The estuarine channel of Vitória Bay was evaluated regarding bioaccumulation of metals (Al, Ba, Mn, Fe, Zn, Cu, Cr, Pb, Ni, Cd, Hg) and As in mollusks. Mussels from an aquaculture farm and ...transplanted into the estuary, whereas oysters were collected in situ in the same area. Concentrations of Al, Mn, Fe, Cr and As were higher in P. perna, whereas C. rhizophorae bioaccumulated more Ba, Zn and Cu. Arsenic concentrations in P. perna exceeded the limit of the Brazilian legislation in the outer estuary. Salinity seemed to influence metal uptake differently for each bivalve, with P. perna absorbing more metal at higher salinities and C. rhizophorae in areas of lower salinity. Hazard index (HI) >1 revealed risk for both bivalves for high level consumers. Target Cancer Risk (TCR) for As revealed threat for human health associated with the consumption of mussels and oysters from the study area.
•The estuarine port channel of Vitória (ES), Brazil, was evaluated for metal pollution•Mussel Perna perna and oyster Crassostrea Rizophorae were used as biomonitors•Al, Ba, Zn, Cr, Cu, Pb, As, Mn, Fe, Pb, Ni, Cd, Hg were analyzed in bivalves’ tissues•Estimated Daily Intake, Hazard Index (HI), Target Cancer risk (TCR) were used•HI and TCR revealed health risk for consumption of mussels and oysters
Abstract
We investigate whether the sky rate of fast radio bursts (FRBs) depends on Galactic latitude using the first catalog of FRBs detected by the Canadian Hydrogen Intensity Mapping Experiment ...Fast Radio Burst (CHIME/FRB) Project. We first select CHIME/FRB events above a specified sensitivity threshold in consideration of the radiometer equation, and then we compare these detections with the expected cumulative time-weighted exposure using Anderson–Darling and Kolmogorov–Smirnov tests. These tests are consistent with the null hypothesis that FRBs are distributed without Galactic latitude dependence (
p
-values distributed from 0.05 to 0.99, depending on completeness threshold). Additionally, we compare rates in intermediate latitudes (∣
b
∣ < 15°) with high latitudes using a Bayesian framework, treating the question as a biased coin-flipping experiment–again for a range of completeness thresholds. In these tests the isotropic model is significantly favored (Bayes factors ranging from 3.3 to 14.2). Our results are consistent with FRBs originating from an isotropic population of extragalactic sources.
The present study developed an experimental metronidazole-based gel and evaluated its efficacy for the adjuvant treatment of chronic periodontitis. Sixteen patients were randomly allocated into two ...groups of eight subjects according to the following proposed treatments: (1) scaling and root planing (active control) or (2) scaling and root planing and direct periodontal intrapocket application of 15% metronidazole-based gel in two sites (≥5 mm in depth) (experimental group). Potential changes in the subgingival microbiota were assessed using a DNA Checkerboard method at three proposed times: baseline and following 7 or 30 days of drug administration. High-performance liquid chromatography (HPLC) monitored metronidazole concentrations in the crevicular fluid during treatment. The metronidazole experimental group presented lower bacterial counts than the control group at the three evaluated times (
p
< 0.01 for baseline,
p
< 0.001 for 7 or 30 days) when the target species were analyzed as a pool of bacteria. Samples revealed significantly lower counts 7 days after drug administration compared with baseline or after 30 days (
p
< 0.05). HPLC analysis detected gel 1 h after application. The metronidazole-based gel significantly decreased the total bacterial count at the three evaluated times. Periodontopathogenic species were not different after gel administration.
Abstract We present a framework for modeling astrophysical pulses from radio pulsars and fast radio bursts (FRBs). This framework, called fitburst , generates synthetic representations of dynamic ...spectra that are functions of several physical and heuristic parameters; the heuristic parameters can nonetheless accommodate a vast range of distributions in spectral energy. fitburst is designed to optimize the modeling of features induced by effects that are intrinsic and extrinsic to the emission mechanism, including the magnitude and frequency dependence of pulse dispersion and scatter broadening. fitburst removes intrachannel smearing through two-dimensional upsampling, and can account for phase-wrapping of “folded” signals that are typically acquired during pulsar-timing observations. We demonstrate the effectiveness of fitburst in modeling data containing pulsars and FRBs observed with the Canadian Hydrogen Intensity Mapping Experiment telescope.
