The paper describes the mechanisms of self-ignition formation in coal liable to spontaneous combustion, on the basis of experimental works performed to analyze heat and mass transfer in the coal-air ...system. A new approach was developed to the coal self-heating suppression and thermodynamic control of the oxidation process. The influence of coal moisture content and thermal behaviour of air in the cooling process was studied during moisture evaporation.
Here we present the analysis of alternative splicing events on an example of glioblastoma cell culture samples using a set of computer tools in combination with database integration. The gene ...expression profiles of glioblastoma were obtained from cell culture samples of primary glioblastoma which were isolated and processed for RNA extraction. Transcriptome profiling of normal brain samples and glioblastoma were done by Illumina sequencing. The significant differentially expressed exon-level probes and their corresponding genes were identified using a combination of the splicing index method. Previous studies indicated that tumor-specific alternative splicing is important in the regulation of gene expression and corresponding protein functions during cancer development. Multiple alternative splicing transcripts have been identified as progression markers, including generalized splicing abnormalities and tumor- and stage-specific events. We used a set of computer tools which were recently applied to analysis of gene expression in laboratory animals to study differential splicing events. We found 69 transcripts that are differentially alternatively spliced. Three cancer-associated genes were considered in detail, in particular: APP (amyloid beta precursor protein), CASC4 (cancer susceptibility candidate 4) and TP53. Such alternative splicing opens new perspectives for cancer research.
The reaction of bis(tetraphenylantimony) succinate with iodine in benzene affords (μ
4
-succinato) hexadecaphenyltetraantimony triiodide solvate with benzene (Ph
4
Sb)
2
O
2
CCH
2
CH
2
-CO
2
(Ph
4
...Sb)
2
I
3
2
· 4PhH (
I
). The symmetrically nonequivalent Sb(1) and Sb(2) atoms in the centrosymmetric cation of compound
I
have a distorted trigonal bipyramidal coordination mode with the oxygen atoms in the axial positions (Sb(1,2)−O 2.347(4) 2.525(4) Å; Sb(1,2)−C
equiv
2.109(7)−2.120(7) Å, 2.082(5)−2.106(7) Å; Sb(1,2)−C
axial
2.158(7), 2.121(9) Å; angles OSb(1,2)C 178.8(2)°, 174.5(3)°). The geometry of the I
3
−
anions is close to linear (angle III 179.41(4)°, I−I distances 2.880(1) and 2.921(1) Å) (CIF file CCDC no. 1486690).
Chemical processes that can occur during aging of sols based on water–alcohol solutions of tetraethoxysilane (TEOS) and hexachloroplatinic acid and during formation of films from these sols are ...analyzed by the results of visible and UV spectroscopy and X-ray powder diffraction. The sizes and compositions of the platinum particles that are formed in xerogels and in thin films on the nanometer and submicron levels are estimated based on X-ray crystallography, energy dispersive spectral analysis, high-resolution scanning and transmission electron microscopy, and grazing incidence small-angle X-ray scattering studies.
Background. The course of the COVID-19 epidemic process depends on population immunity which prevents pathogen spread. Aim: to study an evolution of SARS-CoV-2 humoral immunity in the Belarusian ...population rela- tive to COVID-19 pandemic dynamics.
Materials and methods. The work was carried out according to a methodology for assessing herd immunity developed by Rospotrebnadzor (Russia) and the Belarusian Ministry of Health involving the St. Petersburg Pasteur Institute (SPPI) by taking into account the WHO recommendations. The study was approved by the Bioethics Committee of Belarus and the SPPI Bioethics Committee. Participant selection was carried out by ques- tionnaire using a cloud (internet server) service. To monitor herd immunity, a cohort of 4661 subjects (involved at all stages of seromonitoring) was formed from the total volunteer group. Study subjects were randomized into groups based on age (117, 1829, 3039, 4049, 5059, 6069, 70+ years), geographic region, and occupation. For the detection of antibodies (Abs) against SARS-CoV-2 nucleocapsid (Nc) and S glycoprotein receptor-binding domain (RBD), rel- evant assay systems were used according to the manufacturers instructions. A four-stage study was conducted according to a unified scheme.
Results. At stage 1 (pandemic month 15), herd immunity was mainly accounted for by Nc+RBD+ Ab status alone. By stage 2 (4 months later), its specific proportion decreased by 1.2-fold, whereas percentage of subjects solely bearing RBD-specific Abs increased by 1.7-fold. At stages 3 and 4 (9 and 19 months after the onset) vs. stage 2, percent- age of subjects with RBD+Nc decreased by 3.5%; the proportion of persons with Nc+RBD Abs increased by 1.5-fold.
The most important contributor in herd immunity turned out to be due to population vaccination, with coverage reaching 70% by stage 4. Among vaccines, compared with whole-virion, inactivated BIBP-CorV vaccine the Sputnik V and Sputnik Light vector were used most often.
Conclusion. The evolution of herd SARS-CoV-2 humoral immunity included a series of changes in circulating Ab levels (Nc, RBD). The hybrid immunity formed helped to reduce the incidence of COVID-19 to sporadic level.
New organic–inorganic composites based on aromatic polyamidoimide with ribbon-like particles of fibrous triple chain Na
2
Mg
4
Si
6
O
16
(OH)
2
hydrosilicate have been obtained with the subsequent ...characterization of their structure, morphology, and transport properties. A comparative analysis of polyimide composites with ribbon-like Na
2
Mg
4
Si
6
O
16
(OH)
2
hydrosilicates and tubular Mg
3
Si
2
O
5
(OH)
4
hydrosilicate nanoparticles has been implemented.
Permalloy films with one-dimensional profile modulation of submicron periodicity are fabricated based on commercially available DVD-R discs and studied using ferromagnetic resonance method and ...micromagnetic numerical simulations. The main resonance position shows in-plane angular dependence which is strongly reminiscent of that in ferromagnetic films with uniaxial magnetic anisotropy. The main signal and additional low-field lines are attributed to multiple standing spin-wave resonances defined by the grating period. The results may present interest in magnetic metamaterials and magnonics applications.
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