ABSTRACT
We present a measurement of the extragalactic background light (EBL) based on a joint likelihood analysis of 32 gamma-ray spectra for 12 blazars in the redshift range z = 0.03–0.944, ...obtained by the MAGIC telescopes and Fermi-LAT. The EBL is the part of the diffuse extragalactic radiation spanning the ultraviolet, visible, and infrared bands. Major contributors to the EBL are the light emitted by stars through the history of the Universe, and the fraction of it that was absorbed by dust in galaxies and re-emitted at longer wavelengths.
The EBL can be studied indirectly through its effect on very high energy photons that are emitted by cosmic sources and absorbed via γγ interactions during their propagation across cosmological distances. We obtain estimates of the EBL density in good agreement with state-of-the-art models of the EBL production and evolution. The 1σ upper bounds, including systematic uncertainties, are between 13 per cent and 23 per cent above the nominal EBL density in the models. No anomaly in the expected transparency of the Universe to gamma-rays is observed in any range of optical depth. We also perform a wavelength-resolved EBL determination, which results in a hint of an excess of EBL in the 0.18–0.62 $\mu\mathrm{ m}$ range relative to the studied models, yet compatible with them within systematics.
Context
. We are operating an elastic light detecting and ranging system (LIDAR) for the monitoring of atmospheric conditions during regular observations of the MAGIC telescopes.
Aims
. We present ...and evaluate methods for converting aerosol extinction profiles, obtained with the LIDAR, into corrections of the reconstructed gamma-ray event energy and instrument response functions of Imaging Atmospheric Cherenkov Telescopes.
Methods
. We assess the performance of these correction schemes with almost seven years of Crab Nebula data obtained with the MAGIC telescopes under various zenith angles and different aerosol extinction scenarios of Cherenkov light.
Results
. The methods enable the reconstruction of data taken under nonoptimal atmospheric conditions with aerosol transmissions down to ~0.65 with systematic uncertainties comparable to those for data taken under optimal conditions. For the first time, the correction of data affected by clouds has been included in the assessment. The data can also be corrected when the transmission is lower than 0.65, but the results are less accurate and suffer from larger systematics.
Supermassive black holes with masses of millions to billions of solar masses are commonly found in the centers of galaxies. Astronomers seek to image jet formation using radio interferometry but ...still suffer from insufficient angular resolution. An alternative method to resolve small structures is to measure the time variability of their emission. Here we report on gamma-ray observations of the radio galaxy IC 310 obtained with the MAGIC (Major Atmospheric Gamma-ray Imaging Cherenkov) telescopes, revealing variability with doubling time scales faster than 4.8 min. Causality constrains the size of the emission region to be smaller than 20% of the gravitational radius of its central black hole. We suggest that the emission is associated with pulsar-like particle acceleration by the electric field across a magnetospheric gap at the base of the radio jet.
Epigenetic therapy, using hypomethylating agents (HMA), is known to be effective in the treatment of high-risk myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) patients who are not ...suitable for intensive chemotherapy and/or allogeneic stem cell transplantation. However, response rates to HMA are low and there is an unmet need in finding prognostic and predictive biomarkers of treatment response and overall survival. We performed global methylation analysis of 75 patients with high-risk MDS and secondary AML who were included in CETLAM SMD-09 protocol, in which patients received HMA or intensive treatment according to age, comorbidities and cytogenetic.
Unsupervised analysis of global methylation pattern at diagnosis did not allow patients to be differentiated according to the cytological subtype, cytogenetic groups, treatment response or patient outcome. However, after a supervised analysis we found a methylation signature defined by 200 probes, which allowed differentiating between patients responding and non-responding to azacitidine (AZA) treatment and a different methylation pattern also defined by 200 probes that allowed to differentiate patients according to their survival. On studying follow-up samples, we confirmed that AZA decreases global DNA methylation, but in our cohort the degree of methylation decrease did not correlate with the type of response. The methylation signature detected at diagnosis was not useful in treated samples to distinguish patients who were going to relapse or progress.