The CHIME Pulsar Project: System Overview Amiri, M.; Bandura, K. M.; Boyle, P. J. ...
The Astrophysical journal. Supplement series,
07/2021, Letnik:
255, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Abstract
We present the design, implementation, and performance of the digital pulsar observing system constructed for the Canadian Hydrogen Intensity Mapping Experiment (CHIME). Using accelerated ...computing, this system processes independent, digitally steered beams formed by the CHIME correlator to simultaneously observe up to 10 radio pulsars and transient sources. Each of these independent streams is processed by the CHIME/Pulsar back-end system, which can coherently dedisperse, in real time, up to dispersion measure values of 2500 pc cm
−3
. The tracking beams and real-time analysis system are autonomously controlled by a priority-based algorithm that schedules both known sources and positions of interest for observation with observing cadences as rapid as 1 day. Given the distribution of known pulsars and radio-transient sources and the dynamic scheduling, the CHIME/Pulsar system can monitor 400–500 positions once per sidereal day and observe most sources with declinations greater than −20° once every ∼4 weeks. We also discuss the extensive science program enabled through the current modes of data acquisition for CHIME/Pulsar that centers on timing and searching experiments.
Medication non-adherence in patients with chronic obstructive pulmonary disease is common. The aim is to evaluate the efficacy of two interventions to improve the inhalation technique (IT) in ...patients with pulmonary disease is common. Also determine optimal IT reminder time and to test the role of preferences in the intervention selection.
726 pulmonary disease in common patients (consecutive sampling) from two trials: 1) TECEPOC-study (patients' preference trial/comprehensive cohort design) 2) TIEPOC-study (randomised controlled trial). Interventions: intervention-A (ad-hoc leaflet with instructions about correct IT according Spanish Respiratory Society), intervention B (intervention A+ individual training by instructors). Four visits were performed (baseline, 3, 6 and 12 months). Data on IT, sociodemographic and clinical characteristics, quality of life and respiratory drugs were recorded. Analysis under intention to treat principle. Multivariate analysis was conducted to measure the potential modifying factors of improvement in the IT along follow-up.
660 patients (90.9%) did not perform a correct IT at baseline 89.75% with Handihaler, 86.95% with Turbuhaler, 84.75% with Accuhaler and 87.35% with pMDI. At 12 months, 221 patients 29.9% performed correctly the IT; a decrease in the slope of the curve (correct IT) was detected at 3 months follow-up. Intervention B was the most effective in both trials compared to control group or intervention A, regardless of preferences: 1) TECEPOC Study (preference trial): Intervention B
control group, NNT = 3.22 (IC95%, 2.27-5.52); and
Intervention A, NNT = 3.57 (CI95%, 2.41-6.8). Preferences improved 6.7% in the correct IT without statistical significance. 2) TIEPOC Study (randomized controlled trial): Intervention B
control group, NNT = 1.74 (IC95%, 1.47-2.17), and
intervention A, NNT = 3.33 (CI 95%, 2.43-5.55). No differences were measured between Intervention A and control group.
Individual training significantly improves IT. Reminders every 3 months are recommended. Preferences do not influence the intervention effectiveness.
Abstract
We report the discovery of seven new Galactic pulsars with the Canadian Hydrogen Intensity Mapping Experiment’s Fast Radio Burst (CHIME/FRB) backend. These sources were first identified via ...single pulses in CHIME/FRB, then followed up with CHIME/Pulsar. Four sources appear to be rotating radio transients, pulsar-like sources with occasional single-pulse emission with an underlying periodicity. Of those four sources, three have detected periods ranging from 220 ms to 2.726 s. Three sources have more persistent but still intermittent emission and are likely intermittent or nulling pulsars. We have determined phase-coherent timing solutions for the latter two. These seven sources are the first discovery of previously unknown Galactic sources with CHIME/FRB and highlight the potential of fast radio burst detection instruments to search for intermittent Galactic radio sources.
