Negative mood regulation expectancies (NMRE) describe the expectancies of an individual regarding his or her ability to regulate or reduce negative mood states by certain cognitive or behavioral ...strategies. NMRE are closely associated with the actual emotion regulation and potentially buffer the negative psychological and physical health consequences of stress. In the context of chronic pain, stress plays a central role, as long-term stress can have additional negative consequences regarding pain and its progression. The present study investigated the relationship of NMRE with treatment outcome, and more importantly, its buffering role in the association between stress and treatment outcomes.
Two hundred six chronic pain inpatients (fulfilling the International Classification of Diseases, 10th Revision ICD-10 diagnosis of F45.41) of an interdisciplinary treatment completed standardized self-report questionnaires at intake and discharge. Hierarchical linear regression analyses were used to test the main effects of the Negative Mood Regulation Scale-Short Form on pain intensity, pain-related disability, and psychological distress as treatment outcomes and its moderating role in the association of stress and the 3 outcome measures.
A significant main effect of NMRE on treatment outcome was only found for psychological distress. However, for all 3 outcome measures, a significant moderating effect of NMRE on the association between stress level and treatment outcome was found.
NMRE appear to play an important role for the outcome of inpatient treatment for chronic pain. Due to their buffering effect on the negative association between stress and therapy outcome, they should be targeted in the treatment of chronic pain.
In this paper, we investigate how the COVID-19 health crisis could affect the liquidity of listed firms across 26 countries. We stress-test three liquidity ratios for each firm with full and partial ...operating flexibility in two simulated distress scenarios corresponding to drops in sales of 50% and 75%, respectively. In the most adverse scenario, the average firm with partial operating flexibility would exhaust its cash holdings in about two years. At that point, its current liabilities would increase, on average, by eight times, suggesting that the average firm would have to resort to the debt market to prevent a liquidity crunch. Moreover, about 1/10th of all sample firms would become illiquid within six months. Finally, we study two different fiscal policies, tax deferrals and bridge loans, that governments could implement to mitigate the liquidity risk. Our analysis suggests bridge loans are more cost-effective to prevent a massive cash crunch.
This article presents ORB-SLAM3, the first system able to perform visual, visual-inertial and multimap SLAM with monocular, stereo and RGB-D cameras, using pin-hole and fisheye lens models. The first ...main novelty is a tightly integrated visual-inertial SLAM system that fully relies on maximum a posteriori (MAP) estimation, even during IMU initialization, resulting in real-time robust operation in small and large, indoor and outdoor environments, being two to ten times more accurate than previous approaches. The second main novelty is a multiple map system relying on a new place recognition method with improved recall that lets ORB-SLAM3 survive to long periods of poor visual information: when it gets lost, it starts a new map that will be seamlessly merged with previous maps when revisiting them. Compared with visual odometry systems that only use information from the last few seconds, ORB-SLAM3 is the first system able to reuse in all the algorithm stages all previous information from high parallax co-visible keyframes, even if they are widely separated in time or come from previous mapping sessions, boosting accuracy. Our experiments show that, in all sensor configurations, ORB-SLAM3 is as robust as the best systems available in the literature and significantly more accurate. Notably, our stereo-inertial SLAM achieves an average accuracy of 3.5 cm in the EuRoC drone and 9 mm under quick hand-held motions in the room of TUM-VI dataset, representative of AR/VR scenarios. For the benefit of the community we make public the source code.
We study compensation contracts of individual portfolio managers using handcollected data of over 4,500 U.S. mutual funds. Variations in the compensation structures are broadly consistent with an ...optimal contracting equilibrium. The likelihood of explicit performance-based incentives is positively correlated with the intensity of agency conflicts, as proxied by the advisor's clientele dispersion, its affiliations in the financial industry, and its ownership structure. Investor sophistication and the threat of dismissal in outsourced funds serve as substitutes for explicit performancebased incentives. Finally, we find little evidence of differences in future performance associated with any particular compensation arrangement.
Text matching to measure patent similarity Arts, Sam; Cassiman, Bruno; Gomez, Juan Carlos
Strategic management journal,
01/2018, Letnik:
39, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Research summary: We propose using text matching to measure the technological similarity between patents. Technology experts from different fields validate the new similarity measure and its ...improvement on measures based on the United States Patent Classification System, and identify its limitations. As an application, we replicate prior findings on the localization of knowledge spillovers by constructing a case-control group of text-matched patents. We also provide open access to the code and data to calculate the similarity between any two utility patents granted by the United States Patent and Trademark Office between 1976 and 2013, or between any two patent portfolios. Managerial summary: We propose using text matching to measure the technological similarity between patents. The method can be used by various practitioners such as inventors, attorneys, patent examiners, and managers to search for closely related prior art, to assess the novelty of a patent, to identify R&D opportunities in less crowded areas, to detect in- or out-licensing opportunities, to map companies in technology space, and to find acquisition targets. We use an expert panel to validate the improvement of the new similarity measure on measures based on the United States Patent Classification System, and provide open access to the code and data to calculate the similarity between any two utility patents granted by the USPTO between 1976 and 2013, or between any two patent portfolios.
