We report the detection of pulsed gamma-ray emission from the fast millisecond pulsars (MSPs) B1937+21 (also known as J1939+2134) and B1957+20 (J1959+2048) using 18 months of survey data recorded by ...the Fermi Large Area Telescope and timing solutions based on radio observations conducted at the Westerbork and Nancay radio telescopes. In addition, we analyzed archival Rossi X-ray Timing Explorer and XMM-Newton X-ray data for the two MSPs, confirming the X-ray emission properties of PSR B1937+21 and finding evidence (~4 Delta *s) for pulsed emission from PSR B1957+20 for the first time. In both cases the gamma-ray emission profile is characterized by two peaks separated by half a rotation and are in close alignment with components observed in radio and X-rays. These two pulsars join PSRs J0034--0534 and J2214+3000 to form an emerging class of gamma-ray MSPs with phase-aligned peaks in different energy bands. The modeling of the radio and gamma-ray emission profiles suggests co-located emission regions in the outer magnetosphere.
ABSTRACT
Radio emission from pulsars can be used to map out their distances through dispersion measure (DM), which quantifies the amount of radio pulse dispersion. However, this method relies on ...accurately modelling the free electron density in the line of sight. Here, we present a detailed study of the multiwavelength emission from PSR J1720−0534, a black widow compact binary millisecond pulsar discovered in 2021, which the latest electron density model of the Galaxy places at only 191 pc.
We obtained and analysed deep multiwavelength observations in the γ-ray (Fermi-Large Area Telescope, 2008–2022), optical (Las Cumbres Observatory, 2.7 h), near-infrared (Nordic Optical Telescope, 3.5 h), and X-ray (Swift-X-Ray Telescope, 10 ks) bands. We found no significant detection of γ-ray, optical, near-infrared, or X-ray counterparts around the radio-timing position of PSR J1720−0534, which we thus nickname ‘the invisible black widow’. Employing the most constraining near-infrared limit (J > 23.4 mag), we established a lower limit on the source distance, d > 1.1 kpc, assuming conservative properties for the black widow companion star. This distance lower limit differs drastically (by a factor of more than 5) from the Yao et al. DM distance estimate. We attribute this difference to the inclusion in the Yao et al. model of a large and dense component towards the North Polar Spur. Considering our results and recent parallax distances to other pulsars in this direction, we argue that such a local and large component in the electron density model of the Galaxy is unnecessary.
Multiple myeloma (MM) is characterized by significant genetic diversity at subclonal levels that have a defining role in the heterogeneity of tumor progression, clinical aggressiveness and drug ...sensitivity. Although genome profiling studies have demonstrated heterogeneity in subclonal architecture that may ultimately lead to relapse, a gene expression-based prediction program that can identify, distinguish and quantify drug response in sub-populations within a bulk population of myeloma cells is lacking. In this study, we performed targeted transcriptome analysis on 528 pre-treatment single cells from 11 myeloma cell lines and 418 single cells from 8 drug-naïve MM patients, followed by intensive bioinformatics and statistical analysis for prediction of proteasome inhibitor sensitivity in individual cells. Using our previously reported drug response gene expression profile signature at the single-cell level, we developed an R Statistical analysis package available at https://github.com/bvnlabSCATTome, SCATTome (single-cell analysis of targeted transcriptome), that restructures the data obtained from Fluidigm single-cell quantitative real-time-PCR analysis run, filters missing data, performs scaling of filtered data, builds classification models and predicts drug response of individual cells based on targeted transcriptome using an assortment of machine learning methods. Application of SCATT should contribute to clinically relevant analysis of intratumor heterogeneity, and better inform drug choices based on subclonal cellular responses.
Objectives
People living with HIV (PLWH) have multidimensional concerns requiring person‐centred care. Routine use of patient‐reported outcome measures (PROMs) improves outcomes. No brief PROM ...currently reflects the breadth of concerns for PLWH. This study sought to identify priority outcomes for PLWH, model current practice, explore views on introducing PROMs into routine care, and devise a model for person‐centred care incorporating the PROM.
Methods
A cross‐national multi‐centre study (London, Brighton and Dublin) was carried out. Semi‐structured qualitative interviews with adult PLWH, HIV health care professionals and HIV commissioners (responsible for planning and commissioning services) were performed. Interviews were analysed using thematic and framework analysis.
Results
PLWH (n = 28), professionals (n = 21) and commissioners (n = 8) described concerns related to living with HIV across six domains: physical (e.g. pain and gastrointestinal symptoms), cognitive (e.g. memory and sleep), psychological (e.g. anxiety and depression), social (e.g. isolation and intimacy), welfare (e.g. finances and fears regarding change of immigration status), and information (e.g. long‐term outcomes) needs. Themes were highly inter‐related, impacting across domains of need (e.g. physical and cognitive problems impacting on psychological and social wellbeing). Perceived benefits of using PROMs in routine HIV care included improved person‐centredness, patient empowerment, fewer missed concerns, increased engagement with services, and informed planning of services. Potential challenges included heterogeneity of PLWH, literacy, and utility for those who struggle to engage with care.
Conclusions
This study presents a novel model of person‐centred care incorporating an HIV‐specific PROM. The model reflects priorities of key stakeholders. Explicit use of PROMs in routine HIV care could afford benefits for PLWH, clinical teams and commissioners.
