To investigate the incidence, clinical manifestations, and treatments of gonococcal tysonitis in men. We enrolled men with gonococcal tysonitis and men with gonococcal urethritis from January 2000 to ...December 2020. Demographic data, interval from non-marital sexual contact to the onset of symptoms of gonococcal tysonitis, occurrence sites, and manifestations were recorded for all patients. Ceftriaxone (1 g) was injected intramuscularly once daily for 5 days in patients with lesions comprising abscesses or nodules. A single dose of ceftriaxone (1 g) was injected intramuscularly in patients with sinus-like lesions. Incision and drainage were performed in patients with non-ruptured abscesses. Fifteen patients with gonococcal tysonitis (0.29%; 95% confidence interval: 0.15–0.44%) were observed among 5087 patients with gonococcal urethritis. The mean age was 38.64 years (range, 17–74 years). The mean gonococcal tysonitis incubation period was 6.02 ± 1.37 days (range, 2–11 days). Lesions were present in the right side of the preputial frenulum in seven patients (46.67%), in the left side of the preputial frenulum in six patients (40%), and in both sides of preputial frenulum in two patients (13.33%). The lesions manifested as abscesses in 7 patients (46.67%), nodules in six patients (40%), and sinus-like lesions in two patients (13.33%); all lesions exhibited tenderness. All 15 patients were cured after treatment. Gonococcal tysonitis is a rare local complication of gonorrhea. Gonococcal urethritis with concurrent gonococcal tysonitis was less common than gonococcal urethritis with concurrent paraurethral gonococcal infection or gonococcal urethritis with concurrent gonococcal epididymitis. Gonococcal tysonitis lesions manifest as abscesses, nodules, and sinus-like lesions. Treatment with ceftriaxone is effective for gonococcal tysonitis.
The study aimed to understand the incidence, site, skin lesion manifestations, and treatment of gonococcal infection of the glans skin. We enrolled men with gonococcal infection of the glans skin and ...men with gonococcal urethritis from January 2014 to February 2020. Demographic data, site of onset, and skin lesion manifestations were recorded for all patients. Ceftriaxone (1 g) was injected intramuscularly once daily for 5 days in patients with lesions comprising abscesses or nodules. A single dose of ceftriaxone (1 g) was injected intramuscularly in patients with pustules. Incision and drainage were performed in patients with nonruptured abscesses. Thirteen patients had gonococcal infection of the glans skin (0.65%; 95% confidence interval = 0.30, 1.01) among 1,989 patients with gonococcal urethritis. Mean age was 35.48 ± 2.37 (range = 26–45) years. Nonmarital sexual behavior patterns were genital–genital in eight patients (61.54%) and genital–oral in five patients (38.46%). All skin lesions occurred on the ventral side of the glans. Eleven patients (84.62%) had a single lesion and two (15.38%) had multiple lesions. The lesions manifested as abscesses in five patients (38.46%), nodules in five patients (38.46%), and pustules in three patients (23.08%). All lesions exhibited tenderness. All 13 patients were cured after treatment. The study shows that gonococcal infection of the glans skin is a rare local complication of gonorrhea. Lesions often occur on the ventral side of the glans, presenting as abscesses, nodules, and pustules. Ceftriaxone treatment was effective for gonococcal infection of the glans skin.
Inflammatory diseases may occur within the crypt beside the preputial frenulum in men. This study was performed to gain an understanding of the etiology, clinical manifestations, and management ...methods of cryptitis beside the preputial frenulum in men.
Thirteen patients treated for cryptitis beside the preputial frenulum served as the observation group, and 40 healthy individuals served as the control group. The patients' clinical manifestation was the presence of a yellowish oily substance embedded in the crypt. Wiping off the substance revealed a conical blind cavity-like structure with an opening diameter of 1 to 5 mm (2.8 ± 1.3 mm) and depth of 1 to 4 mm (2.5 ± 1.1 mm). No blind cavity-like structures in the crypt were found in the control group. The shortest distance between the opening edges of the bilateral crypts in the observation and control groups was 6 to 14 mm (10.3 ± 2.4 mm) and 2 to 10 mm (3.9 ± 1.9 mm), respectively, with a statistically significant difference. Examination for pathogens in the secretions from skin lesions showed that the three most common pathogens were Candida albicans, Staphylococcus aureus, and Escherichia coli. All patients recovered after antibiotic treatment.
A blind cavity-like structure in the crypt may be related to excessive width of the preputial frenulum. Cryptitis may be a secondary infection caused by smegma trapped in the blind cavity-like structure. Maintaining cleanliness in the frenulum area may help to prevent the occurrence of cryptitis. Antibiotic treatment is effective.
