We propose that the design and implementation of effectiveSocial Learning Analytics (SLA)present significant challenges and opportunities for both research and enterprise, in three important ...respects. The first is that the learning landscape is extraordinarily turbulent at present, in no small part due to technological drivers. Online social learning is emerging as a significant phenomenon for a variety of reasons, which we review, in order to motivate the concept of social learning. The second challenge is to identify different types of SLA and their associated technologies and uses. We discuss five categories of analytic in relation to online social learning; these analytics are either inherently social or can be socialised. This sets the scene for a third challenge, that of implementing analytics that have pedagogical and ethical integrity in a context where power and control over data are now of primary importance. We consider some of the concerns that learning analytics provoke, and suggest that Social Learning Analytics may provide ways forward. We conclude by revisiting the drivers and trends, and consider future scenarios that we may see unfold as SLA tools and services mature.
Open Technology-Enhanced Learning Ferguson, Rebecca; Scanlon, Eileen
Journal of Interactive Media in Education,
02/2024, Letnik:
2024, Številka:
1
Journal Article
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Editorial introducing this special issue on interdisciplinarity in open technology-enhanced learning, explaining its roots in the work of the OpenTEL group.
Porcupine O-acyltransferase (PORCN) is considered essential for Wnt secretion and signaling. However, we observed that PORCN inhibition does not phenocopy the effects of WNT4 knockdown in ...WNT4-dependent breast cancer cells. This suggests a unique relationship between PORCN and WNT4 signaling. To examine the role of PORCN in WNT4 signaling, here we overexpressed WNT4 or WNT3A in breast cancer, ovarian cancer, and fibrosarcoma cell lines. Conditioned media from these lines and co-culture systems were used to assess the dependence of Wnt secretion and activity on the critical Wnt secretion proteins PORCN and Wnt ligand secretion (WLS) mediator. We observed that WLS is universally required for Wnt secretion and paracrine signaling. In contrast, the dependence of WNT3A secretion and activity on PORCN varied across the cell lines, and WNT4 secretion was PORCN-independent in all models. Surprisingly, WNT4 did not exhibit paracrine activity in any tested context. Absent the expected paracrine activity of secreted WNT4, we identified cell-autonomous Wnt signaling activation by WNT4 and WNT3A, independent of PORCN or Wnt secretion. The PORCN-independent, cell-autonomous Wnt signaling demonstrated here may be critical in WNT4-driven cellular contexts or in those that are considered to have dysfunctional Wnt signaling.
Cyclin E-Cdk2 is known to regulate both DNA replication and centrosome duplication during the G1-S transition in the cell cycle
1–4, and disruption of centrosomes results in a G1 arrest in some cell ...types
5–7. Localization of cyclin E on centrosomes is mediated by a 20 amino acid domain termed the centrosomal localization sequence (CLS), and expression of the GFP-tagged CLS displaces both cyclin E and cyclin A from the centrosome
8. In asynchronous cells, CLS expression inhibits the incorporation of bromodeoxyuridine (BrdU) into DNA, an effect proposed to reflect a G1 arrest. Here we show in synchronized cells that the reduction in BrdU incorporation reflects not a G1 arrest but rather direct inhibition of the initiation of DNA replication in S phase. The loading of essential DNA replication factors such as Cdc45 and proliferating cell nuclear antigen onto chromatin is blocked by CLS expression, but DNA synthesis can be rescued by retargeting active cyclin E-Cdk2 to the centrosome. These results suggest that initial steps of DNA replication require centrosomally localized Cdk activity and link the nuclear cycle with the centrosome cycle at the G1-S transition.
