The Tapajós Mineral Province (TMP) contains evidence of subduction processes during the Paleoproterozoic. Despite well-documented arc magmatism, the lack of solid geological evidence indicating a ...collision raises uncertainties about whether there was an arc-continent collision in the Paleoproterozoic or the process of subduction continued, and the closing of an ocean basin occurred only in Mesoproterozoic times. Additionally, world-class deposits have been linked with lithospheric electrical conductors using magnetotelluric (MT) data. On the lithospheric scale, an assessment of the potential for more significant deposits or correlated commodities is absent in the TMP. Therefore, we acquired MT data to provide constraints for the lithosphere of the TMP. The electrical resistivity model reveals a high resistivity zone (> 10,000 Ω.m) interpreted as the emplacement zone of granitoids in the upper crust. The mid-lower crust presents resistivity between 465 and 45 Ω.m, corresponding to depths of 10–35 km. A low resistivity zone below 35 km (45–10 Ω.m) represents a hydrated upper mantle due to the long-lived arc processes. Based on gravity-forward modeling, we estimate that the degree of serpentinization is <10% due to post-subduction magmatism. The lack of a lower crust conductor and paired high and low long wavelength Bouguer anomalies corroborates that a cryptic suture is unlikely. A low-angle conductor matches the limit of different magnetic domains and reveals the exhumation of the western portion of TMP's crust. The high correlation between the position of the deposits and electrical conductors corroborates that MT is a valuable tool for detecting fossil fluid pathways relevant to finding new mineral deposits.
•The Tapajós Mineral Province presents an upper mantle of low resistivity due to metasomatization processes.•We estimate that the degree of hydration is less than 10% based on gravity data.•We mapped crustal fluid pathways with a high correlation with gold deposits.
Background
A weak correlation has been reported between left ventricular filling pressures and the traditional echocardiographic tools for the evaluation of diastolic function in patients with ...coronary artery disease (CAD) and preserved left ventricular ejection fraction (LVEF). On the other hand, studies that compared invasive measurements with speckle tracking echocardiography have shown promising results, but they were not exclusively targeted on this specific population.
Methods and Results
Immediately before the left heart catheterization, a comprehensive two‐dimensional Doppler echocardiography and speckle tracking analysis was prospectively performed in outpatients referred for coronary angiography. Left ventricular end‐diastolic pressure (LVEDP) was measured before any contrast exposure. Eighty‐one patients with coronary artery disease were studied, and the group with high LVEDP (n = 40) showed increased left atrial volume index (22 ± 6 mL/m2 vs 26 ± 8.26 mL/m2, P = 0.04), E‐wave velocity (65 ± 15 cm/s vs 78 ± 20 cm/s, P = 0.02), E/e` (average) ratio (8.14 ± 2.0 vs 11.54 ± 2.7, P = 0.03), and E/global circumferential strain rate E peak ratio (E/GCSRE) (39 cm vs 46 cm, P < 0.01). There was a positive correlation between LVEDP and E/e` (ρ = 0.56; P = 0.03), and between LVEDP and E/GCSRE ratio (ρ = 0.43; P < 0.01). The area under the receiver operating characteristics (ROC) curve was 0.83 and 0.73, respectively (P < 0.05). E/e` and E/GCSRE were both independent predictors of elevated LVEDP (P < 0.05), with a higher C‐statistic for the model including E/e` (0.89 vs 0.85).
Conclusion
The E/e` ratio was able to identify elevated LVEDP in CAD patients with preserved LVEF with more accuracy than the E/GCSRE ratio.
Traditional risk scores improved the definition of the initial therapeutic strategy in acute coronary syndrome (ACS), but they were not designed for predicting long-term individual risks and costs. ...In parallel, attempts to directly predict costs from clinical variables in ACS had limited success. Thus, novel approaches to predict cardiovascular risk and health expenditure are urgently needed. Our objectives were to predict the risk of major/minor adverse cardiovascular events (MACE) and estimate assistance-related costs.
We used a 2-step approach that: (1) predicted outcomes with a common pathophysiological substrate (MACE) by using machine learning (ML) or logistic regression (LR) and compared with existing risk scores; (2) derived costs associated with noncardiovascular deaths, dialysis, ambulatory-care-sensitive-hospitalizations (ACSH), strokes, and MACE. With consecutive ACS individuals (n = 1089) from 2 cohorts, we trained in 80% of the population and tested in 20% using a 4-fold cross-validation framework. The 29-variable model included socioeconomic, clinical/lab, and coronarography variables. Individual costs were estimated based on cause-specific hospitalization from the Brazilian Health Ministry perspective.
