The former Homestakegold mine in Lead, South Dakota has been transformed into a dedicated facility to pursue underground research in rare-process physics, as well as offering research opportunities ...in other disciplines such as biology, geology and engineering. A key component of the Sanford Underground Research Facility (SURF) is the Davis Campus, which is in operation at the 4850-foot level (4300 m.w.e.) and currently hosts two main physics projects: the LUX dark matter experiment and the MAJORANA DEMONSTRATOR neutrinolessdouble-beta decay experiment. In addition, two low-background counters currently operate at the Davis Campus in support of current and future experiments. Expansion of the underground laboratory space is underway at the 4850L Ross Campus in order to maintain and enhance low- background assay capabilities as well as to host a unique nuclear astrophysics accelerator facility. Plans to accommodate other future experiments at SURF are also underway and include the next generation of direct-search dark matter experiments and the Fermilab-led international long- baseline neutrino program. Planning to understand the infrastructure developments necessary to accommodate these future projects is well advanced and in some cases have already started. SURF is a dedicated research facility with significant expansion capability.
The former Homestake gold mine in Lead, South Dakota, has been transformed into a dedicated facility to pursue underground research in rare-process physics, as well as offering unique research ...opportunities in other disciplines. The Sanford Underground Research Facility (SURF) includes two main campuses at the 4850-foot level (4300 m.w.e.) - the Davis Campus and the Ross Campus - that host a range of significant physics projects: the LUX dark matter experiment, the MAJORANA DEMONSTRATOR neutrinoless double-beta decay experiment and the CASPAR nuclear astrophysics accelerator. Furthermore, the BHUC Ross Campus laboratory dedicated to critical material assays for current and future experiments has been operating since Fall 2015. Research efforts in biology, geology and engineering have been underway at SURF for 10 years and continue to be a strong component of the SURF research program. Plans to accommodate future experiments at SURF are well advanced and include geothermal-related projects, the next generation direct-search dark matter experiment LUX-ZEPLIN (LZ) and the Fermilab-led international Deep Underground Neutrino Experiment (DUNE) at the Long Baseline Neutrino Facility (LBNF). SURF is a dedicated research facility with significant expansion capability, and applications from other experiments are welcome.
Event-related potentials (ERPs) are advantageous for investigating cognitive development. However, their application in infants/children is challenging given children’s difficulty in sitting through ...the multiple trials required in an ERP task. Thus, a large problem in developmental ERP research is high subject exclusion due to too few analyzable trials. Common analytic approaches (that involve averaging trials within subjects and excluding subjects with too few trials, as in ANOVA and linear regression) work around this problem, but do not mitigate it. Moreover, these practices can lead to inaccuracies in measuring neural signals. The greater the subject exclusion, the more problematic inaccuracies can be. We review recent developmental ERP studies to illustrate the prevalence of these issues. Critically, we demonstrate an alternative approach to ERP analysis—linear mixed effects (LME) modeling—which offers unique utility in developmental ERP research. We demonstrate with simulated and real ERP data from preschool children that commonly employed ANOVAs yield biased results that become more biased as subject exclusion increases. In contrast, LME models yield accurate, unbiased results even when subjects have low trial-counts, and are better able to detect real condition differences. We include tutorials and example code to facilitate LME analyses in future ERP research.
•Linear Mixed Effects models (LMEs) have advantages for event-related potential analyses.•For infant/child ERPs especially, LME is superior to traditional ANOVA models.•In simulated ERP data, ANOVAs returned biased results, but LME was unbiased.•In real, child ERP data, LME detected condition differences where ANOVA did not.•Tutorial and sample codes given to guide use of LMEs in future research.
Predictors of long-term functional impairment in acute respiratory failure of all causes are poorly understood. Our objective was to assess the frequency and predictors of long-term functional ...impairment or death after invasive mechanical ventilation for acute respiratory failure of all causes.
Population-based, observational cohort study.
Eight adult ICUs of a single center.
All adult patients from Olmsted County, Minnesota, without baseline functional impairment who received mechanical ventilation in ICUs for acute respiratory failure of all causes from 2005 through 2009.
None.
