ABSTRACT
We report the discovery of the third tidally tilted pulsator, TIC 63328020. Observations with the TESS satellite reveal binary eclipses with an orbital period of 1.1057 d, and δ Scuti-type ...pulsations with a mode frequency of 21.09533 d−1. This pulsation exhibits a septuplet of orbital sidelobes as well as a harmonic quintuplet. Using the oblique pulsator model, the primary oscillation is identified as a sectoral dipole mode with l = 1, |m| = 1. We find the pulsating star to have $M_1 \simeq 2.5 \, {\rm M}_\odot$, $R_1 \simeq 3 \, {\rm R}_\odot$, and Teff, 1 ≃ 8000 K, while the secondary has $M_2 \simeq 1.1 \, {\rm M}_\odot$, $R_2 \simeq 2 \, {\rm R}_\odot$, and Teff, 2 ≃ 5600 K. Both stars appear to be close to filling their respective Roche lobes. The properties of this binary as well as the tidally tilted pulsations differ from the previous two tidally tilted pulsators, HD74423 and CO Cam, in important ways. We also study the prior history of this system with binary evolution models and conclude that extensive mass transfer has occurred from the current secondary to the primary.
Ivermectin (IVM) resistance of Cooperia spp. in cattle has become an increasing and global problem. The early detection of anthelmintic resistance (AR) is important to propose strategies to slow down ...the development of resistance and requires sensitive, reliable, economic high-throughput and practical tests. The purpose of the present study was to apply a larval migration inhibition test (LMIT) for evaluating IVM and MOX efficacy against well-characterized field isolates of Cooperia spp. infecting cattle in Brazil. Eight isolates were used for IVM and seven for MOX. The following EC50 values of IVM were observed for the isolates: susceptible, 1.16ηmol; Nova Alvorada do Sul I, 4.09ηmol (RF=3.52); Campo Grande BNA, 3.57ηmol (RF=3.07); Campo Grande TBR, 4.09ηmol (RF=3,52); Nova Alvorada do Sul II, 2.50ηmol (RF=2.15); Bandeirantes, 11.35ηmol (RF=9.78); Campo Grande II, 6.03ηmol (RF=5.20); and Porto Mortinho, 8.63ηmol (RF=7.44). For MOX, the following EC50 values were observed: susceptible, 0.75ηmol; Campo Grande BNA, 0.93ηmol (RF=1.24); Campo Grande TBR, 0.36ηmol (RF=0.48); Nova Alvorada do Sul II, 2.57ηmol (RF=3.42); Bandeirantes, 1.43ηmol (RF=1.90); Campo Grande II, 1.08ηmol (RF=1.44); and Porto Mortinho, 0.49ηmol (RF=0.65). The LMIT used in the present study can be a useful tool for in vitro evaluation of IVM, but not of MOX. However, such methodology cannot be used in large-scale studies yet. The isolates of Cooperia spp. showed various degrees of resistance to IVM, though remaining susceptible to MOX.
Abstract
We present the discovery of KELT-24 b, a massive hot Jupiter orbiting a bright (
V
= 8.3 mag,
K
= 7.2 mag) young F-star with a period of 5.6 days. The host star, KELT-24 (HD 93148), has a
...T
eff
=
K, a mass of
M
*
=
M
⊙
, a radius of
R
*
= 1.506 ± 0.022
R
⊙
, and an age of
Gyr. Its planetary companion (KELT-24 b) has a radius of
R
P
= 1.272 ± 0.021
R
J
and a mass of
M
P
=
M
J
, and from Doppler tomographic observations, we find that the planet’s orbit is well-aligned to its host star’s projected spin axis (
). The young age estimated for KELT-24 suggests that it only recently started to evolve from the zero-age main sequence. KELT-24 is the brightest star known to host a transiting giant planet with a period between 5 and 10 days. Although the circularization timescale is much longer than the age of the system, we do not detect a large eccentricity or significant misalignment that is expected from dynamical migration. The brightness of its host star and its moderate surface gravity make KELT-24b an intriguing target for detailed atmospheric characterization through spectroscopic emission measurements since it would bridge the current literature results that have primarily focused on lower mass hot Jupiters and a few brown dwarfs.
