ABSTRACT Gamma-ray bursts (GRBs) are characterized by ultra-relativistic outflows, while supernovae are generally characterized by non-relativistic ejecta. GRB afterglows decelerate rapidly, usually ...within days, because their low-mass ejecta rapidly sweep up a comparatively larger mass of circumstellar material. However, supernovae with heavy ejecta can be in nearly free expansion for centuries. Supernovae were thought to have non-relativistic outflows except for a few relativistic ones accompanied by GRBs. This clear division was blurred by SN 2009bb, the first supernova with a relativistic outflow without an observed GRB. However, the ejecta from SN 2009bb was baryon loaded and in nearly free expansion for a year, unlike GRBs. We report the first supernova discovered without a GRB but with rapidly decelerating mildly relativistic ejecta, SN 2012ap. We discovered a bright and rapidly evolving radio counterpart driven by the circumstellar interaction of the relativistic ejecta. However, we did not find any coincident GRB with an isotropic fluence of more than one-sixth of the fluence from GRB 980425. This shows for the first time that central engines in SNe Ic, even without an observed GRB, can produce both relativistic and rapidly decelerating outflows like GRBs.
The Interplanetary Network Hurley, K.; Mitrofanov, I.G.; Golovin, D. ...
EAS Publications Series,
2013, 2013-00-00, 20130101, Letnik:
61
Journal Article
We describe the current, 9-spacecraft Interplanetary Network (IPN). The IPN detects about 325 gamma-ray bursts per year, of which about 100 are not localized by any other missions. We give some ...examples of how the data, which are public, can be utilized.
Molecular diagnostics offers quick access to information but fails to operate at a speed required for clinical decision-making. Our novel methodology, droplet-on-thermocouple silhouette real-time ...polymerase chain reaction (DOTS qPCR), uses interfacial effects for droplet actuation, inhibition relief, and amplification sensing. DOTS qPCR has sample-to-answer times as short as 3 min 30 s. In infective endocarditis diagnosis, DOTS qPCR demonstrates reproducibility, differentiation of antibiotic susceptibility, subpicogram limit of detection, and thermocycling speeds of up to 28 s/cycle in the presence of tissue contaminants. Langmuir and Gibbs adsorption isotherms are used to describe the decreasing interfacial tension upon amplification. Moreover, a log-linear relationship with low threshold cycles is presented for real-time quantification by imaging the droplet-on-thermocouple silhouette with a smartphone. DOTS qPCR resolves several limitations of commercially available real-time PCR systems, which rely on fluorescence detection, have substantially higher threshold cycles, and require expensive optical components and extensive sample preparation. Due to the advantages of low threshold cycle detection, we anticipate extending this technology to biological research applications such as single cell, single nucleus, and single DNA molecule analyses. Our work is the first demonstrated use of interfacial effects for sensing reaction progress, and it will enable point-of-care molecular diagnosis of infections.
We present Interplanetary Network (IPN) data for the gamma-ray bursts in the first Fermi Gamma-Ray BurstMonitor (GBM) catalog. Of the 491 bursts in that catalog, covering 2008 July 12 to 2010 July ...11, 427 wereobserved by at least one other instrument in the nine-spacecraft IPN. Of the 427, the localizations of 149 could beimproved by arrival time analysis (or triangulation). For any given burst observed by the GBM and one otherdistant spacecraft, triangulation gives an annulus of possible arrival directions whose half-width varies betweenabout 0. 4 and 32, depending on the intensity, time history, and arrival direction of the burst, as well as the distancebetween the spacecraft. We find that the IPN localizations intersect the 1 GBM error circles in only 52 of thecases, if no systematic uncertainty is assumed for the latter. If a 6 systematic uncertainty is assumed and added inquadrature, the two localization samples agree about 87 of the time, as would be expected. If we then multiply theresulting error radii by a factor of three, the two samples agree in slightly over 98 of the cases, providing a goodestimate of the GBM 3 error radius. The IPN 3 error boxes have areas between about 1 arcmin2 and 110 deg2,and are, on the average, a factor of 180 smaller than the corresponding GBM localizations. We identify two burstsin the IPNGBM sample that did not appear in the GBM catalog. In one case, the GBM triggered on a terrestrialgamma flash, and in the other, its origin was given as uncertain. We also discuss the sensitivity and calibration ofthe IPN.
THE ULTRALUMINOUS GRB 110918A Frederiks, D. D.; Hurley, K.; Svinkin, D. S. ...