No studies have explored the risk factors for paraurethral duct dilatation following paraurethral duct infection by Neisseria gonorrhoeae in men undergoing ceftriaxone therapy. The present study was ...performed to explore the risk factors for paraurethral duct dilatation following paraurethral duct infection by N. gonorrhoeae in men undergoing ceftriaxone therapy and thus guide clinical interventions. We compared the demographic, behavioral, and clinical data of men with paraurethral duct infection by N. gonorrhoeae with and without dilatation of the paraurethral duct. Univariate analysis showed significant differences in age, disease course of the infected paraurethral duct, Chlamydia trachomatis infection in the paraurethral duct, and a history of paraurethral duct infection by N. gonorrhoeae between the patient and control groups (P<0.05). Multivariate logistic regression analysis showed consistent results (P<0.05). This study that shows delayed treatment may be a major risk factor for paraurethral duct dilatation secondary to paraurethral duct infection by N. gonorrhoeae in men. Age, C. trachomatis infection in the paraurethral duct, and a history of paraurethral duct infection by N. gonorrhoeae are also risk factors. Thus, educating patients to undergo timely therapy and treating the C. trachomatis infection may be effective interventions.
Gonococcal paraurethral duct infection in males has previously been regarded as a
local complication of urethral gonorrhea. To verify this, pathogens were
investigated in urethral secretions from 81 ...male patients with gonococcal
paraurethral duct infection. In patients with gonococcal infections of both the
urethra and the paraurethral duct, the times of onset of the first symptoms
associated with urethral gonorrheal and gonococcal paraurethral duct infection
were compared. Among 81 male patients with gonococcal paraurethral duct
infection, gonococci were detected in the urethras of 76 patients and no
pathogens were detected in the urethras of the remaining 5 patients. The first
symptom associated with urethral gonorrhea and gonococcal paraurethral duct
infection occurred simultaneously in 10 cases. In 7 cases, the first symptom of
gonococcal paraurethral duct infection occurred 2–4 days (2.29 ± 0.76 days)
earlier than that of urethral gonorrhea and in 59 cases, the first symptom of
urethral gonorrhea occurred 1–6 days (3.07 ± 1.19 days) earlier than that of
gonococcal paraurethral duct infection. This study shows that gonococcal
paraurethral duct infection in males can be caused by primary infection of
Neisseria gonorrhoeae.
To investigate the pathogen profile in men with inflammation of the paraurethral glands.
We enrolled 40 patients with first-onset, drug-naive inflammation of the paraurethral glands. Discharge from ...the lesions was collected for Gram staining. Microscopy was performed for screening for trichomonads and detecting Gram-negative intracellular diplococci within phagocytes. Cultures for detection of Neisseria gonorrhoeae, Ureaplasma urealyticum and other bacteria, and Chlamydia-trachomatis-associated antigens were performed. PCR was conducted for herpes simplex virus type 1 or 2.
From these 40 patients, there were nine microbial species, which included Gram-negative bacteria (23 cases, 54.8%), Gram-positive bacteria (15 cases, 35.7%) and other pathogens (4 cases, 9.5%). The top three pathogens were gonococci (38.1%), Staphylococcus aureus (16.7%) and Escherichia coli (14.3%).
Inflammation of paraurethral glands in men may be caused by a variety of pathogens and not just by gonococcal infection.
Gonococcal paraurethral duct infection in males has previously been regarded as alocal complication of urethral gonorrhea. To verify this, pathogens wereinvestigated in urethral secretions from 81 ...male patients with gonococcalparaurethral duct infection. In patients with gonococcal infections of both theurethra and the paraurethral duct, the times of onset of the first symptomsassociated with urethral gonorrheal and gonococcal paraurethral duct infectionwere compared. Among 81 male patients with gonococcal paraurethral ductinfection, gonococci were detected in the urethras of 76 patients and nopathogens were detected in the urethras of the remaining 5 patients. The firstsymptom associated with urethral gonorrhea and gonococcal paraurethral ductinfection occurred simultaneously in 10 cases. In 7 cases, the first symptom ofgonococcal paraurethral duct infection occurred 2–4 days (2.29 ± 0.76 days)earlier than that of urethral gonorrhea and in 59 cases, the first symptom ofurethral gonorrhea occurred 1–6 days (3.07 ± 1.19 days) earlier than that ofgonococcal paraurethral duct infection. This study shows that gonococcalparaurethral duct infection in males can be caused by primary infection ofNeisseria gonorrhoeae.
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