Debates about gender are everywhere. Is it an inner identity, a biological fact, or an oppressive system? Should we respect it or resist it? What Even Is Gender? shifts the conversation in a fresh ...direction, arguing that these debates rest on a shared mistake: the idea that there is one thing called "gender" that both sides are arguing about. The authors distinguish a range of phenomena that established vocabulary often lumps together. This sheds light on the equivocations and false dichotomies of "gender" talk, and how they deny many of us the tools to make our needs, experiences, and concerns intelligible to others or even to ourselves. The authors develop a conceptual toolkit that helps alleviate the harms that result from the limitations of familiar approaches. They propose a pluralistic concept of "gender feels" that distinguishes among our experiences of diverse facets of gendered life. They develop a flexible approach to gender categories that reflects the value of self-determination. And they suggest that what we need is not one universal language of gender but an awareness of individual variation and a willingness to adjust to changing contexts and circumstances. A bold and thought-provoking approach to thinking about gender, What Even Is Gender? will be of great interest to those in philosophy, gender studies, sociology, and LGBTQIA+ studies.
The properties of exotic nuclei on the verge of existence play a fundamental part in our understanding of nuclear interactions. Exceedingly neutron-rich nuclei become sensitive to new aspects of ...nuclear forces. Calcium, with its doubly magic isotopes (40)Ca and (48)Ca, is an ideal test for nuclear shell evolution, from the valley of stability to the limits of existence. With a closed proton shell, the calcium isotopes mark the frontier for calculations with three-nucleon forces from chiral effective field theory. Whereas predictions for the masses of (51)Ca and (52)Ca have been validated by direct measurements, it is an open question as to how nuclear masses evolve for heavier calcium isotopes. Here we report the mass determination of the exotic calcium isotopes (53)Ca and (54)Ca, using the multi-reflection time-of-flight mass spectrometer of ISOLTRAP at CERN. The measured masses unambiguously establish a prominent shell closure at neutron number N = 32, in excellent agreement with our theoretical calculations. These results increase our understanding of neutron-rich matter and pin down the subtle components of nuclear forces that are at the forefront of theoretical developments constrained by quantum chromodynamics.
In omics experiments, variable selection involves a large number of metabolites/ genes and a small number of samples (the n < p problem). The ultimate goal is often the identification of one, or a ...few features that are different among conditions- a biomarker. Complicating biomarker identification, the p variables often contain a correlation structure due to the biology of the experiment making identifying causal compounds from correlated compounds difficult. Additionally, there may be elements in the experimental design (blocks, batches) that introduce structure in the data. While this problem has been discussed in the literature and various strategies proposed, the over fitting problems concomitant with such approaches are rarely acknowledged. Instead of viewing a single omics experiment as a definitive test for a biomarker, an unrealistic analytical goal, we propose to view such studies as screening studies where the goal of the study is to reduce the number of features present in the second round of testing, and to limit the Type II error. Using this perspective, the performance of LASSO, ridge regression and Elastic Net was compared with the performance of an ANOVA via a simulation study and two real data comparisons. Interestingly, a dramatic increase in the number of features had no effect on Type I error for the ANOVA approach. ANOVA, even without multiple test correction, has a low false positive rates in the scenarios tested. The Elastic Net has an inflated Type I error (from 10 to 50%) for small numbers of features which increases with sample size. The Type II error rate for the ANOVA is comparable or lower than that for the Elastic Net leading us to conclude that an ANOVA is an effective analytical tool for the initial screening of features in omics experiments.
The influence of mesoscale dynamics on variability of phytoplankton biomass in terms of chlorophyll-a (chl-a) concentration was studied in the coastal waters of the South Eastern Arabian Sea (SEAS) ...using long-term satellite data. Satellite-derived chl-a, sea level anomaly, sea surface temperature, and sea surface wind data for the period 1998-2016 were compiled from various sources and analysed to investigate the chl-a variability associated with coastal upwelling and mesoscale eddies. The Empirical Orthogonal Function and Morlet wavelet analyses were performed to estimate the quantitative variability and the result showed strong seasonal and interannual modulation in chl-a concentration and associated environmental variables. The Okubo-Weiss criterion was applied for the identification of mesoscale eddies. The results indicated the presence of cyclonic (cold core) eddies during the summer monsoon season (June-September). The wind-induced upwelling and the cyclonic eddies were most intense during the summer monsoon season, causing higher values of chl-a compared with other season. It is revealed that the variability of chl-a, which might be attributed to seasonal and interannual differences in the surface and sub-surface nutrients, is caused either by coastal upwelling or cyclonic eddies. In particular, the wind-induced upwelling strongly controls the spatial and temporal variability of chl-a compared with mesoscale eddies along the SEAS. The regression model we adopted points out the dominant role played by the wind and its forcing bring about variability in chl-a. The occurrence of extreme climatic events such as El Niño, La Niña and Indian Ocean Dipole (IOD) was noticed during the study period and particularly taken into account to understand the interannual fluctuations in chl-a and associated environmental variables. The relative variability in chl-a concentration was prominent during strong El Niño, La Niña, and IOD. We have attempted to determine the relationship between chl-a with coastal upwelling and mesoscale eddies, the overall importance of such physical forcings, and their influence on bio-production in the SEAS.