The Astrophysical journal,
12/2013, Letnik:
779, Številka:
2
Journal Article
Recenzirano
Odprti dostop
We report on the final Interplanetary Network localization of this event and its detailed multiwavelength study with a number of space-based instruments. The prompt emission is characterized by a ...typical duration, a moderate peak energy of the time-integrated spectrum, and strong hard-to-soft evolution. The high observed energy fluence yields, at z = 0.984, a huge isotropic-equivalent energy release E sub(iso) = (2.1 + or - 0.1) x 10 super(54) erg. The record-breaking energy flux observed at the peak of the short, bright, hard initial pulse results in an unprecedented isotropic-equivalent luminosity L sub(iso) = (4.7 + or - 0.2) x 10 super(54) erg s super(-1). A tail of the soft gamma -ray emission was detected with temporal and spectral behavior typical of that predicted by the synchrotron forward-shock model. The Swift/X-Ray Telescope and the Swift/Ultraviolet Optical Telescope observed the bright afterglow from 1.2 to 48 days after the burst and revealed no evidence of a jet break.
The binding sites of Hoechst 33258, netropsin and distamycin on three DNA restriction fragments from plasmid pBR322 were compared by footprinting with methidiumpropyl EDTA·Fe(II) MPE·Fe(II). ...Hoechst, netropsin and distamycin share common binding sites that are five ± one bp in size and rich in A·T DNA base pairs. The five base pair protection patterns for Hoechst may result from a central three base pair recognition site bound by two bisbenzimidazole NHs forming a bridge on the floor of the minor groove between adjacent adenine N3 and thymine O2 atoms on opposite helix strands. Hydrophobic interaction of the flanking phenol and N-methylpiperazine rings would afford a steric blockade of one additional base pair on each side.
The consensus recognition element for the mammalian transcription factor AP-1 is very similar to that of the transcriptional activator GCN4. Here, we show that the AP-1 recognition element (ARE) ...found in the SV40 enhancer can activate transcription from a heterologous promoter in S. cerevisiae. This activation, however, is not dependent on the presence of GCN4 as evidenced by ARE-dependent transcription in a gcn4 yeast strain. A previously unknown yeast transcription factor that is probably responsible for this activation was identified and highly purified. The yeast factor, designated yAP-1, shares remarkably similar biochemical and DNA-binding characteristics with mammalian AP-1. These data suggest that the yeast and mammalian AP-1 are evolutionarily conserved and perhaps functionally related. Also note-worthy is that GCN4 can bind to a GCN4 recognition element (GCRE) and to the ARE with approximately equal affinities; yAP-1, however, has a much lower affinity for the GCRE than the ARE, suggesting that yAP-1 can discriminate between these elements in vivo.
Coronary heart disease (CHD) accounts for half of the 1 million deaths annually ascribed to cardiovascular disease and for almost all of the 1.5 million acute myocardial infarctions. Within families ...affected by early and apparently heritable CHD, dyslipidemias have a much higher prevalence than in the general population; 20%-30% of early familial CHD has been ascribed to primary hypoalphalipoproteinemia (low HDL-C). This study assesses the evidence for linkage of low HDL-C to chromosomal region 11q23 in 105 large Utah pedigrees ascertained with closely related clusters of early CHD and expanded on the basis of dyslipidemia. Linkage analysis was performed by use of 22 STRP markers in a 55-cM region of chromosome 11. Two-point analysis based on a general, dominant-phenotype model yielded LODs of 2.9 for full pedigrees and 3.5 for 167 four-generation split pedigrees. To define a localization region, model optimization was performed using the heterogeneity, multipoint LOD score (mpHLOD). This linkage defines a region on 11q23.3 that is ∼10 cM distal to—and apparently distinct from—the ApoAI/CIII/AIV gene cluster and thus represents a putative novel localization for the low HDL-C phenotype.
Searching for water in the soil of Gale Crater is one of the primary tasks for the NASA Mars Science Laboratory rover named Curiosity. The primary task of the Dynamic Albedo of Neutrons (DAN) ...experiment on board the rover is to investigate and qualitatively characterize the presence of water along the rover’s traverse across Gale Crater. The water depth distribution may be found from measurements of neutrons generated by the Pulsing Neutron Generator (PNG) included in the DAN instrument, scattered by the regolith and returned back to the detectors. This paper provides a description of the data processing of such measurements and data products of DAN investigation.
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