We present the discovery of KELT-24 b, a massive hot Jupiter orbiting a bright (V=8.3 mag, K=7.2 mag) young F-star with a period of 5.6 days. The host star, KELT-24 (HD 93148), has a ...Teff=-+65094950K, a mass of M*=+1.4600.0590.055Me, a radius of R*=1.506±0.022Re, and an age of +0.780.420.61Gyr. Its planetary companion (KELT-24 b) has a radius of RP=1.272±0.021RJ and a mass of MP=-+5.180.220.21MJ, and from Doppler tomographic observations, we find that the planet’s orbit is well aligned to its host star’s projected spin axis (l=-+2.63.65.1). The young age estimated for KELT-24 suggests that it only recently started to evolve from the zero-age main sequence. KELT-24 is the brightest star known to host a transiting giant planet with a period between 5 and 10 days. Although the circularization timescale is much longer than the age of the system, we do not detect a large eccentricity or significant misalignment that is expected from dynamical migration. The brightness of its host star and its moderate surface gravity make KELT-24b an intriguing target for detailed atmospheric characterization through spectroscopic emission measurements since it would bridge the current literature results that have primarily focused on lower mass hot Jupiters and a few brown dwarfs.
Aims of the study
The safety and efficacy of a hemostatic powder (HP) versus a control agent, absorbable gelatin sponge and thrombin (G + T), were assessed, using a validated, quantitative bleeding ...severity scale.
Methods
Subjects were randomized to receive HP (256 subjects) or G + T (132 subjects) for treatment of minimal, mild, or moderate bleeding at 20 investigational sites. The primary efficacy endpoint was non‐inferiority of HP relative to G + T for success at achieving hemostasis within 6 minutes. Secondary endpoints in rank order included: superiority of HP relative to G + T in mean preparation time; non‐inferiority of HP relative to G + T for achieving hemostasis within 3 min; superiority of HP relative to G + T for achieving hemostasis within 6 min; and superiority of HP relative to G + T for success for achieving hemostasis within 3 min.
Results
A total of 388 subjects were included in the primary efficacy analysis. At 6 min, hemostasis was achieved in 93.0% (238/256) of the HP group compared to 77.3% (102/132) of the G + T group (non‐inferiority P < 0.0001, superiority P < 0.0001). All secondary endpoints were met. Complications were comparable between treatment groups.
Conclusions
HP had superior rates of hemostasis, shorter preparation time, and a similar safety profile compared to G + T in this prospective, randomized trial using quantitative bleeding severity criteria.
Abstract Objective This study investigates whether health disparities exist in infants with hypertrophic pyloric stenosis (HPS), to identify factors affecting definitive treatment, and if more ...morbidity occurs. Methods A six-year retrospective analysis was performed on infants with HPS. Analysis of variance was used to evaluate the impact of socioeconomic factors on disease severity and hospitalization. General linear models were used to assess the impact of risk factors on the outcomes. Results There were a total of 584 infants. African-American’s had lower serum chloride ( p <0.001), higher bicarbonate ( p =0.001), and sodium levels ( p =0.006), adding to longer hospitalization than Whites ( p =0.03). Uninsured infants had lower sodium and chloride ( p <0.001) and higher bicarbonate ( p <0.001), resulting in a longer time to operation ( p =0.05) than privately insured infants. In multivariable analyses, African-American’s were associated with chloride ( p =0.002) and higher bicarbonate ( p =0.009) and uninsured status remained significantly associated with all electrolyte abnormalities. Conclusions African-American and poorly insured infants with HPS had greater risk of metabolic derangements. This required more time to correct dehydration and electrolytes, adding to longer hospitalizations.
