Data preservation in high energy physics Basaglia, T.; Bellis, M.; Blomer, J. ...
The European physical journal. C, Particles and fields,
09/2023, Letnik:
83, Številka:
9
Journal Article
Recenzirano
Odprti dostop
Data preservation is a mandatory specification for any present and future experimental facility and it is a cost-effective way of doing fundamental research by exploiting unique data sets in the ...light of the continuously increasing theoretical understanding. This document summarizes the status of data preservation in high energy physics. The paradigms and the methodological advances are discussed from a perspective of more than ten years of experience with a structured effort at international level. The status and the scientific return related to the preservation of data accumulated at large collider experiments are presented, together with an account of ongoing efforts to ensure long-term analysis capabilities for ongoing and future experiments. Transverse projects aimed at generic solutions, most of which are specifically inspired by open science and FAIR principles, are presented as well. A prospective and an action plan are also indicated.
In this paper we present newly launched services for open data and for long-term preservation and reuse of high-energy-physics data analyses based on the digital library software Invenio. We track ...the "data continuum" practices through several progressive data analysis phases up to the final publication. The aim is to capture for subsequent generations all digital assets and associated knowledge inherent in the data analysis process, and to make a subset available rapidly to the public. The ultimate goal of the analysis preservation platform is to capture enough information about the processing steps in order to facilitate reproduction of an analysis even many years after its initial publication, permitting to extend the impact of preserved analyses through future revalidation and recasting services. A related "open data" service was launched for the benefit of the general public.
This document summarizes the status of data preservation in high energy physics. The paradigms and the methodological advances are discussed from a perspective of more than ten years of experience ...with a structured effort at international level. The status and the scientific return related to the preservation of data accumulated at large collider experiments are presented, together with an account of ongoing efforts to ensure long-term analysis capabilities for ongoing and future experiments. Transverse projects aimed at generic solutions, most of which are specifically inspired by open science and FAIR principles, are presented as well. A prospective and an action plan are also indicated.
Data preservation is a mandatory specification for any present and future experimental facility and it is a cost-effective way of doing fundamental research by exploiting unique data sets in the ...light of the continuously increasing theoretical understanding. This document summarizes the status of data preservation in high energy physics. The paradigms and the methodological advances are discussed from a perspective of more than ten years of experience with a structured effort at international level. The status and the scientific return related to the preservation of data accumulated at large collider experiments are presented, together with an account of ongoing efforts to ensure long-term analysis capabilities for ongoing and future experiments. Transverse projects aimed at generic solutions, most of which are specifically inspired by open science and FAIR principles, are presented as well. A prospective and an action plan are also indicated.
Oral food challenge (OFC) is the criterion standard for diagnosis of acute food protein–induced enterocolitis syndrome (FPIES). No diagnostic/prognostic biomarkers are available, and OFC assessment ...criteria are not validated.
To assess clinical-hematological changes and predictors of severity of FPIES reactions at OFC.
This was an observational multicenter prospective study. Children aged 0 to 18 years diagnosed with acute FPIES were recruited at follow-up OFC in 12 tertiary centers in Spain and Italy. OFC outcomes (as positive/negative/inconclusive and mild/moderate/severe) were assessed on the basis of published “2017 FPIES Consensus” criteria. Clinical characteristics were recorded, and full blood cell count was done at baseline, reaction onset, and 4 hours later. Regression analysis was performed to assess predictors of severe reactions at OFC.
A total of 81 children had positive OFC (mild in 11% 9 of 81, moderate in 61% 49 of 81, and severe in 28% 23 of 81). Increase in neutrophils and reduction in eosinophils, basophils, and lymphocytes were observed (P < .05). OFC was inconclusive in 19 cases despite objective signs or neutrophilia. Regression analysis showed that a 2-day OFC protocol where only 25% of an age-appropriate portion is given on day 1 (not sex, age, culprit food, cumulative dose, and previous reaction severity) was associated with reduced odds of severe reaction compared with giving multiple doses in a single day.
Distinct hematological changes may help support FPIES diagnosis. Current OFC assessment criteria may not capture the broad spectrum of acute FPIES presentations. This 2-day protocol may be associated with a reduced risk of severe reactions. Future work should aim to develop safer OFC and non-OFC diagnostics for FPIES.
PDF
