We have conducted a multiwavelength survey of 42 radio loud narrow-1ine Seyfert 1 galaxies (RLNLS1s), selected by searching among all the known sources of this type and omitting those with steep ...radio spectra. We analyse data from radio frequencies to X-rays, and supplement these with information available from online catalogues and the literature in order to cover the full electromagnetic spectrum. This is the largest known multiwavelength survey for this type of source. We detected 90% of the sources in X-rays and found 17% at γ rays. Extreme variability at high energies was also found, down to timescales as short as hours. In some sources, dramatic spectral and flux changes suggest interplay between a relativistic jet and the accretion disk. The estimated masses of the central black holes are in the range ~106−8 M⊙, lower than those of blazars, while the accretion luminosities span a range from ~0.01 to ~0.49 times the Eddington limit, with an outlier at 0.003, similar to those of quasars. The distribution of the calculated jet power spans a range from ~1042.6 to ~1045.6 erg s-1, generally lower than quasars and BL Lac objects, but partially overlapping with the latter. Once normalised by the mass of the central black holes, the jet power of the three types of active galactic nuclei are consistent with each other, indicating that the jets are similar and the observational differences are due to scaling factors. Despite the observational differences, the central engine of RLNLS1s is apparently quite similar to that of blazars. The historical difficulties in finding radio-loud narrow-line Seyfert 1 galaxies might be due to their low power and to intermittent jetactivity.
In order to determine the location of the gamma-ray emission site in blazars, we investigate the time-domain relationship between their radio and gamma-ray emission. Light curves for the brightest ...detected blazars from the first 3 yr of the mission of the Fermi Gamma-ray Space Telescope are cross-correlated with 4 yr of 15 GHz observations from the Owens Valley Radio Observatory 40 m monitoring programme. The large sample and long light-curve duration enable us to carry out a statistically robust analysis of the significance of the cross-correlations, which is investigated using Monte Carlo simulations including the uneven sampling and noise properties of the light curves. Modelling the light curves as red noise processes with power-law power spectral densities, we find that only one of 41 sources with high-quality data in both bands shows correlations with significance larger than 3σ (AO 0235+164), with only two more larger than even 2.25σ (PKS 1502+106 and B2 2308+34). Additionally, we find correlated variability in Mrk 421 when including a strong flare that occurred in 2012 July–September. These results demonstrate very clearly the difficulty of measuring statistically robust multiwavelength correlations and the care needed when comparing light curves even when many years of data are used. This should be a caution. In all four sources, the radio variations lag the gamma-ray variations, suggesting that the gamma-ray emission originates upstream of the radio emission. Continuous simultaneous monitoring over a longer time period is required to obtain high significance levels in cross-correlations between gamma-ray and radio variability in most blazars.
We present a γ-ray photon flux and spectral variability study of the flat-spectrum radio quasar 3C 273 over a rapid flaring activity period between September 2009 to April 2010. Five major flares ...were observed in the source during this period. The most rapid flare observed in the source has a flux doubling time of 1.1 hr. The rapid γ-ray flares allow us to constrain the location and size of the γ-ray emission region in the source. The γγ-opacity constrains the Doppler factor δγ ≥ 10 for the highest energy (15 GeV) photon observed by the Fermi-Large Area Telescope (LAT). Causality arguments constrain the size of the emission region to 1.6 × 1015 cm. The γ-ray spectra measured over this period show clear deviations from a simple power law with a break in the 1−2 GeV energy range. We discuss possible explanations for the origin of the γ-ray spectral breaks. Our study suggests that the γ-ray emission region in 3C 273 is located within the broad line region (< 1.6 pc). The spectral behavior and temporal characteristics of the individual flares indicate the presence of multiple shock scenarios at the base of the jet.
We present first results on polarization swings in optical emission of blazars obtained by RoboPol, a monitoring programme of an unbiased sample of gamma-ray bright blazars specially designed for ...effective detection of such events. A possible connection of polarization swing events with periods of high activity in gamma-rays is investigated using the data set obtained during the first season of operation. It was found that the brightest gamma-ray flares tend to be located closer in time to rotation events, which may be an indication of two separate mechanisms responsible for the rotations. Blazars with detected rotations during non-rotating periods have significantly larger amplitude and faster variations of polarization angle than blazars without rotations. Our simulations show that the full set of observed rotations is not a likely outcome (probability ≤1.5 × 10−2) of a random walk of the polarization vector simulated by a multicell model. Furthermore, it is highly unlikely (∼5 × 10−5) that none of our rotations is physically connected with an increase in gamma-ray activity.
ABSTRACT
We present the design and performance of RoboPol, a four-channel optical polarimeter operating at the Skinakas Observatory in Crete, Greece. RoboPol is capable of measuring both relative ...linear Stokes parameters q and u (and the total intensity I) in one sky exposure. Though primarily used to measure the polarization of point sources in the R band, the instrument features additional filters (B, V, and I), enabling multiwavelength imaging polarimetry over a large field of view (13.6′ × 13.6′). We demonstrate the accuracy and stability of the instrument throughout its 5 yr of operation. Best performance is achieved within the central region of the field of view and in the R band. For such measurements the systematic uncertainty is below 0.1 per cent in fractional linear polarization, p (0.05 per cent maximum likelihood). Throughout all observing seasons the instrumental polarization varies within 0.1 per cent in p and within ∼1° in polarization angle.