ABSTRACT
The Fermi Large Area Telescope gamma-ray source 3FGL J2039.6–5618 contains a periodic optical and X-ray source that was predicted to be a ‘redback’ millisecond pulsar (MSP) binary system. ...However, the conclusive identification required the detection of pulsations from the putative MSP. To better constrain the orbital parameters for a directed search for gamma-ray pulsations, we obtained new optical light curves in 2017 and 2018, which revealed long-term variability from the companion star. The resulting orbital parameter constraints were used to perform a targeted gamma-ray pulsation search using the Einstein@Home-distributed volunteer computing system. This search discovered pulsations with a period of 2.65 ms, confirming the source as a binary MSP now known as PSR J2039–5617. Optical light-curve modelling is complicated, and likely biased, by asymmetric heating on the companion star and long-term variability, but we find an inclination i ≳ 60°, for a low pulsar mass between $1.1\, \mathrm{M}_{\odot } \lt M_{\rm psr} \lt $ 1.6 M⊙, and a companion mass of 0.15–$0.22\, \mathrm{M}_{\odot }$, confirming the redback classification. Timing the gamma-ray pulsations also revealed significant variability in the orbital period, which we find to be consistent with quadrupole moment variations in the companion star, suggestive of convective activity. We also find that the pulsed flux is modulated at the orbital period, potentially due to inverse Compton scattering between high-energy leptons in the pulsar wind and the companion star’s optical photon field.
Terzan 5 is the only Galactic globular cluster that has plausibly been detected at very high energies by the High Energy Stereoscopic System. It has an unexpectedly asymmetric very high energy ...morphology that is offset from the cluster center, in addition to a large-scale, offset radio structure and compact diffuse X-ray emission associated with this cluster. We present new data from the Fermi Large Area Telescope on this source. We model the updated broadband spectral energy distribution, attributing this to cumulative pulsed emission from a population of embedded millisecond pulsars, as well as unpulsed emission from the interaction of their leptonic winds with the ambient magnetic and soft-photon fields. In particular, our model invokes unpulsed synchrotron and inverse Compton components to model the radio and TeV data and cumulative pulsed curvature radiation to fit the Fermi data, and it explains the hard Chandra X-ray spectrum via a "new" cumulative synchrotron component from electron-positron pairs within the pulsar magnetospheres that has not been implemented before. We find reasonable spectral fits for plausible model parameters. We also derive constraints on the millisecond pulsar luminosity function using the diffuse X-ray data and the Chandra sensitivity. Future higher-quality spectral and spatial data will help discriminate between competing scenarios (such as dark matter annihilation, white dwarf winds, or hadronic interactions) proposed for the broadband emission, as well as constraining degenerate model parameters.
ABSTRACT We performed geometric pulsar light curve modeling using static, retarded vacuum, and offset polar cap (PC) dipole B-fields (the latter is characterized by a parameter ϵ), in conjunction ...with standard two-pole caustic (TPC) and outer gap (OG) emission geometries. The offset-PC dipole B-field mimics deviations from the static dipole (which corresponds to ). In addition to constant-emissivity geometric models, we also considered a slot gap (SG) E-field associated with the offset-PC dipole B-field and found that its inclusion leads to qualitatively different light curves. Solving the particle transport equation shows that the particle energy only becomes large enough to yield significant curvature radiation at large altitudes above the stellar surface, given this relatively low E-field. Therefore, particles do not always attain the radiation-reaction limit. Our overall optimal light curve fit is for the retarded vacuum dipole field and OG model, at an inclination angle and observer angle . For this B-field, the TPC model is statistically disfavored compared to the OG model. For the static dipole field, neither model is significantly preferred. We found that smaller values of ϵ are favored for the offset-PC dipole field when assuming constant emissivity, and larger ϵ values favored for variable emissivity, but not significantly so. When multiplying the SG E-field by a factor of 100, we found improved light curve fits, with and ζ being closer to best fits from independent studies, as well as curvature radiation reaction at lower altitudes.
Abstract
Black widow and redback systems are compact binaries in which a millisecond pulsar heats and may even ablate its low-mass companion by its intense wind of relativistic particles and ...radiation. In such systems, an intrabinary shock can form as a site of particle acceleration and associated nonthermal emission. We model the X-ray and gamma-ray synchrotron and inverse Compton spectral components for select spider binaries, including diffusion, convection, and radiative energy losses in an axially symmetric, steady-state approach. Our new multizone code simultaneously yields energy-dependent light curves and orbital-phase-resolved spectra. Using parameter studies and matching the observed X-ray spectra and light curves, as well as Fermi Large Area Telescope spectra where available, with a synchrotron component, we can constrain certain model parameters. For PSR J1723–2837 these are notably the magnetic field and bulk flow speed of plasma moving along the shock tangent, the shock acceleration efficiency, and the multiplicity and spectrum of pairs accelerated by the pulsar. This affords a more robust prediction of the expected high-energy and very high energy gamma-ray flux. We find that nearby pulsars with hot or flaring companions may be promising targets for the future Cerenkov Telescope Array. Moreover, many spiders are likely to be of significant interest to future MeV-band missions such as AMEGO and e-ASTROGAM.
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