Biosensors are powerful diagnostic tools defined as having a biorecognition element for analyte specificity and a transducer for a quantifiable signal. There are a variety of different biorecognition ...elements, each with unique characteristics. Understanding the advantages and disadvantages of each biorecognition element and their influence on overall biosensor performance is crucial in the planning stages to promote the success of novel biosensor development. Therefore, this review will focus on selecting the optimal biorecognition element in the preliminary design phase for novel biosensors. Included is a review of the typical characteristics and binding mechanisms of various biorecognition elements, and how they relate to biosensor performance characteristics, specifically sensitivity, selectivity, reproducibility, and reusability. The goal is to point toward language needed to improve the design and development of biosensors toward clinical success.
Abstract
We present a detection of 21 cm emission from large-scale structure (LSS) between redshift 0.78 and 1.43 made with the Canadian Hydrogen Intensity Mapping Experiment. Radio observations ...acquired over 102 nights are used to construct maps that are foreground filtered and stacked on the angular and spectral locations of luminous red galaxies (LRGs), emission-line galaxies (ELGs), and quasars (QSOs) from the eBOSS clustering catalogs. We find decisive evidence for a detection when stacking on all three tracers of LSS, with the logarithm of the Bayes factor equal to 18.9 (LRG), 10.8 (ELG), and 56.3 (QSO). An alternative frequentist interpretation, based on the likelihood ratio test, yields a detection significance of 7.1
σ
(LRG), 5.7
σ
(ELG), and 11.1
σ
(QSO). These are the first 21 cm intensity mapping measurements made with an interferometer. We constrain the effective clustering amplitude of neutral hydrogen (H
i
), defined as
H
I
≡
10
3
Ω
H
I
b
H
I
+
〈
f
μ
2
〉
, where Ω
H
i
is the cosmic abundance of H
i
,
b
H
i
is the linear bias of H
i
, and 〈
f
μ
2
〉 = 0.552 encodes the effect of redshift-space distortions at linear order. We find
H
I
=
1.51
−
0.97
+
3.60
for LRGs (
z
= 0.84),
H
I
=
6.76
−
3.79
+
9.04
for ELGs (
z
= 0.96), and
H
I
=
1.68
−
0.67
+
1.10
for QSOs (
z
= 1.20), with constraints limited by modeling uncertainties at nonlinear scales. We are also sensitive to bias in the spectroscopic redshifts of each tracer, and we find a nonzero bias Δ
v
= − 66 ± 20 km s
−1
for the QSOs. We split the QSO catalog into three redshift bins and have a decisive detection in each, with the upper bin at
z
= 1.30 producing the highest-redshift 21 cm intensity mapping measurement thus far.
Abstract
We report on the serendipitous discovery of three transient millimeter-wave sources using data from the Atacama Cosmology Telescope. The first, detected at R.A
.
= 273.8138, decl. = −49.4628 ...at ∼50
σ
total, brightened from less than 5 mJy to at least 1100 mJy at 150 GHz with an unknown rise time shorter than 13 days, during which the increase from 250 mJy to 1100 mJy took only 8 minutes. Maximum flux was observed on 2019 November 8. The source’s spectral index in flux between 90–150 GHz was positive,
α
= 1.5 ± 0.2. The second, detected at R.A. = 105.1584, decl
.
= −11.2434 at ∼20
σ
total, brightened from less than 20 mJy to at least 300 mJy at 150 GHz with an unknown rise time shorter than 8 days. Maximum flux was observed on 2019 December 15. Its spectral index was also positive,
α
= 1.8 ± 0.2. The third, detected at R.A
.
= 301.9952, decl. = 16.1652 at ∼40
σ
total, brightened from less than 8 mJy to at least 300 mJy at 150 GHz over a day or less but decayed over a few days. Maximum flux was observed on 2018 September 11. Its spectrum was approximately flat, with a spectral index of
α
= −0.2 ± 0.1. None of the sources were polarized to the limits of these measurements. The two rising-spectrum sources are coincident in position with M and K stars, while the third is coincident with a G star.
We use Atacama Cosmology Telescope (ACT) observations at 98 GHz (2015–2019), 150 GHz (2013–2019), and 229 GHz (2017–2019) to perform a blind shift-and-stack search for Planet 9. The search explores ...distances from 300 au to 2000 au and velocities up to 6\farcm3 per year, depending on the distance (r). For a 5 Earth-mass Planet 9 the detection limit varies from 325 au to 625 au, depending on the sky location. For a 10 Earth-mass planet the corresponding range is 425 au to 775 au. The predicted aphelion and most likely location of the planet corresponds to the shallower end of these ranges. The search covers the whole 18,000 square degrees of the ACT survey. No significant detections are found, which is used to place limits on the millimeter-wave flux density of Planet 9 over much of its orbit. Overall we eliminate roughly 17% and 9% of the parameter space for a 5 and 10 Earth-mass Planet 9, respectively. These bounds approach those of a recent INPOP19a ephemeris-based analysis, but do not exceed it. We also provide a list of the 10 strongest candidates from the search for possible follow-up. More generally, we exclude (at 95% confidence) the presence of an unknown solar system object within our survey area brighter than 4–12 mJy (depending on position) at 150 GHz with current distance 300 au < r < 600 au and heliocentric angular velocity 1\farcm5 per yr < v x (500au/r) < 2\farcs3 per yr, corresponding to low-to-moderate eccentricities. These limits worsen gradually beyond 600 au, reaching 5–15 mJy by 1500 au.
Abstract We report the detection of 21 cm emission at an average redshift z ¯ = 2.3 in the cross-correlation of data from the Canadian Hydrogen Intensity Mapping Experiment (CHIME) with measurements ...of the Ly α forest from eBOSS. Data collected by CHIME over 88 days in the 400–500 MHz frequency band (1.8 < z < 2.5) are formed into maps of the sky and high-pass delay filtered to suppress the foreground power, corresponding to removing cosmological scales with k ∥ ≲ 0.13 Mpc −1 at the average redshift. Line-of-sight spectra to the eBOSS background quasar locations are extracted from the CHIME maps and combined with the Ly α forest flux transmission spectra to estimate the 21 cm–Ly α cross-correlation function. Fitting a simulation-derived template function to this measurement results in a 9 σ detection significance. The coherent accumulation of the signal through cross-correlation is sufficient to enable a detection despite excess variance from foreground residuals ∼6–10 times brighter than the expected thermal noise level in the correlation function. These results are the highest-redshift measurement of 21 cm emission to date, and they set the stage for future 21 cm intensity mapping analyses at z > 1.8.
This paper shows how to choose compensation capacitors for optimal performance in two-coil fixed-frequency inductive wireless power links having a series-parallel (SP) configuration. First, for the ...SP circuit with given coils, coupling and sinusoidal input voltage, it is shown how to calculate nonnegative valued capacitors to maximize power delivered to a given resistive load. Exact conditions for such a compensated system to deliver the maximum power obtainable from a circuit with the same resistances and an ideal transformer with optimal turns ratio are presented. The second main contribution is a method for selecting compensation capacitors to maximize a weighted sum of efficiency and delivered power to obtain a trade-off between these two quantities. This can allow flexible performance with a given set of coils. All of this can be implemented without numerical optimization software. The results are illustrated by numerical examples and supported by experimental measurements.
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