Immune checkpoint inhibitors are associated with a spectrum of cutaneous immune-related adverse events. While maculopapular eruptions are the most common cutaneous adverse event, scleroderma can ...rarely develop. Herein, we report a case of new-onset scleroderma associated with avelumab treatment in the setting of metastatic squamous cell carcinoma of the lung. The pathophysiology of immune checkpoint inhibitor-induced scleroderma is not completely understood. A proposed mechanism is discussed along with the clinical presentation of symptoms and associated therapeutic response in cancer treatment. This case contributes to the few existing reports of immune checkpoint inhibitor-induced scleroderma to better understand the implications in the management of cutaneous immune-related adverse events.
We give an analytical demonstration of the possibility to realize a simple magnonic demultiplexer based on induced transparency resonances. The demultiplexer consists on an Y-shaped waveguide with an ...input line and two output lines. Each line contains two grafted stubs at a given position far from the input line. We derive in closed form the analytical expressions for selective transfer of a single propagating mode through one line keeping the other line unaffected. This is performed through magnonic induced transparency resonances (MIT) characterized by a resonance squeezed between two transmission zeros. The existence of a complete transmission beside a zero transmission, enables to select a given frequency on one output line, by canceling the transmission on the second line as well as the reflection in the input line. Also, we show that despite the existence of a bifurcation of the input line on two output lines, the transmission through each line can be written following a Fano line shape. In addition, in order to understand better the scattering properties of the filtered resonances, we give the analytical expressions of Fano parameter q and quality factor Q of the MIT resonance in each line. The spatial distribution of the spin waves associated to different MIT resonances is performed through an analysis of the magnetization of these modes. Also, the effect of attenuation on the transmission spectra and the quality of demultiplexing is also discussed. The theoretical results are performed using the Green’s function approach which enables to deduce in closed form, the transmission and reflection coefficients as well as the densities of states.
Magnetic Demultiplexer Circuit with Four Channels Mouadili, A.; Akjouj, A.; El Boudouti, E. H. ...
Journal of experimental and theoretical physics,
06/2020, Letnik:
130, Številka:
6
Journal Article
Recenzirano
We present a magnetic demultiplexer that allows us to transfer a magnon from one guide to another without perturbation the other guides. The proposed devise is formed by introducing a resonant system ...between two infinite guides. The resonant system has the role of coupling the guides to allow the magnons to pass from one guide to another for a well-defined frequency. The filtered frequency depends on the lengths of the different elements that constitute the system. In the analytical calculations we demonstrate how to choose the geometrical parameters to get total transmission.
This is a comprehensive theoretical survey of acoustic wave propagation in layered materials including elastic, viscoelastic and piezoelectric layers. The phonon modes are particularly emphasized in ...the case of periodic multilayered structures such as superlattices though other layered materials such as adsorbed layers and quasiperiodic structures are also discussed. Besides the bulk waves propagating in the whole materials, specific attention is paid to the effect of inhomogeneities within the perfect superlattice such as a free surface (with or without a cap layer), a superlattice/substrate interface and a defect layer embedded in the superlattice. Such inhomogeneities are usually present in actual device structures as a support (substrate) or as a protection (cap layer) for the superlattice; the defect layers offer the possibility of wave filtering and sometimes they can be introduced as an imperfection during the epitaxial growth process. The superlattices are considered as semi-infinite or finite size structures. The symmetry of the materials are chosen such that the transverse acoustic waves are decoupled from the sagittal one (i.e., those having components of the acoustic displacement in the sagittal plane formed by the propagation direction and the normal to the interfaces). A general rule about the existence of localized surface modes in elastic, viscoelastic and piezoelectric semi-infinite superlattices with a free surface is presented. The adsorption of a hard material on the top of the superlattice (cap layer) has been shown to be appropriate for detecting experimentally high frequency guided modes within the adsorbed layer. Also, the superlattice/substrate interface may exhibit interface modes which are without analogue in the case of an interface between two homogeneous media. For a finite size superlattice, due to the interaction between the surface, interface and bulk waves, different localized and resonant modes are obtained and their properties are investigated. In particular, the effect of a buffer layer embedded between the superlattice and the substrate in confining guided modes in the superlattice is highlighted. These results are obtained in the frame of a Green’s function formalism that enables us to deduce the dispersion curves, local and total densities of states, as well as the transmission and reflection coefficients and the corresponding phase times. In particular, an exact relation between the density of states and the phase times is pointed out. The application of elastic layered periodic structures as acoustic mirrors that exhibit total reflection of waves for all incident angles and polarizations in a given frequency range is indicated. These structures may also be used as acoustic filters when a defect layer is inserted within the finite size layered structure. A discussion is also included about some spectroscopic techniques used to probe the acoustic waves such as Raman and Brillouin light scattering and other acoustic techniques such as the surface acoustic waves and the picosecond laser techniques among others. A comparison of the theoretical results with experimental data available in the literature is also presented and the reliability of the theoretical predictions is indicated. Finally, other acoustic wave properties in quasiperiodic structures are briefly reviewed.
Male germ cell tumor (GCT) is a highly curable malignancy, which exhibits exquisite sensitivity to cisplatin treatment. The genetic pathway(s) that determine the chemotherapy sensitivity in GCT ...remain largely unknown.
We studied epigenetic changes in relation to cisplatin response by examining promoter hypermethylation in a cohort of resistant and sensitive GCTs. Here, we show that promoter hypermethylation of RASSF1A and HIC1 genes is associated with resistance. The promoter hypermethylation and/or the down-regulated expression of MGMT is seen in the majority of tumors. We hypothesize that these epigenetic alterations affecting MGMT play a major role in the exquisite sensitivity to cisplatin, characteristic of GCTs. We also demonstrate that cisplatin treatment induce de novo promoter hypermethylation in vivo. In addition, we show that the acquired cisplatin resistance in vitro alters the expression of specific genes and the highly resistant cells fail to reactivate gene expression after treatment to demethylating and histone deacetylase inhibiting agents.
Our findings suggest that promoter hypermethylation of RASSF1A and HIC1 genes play a role in resistance of GCT, while the transcriptional inactivation of MGMT by epigenetic alterations confer exquisite sensitivity to cisplatin. These results also implicate defects in epigenetic pathways that regulate gene transcription in cisplatin resistant GCT.
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