In total, 743 patients without baseline functional impairment received mechanical ventilation in the ICU. At 1- and 5-year follow-up, the rates of survival with return to baseline functional ability were 61% (366/597) and 53% (356/669). Among 71 patients with new functional impairment at 1 year, 55% (39/71) had recovered and were alive without functional impairment at 5 years. Factors predictive of new functional impairment or death at 1 year were age, comorbidities, discharge to other than home, mechanical ventilation of 7 days or longer, and stroke. Of factors known at the time of intubation, the following are predictive of new functional impairment or death: age, comorbidities, nonsurgical condition, Acute Physiology and Chronic Health Evaluation III score, stroke, and sepsis. Post hoc sensitivity analyses revealed no significant change in predictor variables in patient populations when stroke was excluded or who received more than 48 hours of mechanical ventilation.
At 1- and 5-year follow-up, many patients who received mechanical ventilation for acute respiratory failure from all causes are no longer alive or have new moderate-to-severe functional impairment. Functional recovery between year 1 and year 5 is possible and common. Sepsis, stroke, illness severity, age, and comorbidities predict long-term functional outcome at intubation.
Quality preschool programs that develop the whole child through age-appropriate socioemotional and cognitive skill-building hold promise for significantly improving child outcomes. However, preschool ...programs tend to either be teacher-led and didactic, or else to lack academic content. One preschool model that involves both child-directed, freely chosen activity and academic content is Montessori. Here we report a longitudinal study that took advantage of randomized lottery-based admission to two public Montessori magnet schools in a high-poverty American city. The final sample included 141 children, 70 in Montessori and 71 in other schools, most of whom were tested 4 times over 3 years, from the first semester to the end of preschool (ages 3-6), on a variety of cognitive and socio-emotional measures. Montessori preschool elevated children's outcomes in several ways. Although not different at the first test point, over time the Montessori children fared better on measures of academic achievement, social understanding, and mastery orientation, and they also reported relatively more liking of scholastic tasks. They also scored higher on executive function when they were 4. In addition to elevating overall performance on these measures, Montessori preschool also equalized outcomes among subgroups that typically have unequal outcomes. First, the difference in academic achievement between lower income Montessori and higher income conventionally schooled children was smaller at each time point, and was not (statistically speaking) significantly different at the end of the study. Second, defying the typical finding that executive function predicts academic achievement, in Montessori classrooms children with lower executive function scored as well on academic achievement as those with higher executive function. This suggests that Montessori preschool has potential to elevate and equalize important outcomes, and a larger study of public Montessori preschools is warranted.
Pretend play is a quintessential activity of early childhood, and adults supply children with many toys to encourage it. Do young children actually prefer to pretend, or do they do it because they ...are unable to engage in some activities for real? Here we examined, for nine different activities, American middle‐class preschoolers' preferences for pretend and real activities. The 100 children we tested (M = 58.5 months, range 36 to 82 months) overwhelmingly preferred real activities to pretend ones, and this preference increased from age 3 to age 4, then remained steady through age 6. Children provided cogent justifications for their preferences. The results are discussed with reference to other domains in which children show reality preferences and with respect to the content of preschool curricula.
When given a choice, preschoolers overwhelmingly preferred real activities to their pretend equivalents. This preference for real activities appeared between ages 3 and 4, and then was constant through age 6.
Push enteroscopy, balloon-guided, and single- and double-balloon enteroscopy (DBE) are now well established techniques in gastrointestinal endoscopy for small-bowel imaging and therapy. There are no ...published prospective studies comparing DBE with spiral enteroscopy and so the aim of the current study was to compare the performance of the two techniques in patients undergoing diagnostic enteroscopy.
Between January and December 2009, 35 patients referred for diagnostic enteroscopy were prospectively assigned to either spiral enteroscopy (n=18) or DBE (n=17). The performance of the two techniques was compared.
The patients were comparable with regard to age, sex, and indication for enteroscopy. Investigation performance, as assessed by time of insertion into the pylorus, the depth of insertion, the duration of the enteroscopy, and the amount of sedoanalgesia required were not significantly different between spiral enteroscopy and DBE. In 40% of the investigations, enteroscopy could detect abnormalities in the intestinal mucosa, in particular inflammatory changes and ulcers and, to a lesser extent, angiodysplasia. No significant difference in pathological findings could be detected between the two groups; however, clinically, diagnostic yield appeared to be higher for DBE (47.1% vs. 33.4%; n.s.).
Although this small study appears to show that DBE has a clinically higher diagnostic yield than spiral enteroscopy, larger studies are needed to confirm this preliminary finding.
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