After up to 12 years follow-up (mean = 3.3 ± 3.1; MACE = 169), the gradient-boosting machine model was superior to LR and reached an area under the curve (AUROC) of 0.891 95% CI 0.846-0.921 (test set), outperforming the Syntax Score II (AUROC = 0.635 95% CI 0.569-0.699). Individuals classified as high risk (>90th percentile) presented increased HbA1c and LDL-C both at <24 hours post-ACS and 1-year follow-up. High-risk individuals required 33.5% of total costs and showed 4.96-fold (95% CI 3.71-5.48, P < .00001) greater per capita costs compared with low-risk individuals, mostly owing to avoidable costs (ACSH). This 2-step approach was more successful for finding individuals incurring high costs than predicting costs directly from clinical variables.
ML methods predicted long-term risks and avoidable costs after ACS.
•In acute coronary syndrome (ACS), traditional risk scores are not designed to consider the repercussions of in-hospital therapies or the risk of minor but expensive outcomes, such as reinterventions (including recurrent coronary catheterization), dialysis, recurrent angina, and rehospitalization. Therefore, there are no available tools/scores to predict individual health expenditure and no available mechanism to predict avoidable costs.•With 35 variables derived from clinical, socioeconomic, and coronary angiography assessments, we designed a machine learning (ML) model that efficiently predicts long-term risks after ACS. The model helped to identify individuals with a large burden of avoidable costs. In individuals at the top 10% risk threshold, 21.9% of costs were attributed to avoidable costs. Indeed, we also show that individuals at high risk also presented a higher burden of uncontrolled modifiable risk factors, such as hypercholesterolemia/diabetes, than individuals at low risk.•ML could be useful to select individuals at higher risk for clinical events and who are more likely to incur higher costs in the long term. In Brazil and the United States, the avoidable cost threshold is much higher than the cost of many high-priced therapies. Thus, this ML approach could also turn into a framework to favor access of high-cost therapies to individuals predicted as high risk, including therapies that are not considered cost-effective in the general population.
•New tectonic map of the Neoproterozoic basement of Phanerozoic Parnaiba basin.•Updated crustal thickness map of Parnaiba basin and new seismic interpretations.•Two main pre-Brasiliano inliers ...surrounded by mobile belts under the basin.•Mid-crustal reflectivity interpreted as a suture zone in central Parnaiba basement.•Two different pre-Silurian basin systems prior to Parnaiba basin sedimentation.
A regional Pre-Silurian unconformity marks the erosive planar base of the Phanerozoic Parnaíba Basin (PB), and indistinctly truncates key tectonic units for the understanding of the Neoproterozoic evolution of western Gondwana in northeastern Brazil. We present a comparative analysis of geophysical and geological datasets in the PB and propose a new tectonic configuration for its pre-Silurian basement, composed of different terranes amalgamated during the Brasiliano orogeny. Using integrated seismic interpretation and gravity modelling, constrained by an updated crustal thickness map, well data and a compilation of recent geophysical studies, we have identified two main blocks in the center of the basin. They represent pre-Brasiliano inliers, surrounded by Brasiliano mobile belts, and assigned to two major crustal building blocks of western Gondwana: the Amazonian-West Africa (AWB; to the west/north) and the Central African blocks (CAB; to the east/northeast). The Grajaú block belongs to the AWB and is characterized by low gravity anomaly, thicker crust (41–45 km), transparent seismic character of the basement and a high velocity lower crust. The Teresina block belongs to the CAB and is characterized by slightly thinner crust (39–41 km), higher values of gravity and magnetic anomalies and by the presence of mid-crustal reflectors (MCR), observed in seven seismic lines and here interpreted as a remnant of a paleosuture zone between the two blocks. Along a NE-SW 500-km seismic and gravity profile, we interpreted the MCR as composed of crustal-scale thrust faults verging westwards and defining the Barra do Corda belt, which was formed by the closure of the Goiás-Pharusian ocean along the Transbrasiliano-Kandi corridor and subsequent collision of the Grajaú and Teresina blocks. This belt deforms the eastern margin of the Ediacaran Riachão foreland basin (RB), observed in seismic and well data beneath the SW portion of PB and overlying the southern Grajaú block. The western margin of RB is bounded by eastwards verging thrust faults, interpreted as a zone of back-thrusts and thinned crust (∼36 km) in the eastern prolongation of the Araguaia belt beneath PB. To the east, the limit between the Teresina block and the Borborema Province is marked by the NE-SW Transbrasiliano Shear Zone, along which Neoproterozoic mylonites were recovered from wellbores, and a system of narrow pull-apart basins is interpreted in the seismic data, triggered by Early Paleozoic transtensional reactivations of the TBSZ, prior to the deposition of the basal Ordovician-Silurian sequence of PB. This complex collisional tectonic setting of PB basement contradicts the idea of a stable cratonic block beneath it, inciting new formation models that account for the observed crustal and lithospheric heterogeneities.
