Background: Implant sealing capability is a crucial issue in assessment of implant success and peri‐implant marginal bone loss. Clinical studies demonstrated presence of viable bacteria in the ...internal part of functioning implants during tissue healing. For this study, a volatile organic compounds (VOCs) emission test was developed to evaluate the existing “seal” between implant and healing screw. Two kinds of implant–screw connection were compared: 1) internal hexagon; and 2) cone Morse.
Methods: Fifteen patients were enrolled in the study, three males and 12 females, who required fixed prosthetic rehabilitation. A total of 37 implants was placed, 23 with a cone Morse taper internal connection and 14 with a screw‐retained internal hexagon abutment. VOCs real‐time measures were performed in the implant site immediately after removing the healing screw.
Results: Statistical analysis was carried out. Results showed VOCs maximum peak amplitude in cone Morse versus internal hexagon showed significant difference (P <0.001), whereas VOCs time to peak showed no significant difference (P = 0.7).
Conclusions: Use of the new methodology for the VOCs emission test may lead to important new data for understanding how the “failed” attachment of implant components, in two‐part assemblies, may contribute to implant losses. In particular, study results support the hypothesis that the microgap of the implant–screw healing junction could cause differences in bacterial penetration. VOCs emission test evaluation represents a new diagnostic tool with an effective approach to quickly analyze, in real time, sealing capability of dental implants with healing screw interfaces.
Abstract
In the framework of LATINO project (Laboratory in Advanced Technologies for INnOvation) funded by Lazio regional government, the commissioning of the TEst stand for X-band (TEX) facility has ...started in 2021 at Frascati National Laboratories of INFN. Born as a collaboration with CERN to test high gradient accelerating structures, during 2022 TEX aims at feeding the first EuPRAXIA@SPARC_LAB X-band structure prototype. During 2021 the commissioning has been successfully carried out up to 48 MW. The power unit is driven by an X-band low level RF system, that employs a commercial S-band (2.856 GHz) Libera digital LLRF (manufactured by Instrumentation Technologies), with an up/down conversion stage and a reference generation and distribution system able to produce coherent frequencies for the American S-band and European X-band (11.994 GHz), both designed and realized at LNF. The performance of the system, with a particular focus on amplitude and phase resolution, together with klystron and driver amplifier jitter measurements, will be reviewed in this paper. Moreover, considerations on its suitability and main limitations in view of EuPRAXIA@SPARC_LAB project will be discussed.
The PADME beam line Monte Carlo simulation Bossi, F.; Branchini, P.; Buonomo, B. ...
The journal of high energy physics,
09/2022, Letnik:
2022, Številka:
9
Journal Article
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A
bstract
The PADME experiment at the DAΦNE Beam-Test Facility (BTF) of the INFN Laboratory of Frascati is designed to search for invisible decays of dark sector particles produced in ...electron-positron annihilation events with a positron beam and a thin fixed target, by measuring the missing mass of single-photon final states. The presence of backgrounds originating from beam halo particles can significantly reduce the sensitivity of the experiment. To thoroughly understand the origin of the beam background contribution, a detailed G
eant
4-based Monte Carlo simulation has been developed, containing a full description of the detector together with the beam line and its optical elements. This simulation allows the full interactions of each particle to be described, both during beam line transport and during detection, a possibility which represents an innovative way to obtain reliable background predictions.
Surgical resection is a first-line curative option for hepatocellular carcinoma, but its role is still unclear in elderly patients. The aim of our study was to compare short- and long-term outcomes ...of laparoscopic and open liver resection in elderly patients with hepatocellular carcinoma.
The study included 665 consecutive hepatocellular carcinoma liver resection cases in patients with ≥70 years of age treated in eight European hospital centres. Patients were divided into laparoscopic and open liver resection groups. Perioperative and long-term outcomes were compared between these groups.
After a 1:1 propensity score matching, 219 patients were included in each group. Clavien-Dindo grades III/IV (6 vs. 20%, p = 0.04) were lower in the laparoscopic than in the open matched group. Hospital stay was shorter in the laparoscopic than in the open matched group (5 vs. 7 days, p < 0.001). There were no significant differences between laparoscopic and open groups regarding overall survival and disease-free survival at 1-, 3- and 5- year periods.
Laparoscopic liver resection for hepatocellular carcinoma is associated with good short-term outcomes in patients with ≥70 years of age compared to open liver resection. Laparoscopic liver resection is safe and feasible in elderly patients with hepatocellular carcinoma.
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Laparoscopic liver resection (LLR) and radiofrequency ablation (RFA) represented potential treatments for patients with a single hepatocellular carcinoma (HCC) smaller than 3 cm. As the aging ...population soared, our study aimed to examine the advantage/drawback balance for these treatments, which should be reassessed in elderly patients.
