Abstract
The length of rotor blades is showing continuous growth for future wind energy turbines leading to high bending moments, which must be transferred to the hub by the root section. As the ...growth of the root diameter is limited by factors such as transportability, motivation to improve the load carrying capacity without changing the geometry is high. Hybridisation with metals shows a possibility to intrinsically increase the bearing strength of fibre-reinforced plastics. This publication presents experimental investigations into hybrid laminates to be used in so-called T-joints for connecting rotor blades to the hub of the nacelle of a wind energy turbine. An overview is given about the bearing strength of several material combinations hybridising glass- and carbon fibre-reinforced plastics (GFRP, CFRP) with aluminium, titanium and steel alloys. A GFRP-steel-hybrid can be identified as a material with a high reinforcing effect even for low amounts of steel. A hybrid T-joint demonstrator is manufactured by resin infusion and tested under static tension. In comparison with a GFRP reference, a joining strength increase of about 33% is achieved for a steel content of 3%. Further coupon level tests reveal a weak spot in the transition zone between the monolithic GFRP region and full hybrid region as the static and fatigue resistance clearly decreases in comparison with monolithic GFRP and full hybrid references.
The European XFEL comprises three undulator systems. All of the systems use standardized mechanical, magnetic and control components. The key elements such as undulators, phase shifters and ...quadrupole movers as well as their controls are described, with special emphasis on the SASE1 undulator system, which was the first to become operational and has been lasing since May 2017. The role of these systems for the commissioning is outlined with special emphasis on beam‐based alignment, which was important to achieve first lasing. Radiation damage was observed. The exposure doses were measured with the online radiation dosimetry system. Countermeasures and latest results are reported, which are important for a high‐duty‐cycle machine such as the European XFEL.
The SASE1 undulator system and its commissioning are described in detail.
Amongst schizophrenia patients, a large subgroup of up to 25% also suffers from comorbid obsessive-compulsive symptoms (OCSs). The association between comorbid OCSs in these patients and ...neuropsychological impairment remains unclear and somewhat contradictory. Longitudinal approaches investigating the stability of OCS-associated cognitive deficits are missing.
Thirty-seven patients with schizophrenia and comorbid OCSs and 43 schizophrenia patients without OCS were assessed with a comprehensive cognitive test battery and compared at baseline and, again, 12 months later.
Schizophrenia patients with comorbid OCSs showed significant pronounced deficits, with increasing effect sizes over the 12-month assessment period in specific cognitive areas such as visuospatial perception and visual memory (WAIS-R block design, Rey-Osterrieth Complex Figure Test), executive functioning (perseveration in the Wisconsin Card Sorting test), and cognitive flexibility (Trail Making test B). These cognitive domains are correlated with OCS severity and are known to be candidate cognitive domains in obsessive-compulsive disorder (OCD).
OCSs in schizophrenia is associated with specific and longitudinally stable cognitive deficits, strongly arguing for at least partially overlapping neurobiological mechanisms with OCD. Prospective studies involving patients with at-risk mental states for psychosis are necessary to decipher the interaction of cognitive impairment and the clinical manifestations of schizophrenia and OCSs. This might facilitate the definition of patients at high risk for OCSs, an early detection of subclinical levels, therapeutic interventions, and clinical monitoring.
Objective
Obsessive–compulsive symptoms (OCS) constitute a major comorbidity in schizophrenia. Prevalence estimations of OCS for patients with at‐risk mental states (ARMS) for psychosis vary largely. ...It is unclear how ARMS patients with or without comorbid OCS differ regarding general psychosocial functioning, psychotic and affective symptoms and neurocognitive abilities.
Method
At‐risk mental states patients (n = 233) from the interventional trial PREVENT (Secondary Prevention of Schizophrenia) were stratified according to the presence or absence of comorbid OCS and compared on several clinical variables.
Results
Patients, who fulfilled the criteria for obsessive–compulsive disorder (OCD) or presented with subclinical OCS (ARMSposOCS sample), did not significantly differ from patients without OCS (ARMSnegOCS) with regard to gender, age, premorbid verbal intelligence and levels of education. Furthermore, similar severity of depressive syndromes, basic cognitive, attenuated psychotic and brief limited intermittent psychotic symptoms were found. However, ARMSposOCS patients showed more impairment of psychosocial functioning and higher general psychopathology. In contrast, they scored higher in cognitive tasks measuring working memory and immediate verbal memory.
Conclusion
Findings extend upon previous results due to the multidimensional assessment. Subsequent longitudinal studies might elucidate how comorbid OCS influence differential treatment response, especially to cognitive behavioural interventions and the transition rates to psychosis.
Metamemory describes the monitoring and knowledge about one's memory capabilities. Patients with schizophrenia have been found to be less able in differentiating between correct and false answers ...(smaller confidence gap) when asked to provide retrospective confidence ratings in previous studies. Furthermore, higher proportions of very-high-confident but false responses have been found in this patient group (high knowledge corruption). Whether and how these biases contribute to the early pathogenesis of psychosis is yet unclear. This study thus aimed at investigating metamemory function in the early course of psychosis.
Patients in an at-risk mental state for psychosis (ARMS, n = 34), patients with a first episode of psychosis (FEP, n = 21) and healthy controls (HCs, n = 38) were compared on a verbal recognition task combined with retrospective confidence-level ratings.
FEP patients showed the smallest confidence gap, followed by ARMS patients, followed by HCs. All groups differed significantly from each other. Regarding knowledge corruption, FEP patients differed significantly from HCs, whereas a statistical trend was revealed in comparison of ARMS and FEP groups. Correlations were revealed between metamemory, measures of positive symptoms and working memory performance.
These data underline the presence of a metamemory bias in ARMS patients which is even more pronounced in FEP patients. The bias might represent an early cognitive marker of the beginning psychotic state. Longitudinal studies are needed to unravel whether metacognitive deficits predict the transition to psychosis and to evaluate therapeutic interventions.
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