We report the discovery of the third tidally tilted pulsator, TIC 63328020. Observations with the TESS satellite reveal binary eclipses with an orbital period of 1.1057 d, and \(\delta\) Scuti-type ...pulsations with a mode frequency of 21.09533 d\(^{-1}\). This pulsation exhibits a septuplet of orbital sidelobes as well as a harmonic quintuplet. Using the oblique pulsator model, the primary oscillation is identified as a sectoral dipole mode with \(l = 1, |m| = 1\). We find the pulsating star to have \(M_1 \simeq 2.5\, {\rm M}_\odot\), \(R_1 \simeq 3 \, {\rm R}_\odot\), and \(T_{\rm eff,1} \simeq 8000\) K, while the secondary has \(M_2 \simeq 1.1 \, {\rm M}_\odot\), \(R_2 \simeq 2 \, {\rm R}_\odot\), and \(T_{\rm eff,2} \simeq 5600\) K. Both stars appear to be close to filling their respective Roche lobes. The properties of this binary as well as the tidally tilted pulsations differ from the previous two tidally tilted pulsators, HD74423 and CO Cam, in important ways. We also study the prior history of this system with binary evolution models and conclude that extensive mass transfer has occurred from the current secondary to the primary.
The effect of dipalmitoyl phosphatidylcholine (DPPC)/dihexanoyl phosphatidylcholine (DHPC) bicelles on the microstructure of pig stratum corneum (SC) in vitro was evaluated. The physicochemical ...characterization of these nanoaggregates revealed small disks with diameters around 15 nm and a thickness of 5.4 nm. Upon dilution, the bicelles grow and transform into vesicles. Cryogenic scanning electron microscopy (cryo-SEM) images of the SC pieces treated with this system showed vesicles of about 200 nm and lamellar-like structures in the intercellular lipid areas. These vesicles probably resulted from the growth and molecular rearrangement of the DPPC/DHPC bicelles after penetrating the SC. The presence of lamellar-like structures is ascribed to the interaction of the lipids from bicelles with the SC lipids. The bicellar system used is suitable to penetrate the skin SC and to reinforce the intercellular lipid areas, constituting a promising tool for skin applications.
Objective:. We sought to confirm and extend the understanding of clinical outcomes following creation of a common distal autogenous access, the radiocephalic arteriovenous fistula (RCAVF). ...Background:. Interdisciplinary guidelines recommend distal autogenous arteriovenous fistulae as the preferred hemodialysis (HD) access, yet uncertainty about durability and function present barriers to adoption. Methods:. Pooled data from the 2014-2019 multicenter randomized-controlled PATENCY-1 and PATENCY-2 trials were analyzed. New RC-AVFs were created in 914 patients, and outcomes were tracked prospectively for 3-years. Cox proportional hazards and Fine-Gray regression models were constructed to explore patient, anatomic, and procedural associations with access patency and use. Results:. Mean (SD) age was 57 (13) years; 45% were on dialysis at baseline. Kaplan-Meier estimates of 3-year primary, primary-assisted, and secondary patency were 27.6%, 56.4%, and 66.6%, respectively. Cause-specific 1-year cumulative incidence estimates of unassisted and overall RC-AVF use were 46.8% and 66.9%, respectively. Patients with larger baseline cephalic vein diameters had improved primary (per mm, hazard ratio HR 0.89, 95% confidence intervals 0.81–0.99), primary-assisted (HR 0.75, 0.64–0.87), and secondary (HR 0.67, 0.57–0.80) patency; and higher rates of unassisted (subdistribution hazard ratio 1.21, 95% confidence intervals 1.02–1.44) and overall RCAVF use (subdistribution hazard ratio 1.26, 1.11–1.45). Similarly, patients not requiring HD at the time of RCAVF creation had better primary, primary-assisted, and secondary patency. Successful RCAVF use occurred at increased rates when accesses were created using regional anesthesia and at higher volume centers. Conclusions:. These insights can inform patient counseling and guide shared decision-making regarding HD access options when developing an individualized end-stage kidney disease life-plan.
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