Recent GIS technologies are shaping the direction of Precision Agriculture and Viticulture. Sentinel-2 satellites and UAVs are key resources for multi-spectral analyses of vegetation. Despite being ...extensively adopted in numerous applications and scenarios, the pros and cons of both platforms are still debated. Researchers have currently investigated different aspects of these sources, mainly comparing different vegetation indexes and exploring potential relationships with agronomic variables. However, due to the costs and limitations of such an approach, a standardized methodology for agronomic purposes is still missing. This study aims to fill such a methodology gap by overcoming the potential flaws or shortages of previous works. To achieve this, an image acquisition campaign covering 6 months and over 17 hectares was carried out, followed by an NDVI comparison between Sentinel-2 and UAV to eventually explore relationships with agronomic variables. Comparative analyses were performed by using both classical (Ordinary Least Squares regression and Pearson Correlation) and spatial (Moran’s Index) statistical approaches: here, 90% of cases show r and MI scores above 0.6 for plain images, with these scores expectedly lowering to 72% and 52% when considering segmented images. Moreover, NDVI thematic maps were classified into clusters and validated by the Chi-squared test. Finally, the relationship and distribution of agronomic variables within NDVI and clustered maps were consistently validated through the ANOVA test. The proposed open-source pipeline allows to strengthen existing UAV and satellite applications in Precision Agriculture by integrating more agronomic variables.
Summary
‘Multifocal bone lymphoma’ or ‘polyostotic lymphoma’ is a neoplasm with exclusive multifocal involvement of the skeleton, without affecting lymph nodes or other soft tissues. Knowledge on ...this uncommon condition is limited because the related literature is sparse and fragmentary. We reviewed cases of multifocal bone diffuse large B‐cell lymphoma (MB‐DLBCL) registered in a clinico‐pathological database of the International Extranodal Lymphoma Study Group that includes 499 cases of bone lymphoma. Clinical features, management and prognosis of 37 MB‐DLBCL patients and 63 ‘controls’ (stage‐IV DLBCL and skeletal involvement) were analysed. Presentation and treatment of MB‐DLBCL and controls were identical. At a median follow‐up of 52 months (10–189), MB‐DLBCL patients exhibited a significantly better response rate (92% vs. 65%; P = 0·002), progression‐free survival (5‐year: 56 ± 9% vs. 34 ± 6%; P = 0·003) and overall survival (5‐year: 74 ± 8% vs. 36 ± 7%; P = 0·002). Among MB‐DLBCL patients, the use of post‐chemo radiotherapy was associated with better overall survival (5‐year: 83 ± 12% vs. 55 ± 16%; P = 0·003). Two MB‐DLBCL patients (5·4%) with spine and skull involvement experienced central nervous system (CNS) relapse. Thus, MB‐DLBCL patients exhibit a significantly better prognosis compared to patients with advanced‐stage DLBCL, and should be treated with conventional anthracycline‐based chemotherapy, keeping intensified treatment for relapsing cases, considering involved‐field radiotherapy, and CNS prophylaxis in high‐risk patients.
Learning Objectives
Compare outcomes in patients with diffuse large B‐cell lymphoma of the bone treated with different modalities.
Compare relapse rates and relapse sites in patients with diffuse ...large B‐cell lymphoma of the bone treated with different modalities.
Introduction.
The clinical features, management, and prognosis of stage I–II diffuse large B‐cell lymphoma of the bone (PB‐DLBCL) included in an international database of 499 lymphoma patients with skeletal involvement were reviewed.
Methods.
HIV‐negative patients (n = 161) with diffuse large B‐cell lymphoma of the bone (PB‐DLBCL) after complete staging workup were considered. The primary objective of this study was to identify the most effective treatment modality; the secondary objectives were to define the contribution of irradiation fields and doses and the pattern of relapse.
Results.