This paper presents the design of a wireless sensor network particularly designed for remote monitoring and control of industrial parameters. The article describes the network components, protocol ...and sensor deployment, aimed to accomplish industrial constraint and to assure reliability and low power consumption. A particular case of study is presented. The system consists of a base station, gas sensing nodes, a tree-based routing scheme for the wireless sensor nodes and a real-time monitoring application that operates from a remote computer and a mobile phone. The system assures that the industrial safety quality and the measurement and monitoring system achieves an efficient industrial monitoring operations. The robustness of the developed system and the security in the communications have been guaranteed both in hardware and software level. The system is flexible and can be adapted to different environments. The testing of the system confirms the feasibility of the proposed implementation and validates the functional requirements of the developed devices, the networking solution and the power consumption management.
Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role as a ...central regulator in energy homeostasis has been largely described during the past 20 years. Once secreted into the circulation, leptin reaches the central and peripheral nervous systems and acts by binding and activating the long form of leptin receptor (LEPR), regulating appetite and food intake, bone mass, basal metabolism, reproductive function and insulin secretion, among other processes. Research on the regulation of different adipose tissues has provided important insights into the intricate network that links nutrition, metabolism and immune homeostasis. The neuroendocrine and immune systems communicate bi-directionally through common ligands and receptors during stress responses and inflammation, and control cellular immune responses in several pathological situations including immune-inflammatory rheumatic diseases. This Review discusses the latest findings regarding the role of leptin in the immune system and metabolism, with particular emphasis on its effect on autoimmune and/or inflammatory rheumatic diseases, such as rheumatoid arthritis and osteoarthritis.
Ribosomes are the highly complex macromolecular assemblies dedicated to the synthesis of all cellular proteins from mRNA templates. The main principles underlying the making of ribosomes are ...conserved across eukaryotic organisms and this process has been studied in most detail in the yeast Saccharomyces cerevisiae. Yeast ribosomes are composed of four ribosomal RNAs (rRNAs) and 79 ribosomal proteins (r-proteins). Most r-proteins need to be transported from the cytoplasm to the nucleus where they get incorporated into the evolving pre-ribosomal particles. Due to the high abundance and difficult physicochemical properties of r-proteins, their correct folding and fail-safe targeting to the assembly site depends largely on general, as well as highly specialized, chaperone and transport systems. Many r-proteins contain universally conserved or eukaryote-specific internal loops and/or terminal extensions, which were shown to mediate their nuclear targeting and association with dedicated chaperones in a growing number of cases. The 60S r-protein Rpl4 is particularly interesting since it harbours a conserved long internal loop and a prominent C-terminal eukaryote-specific extension. Here we show that both the long internal loop and the C-terminal eukaryote-specific extension are strictly required for the functionality of Rpl4. While Rpl4 contains at least five distinct nuclear localization signals (NLS), the C-terminal part of the long internal loop associates with a specific binding partner, termed Acl4. Absence of Acl4 confers a severe slow-growth phenotype and a deficiency in the production of 60S subunits. Genetic and biochemical evidence indicates that Acl4 can be considered as a dedicated chaperone of Rpl4. Notably, Acl4 localizes to both the cytoplasm and nucleus and it has the capacity to capture nascent Rpl4 in a co-translational manner. Taken together, our findings indicate that the dedicated chaperone Acl4 accompanies Rpl4 from the cytoplasm to its pre-60S assembly site in the nucleus.
The urgent need for optimizing the available energy through smart grids and efficient large‐scale energy storage systems is pushing the construction and deployment of Li‐ion batteries in the MW range ...which, in the long term, are expected to hit the GW dimension while demanding over 1000 ton of positive active material per system. This amount of Li‐based material is equivalent to almost 1% of current Li consumption and can strongly influence the evolution of the lithium supply and cost. Given this uncertainty, it becomes mandatory to develop an energy storage technology that depends on almost infinite and widespread resources: Na‐ion batteries are the best technology for large‐scale applications. With small working cells in the market that cannot compete in cost ($/W h) with commercial Li‐ion batteries, the consolidation of Na‐ion batteries mainly depends on increasing their energy density and stability, the negative electrodes being at the heart of these two requirements. Promising Na‐based negative electrodes for large‐scale battery applications are reviewed, along with the study of the solid electrolyte interphase formed in the anode surface, which is at the origin of most of the stability problems.
The rapid increase of Li‐ion battery demand, along with its forecasted growth owing to the expansion of electric vehicles and smart grids, is positioning Na‐ion batteries as an alternative technology of choice in the next years to come. The anode, one of the most crucial components in further advancements with Na‐ion batteries, is reviewed and future perspectives are provided.
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