Abstract
Objectives
Group‐2 reviewed the scientific evidence in the field of «Technology». Focused research questions were: (1) additive versus subtractive manufacturing of implant restorations; (2) ...survival, complications, and esthetics comparing prefabricated versus customized abutments; and (3) survival of posterior implant‐supported multi‐unit fixed dental prostheses.
Materials and Methods
Literature was systematically screened, and 67 publications could be critically reviewed following PRISMA guidelines, resulting in three systematic reviews. Consensus statements were presented to the plenary where after modification, those were accepted.
Results
Additively fabricated implant restorations of zirconia and polymers were investigated for marginal/internal adaptation and mechanical properties without clear results in favor of one technology or material. Titanium base abutments for screw‐retained implant single crowns compared to customized abutments did not show significant differences concerning 1‐year survival. PFM, veneered and monolithic zirconia implant‐supported multi‐unit posterior fixed dental prostheses demonstrated similar high 3‐year survival rates, whereas veneered restorations exhibited the highest annual ceramic fracture and chipping rates.
Conclusions
For interim tooth‐colored implant single crowns both additive and subtractive manufacturing are viable techniques. The clinical performance of additively produced restorations remains to be investigated. Implant single crowns on titanium base abutments show similar clinical performance compared to other type of abutments; however, long‐term clinical data from RCTs are needed. The abutment selection should be considered already during the planning phase. Digital planning facilitates 3D visualization of the prosthetic design including abutment selection. In the posterior area, monolithic zirconia is recommended as the material of choice for multi‐unit implant restorations to reduce technical complications.
We retrospectively evaluated the clinical and radiological outcomes of a consecutive cohort of patients aged > 70 years with a displaced fracture of the olecranon, which was treated non-operatively ...with early mobilisation. We identified 28 such patients (27 women) with a mean age of 82 years (71 to 91). The elbow was initially immobilised in an above elbow cast in 90° of flexion of the elbow for a mean of five days. The cast was then replaced by a sling. Active mobilisation was encouraged as tolerated. No formal rehabilitation was undertaken. At a mean follow-up of 16 months (12 to 26), the mean ranges of flexion and extension were 140° and 15° respectively. On a visual analogue scale of 1 (no pain) to 10, the mean pain score was 1 (0 to 8). Of the original 28 patients 22 developed nonunion, but no patients required surgical treatment. We conclude that non-operative functional treatment of displaced olecranon fractures in the elderly gives good results and a high rate of satisfaction.
An updated overview of the HOLMES status Borghesi, M.; Alpert, B.; Balata, M. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
06/2023, Letnik:
1051
Journal Article
Recenzirano
Odprti dostop
HOLMES is an ERC project started in 2014 that will perform a model independent measurement of the neutrino mass with a sensitivity of the order of 1 eV. In order to reach its goal sensitivity, HOLMES ...will use 1000 low temperature microcalorimeters, each implanted with an activity of 300 Bq of 163Ho, performing thus a calorimetric measurement. This contribution presents the recent results achieved that lay the grounds for the low-activity phase of the HOLMES experiment, that will lead to its first limit on the neutrino mass.
We are developing the Cryogenic AntiCoincidence detector (CryoAC) of the ATHENA X-IFU spectrometer. It is a TES-based particle detector aimed to reduce the background of the instrument. Here, we ...present the result obtained with the last CryoAC single-pixel prototype. It is based on a 1 cm
2
silicon absorber sensed by a single 2 mm × 1 mm Ir/Au TES, featuring an on-chip heater for calibration and diagnostic purposes. We have illuminated the sample with
55
Fe (6 keV line) and
241
Am (60 keV line) radioactive sources, thus studying the detector response and the heater calibration accuracy at low energy. Furthermore, we have operated the sample in combination with a past-generation CryoAC prototype. Here, by analyzing the coincident detections between the two detectors, we have been able to characterize the background spectrum of the laboratory environment and disentangle the primary (i.e. cosmic muons) and secondaries (mostly secondary photons and electrons) signatures in the spectral shape.
This paper describes the production and chemical separation of the 163Ho isotope that will be used in several nuclear physics experiments aiming at measuring the neutrino mass as well as the neutron ...cross section of the 163Ho isotope. For this purpose, several batches of enriched 162Er have been irradiated at the Institut Laue-Langevin high flux reactor to finally produce 6 mg or 100 MBq of the desired 163Ho isotope. A portion of the Er/Ho mixture is then subjected to a sophisticated chemical separation involving ion exchange chromatography to isolate the Ho product from the Er target material. Before irradiation, a thorough analysis of the impurity content was performed and its implication on the produced nuclide inventory will be discussed.
The X-IFU is the cryogenic spectrometer onboard the future ATHENA X-ray observatory. It is based on a large array of TES microcalorimeters, which work in combination with a Cryogenic AntiCoincidence ...detector (CryoAC). This is necessary to reduce the particle background level thus enabling part of the mission science goals. Here we present the first joint test of X-IFU TES array and CryoAC Demonstration Models, performed in a FDM setup. We show that it is possible to operate properly both detectors, and we provide a preliminary demonstration of the anti-coincidence capability of the system achieved by the simultaneous detection of cosmic muons.
Anthracycline-mediated adverse cardiovascular events are among the leading causes of morbidity and mortality in patients with cancer. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) exert multiple ...cardiometabolic benefits in patients with/without type 2 diabetes, chronic kidney disease, and heart failure with reduced and preserved ejection fraction. We hypothesized that the SGLT2i dapagliflozin administered before and during doxorubicin (DOXO) therapy could prevent cardiac dysfunction and reduce pro-inflammatory pathways in preclinical models.