Given the mounting apprehension surrounding the recurrence of incidents involving accidents and the failure of earthen dams in the past two decades, a significant number of which can be attributed to ...phenomena such as seepage-induced piping and overtopping, this research was conducted utilizing non-destructive geoelectrical techniques at an earthen dam site. The primary objective was to monitor the stability of the landfill and identify potential abnormal pathways for fluid infiltration. We propose the combined application of electric resistivity tomography and induced polarization methods as indirect, non-invasive mechanisms to evaluate the structural and hydrodynamic stability of the embankment dike and its foundation. This approach complements conventional instrumentation, often referred to as auscultation, which relies on piezometric level analyses, displacement measurements, and visual inspections. A geophysical survey was conducted at an earthen dam in Rio de Janeiro, Brazil. The reservoir was specifically engineered for industrial water storage. During the study period, resistivity and chargeability measurements were systematically conducted in both rainy and dry periods, facilitating the observation of dam slope behavior under diverse climatic conditions. Consequently, we observed increased conductivity values during periods of increased humidity, and decreased chargeability values served as indicators of water saturation within the dam structure. This comprehensive data interpretation proved to be highly efficient, and the proposed methodology holds the potential for application to a wide array of landfill dams, with a particular emphasis on ore tailing dams.
The RVB proteins, composed of the conservative paralogs, RVB1 and RVB2, belong to the AAA+ (ATPases Associated with various cellular Activities) protein superfamily and are present in archaea and ...eukaryotes. The most distinct structural features are their ability to interact with each other forming the RVB1/2 complex and their participation in several macromolecular protein complexes leading them to be involved in many biological processes. We report here the biochemical and biophysical characterization of the Neurospora crassa RVB-1/RVB-2 complex. Chromatographic analyses revealed that the complex (APO) predominantly exists as a dimer in solution although hexamers were also observed. Nucleotides influence the oligomerization state, while ATP favors hexamers formation, ADP favors the formation of multimeric states, likely dodecamers, and the Molecular Dynamics (MD) simulations revealed the contribution of certain amino acid residues in the nucleotide stabilization. The complex binds to dsDNA fragments and exhibits ATPase activity, which is strongly enhanced in the presence of DNA. In addition, both GFP-fused proteins are predominantly nuclear, and their nuclear localization signals (NLS) interact with importin-α (NcIMPα). Our findings show that some properties are specific of the fungus proteins despite of their high identity to orthologous proteins. They are essential proteins in N. crassa, and the phenotypic defects exhibited by the heterokaryotic strains, mainly related to growth and development, indicate N. crassa as a promising organism to investigate additional biological and structural aspects of these proteins.
•The essential RVB-1 and RVB-2 proteins are the RuvBL/RVB homologues in Neurospora crassa.•The proteins are functionally related to growth and development.•The RVB-1/RVB-2 complex predominantly exists as a dimer in solution and nucleotides strongly influence the oligomerization state.•Binding of nucleotides leads to conformational changes that may influence the interaction with DNA.•The RVB-1/RVB-2 complex exhibits ATPase activity, binds to dsDNA fragments and DNA strongly increase the ATPase activity.•The GFP-fused RVB-1 and RVB-2 are nuclear proteins and their NLSs interact with the N. crassa importin-α (NcIMPα).
The experiment was conducted to evaluate the addition of phytase on productive performance and egg quality of Japanese quails fed diets containing different levels of phytase. It was used 320 ...Japanese quails at 167 days of age, weighing 182.3 ± 3.8 g distributed in a completely randomized design with four experimental diets and eight repetitions of ten birds per experimental unit. Diets were formulated from a basal diet (control) and they were corn and soybean meal based, without supplementation, added with 200, 400 or 600 phytase activity unit (ftu). Supplementation of phytase in the diets improved productive performance and quality of eggs. Efficiency of phosphorus use for egg mass, from 0.13% of availability of this mineral in the ration, improved with supplementation of 463 ftu/kg. Optimum levels of phytase for the other performance traits and egg quality were also reached with 463 ftu/kg.
O experimento foi realizado para avaliar a adição de fitase sobre o desempenho produtivo e a qualidade dos ovos de codornas japonesas alimentadas com rações contendo diferentes níveis de fitase. Foram utilizadas 320 codornas japonesas, com 167 dias de idade, peso de 182,3 ± 3,8 g, distribuídas em delineamento inteiramente casualizado com quatro dietas experimentais e oito repetições de dez aves por unidade experimental. As dietas foram formuladas a partir de uma dieta basal (controle), à base de milho e farelo de soja, sem suplementação, e foram acrescidas de 200, 400 ou 600 unidades de atividade de fitase (uft). A suplementação de fitase na ração melhorou o desempenho produtivo e a qualidade dos ovos. A eficiência do uso de fósforo para massa de ovos, a partir de 0,13% de disponibilidade deste mineral na ração, melhorou com a suplementação de 463 uft/kg. Os níveis ideais de fitase para as demais características de desempenho produtivo e qualidade dos ovos também foram alcançados com 463 uft/kg.
Pulmonary function and symptoms in asthmatics adolescents Fontes, Vitor Joaquim Barreto; Simões, Silvia De Magalhães; De Andrade, Bárbara Bruna Fernandes ...
The World Allergy Organization journal,
04/2015, Letnik:
8, Številka:
135
Journal Article
PDF
