Purpose: Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results. Methods: In eight studies participating in the Ovarian Cancer ...Association Consortium, we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios and 95 % confidence intervals were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis. Results: Compared to blood group O, the A blood group was associated with a modestly increased ovarian cancer risk: (OR: 1.09; 95 % CI: 1.01—1.18; p = 0.03). In diplotype analysis, the AO, but not the AA diplotype, was associated with increased risk (AO: OR: 1.11; 95 % CI: 1.01—1.22; p = 0.03; AA: OR: 1.03; 95 % CI: 0.87—1.21; p = 0.76). Neither AB nor the B blood groups were associated with risk. Results were similar across ovarian cancer histologic subtypes. Conclusion: Consistent with most previous reports, the A blood type was associated modestly with increased ovarian cancer risk in this large analysis of multiple studies of ovarian cancer. Future studies investigating potential biologic mechanisms are warranted.
This study investigated the existence and outcomes of support gaps between perceptions of desired and received support surrounding conversations about coping with a relational transgression. Support ...gaps were measured immediately surrounding an interaction between 50 transgressed individuals and a third-party personal network member. Participants generally desired more support than they received across all types of support considered in this study. Findings show surpluses in esteem support were associated with less anger and dejection stemming from the transgression, whereas surpluses in emotional support corresponded with less motivation to avoid the transgressor.
Our Recipe for Good Inclusive Research Crowther, Felicity; Beinke, Hannah; High, Rachel ...
Social sciences (Basel),
07/2024, Letnik:
13, Številka:
8
Journal Article
Recenzirano
Odprti dostop
Co-researchers with intellectual disabilities and a Ph.D. student formed an inclusive research team. The co-researchers joined the inclusive research team so they could learn more about research and ...have control over the research. Our team have held regular research skills meetings. The focus of these meetings was getting to know each other and learning what each person brought to the team, as well as learning what inclusive research is and how to conduct research together. Learning these things has helped to design and undertake an inclusive research project about pets for people with intellectual disabilities. In this article, our team shares our experience of conducting inclusive research. We have learnt that each team member brings their own strengths to the team and we have connected and formed friendships. We completed an inclusive research project and found there were some challenges our team had to overcome. We conclude that people with intellectual disabilities are capable of leading research. Being part of an inclusive research team enables co-researchers to show others what they can do. Sharing what our team has found out can help others to conduct inclusive research.
The learning health system (LHS) has emerged over the past 15 years as a concept for improving health care delivery. Core aspects of the LHS concept include: promoting improved patient care through ...organizational learning, innovation, and continuous quality improvement; identifying, critically assessing, and translating knowledge and evidence into improved practices; building new knowledge and evidence around how to improve health care and health outcomes; analyzing clinical data to support learning, knowledge generation, and improved patient care; and engaging clinicians, patients, and other stakeholders in processes of learning, knowledge generation, and translation. However, the literature has paid less attention to how these LHS aspects may integrate with the multiple missions of academic medical centers (AMCs). The authors define an academic learning health system (aLHS) as an LHS built around a robust academic community and central academic mission, and they propose 6 features that emphasize how an aLHS differs from an LHS. An aLHS capitalizes on embedded academic expertise in health system sciences; engages the full spectrum of translational investigation from mechanistic basic sciences to population health; builds pipelines of experts in LHS sciences and clinicians with fluency in practicing in an LHS; applies core LHS principles to the development of curricula and clinical rotations for medical students, housestaff, and other learners; disseminates knowledge more broadly to advance the evidence for clinical practice and health systems science methods; and addresses social determinants of health, creating community partnerships to mitigate disparities and improve health equity. As AMCs evolve, the authors expect that additional differentiating features and ways to operationalize the aLHS will be identified and hope this article stimulates further discussion around the intersection of the LHS concept and AMCs.
Cyberbullying is an increasingly common experience that produces psychosocial consequences for targets. Interventions encouraging bystanders to support targets of cyberbullying are limited by a lack ...of focus on what to communicate. This study considers supportive messages that emphasize emotional comfort, attributions of responsibility, and beliefs that people can change as relevant to this context, and it examines how perceptions of messages differ based on whether support providers have or lack experience with cyberbullying. We extend research on the indirect effects model of supportive communication by randomly assigning participants (N = 304), who self-identify as targets of cyberbullying, to message and source conditions and assessing their perceptions of messages, providers, and outcomes. Impressions of messages mediate their influence on outcomes, and the experiential similarity of support providers moderates these effects. Certain messages, notably those contending that bullies can change, are less effective when delivered by sources who lack experience with bullying.
Purpose of Review
This review is meant to guide female pelvic medicine providers on treatment of pelvic floor disorders in the relatively uncommon population of younger women.
Recent Findings
...Presented herein are recent data on pelvic floor muscle training in the postpartum period to help with prevention of pelvic floor disorders as well as surgical outcomes in younger women.
Summary
Although new evidence is available on prevention and treatment for younger patients, more RCTs and cohort studies are needed.
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