El presente trabajo de investigación versa sobre las relaciones “paradójicas” entre territorio y educación en España, tomando como referente el espacio castellanoleonés que ofrece, en base a informes ...nacionales e internacionales, unas cotas educativas plenamente comparables internacionalmente. Esta “buena educación” presenta un importante margen de mejora. El equipo de investigación ha realizado 59 entrevistas abiertas (a una muestra de 8 centros). Se han entrevistado dos tipos de actores: sociales y educativos. El estudio se estructura en dos partes. Una “política” en la que los retos se han diagnosticado a partir del enfoque metodológico SLR (Sistematic Literature Review) y, una segunda, “pedagógica”, en la que el tratamiento de las fuentes orales se ha realizado a partir del CCS (Comparative Case Study) (Bartlett y Vavrus). Los resultados nos indican que en el imaginario de los actores aparecen desafíos que requieren respuesta (política y social). Se refieren a las condiciones laborales y formativas de los docentes, a los recursos y medios, a las relaciones entre actores y a los ajustes curriculares. También exigen reforzar las relaciones con el entorno (socioeconómico e institucional), la estabilidad de las políticas educativas, la confianza y responsabilidad de y en la educación, un refuerzo de la autonomía escolar y pedagógica y la mejora de la formación de los equipos directivos.
Pre-exposure prophylaxis (PrEP) is a promising strategy to break COVID-19 transmission. Although hydroxychloroquine was evaluated for treatment and post-exposure prophylaxis, it is not evaluated for ...COVID-19 PrEP yet. The aim of this study was to evaluate the efficacy and safety of PrEP with hydroxychloroquine against placebo in healthcare workers at high risk of SARS-CoV-2 infection during an epidemic period.
We conducted a double-blind placebo-controlled randomized clinical trial in three hospitals in Barcelona, Spain. From 350 adult healthcare workers screened, we included 269 participants with no active or past SARS-CoV-2 infection (determined by a negative nasopharyngeal SARS-CoV-2 PCR and a negative serology against SARS-CoV-2). Participants allocated in the intervention arm (PrEP) received 400 mg of hydroxychloroquine daily for the first four consecutive days and subsequently, 400 mg weekly during the study period. Participants in the control group followed the same treatment schedule with placebo tablets.
52.8% (142/269) of participants were in the hydroxychloroquine arm and 47.2% (127/269) in the placebo arm. Given the national epidemic incidence decay, only one participant in each group was diagnosed with COVID-19. The trial was stopped due to futility and our study design was deemed underpowered to evaluate any benefit regarding PrEP efficacy. Both groups showed a similar proportion of participants experiencing at least one adverse event (AE) (p=0.548). No serious AEs were reported. Almost all AEs (96.4%, 106/110) were mild. Only mild gastrointestinal symptoms were significantly higher in the hydroxychloroquine arm compared to the placebo arm (27.4% (39/142) vs 15.7% (20/127), p=0.041).
Although the efficacy of PrEP with hydroxychloroquine for preventing COVID-19 could not be evaluated, our study showed that PrEP with hydroxychloroquine at low doses is safe.
ClinicalTrials.gov NCT04331834 . Registered on April 2, 2020.
Este trabajo recoge las evidencias materiales de época calcolítica documentadas en las diferentes intervenciones arqueológicas llevadas a cabo en las laderas del cerro del Castillo de Medellín ...(Badajoz). La aparición de varias estructuras y un significativo lote de materiales cerámicos, avalan la existencia de un momento de ocupación de este estratégico punto del valle medio del Guadiana durante el III Milenio a.C., lo que suma un punto más en el dinámico paisaje del poblamiento calcolítico de este territorio.
Memoria ID-0047. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2009-2010.
El proyecto se ha basado en un objetivo global a través del cual se pretendía la integración social ...y adaptación del colectivo de estudiantes mayores a la evolución social, económica y tecnológica del momento, para que conozcan, utilicen y comprendan las posibilidades de enseñanza/aprendizaje que les ofrecen las TICs. Esta meta global se ha dividido en dos objetivos operativos: 1. Abrir al alumnado adulto las posibilidades del aprendizaje virtual, formándoles para el uso y la participación en la plataforma telemática donde se encuentran a su disposición los materiales de las asignaturas y cursos. 2. Facilitar a los estudiantes mayores el acceso a cursos, contenidos y materias regladas de la Universidad de Salamanca, pudiendo así aspirar a una formación universitaria más allá del Programa de la Experiencia.
The coronavirus disease 2019 (COVID-19) has spread worldwide since December 2019. Neurologic symptoms have been reported as part of the clinical spectrum of the disease. We aimed to determine whether ...neurologic manifestations are common in hospitalized patients with COVID-19 and to describe their main characteristics.
We systematically reviewed all patients diagnosed with COVID-19 admitted to the hospital in a Spanish population during March 2020. Demographic characteristics, systemic and neurologic clinical manifestations, and complementary tests were analyzed.
Of 841 patients hospitalized with COVID-19 (mean age 66.4 years, 56.2% men), 57.4% developed some form of neurologic symptom. Nonspecific symptoms such as myalgias (17.2%), headache (14.1%), and dizziness (6.1%) were present mostly in the early stages of infection. Anosmia (4.9%) and dysgeusia (6.2%) tended to occur early (60% as the first clinical manifestation) and were more frequent in less severe cases. Disorders of consciousness occurred commonly (19.6%), mostly in older patients and in severe and advanced COVID-19 stages. Myopathy (3.1%), dysautonomia (2.5%), cerebrovascular diseases (1.7%), seizures (0.7%), movement disorders (0.7%), encephalitis (n = 1), Guillain-Barré syndrome (n = 1), and optic neuritis (n = 1) were also reported, but less frequent. Neurologic complications were the main cause of death in 4.1% of all deceased study participants.
Neurologic manifestations are common in hospitalized patients with COVID-19. In our series, more than half of patients presented some form of neurologic symptom. Clinicians need to maintain close neurologic surveillance for prompt recognition of these complications. The mechanisms and consequences of severe acute respiratory syndrome coronavirus type 2 neurologic involvement require further studies.
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