In recent years, research has witnessed an increasing interest in the bidirectional relationship between emotion and sleep. Sleep seems important for restoring daily functioning, whereas deprivation ...of sleep makes us more emotionally aroused and sensitive to stressful stimuli and events. Sleep appears to be essential to our ability to cope with emotional stress in everyday life. However, when daily stress is insufficiently regulated, it may result in mental health problems and sleep disturbances too. Not only does emotion impact sleep, but there is also evidence that sleep plays a key role in regulating emotion. Emotional events during waking hours affect sleep, and the quality and amount of sleep influences the way we react to these events impacting our general well-being. Although we know that daytime emotional stress affects sleep by influencing sleep physiology, dream patterns, dream content and the emotion within a dream, its exact role is still unclear. Other effects that have been found are the exaggeration of the startle response, decrease in dream recall and elevation of awakening thresholds from rapid eye movement (REM), REM-sleep, increased or decreased latency to REM-sleep, increase in percentage of REM-density, REM-sleep duration, as well as the occurrence of arousals in sleep as a marker of sleep disruption. Equally, the way an individual copes with emotional stress, or the way in which an individual regulates emotion may modulate the effects of emotional stress on sleep. The research presented here supports the idea that adaptive emotion regulation benefits our follow-up sleep. We thus conclude the current review with a call for future research in order to clarify further the precise relationship between sleep, emotion and emotion regulation, as well as to explain further how sleep dissolves our emotional stress.
Zero-dimensional semiconductor nanocrystals (quantum dots) are known to interact with other metallic or semiconductor medium by means of resonant energy transfer or transfer of electronic charge. In ...the present work we demonstrate efficient electronic interaction of quantum dots and recently discovered graphene, single atom thick two-dimensional carbon crystal. Transfer of optically generated carriers from a quantum dot to graphene is seen by the quench of quantum dots photoluminescence and confirmed by the electrical measurements on single-layer graphene transistor. The phenomenon reported could find an application in graphene-based optical switching and light harvesting.
► Photoluminescence of quantum dots is suppressed when they are deposited on graphene. ► Charge transfer from optically excited quantum dots to graphene is demonstrated. ► We propose the use of graphene as a scaffold for efficient light harvesting devices.
The volume brings together academics and practitioners from across the EU to address the question of 'facultative mixity' in the EU's external relations, i.e. the situation whereby both the EU and ...its Member States enter into an international agreement with a third country even if legally the EU could act on its own.
ObjectiveTo quantify the implementation of the third Joint British Societies’ Consensus Recommendations for the Prevention of Cardiovascular Disease (JBS3) after coronary event.MethodsUsing a ...cross-sectional survey design, patients were consecutively identified in 36 specialist and district general hospitals between 6 months and 2 years, after acute coronary syndrome or revascularisation procedure and invited to a research interview. Outcomes included JBS3 lifestyle, risk factor and therapeutic management goals. Data were collected using standardised methods and instruments by trained study nurses. Blood was analysed in a central laboratory and a glucose tolerance test was performed.Results3926 eligible patients were invited to participate and 1177 (23.3% women) were interviewed (30% response). 12.5% were from black and minority ethnic groups. 45% were persistent smokers, 36% obese, 52.9% centrally obese, 52% inactive; 30% had a blood pressure >140/90 mm Hg, 54% non-high-density lipoprotein ≥2.5 mmol/L and 44.3% had new dysglycaemia. Prescribing was highest for antiplatelets (94%) and statins (85%). 81% were advised to attend cardiac rehabilitation (86% <60 years vs 79% ≥60 years; 82% men vs 77% women; 93% coronary artery bypass grafting vs 59% unstable angina), 85% attended if advised; 69% attended overall. Attenders were significantly younger (p=0.03) and women were less likely to attend (p=0.03).ConclusionsPatients with coronary heart disease (CHD) are not being adequately managed after event with preventive measures. They require a structured preventive cardiology programme addressing lifestyle, risk factor management and adherence to cardioprotective medications to achieve the standards set by the British Association for Cardiovascular Prevention and Rehabilitation and JBS3 guidelines.
Traditionally, locomotive engineers begin sounding the train horn approximately one-quarter mile from the crossing to warn motorists and pedestrians approaching the intersection. To be heard over ...this distance, the train horn must be very loud. This combination of loud horns and the length along the tracks that the horn is sounded creates a large area adversely impacted by the horn noise. In urban areas, this area likely includes many nearby residents. The automated-horn system provides a similar audible warning to motorists and pedestrians by using two stationary horns mounted at the crossing. Each horn directs its sound toward the approaching roadway. The horn system is activated using the same track–signal circuitry as the gate arms and bells located at the crossing. Once the horn is activated, a strobe light begins flashing to inform the locomotive engineer that the horn is working. Horn volume data collected near the crossings clearly demonstrate the significant reduction of land area negatively impacted by using the automated horns. Residents overwhelmingly accepted the automated-horn systems and noted a significant improvement in their quality of life. Motorists preferred the automated-horn systems, and locomotive engineers rated these crossings slightly safer compared with the same crossings in the before (train horn) condition.
The Alzheimer Precision Medicine Initiative Hampel, Harald; Vergallo, Andrea; Perry, George ...
Journal of Alzheimer's disease,
01/2019, Letnik:
68, Številka:
1
Journal Article
Recenzirano
Precision medicine (PM) is an evolving scientific renaissance movement implementing key breakthrough technological and scientific advances to overcome the limitations of traditional symptom- and ...sign-based phenotypic diagnoses and clinical "one-size-fits-all, magic bullet drug development" in these largely heterogeneous target populations. It is a conceptual shift from ineffective treatments for biologically heterogeneous "population averages" to individually-tailored biomarker-guided targeted therapies. PM is defining which therapeutic approach will be the most effective for a specific individual, at a determined disease stage, across multiple medical research fields, including neuroscience, neurology and psychiatry. The launch of the Alzheimer Precision Medicine Initiative (APMI) and its associated cohort program in 2016-facilitated by the academic core coordinating center run by the Sorbonne University Clinical Research Group in Alzheimer Precision Medicine (Sorbonne University GRC n°21 APM)"-is geared at transforming healthcare, conventional clinical diagnostics, and drug development research in Alzheimer's disease. Ever since the commencement of the APMI, the international interdisciplinary research network has introduced groundbreaking translational neuroscience programs on the basis of agnostic exploratory genomics, systems biology, and systems neurophysiology applying innovative "big data science", including breakthrough artificial intelligence-based algorithms. Here, we present the scientific breakthrough advances and the pillars of the theoretical and conceptual development leading to the APMI.
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