Our findings suggest that in a subset of specific CpGs, altered DNA methylation patterns at diagnosis may be useful as a biomarker for predicting AZA response and survival.
Acipenserids (sturgeons) live in large rivers and lakes in North America and Eurasia, where many species and populations are considered imperiled. One of the most pervasive threats across the global ...range of sturgeon is water resource development (e.g., hydropower dams, water intakes for irrigation, industrial use, or human consumption). We report on the outcome of a literature review focused on interactions between sturgeon and water resource development. We focused on the persistent issue of dam passage (both upstream and downstream), impingement, and entrainment, which are all relevant issues for both existing and planned facilities. We discuss aspects of sturgeon sensory physiology, and how knowledge of sensory physiology can be used for behavioural guidance. We also consider how the swimming ability and style of sturgeon is relevant for passage. Most of the literature emanated from research on just a few species (especially lake sturgeon, white sturgeon, green sturgeon, and shortnose sturgeon). Although there are several examples of apparent “success stories” (e.g., successful upstream fish passage, efforts to reduce impingement and entrainment), there are also many failures, and such examples are likely under-reported. Without significant investments in solutions-oriented research related to sturgeon-water resource development interactions, we submit that fish passage, entrainment and impingement problems for acipenserids will remain. There is a need for research that spans life-stages, compares different species, and considers how passage, entrainment, and impingement influence demography. Further, there is a need for investment into evidence-based implementation of mitigation infrastructure and management strategies to ensure conservation needs of sturgeons are adequately considered.
Spontaneous breaking of Lorentz symmetry at energies on the order of the Planck energy or lower is predicted by many quantum gravity theories, implying non-trivial dispersion relations for the photon ...in vacuum. Consequently, gamma-rays of different energies, emitted simultaneously from astrophysical sources, could accumulate measurable differences in their time of flight until they reach the Earth. Such tests have been carried out in the past using fast variations of gamma-ray flux from pulsars, and more recently from active galactic nuclei and gamma-ray bursts. We present new constraints studying the gamma-ray emission of the galactic Crab Pulsar, recently observed up to TeV energies by the Major Atmospheric Gamma-ray Imaging Cherenkov (MAGIC) collaboration. A profile likelihood analysis of pulsar events reconstructed for energies above 400 GeV finds no significant variation in arrival time as their energy increases. Ninety-five percent CL limits are obtained on the effective Lorentz invariance violating energy scale at the level of ( ) for a linear, and ( ) for a quadratic scenario, for the subluminal and the superluminal cases, respectively. A substantial part of this study is dedicated to calibration of the test statistic, with respect to bias and coverage properties. Moreover, the limits take into account systematic uncertainties, which are found to worsen the statistical limits by about 36%-42%. Our constraints would have been much more stringent if the intrinsic pulse shape of the pulsar between 200 GeV and 400 GeV was understood in sufficient detail and allowed inclusion of events well below 400 GeV.
ABSTRACT
We report multiwavelength observations of the gravitationally lensed blazar QSO B0218+357 in 2016–2020. Optical, X-ray, and GeV flares were detected. The contemporaneous MAGIC observations ...do not show significant very high energy (VHE; ≳100 GeV) gamma-ray emission. The lack of enhancement in radio emission measured by The Owens Valley Radio Observatory indicates the multizone nature of the emission from this object. We constrain the VHE duty cycle of the source to be <16 2014-like flares per year (95 per cent confidence). For the first time for this source, a broad-band low-state spectral energy distribution is constructed with a deep exposure up to the VHE range. A flux upper limit on the low-state VHE gamma-ray emission of an order of magnitude below that of the 2014 flare is determined. The X-ray data are used to fit the column density of (8.10 ± 0.93stat) × 1021 cm−2 of the dust in the lensing galaxy. VLBI observations show a clear radio core and jet components in both lensed images, yet no significant movement of the components is seen. The radio measurements are used to model the source-lens-observer geometry and determine the magnifications and time delays for both components. The quiescent emission is modelled with the high-energy bump explained as a combination of synchrotron-self-Compton and external Compton emission from a region located outside of the broad-line region. The bulk of the low-energy emission is explained as originating from a tens-of-parsecs scale jet.