Objectives
The oral rehydration solution is the most efficient method to treat cholera; however, it does not interfere in the action mechanism of the main virulence factor produced by Vibrio ...cholerae, the cholera toxin (CT), and this disease still stands out as a problem for human health worldwide. This review aimed to describe therapeutic alternatives available in the literature, especially those related to the search for molecules acting upon the physiopathology of cholera.
Key findings
New molecules have offered a protection effect against diarrhoea induced by CT or even by infection from V. cholerae. The receptor regulator cystic fibrosis channel transmembrane (CFTR), monosialoganglioside (GM1), enkephalinase, AMP‐activated protein kinase (AMPK), inhibitors of expression of virulence factors and activators of ADP‐ribosylarginine hydrolase are the main therapeutic targets studied. Many of these molecules or extracts still present unclear action mechanisms.
Conclusions
Knowing therapeutic alternatives and their molecular mechanisms for the treatment of cholera could guide us to develop a new drug that could be used in combination with the rehydration solution.
This work reports the synthesis of kappa-carrageenan aerogels using different dissolution and crosslinking media in order to evaluate its effects on the textural properties of the matrixes and ...further on the drug loading and release performance. The different aerogel samples were produced through the dissolution of the biopolymer in water with addition of potassium salts as crosslinking agents and, in two different ionic liquids (ILs) derived from imidazolium ion, being further dried with supercritical CO2. The samples were characterized by Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR), Scanning Electron Microscopy (SEM), Nitrogen Adsorption-Desorption Analysis, Thermogravimetry (TGA) and Differential Scanning Calorimetry (DSC). The synthesized samples presented surface areas similar to the carrageenan aerogels being their structure constituted mainly by meso and macropores. The absence of ionic liquid in samples was demonstrated by DSC analysis and was corroborated by the cytotoxicity assays which revealed that cellular viability in Caco-2 cells was preserved. Tetracycline was used as a model drug and loaded in two of the prepared aerogels samples. The release experiments were performed with the composites to test in vitro drug release at physiologic pH. With a higher macroporosity, the kappa-carrageenan aerogel prepared by dissolution into ionic liquid showed a higher loading capacity than the one prepared by dissolution into water and a slightly higher release rate. The matrixes were considered to present a good potential to be used as biocompatible carriers on drug controlled delivery.
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•Kappa-carrageenan aerogel materials were successfully prepared by dissolution into ionic liquids.•Dissolution into ionic liquids allows for a lower volume shrinkage with repercussions on the porosity of the aerogels.•Aerogel matrixes prepared by dissolution into ionic liquids showed to not reduce Caco-2 cell viability.•Controlled release of tetracycline from kappa-carrageenan matrixes was achieved at pH 7.4.•The synthesized matrixes are promissory to be used on biocompatible controlled delivery formulations.
Background
Data on the prevalence of chronic pulmonary aspergillosis (CPA) in patients with active or cured tuberculosis (TB) are scarce, mainly due to diagnostic difficulties. The diagnosis of CPA ...is based on pulmonary symptoms and chest computed tomography (CT) scans and is considered confirmed when there is microbiological or serological evidence of Aspergillus spp. infection.
Objectives
To estimate the prevalence of CPA in patients treated or undergoing treatment for PTB, seen in two referral hospitals in Mato Grosso do Sul, Brazil.
Patients and Methods
A total of 193 consecutive patients who were treated or previously treated for pulmonary tuberculosis underwent prospective evaluation: (a) clinical evaluation; (b) chest CT scan; (c) sputum examination—culture for fungi and smears for direct mycology; (d) detection of anti‐Aspergillus fumigatus antibodies using an enzyme‐linked immunosorbent assay Platelia® test; and (e) anti‐Aspergillus spp. antibodies were assessed via a DID test.
Results
The global prevalence of CPA was 10.9% (95% confidence interval, 7.2%–16.1%), but it increased with the time of TB diagnosis. The variables independently associated with CPA were previous pulmonary tuberculosis over 4 years ago and haemoptysis. Cavities, pleural thickening and the presence of a fungal ball were the most frequent tomographic findings in patients with CPA.
Conclusions
The high prevalence observed and its increase over time suggest the need for continuous surveillance of CPA in patients with active or previous pulmonary tuberculosis and throughout life, with clinical, tomographic and serological evaluations (ELISA) for a timely diagnosis and a better prognosis.
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