IDEA (Innovative Detector for Electron–positron Accelerators) is a detector concept designed for a future leptonic collider operating as a Higgs factory. It is based on innovative detector ...technologies developed over years of R&D. In September 2018, prototypes of the proposed sub-detectors have been tested for the first time on a beam line at CERN. The preliminary results from this test of a full slice of the IDEA detector and standalone measurements of dual read-out calorimeter prototypes are presented.
The reactivation of latent tuberculosis (TB) is a major complication of tumor necrosis factor (TNF)-α inhibitors. Screening for TB infection is recommended before anti-TNF therapy is initiated; ...however, the use of tuberculin skin testing (TST) is controversial, due to the high rate of false-negative results in patients receiving immunosuppressive treatment. To compare the performance of two commercial interferon (IFN)-γ release assays (IGRA), T-SPOT.
TB
(TS-TB) and QuantiFERON-TB Gold “In-tube” (QFT-GIT), with TST for the detection of TB infection in patients due to start anti-TNF therapy, 69 human immunodeficiency virus (HIV)-negative Italian patients (mean age: 45.2 ± 12.6 years; male=39) were enrolled between September 2005 to August 2006. Patients affected by rheumatoid arthritis (
n
= 18), psoriatic arthritis (
n
= 26), ulcerous rectocolitis (
n
= 6), and Crohn’s disease (
n
= 19) were tested simultaneously with TST, TS-TB, and QFT-GIT. Overall, 26% of patients were positive by TST, 30.4% by TS-TB, and 31.8% by QFT-GIT. Agreement with TST was similar (
κ
= 0.21,
p
= 0.0002 and
κ
= 0.26,
p
< 0.001, respectively). In 11 TST-negative cases, IFN-γ release assays were positive. In addition, in seven Mantoux-positive cases with no TB risk factors, TST result agreement was achieved with at least one blood test. Indeterminate results were detected in 5.8% and 2.8% of cases, respectively, with TS-TB and with QFT-GIT (
p
= not significant ns). In conclusion, our results suggest that IGRAs may be helpful for screening purposes in patient candidates for anti-TNF therapy to confirm positive TST results and in selected cases when false-negative results are suspected. The utility of blood tests in patients with low or no TB risk remains to be assessed.
The CMS muon detector Giacomelli, P.
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
02/2002, Letnik:
478, Številka:
1
Journal Article
Recenzirano
The muon detection system of the Compact Muon Solenoid experiment is described. It consists of three different detector technologies: drift tubes in the barrel region, cathode strip chambers in the ...endcap region and resistive plate chambers in both barrel and endcap regions. The CMS muon detection system ensures excellent muon detection and efficient triggering in the pseudorapidity range 0<
η<2.4. The most recent developments and some results from the R&D program will also be discussed.
Test beam results of the fiber-sampling dual-readout calorimeter Giaz, A.; Santoro, R.; Ampilogov, N. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
March 2023, 2023-03-00, Letnik:
1048
Journal Article
Recenzirano
The dual-readout calorimetric technique reconstructs the event-by-event electromagnetic fraction of the hadronic shower through the simultaneous measurement of scintillating (S) and Cherenkov (C) ...light produced by the shower development. The new generation of prototypes, based on Silicon Photomultipliers (SiPMs) readout, adds unprecedented granularity to the well-known high-energy resolution. A highly granular prototype (10×10×100cm3), designed to fully contain electromagnetic showers, was recently built and qualified on beam. It consists of 9 modules, each made of 320 brass capillaries equipped with both scintillating and clear fibers. All the fibers of the central module are coupled with SiPMs, while the PMTs are used for the others. Furthermore, the new FERS-System, designed by Caen to exploit the CITIROC1A ASICs performances, is at the core of the SiPM readout.
The recent test beam at DESY allowed us to qualify the readout system and define a procedure to calibrate the SiPM response from ADC to ph-e in a wide dynamic range. We measured the number of ph-e per GeV for scintillating and Cherenkov light together with the calorimetric performances in the energy range of 1–6 GeV. This work reports the system qualification and the test beam results regarding SiPM calibration.
Performance of T-SPOT.TB™ (TS-TB) and QuantiFERON TB Gold-In tube (QFT-IT) assays was evaluated for detection of M. tuberculosis (Mtb) infection in patients with suspected extra-pulmonary or ...smear-negative pulmonary tuberculosis (TB) in a low prevalence country. Twenty-one out of 35 patients were affected by active TB. Mtb culture isolation was achieved in 76% of cases. Tuberculin skin testing (TST), TS-TB, and QFT-IT yielded a positive result in 67%, 95% and 81% of cases, respectively. Agreement of interferon-γ release assays and TST was 70% (κ=0.18 for TS-TB; κ=0.46 for QFT-IT). Increased sensitivity of blood assays (>80%) improved diagnostic evaluation of difficult TB cases.
The forward muon detector of the CMS experiment Giacomelli, P.
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
05/1998, Letnik:
409, Številka:
1-3
Journal Article
Recenzirano
We describe the forward muon detector of the CMS experiment at the LHC accelerator. The CMS forward muon detector is composed of 4 independent stations, each station being made of a mosaic of ...six-layer cathode strip chambers. Cathode strip chambers are multiwire proportional chambers with a cathode segmented in strips to provide a precise measurement of the coordinate across the strip direction. The forward muon detector has to be able to measure hits along muon tracks with a precision of 75–150μm per station as well as providing an accurate time tag to be used by the first level trigger. The forward muon detector will cover an area of more than 1000m2 representing one of the largest system of proportional chambers ever built. We also present some results obtained using muon test beams with some cathode strip chamber prototypes.
The IDEA detector concept has been designed to operate at a future large circular e+e− collider, like FCC-ee or CEPC. The IDEA detector has an innovative design with a central tracker enclosed in a ...superconducting solenoidal magnet. Going outwards, a preshower system followed by a dual readout calorimeter is foreseen. In the iron yoke, that closes the magnetic field, are then located three stations of muon detectors. The preshower and muon detectors are based on the μ-RWELL technology that inherits the best characteristics of the GEM, in particular the layout of the amplification stage, and Micromega detectors, that inspired the presence of a resistive stage. To profit of the industrial production capabilities of this technology, a modular design has been adopted for both systems: the μ-RWELL tile will have an active area of 50 × 50 cm2, but with a pitch between the readout strips of 400μm for the preshower and about 1 mm for the muon system. Other requirements are: a spatial resolution of the order of 100μm for the preshower and a reasonable total number of front-end channels for the muon system. To optimize the resistivity and the strip pitch, we have built a set of prototypes with active area of 5 × 40 cm2 and 40 cm long strips. The DLC resistivity is ranging from 10 to 80 MΩ/□. All these detectors have been exposed in October 2021 to a muon beam at the CERN SPS. The very positive results obtained pave the way for a completely new and competitive MPGD tracking device for high energy physics experiments.
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