The origin of bimodal (mafic-felsic) rock suites is a fundamental question in volcanology. Here we use major and trace elements, high-resolution Sr, Nd and Pb isotope analyses, experimental petrology ...and thermodynamic modelling to investigate bimodal magmatism at the iconic Carlingford Igneous Centre, Ireland. We show that early microgranites are the result of extensive assimilation of trace element-enriched partial melts of local metasiltstones into mafic parent magmas. Melting experiments reveal the crust is very fusible, but thermodynamic modelling indicates repeated heating events rapidly lower its melt-production capacity. Granite generation ceased once enriched partial melts could no longer form and subsequent magmatism incorporated less fertile restite compositions only, producing mafic intrusions and a pronounced compositional gap. Considering the frequency of bimodal magma suites in the North Atlantic Igneous Province, and the ubiquity of suitable crustal compositions, we propose 'progressively inhibited crustal assimilation' (PICA) as a major cause of bimodality in continental volcanism.
ABSTRACT
Extreme high-frequency BL Lacs (EHBL) feature their synchrotron peak of the broad-band spectral energy distribution (SED) at νs ≥ 1017 Hz. The BL Lac object 1ES 2344+514 was included in the ...EHBL family because of its impressive shift of the synchrotron peak in 1996. During the following years, the source appeared to be in a low state without showing any extreme behaviours. In 2016 August, 1ES 2344+514 was detected with the ground-based γ-ray telescope FACT during a high γ-ray state, triggering multiwavelength (MWL) observations. We studied the MWL light curves of 1ES 2344+514 during the 2016 flaring state, using data from radio to very-high-energy (VHE) γ-rays taken with OVRO, KAIT, KVA, NOT, some telescopes of the GASP-WEBT collaboration at the Teide, Crimean, and St. Petersburg observatories, Swift-UVOT, Swift-XRT, Fermi-LAT, FACT, and MAGIC. With simultaneous observations of the flare, we built the broad-band SED and studied it in the framework of a leptonic and a hadronic model. The VHE γ-ray observations show a flux level of 55 per cent of the Crab Nebula flux above 300 GeV, similar to the historical maximum of 1995. The combination of MAGIC and Fermi-LAT spectra provides an unprecedented characterization of the inverse-Compton peak for this object during a flaring episode. The Γ index of the intrinsic spectrum in the VHE γ-ray band is 2.04 ± 0.12stat ± 0.15sys. We find the source in an extreme state with a shift of the position of the synchrotron peak to frequencies above or equal to 1018 Hz.
Motivation is a complex neurobiological process that initiates, directs, and maintains goal-oriented behavior. Although distinct components of motivated behavior are difficult to investigate, ...appetitive and consummatory phases of motivation are experimentally separable. Different neurotransmitter systems, particularly the mesolimbic dopaminergic system, have been associated with food motivation. Over the last two decades, however, research focusing on the role of opioid signaling has been particularly growing in this area. Opioid receptors seem to be involved, via neuroanatomically distinct mechanisms, in both appetitive and consummatory aspects of food reward. In the present chapter, we review the pharmacology and functional neuroanatomy of opioid receptors and their endogenous ligands, in the context of food reinforcement. We examine literature aimed at the development of laboratory animal techniques to better understand different components of motivated behavior. We present recent data investigating the effect of opioid receptor antagonists on food preference and effort-related decision making in rats, which indicate that opioid signaling blockade selectively affects intake of relatively preferred foods, resulting in reduced willingness to exert effort to obtain them. Finally, we elaborate on the potential role of opioid system manipulations in disorders associated with excessive eating and obesity.