Median age was 55 years (range, 18–99 years), with a male/female ratio of 1:2; 141 (87%) patients had stage I, 14 (9%) had B symptoms, 37 (23%) had bulky lesion, 54 (33%) showed elevated lactate dehydrogenase serum levels, and 25 (15%) had fracture. Thirteen (8%) patients received chemotherapy alone, 23 (14%) received radiotherapy alone, and 125 (78%) received both treatments. The response to the first‐line treatment was complete in 131 of 152 assessed patients (complete response rate, 86%; 95% confidence interval CI, 81%–91%) and partial in 7, with an overall response rate of 91% (95% CI, 87%–95%). At a median follow‐up of 54 months (range, 3–218), 107 (67%) patients remained relapse‐free, with a 5‐year progression‐free survival of 68% (SE: 4). Four (2.5%) patients had meningeal relapse; 119 patients were alive (113 disease‐free), with a 5‐year overall survival of 75% (SE: 4). Patients managed with primary chemotherapy, whether followed by radiotherapy or not, had a significantly better outcome than patients treated with primary radiotherapy, whether followed by chemotherapy or not. The addition of consolidative radiotherapy after primary chemotherapy was not associated with improved outcome; doses >36 Gy and the irradiation of the whole affected bone were not associated with better outcome.
Conclusion.
Patients with PB‐DLBCL exhibit a favorable prognosis when treated with primary anthracycline‐based chemotherapy whether followed by radiotherapy or not. In patients treated with chemoradiotherapy, the use of larger radiation fields and doses is not associated with better outcome. Central nervous system dissemination is a rare event in PB‐DLBCL patients.
The authors reviewed the clinical features, management, and prognosis of 161 patients with stage I–II diffuse large B‐cell lymphoma of the bone. Patients managed with primary chemotherapy had a significantly better outcome than patients treated with primary radiotherapy. The addition of consolidative radiotherapy after primary chemotherapy was not associated with improved outcome.
Abstract
Indolent lymphomas primarily involving the skeleton (iPBL) represent < 1% of all primary bone lymphomas. The management and prognosis have not been previously described. Patients with ...primary and secondary iPBL were selected from an international database of 499 patients with a histopathological diagnosis of non-Hodgkin lymphoma and skeleton involvement, and clinical features, management and prognosis were analyzed. Twenty-six (5%) patients had an iPBL. Ten patients had small lymphocytic lymphoma, 10 had follicular lymphoma and six had lymphoplasmacytic lymphoma. Eleven patients had limited stage and 15 had advanced disease. The overall response rate was 73% (95% confidence interval CI = 57-89%). Median follow-up was 58 months, and the 5- and 10-year progression-free survival (PFS) rates were 37 ± 10% and 25 ± 12%, respectively. Nine patients are alive, with 5- and 10-year overall survival (OS) rates of 46 ± 10% and 29 ± 11%, respectively. Patients with small lymphocytic lymphoma showed significantly better outcome than patients with follicular lymphoma. Performance status and stage of disease were independently associated with OS. The prognosis of patients with primary bone lymphoplasmacytic or follicular lymphoma was less favorable.
Reliable population of the condition databases is critical for the correct operation of the online selection as well as of the offline reconstruction and analysis of data. We will describe here the ...system put in place in the CMS experiment to populate the database and make condition data promptly available both online for the high-level trigger and offline for reconstruction. The system, designed for high flexibility to cope with very different data sources, uses POOL-ORA technology in order to store data in an object format that best matches the object oriented paradigm for C++ programming language used in the CMS offline software. In order to ensure consistency among the various subdetectors, a dedicated package, PopCon (Populator of Condition Objects), is used to store data online. The data are then automatically streamed to the offline database hence immediately accessible offline worldwide. This mechanism was intensively used during 2008 in the test-runs with cosmic rays. The experience of this first months of operation will be discussed in detail.
To produce the best physics results, high energy physics experiments require access to calibration and other non-event data during event data processing. These conditions data are typically stored in ...databases that provide versioning functionality, allowing physicists to make improvements while simultaneously guaranteeing the reproducibility of their results. With the increased complexity of modern experiments, and the evolution of computing models that demand large scale access to conditions data, the solutions for managing this access have evolved over time. In this white paper we give an overview of the conditions data access problem, present convergence on a common solution and present some considerations for the future.
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