ABSTRACT As a radio-loud narrow-line Seyfert 1 galaxy (NLS1) detected by Fermi/LAT in GeV γ-rays, 1H 0323+342 is a remarkable active galactic nucleus showing properties characteristic of both NLS1s ...and blazars. Here we present results of simultaneous X-ray and UV/optical monitoring observations on 1H 0323+342 taken with the UV/Optical Telescope and X-ray Telescope onboard the Swift satellite over six years from 2006. Overall, the object showed statistically correlated variations in both the UV and X-ray bands on timescales of years as well as on timescales of days. A deep Suzaku observation reveals X-ray variability on timescales as short as a few tens of thousand seconds, and an X-ray spectrum typical of Seyfert galaxies. The broadband spectral energy distribution, for which the data of UV and X-ray observations taken on 2009 July 26-27 were used, can be well modeled with a simple one-zone leptonic jet model plus accretion disk/corona emission. The latter is predominantly responsible for the UV/optical and X-ray (0.3-10 keV) emission and their observed variations. The correlated UV-X-ray variability on the timescale of days is consistent with reprocessing of the X-ray radiation by the accretion disk. The shortest timescale and large normalized excess variance of the X-ray variability detected with Suzaku suggest a relatively small black hole mass of the order of , consistent with the estimation based on the broad Hβ line in the optical.
Physicians' letters are the optimal source of diagnoses for registries. However, most registries demand for diagnosis codes such as ICD-10. We herein describe an algorithm that infers ICD-10 codes ...from German ophthalmologic physicians' letters. We assess the method in three German eye hospitals. Our algorithm is based on the nearest-neighbor method as well as on a large thesaurus for ICD-10 codes. This thesaurus was embedded into a Word2Vec space created from anonymized physicians' reports of the first hospital. For evaluation, each of the three hospitals sent all diagnoses taken from 100 letters. The inferred ICD-10 codes were evaluated for correctness by the senders. A total of 3332 natural language terms had been sent in (812 hospital one, 1473 hospital two, 1047 hospital three). A total of 526 non-diagnoses were excluded upfront. 2806 ICD-10 codes were inferred (771 hospital one, 1226 hospital two, 809 hospital three). In the first hospital, 98% were fully correct and 99% correct at the level of the superordinate disease concept. The percentages in hospital two were 69% and 86%. The respective numbers for hospital three were 69% and 91%. Our simple method is capable of inferring ICD-10 codes for German natural language diagnoses, especially when the embedding space has been built with physicians' letters from the same hospital. The method may yield sufficient accuracy for many tasks in the multi-centric setting and can easily be adapted to other languages/specialities.
Purpose
The use of face masks has been proposed to cause or exacerbate the symptoms of dry eye disease (DED), which has been widely discussed under the term mask-associated dry eye (MADE). However, ...no studies have systematically investigated tear film parameters during the use of different face masks. Therefore, the objective of the present study was to investigate clinically relevant parameters of the tear film before and during the short-time use of face masks in dry and normal eyes.
Methods
In a prospective study, the tear film parameters of 42 DED patients and 42 healthy volunteers were examined while wearing different types of face masks in a randomized order. This included measurements of non-invasive tear break-up time (NIBUT), lipid layer thickness, tear meniscus height, and bulbar redness after 30 min of wearing no mask, a surgical face mask or an FFP2/K95 mask. The equivalence of the means was assessed using the two one-sided
t
-test (TOST) method.
Results
In healthy volunteers’ lipid layer thickness, NIBUT and tear meniscus height were not significantly altered by 30 min of surgical or FFP2 mask wear (
p
> 0.016). The use of either type of mask was significantly associated with decreased bulbar redness (
p
< 0.001) in healthy eyes. In patients with DED, none of the tear film parameters or bulbar redness were significantly altered by 30 min of mask wear (
p
> 0.016).
Conclusions
Based on these results, the short-term wearing of face masks, regardless of type, did not produce a significant difference in tear film parameters of lipid layer thickness, NIBUT, and tear meniscus in healthy or dry eyes, while bulbar redness was reduced after mask wear only in healthy volunteers.
Nuclear factor of activated T cells 1 (NFAT1) expression has been associated with increased migratory/invasive properties of mammary tumor-derived cell lines in vitro. It is unknown, however, if NFAT ...activation actually occurs in breast cancer cases and whether the calcineurin/NFAT pathway is important to mammary tumorigenesis. Using a cohort of 321 diagnostic cases of the major subgroup of breast cancer, we found Cn/NFAT pathway activated in ER(-)PR(-)HER2(-) triple-negative breast cancer subtype, whereas its prevalence is less in other subgroups. Using a small hairpin RNA-based gene expression silencing approach in murine mammary tumor cell line (4T1), we show that not only NFAT1 but also NFAT2 and their upstream activator Cn are essential to the migratory and invasive properties of mammary tumor cells. We also demonstrate that Cn, NFAT1 and NFAT2 are essential to the tumorigenic and metastatic properties of these cells in mice, a phenotype which coincides with increased apoptosis in vivo. Finally, global gene expression analyses identified several NFAT-deregulated genes, many of them being previously associated with mammary tumorigenesis. In particular, we identified the gene encoding a disintegrin and metalloproteinase with thrombonspondin motifs 1, as being a potential direct target of NFAT1. Thus, our results show that the Cn/NFAT pathway is activated in diagnostic cases of breast cancers and is essential to the tumorigenic and metastatic potential of mammary tumor cell line. These results suggest that pharmacological inhibition of the Cn/NFAT pathway at different levels could be of therapeutical interest for breast cancer patients.
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