakebite victims as observed by health workers. Study was conducted in purposively sampled 10 Dzongkhags (district level administrative units) with higher incidence of snakebites.
Heath workers scored 27-91% (with an average of 63%, SD = 14) for 52 questions related to snake identification and snakebite management. Among 118 health workers interviewed, 23% had adequate knowledge on snakes and snakebite management while 77% had inadequate knowledge. Among 32 Doctors, 63% of them scored above or equal to 75%. Health workers from Sarpang scored higher (76%, SD = 11) than those from other Dzongkhags. Snakebite victim's visit to local (traditional) healers prior to seeking medical help from hospital was observed by 75 (63%) health workers. Fifty one percent of health workers observed patients treated with local methods such as the use of black stone called Jhhar Mauro (believed to absorb snake venom), application of honey, rubbing of green herbal paste made up of Khenpa Shing (Artemisia myriantha Wallich ex Besser var. paleocephala Pamp Ling) and consumption of fluid made up of Neem leaf (Azadirachta indica Juss). Use of tight tourniquet as a first aid to snakebite was observed by 80% of the health workers.
Health workers lack confidence in snakebite management. Snakebite victims are likely to suffer from harmful local practices and traditional beliefs on local treatment practices. Empowering health workers with adequate knowledge on snakebite management and making locals aware in pre-hospital care of snakebites are needed to improve the pre- and in-hospital management of snakebite in Bhutan.
Abstract Background Pulmonary hypertension and associated right ventricular (RV) dysfunction are important determinants of morbidity and mortality, which are optimally characterized by invasive ...hemodynamic measurements. Objectives This study sought to determine whether metabolite profiling could identify plasma signatures of right ventricular-pulmonary vascular (RV-PV) dysfunction. Methods We measured plasma concentrations of 105 metabolites using targeted mass spectrometry in 71 individuals (discovery cohort) who underwent comprehensive physiological assessment with right-sided heart catheterization and radionuclide ventriculography at rest and during exercise. Our findings were validated in a second cohort undergoing invasive hemodynamic evaluations (n = 71), as well as in an independent cohort with or without known pulmonary arterial (PA) hypertension (n = 30). Results In the discovery cohort, 21 metabolites were associated with 2 or more hemodynamic indicators of RV-PV function (i.e., resting right atrial pressure, mean PA pressure, pulmonary vascular resistance PVR, and PVR and PA pressure-flow response ΔPQ during exercise). We identified novel associations of RV-PV dysfunction with circulating indoleamine 2,3-dioxygenase (IDO)–dependent tryptophan metabolites (TMs), tricarboxylic acid intermediates, and purine metabolites and confirmed previously described associations with arginine–nitric oxide metabolic pathway constituents. IDO-TM levels were inversely related to RV ejection fraction and were particularly well correlated with exercise PVR and ΔPQ. Multisite sampling demonstrated transpulmonary release of IDO-TMs. IDO-TMs also identified RV-PV dysfunction in a validation cohort with known risk factors for pulmonary hypertension and in patients with established PA hypertension. Conclusions Metabolic profiling identified reproducible signatures of RV-PV dysfunction, highlighting both new biomarkers and pathways for further functional characterization.
Magnetic flux trapped during the cooldown of superconducting radio-frequency cavities through the transition temperature due to incomplete Meissner state is known to be a significant source of ...radio-frequency losses. The sensitivity of flux trapping depends on the distribution and the type of defects and impurities which pin vortices, as well as the cooldown dynamics when the cavity transitions from a normal to superconducting state. Here we present the results of measurements of the flux trapping sensitivity on 1.3 GHz elliptical cavities made from large-grain niobium with different purity for different cooldown dynamics and surface treatments. The results show that lower purity material results in a higher fraction of trapped flux and that the trapped flux sensitivity parameterSis significantly affected by surface treatments but without much change in the mean free pathl. We discuss our results within an overview of published data on the dependencies ofS(l,f)onland frequencyfusing theoretical models of rf losses of elastic vortex lines driven by weak rf currents in the cases of sparse strong pinning defects and collective pinning by many weak defects. Our analysis shows how multiscale pinning mechanisms in cavities can result in a maximum inS(l)similar to that observed by the FNAL and Cornell groups and how pinning characteristics can be extracted from the experimental data. Here the main contribution toScome from weak pinning regions at the cavity surface, where dissipative oscillations along trapped vortices perpendicular to the surface propagate into the bulk well beyond the layer of rf screening current. However, the analysis ofSas a function of only the mean free path is incomplete since cavity treatments change not onlylbut pinning characteristics as well. The effect of cavity treatments on pinning is primarily responsible for the change ofSwithout much effect onlobserved in this work. It also manifests itself in different magnitudes and peak positions inS(l), and scatter of theS-data coming from the measurements on different cavities which have undergone different treatments affecting bothland pinning. Optimizations of flux pinning to reduce flux sensitivity at low rf fields is discussed.
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