► Displacement of cyclin E from centrosomes inhibits DNA synthesis ► DNA synthesis can be restored by retargeting cyclin E to centrosomes ► Restoration of DNA synthesis requires cyclin E binding to Cdk2 ► Centrosomal cyclin E promotes chromatin loading of Cdc45
Centrosomes are the major microtubule-organizing centers in animal cells and regulate formation of a bipolar mitotic spindle. Aberrant centrosome number causes chromosome mis-segregation, and has ...been implicated in genomic instability and tumor development. Previous studies have demonstrated a role for the DNA replication factors MCM5 and Orc1 in preventing centrosome reduplication. Cyclin A-Cdk2 localizes on centrosomes by means of a modular centrosomal localization sequence (CLS) that is distinct from that of cyclin E. Here, we show that cyclin A interacts with both MCM5 and Orc1 in a CLS-dependent but Cdk-independent manner. Although the MRAIL hydrophobic patch is contained within the cyclin A CLS, binding of both MCM5 and Orc1 to cyclin A does not require a wild-type hydrophobic patch. The same domain in MCM5 that mediates interaction with cyclin E also binds cyclin A, resulting in centrosomal localization of MCM5. Finally, unlike its function in DNA synthesis, MCM5-mediated inhibition of centrosome reduplication in S-phase-arrested CHO cells does not require binding to other MCM family members. These results suggest that cyclins E and A sequentially prevent centrosome reduplication throughout interphase by recruitment of DNA replication factors such as MCM5 and Orc1.
Visual discomfort is related to the statistical regularity of visual images. The contribution of luminance contrast to visual discomfort is well understood and can be framed in terms of a theory of ...efficient coding of natural stimuli, and linked to metabolic demand. While color is important in our interaction with nature, the effect of color on visual discomfort has received less attention. In this study, we build on the established association between visual discomfort and differences in chromaticity across space. We average the local differences in chromaticity in an image and show that this average is a good predictor of visual discomfort from the image. It accounts for part of the variance left unexplained by variations in luminance. We show that the local chromaticity difference in uncomfortable stimuli is high compared to that typical in natural scenes, except in particular infrequent conditions such as the arrangement of colorful fruits against foliage. Overall, our study discloses a new link between visual ecology and discomfort whereby discomfort arises when adaptive perceptual mechanisms are overstimulated by specific classes of stimuli rarely found in nature.
Many governments invest in digital education and deliver multi-faceted initiatives to develop the capacity of educational institutions and staff confidence in use of technology for enhanced learning ...and better student outcomes. However, the impact of these initiatives does not always result in improved technology-supported learning or successful digital educational products. Research shows many factors impede the achievement of such objectives. Yet, they are not well understood particularly in low-resourced educational settings. Thus, this paper as part of a larger study aimed to explore barriers to implementing TEL for higher education in low-resourced contexts and potential solutions from the perspective of educators, managers and support staff. The unique inclusion of support staff and management in this research provides a deeper understanding of current barriers to TEL, and the value of multi-stakeholder engagement to develop meaningful context-driven solutions. Using a qualitative oriented mixed-method approach underpinned by Beyond Prototypes conceptual model of TEL complex, the study found that most barriers and enablers of effective TEL implementation are related to the ecology in which it is practised, together with the influence of the salient communities. Findings also suggest that most stakeholders are aware and prioritise barriers related to their role, but have limited awareness of barriers faced by other stakeholders or how others perceived their role in supporting TEL. While the study supports findings of previous research, it adds further insight by considering the views of all implementing stakeholders and the relationships between them.
"Educational Visions looks to future developments in educational technology by reviewing its history, covering themes such as learning analytics and design, inquiry learning, citizen science, ...inclusion, and learning at scale. The book shows how successful innovations can be built over time, informs readers about current practice and demonstrates how they can use this work themselves. The chapters show how one research group has worked persistently over 40 years with four visions in mind, of a future where: • learning is accessible for everyone • teaching is adapted to meet learners’ needs • teams can successfully teach any number of students at a distance • learners engage enthusiastically with STEM learning. Each vision is covered in a pair of chapters: the first brings together four decades of research in the area; the second introduces current work, showing how they are united by a consistent framework and a persistent vision."
This response to Neil Selwyn’s paper, ‘What’s the problem with learning analytics?’, relates his work to the ethical challenges associated with learning analytics and proposes six ethical challenges ...for the field.
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