A multicentric retrospective study compared 184 elderly patients (aged >70 years) (86 patients underwent LLR and 98 had RFA) with single ≤3 cm HCC, observed from January 2009 to January 2019.
After propensity score matching (PSM), the estimated 1- and 3-year overall survival rates were 96.5 and 87.9% for the LLR group, and 94.6 and 68.1% for the RFA group (p = 0.001) respectively. The estimated 1- and 3-year disease-free survival rates were 92.5 and 67.4% for the LLR group, and 68.5 and 36.9% for the RFA group (p = 0.001). Patients with HCC of anterolateral segments were more often treated with laparoscopic resection (47 vs. 36, p = 0.04). The median operative time in the resection group was 205 min and 25 min in the RFA group (p = 0.01). Length of hospital stay was 5 days in the resection group and 3 days in the RFA group (p = 0.03).
Despite a longer length of hospital stay and operative time, LLR guarantees a comparable postoperative course and a better overall and disease-free survival in elderly patients with single HCC (≤3 cm), located in anterolateral segments.
The real-time exhaled volatile organic compounds (VOCs) have been suggested as a new biomarker to detect and monitor physiological processes in the respiratory system. The VOCs profile in exhaled ...breath reflects the biochemical alterations related to metabolic changes, organ failure, and neuronal activity, which are, at least in part, transmitted via the lungs to the alveolar exhaled breath. Breath analysis has been applied to investigate cancer, lung failure, and neurodegenerative diseases. There are by far no studies on the real-time monitoring of VOCs in sensory stimulation in healthy subjects. Therefore, in this study we investigated the breath parameters and exhaled VOCs in humans during sensory stimulation: smell, hearing, sight, and touch. Responses sensory stimulations were recorded in 12 volunteers using an iAQ-2000 sensor. We found significant effects of sensory stimulation. In particular, olfactory stimulation was the most effective stimulus that elicited the greatest VOCs variations in the exhaled breath. Since the olfactory pathway is distinctly driven by the hypothalamic and limbic circuitry, while other senses project first to the thalamic area and then re-project to other brain areas, the findings suggest the importance of olfaction and chemoreception in the regulation lung gas exchange. VOCs variations during sensory activation may become putative indicators of neural activity.
Summary
Human exposure to altitude is a model to study the role of oxygen in different areas of physiology and pathophysiology. The aim of this study was to evaluate whether a short exposure to ...hypoxia (5 days) combined with exercise, at altitude ranging from 900 m above sea level to 5895 m above sea level (Kilimanjaro Expedition) can modify seminal and reproductive hormonal parameter levels in human beings. During the ascent, blood oxygen saturation at 3.848 m above sea level was found to be decreased when compared to sea level (P < 0.02). The sperm forward motility at sea level after the expedition showed a significant reduction (P < 0.02). There were no changes in other seminal parameters among those compared. Determination of the hormonal plasma concentrations showed that baseline values of follicle‐stimulating hormone, total testosterone, prolactin and oestradiol were unchanged at sea level after the hypoxic experience, with respect to baseline values at sea level. On the other hand, luteinising hormone levels after altitudes trekking significantly increased compared to levels before the expedition (P < 0.05). Because of the short‐term exposure, we can assume that the reduced forward motility described here may result from the effects of the acute altitude hypoxia on spermatozoa during the epididymal transit where they mature acquiring their motility.
In recent years, increasing interest has been devoted to the susceptibility gene polymorphisms in type 1 diabetes (T1D) as well as in other autoimmune diseases. Among these, a nucleotide polymorphism ...of the gene encoding for the protein tyrosine phosphatase non-receptor type 22 (PTPN22) has been associated with T1D in several studies. The aim of this study is to define the frequency of the C1858T polymorphism in the PTPN22 gene in a cohort of 113 Caucasian patients (58 males and 55 females) with T1D, and to assess a possible correlation with a group of clinically relevant variables: age at onset, gender, diabetes-related autoantibodies, residual β-cell function and daily insulin requirement (IR) 6 months after diagnosis. Using a PCR-RFLP approach, we evidenced a 17.7% frequency of the PTPN22 C1858T polymorphism in diabetic patients, higher than the frequency showed in the general population. A statistically significant correlation between this polymorphism and higher levels of C-peptide at diagnosis and lower IR at 6 months from diagnosis was observed (P=0.001 and P=0.04). Moreover, 1858T variant carriers were more frequently positive for glutamic acid decarboxylase (GAD) autoantibodies at diagnosis than wild-type subjects (P=0.19). On the other hand, no significant difference regarding age at onset, gender distribution, insulinoma-associated 2 molecule (IA2) and islet cell antibodies (ICA) positivity was found. These findings, if adequately confirmed in the future and extended to larger samples, may characterize a subset of T1D patients with a defined genetic pattern, who may be eligible for trials aimed to preserve residual β-cell function in the coming years.
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