Cardiomyocytes were exposed to DOXO alone or combined with dapagliflozin (DAPA) at 10 and 100 nM for 24 h; cell viability, iATP, and Ca
were quantified; lipid peroxidation products (malondialdehyde and 4-hydroxy 2-hexenal), NLRP3, MyD88, and cytokines were also analyzed through selective colorimetric and enzyme-linked immunosorbent assay (ELISA) methods. Female C57Bl/6 mice were treated for 10 days with a saline solution or DOXO (2.17 mg/kg), DAPA (10 mg/kg), or DOXO combined with DAPA. Systemic levels of ferroptosis-related biomarkers, galectin-3, high-sensitivity C-reactive protein (hs-CRP), and pro-inflammatory chemokines (IL-1
, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12, IL17-α, IL-18, IFN-γ, TNF-α, G-CSF, and GM-CSF) were quantified. After treatments, immunohistochemical staining of myocardial and renal p65/NF-kB was performed.
DAPA exerts cytoprotective, antioxidant, and anti-inflammatory properties in human cardiomyocytes exposed to DOXO by reducing iATP and iCa
levels, lipid peroxidation, NLRP-3, and MyD88 expression. Pro-inflammatory intracellular cytokines were also reduced. In preclinical models, DAPA prevented the reduction of radial and longitudinal strain and ejection fraction after 10 days of treatment with DOXO. A reduced myocardial expression of NLRP-3 and MyD-88 was seen in the DOXO-DAPA group compared to DOXO mice. Systemic levels of IL-1β, IL-6, TNF-α, G-CSF, and GM-CSF were significantly reduced after treatment with DAPA. Serum levels of galectine-3 and hs-CRP were strongly enhanced in the DOXO group; on the other hand, their expression was reduced in the DAPA-DOXO group. Troponin-T, B-type natriuretic peptide (BNP), and N-Terminal Pro-BNP (NT-pro-BNP) were strongly reduced in the DOXO-DAPA group, revealing cardioprotective properties of SGLT2i. Mice treated with DOXO and DAPA exhibited reduced myocardial and renal NF-kB expression.
The overall picture of the study encourages the use of DAPA in the primary prevention of cardiomyopathies induced by anthracyclines in patients with cancer.
The HOLMES experiment aims to directly measure the
ν
mass studying the
163
Ho electron capture decay spectrum developing arrays of TES-based microcalorimeters implanted with O(300 Bq/detector) Ho ...atoms. The embedding of the source inside detectors is a crucial step of the experiment. Because the
163
Ho production process (neutron irradiation of a
162
Er sample) is not perfectly free from impurities, Ho source must be separated from a lot of contaminants. A chemical processing removes every species other than Ho, but it is not sufficient to remove all isotope-related background sources: Indeed,
166
m
Ho beta decay can produce fake signal in the region of interest. For this reason, a dedicated implantation system was set up. It is designed to achieve the separation power better than 5
σ
at 163/166 a.m.u. allowing an efficient Ho ions implantation inside microcalorimeter absorbers. Its main components are a 50 kV sputter-based ion source, a magnetic dipole and a target chamber. A specially designed co-evaporation system was designed to “grow” the gold microcalorimeter absorber during the implantation process, increasing the maximum achievable activity which can be implanted. The machine performances were evaluated by means of calibration runs using
63
Cu/
65
Cu and Mo beams. A special care was given to the study of the more effective way to populate source plasma with Ho ions obtained from different Ho compounds by sputtering process. In this work, the machine development and commissioning are described.
The TORIO-229 experiment aims for a direct model-independent determination of the transition energy of
229
m
Th produced in
233
U alpha decay. This knowledge will be of interest for the development ...of a scientific clock exploiting the thorium isomeric state, which would be able to significantly surpass the precision of the presently best clocks. As a detector for the isomeric transition, it is planned to use an array of fast transition-edge sensors (TESs) which demonstrated to be feasible in our previous work where the Ir/Au TES prototype demonstrated
4.6
±
1.7
µs rise time,
5.8
±
2.1
µs fall time and
0.789
±
0.023
eV energy resolution and signal-to-noise ratio of
∼
10 with one-photon (2.824 eV) signal, satisfying the experimental requirements. Such a microcalorimeter will allow to register the transition in every possible channel in the energy range from 3 to 50 eV and with a lifetime of > 5 µs. To have a full characterization of a single TES for the final detector array design, its thermal conductance has to be measured. In this contribution, we report on a test measurement of thermal coupling of a TORIO-229 prototype-like iridium-gold TES.
The HOLMES experiment will perform a precise calorimetric measurement of the end point of the Electron Capture (EC) decay spectrum of 163 Ho in order to extract information on neutrino mass with a ...sensitivity below 2 eV. In its final configuration, HOLMES will deploy 1000 detectors of low temperature microcalorimeters with implanted 163 Ho nuclei. The baseline sensors for HOLMES are Mo/Cu TESs (Transition Edge Sensors) on SiN x membrane with gold absorbers. Considering the large number of pixels and an event rate of about 300 Hz/pixel, a large multiplexing factor and a large bandwidth are needed. To fulfill this requirement, HOLMES will exploit recent advances on microwave multiplexing. In this contribution we present the status of the activities in development, the performances of the developed microwave-multiplexed readout system, and the results obtained with the detectors specifically designed for HOLMES in terms of noise, time and energy resolutions.
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