SS 316LN with varying nitrogen content is subjected to thermal aging for 20,000 h at 650 °C to assess long-term structural integrity under operational conditions in nuclear reactors. While the ...annealing twins and heterogeneous grain evolution by bimodal division are independent of chemical composition, the type, size, and morphology of evolving secondary phases are characteristic of nitrogen concentration. Color contrast in bright field optical microscopy combined with transmission electron microscopy reveals the presence of three major precipitate phases; M
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(C, N)
6
, Fe
2
Mo intermetallics, and Cr
2
N. Contiguously formed hetero-structures of Fe
2
Mo/Cr
2
N are quantified, and extensive formation has been observed in steels with high nitrogen content (0.14 wt. % and 0.22 wt. %). In addition to the grain boundary carbo-nitrides, the morphological derivatives of intra-granular M
23
(C, N)
6
precipitates with cube-on-cube orientation relationship such as (1) isolated cubes, (2) primary stringers/strings of cubes, (3) secondary stringers/clusters of branched primary strings, and (4) clusters of laths are identified. The stringers and laths are preferentially grown in {111}/ < 110 > γ. The growth plane and crystallographic variants of primary and secondary stringers are exclusively identified from optical micrographs. All varieties of M
23
(C, N)
6
are prominent in the sample with 0.22 wt. % nitrogen whereas, clustering of stringers and laths are absent in steels with lower nitrogen concentration. Overall mechanical properties reform by the precipitation strengthening effect due to the excess nitrogen content.
Graphical abstract
TGF-β-activated kinase-1 (TAK1), also known as MAPKK kinase-7 (MAP3K7), is a candidate effector of multiple circuits in cardiac biology and disease. Here, we show that inhibition of TAK1 in mice by a ...cardiac-specific dominant-negative mutation evokes electrophysiological and biochemical properties reminiscent of human Wolff-Parkinson-White syndrome, arising from mutations in AMPactivated protein kinase (AMPK), most notably, accelerated atrioventricular conduction and impaired AMPK activation. To test conclusively the biochemical connection from TAK1 to AMPK suggested by this phenotype, we disrupted TAK1 in mouse embryos and embryonic fibroblasts by Cre-mediated recombination. In TAK1-null embryos, the activating phosphorylation of AMPK at T172 was blocked, accompanied by defective AMPK activity. However, loss of endogenous TAK1 causes midgestation lethality, with defective yolk sac and intraembryonic vasculature. To preclude confounding lethal defects, we acutely ablated floxed TAK1 in culture by viral delivery of Cre. In culture, endogenous TAK1 was activated by oligomycin, the antidiabetic drug metformin, 5-aminoimidazole-4-carboxamide riboside (AICAR), and ischemia, well established triggers of AMPK activity. Loss of TAK1 in culture blocked T172 phosphorylation induced by all three agents, interfered with AMPK activation, impaired phosphorylation of the endogenous AMPK substrate acetyl CoA carboxylase, and also interfered with activation of the AMPK kinase LKB1. Thus, by disrupting the endogenous TAK1 locus, we prove a pivotal role for TAK1 in the LKB1/AMPK signaling axis, an essential governor of cell metabolism.
We sought to examine the short- and long-term outcomes of patients who developed contrast-induced acute kidney injury (CI-AKI; defined as an increase in serum creatinine of ≥0.5 mg/dL or a 25% ...relative rise within 48 h after contrast exposure) from the large-scale HORIZONS-AMI trial.
Multivariable analyses were used to identify predictors of CI-AKI, as well predictors of the primary and secondary endpoints. The incidence of CI-AKI in this cohort of ST-segment elevation myocardial infarction (STEMI) patients was 16.1% (479/2968). Predictors of CI-AKI were contrast volume, white blood cell count, left anterior descending infarct-related artery, age, anaemia, creatinine clearance <60 mL/min, and history of congestive heart failure. Patients with CI-AKI had higher rates of net adverse clinical events NACE; a combination of major bleeding or composite major adverse cardiac events (MACE; consisting of death, reinfarction, target vessel revascularization for ischaemia, or stroke) at 30 days (22.0 vs. 9.3%; P < 0.0001) and 3 years (40.3 vs. 24.6%; P < 0.0001). They also had higher rates of mortality at 30 days (8.0 vs. 0.9%; P < 0.0001) and 3 years (16.2 vs. 4.5%; P < 0.0001). Multivariable analysis confirmed CI-AKI as an independent predictor of NACE hazard ratio (HR), 1.53; 95% confidence interval (CI), 1.23-1.90; P = 0.0001, MACE (HR, 1.56; 95% CI, 1.23-1.98; P = 0.0002), non-coronary artery bypass grafting major bleeding (HR, 2.07; 95% CI, 1.57-2.73; P < 0.0001), and mortality (HR, 1.80; 95% CI, 1.19-2.73; P = 0.005) at 3-year follow-up.
Contrast-induced acute kidney injury is associated with poor short- and long-term outcomes after primary percutaneous coronary intervention in STEMI.
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