The synthesis of several acridine thioethers is described. These compounds were oxidized to give new sulfoxides and sulfones. Among 23 compounds prepared, 19 were tested in vitro against the human ...cancer cell lines panel of NCI screening. Activity is increased 5–10 times from sulfides to sulfoxides. Among substituted groups in the side chain, sulfur mustard, epoxy sulfide and sulfoxide displayed the most interesting activity.
To identify cis-acting regulatory variants influencing the expression of the schizophrenia susceptibility gene chitinase 3-like 1 gene (CHI3L1) in human lymphoblasts and post-mortem brain tissue.
To ...investigate the role of cis-acting regulatory variants in controlling gene expression of CHI3L1 we quantified relative allelic abundance in individuals heterozygous for the transcribed polymorphism rs880633. Allelic quantification was performed using RNA derived from 45 individuals from the HapMap CEU panel and 41 postmortem brain samples. Association of allelic imbalance with genetic variants was determined at a gene-wide level for the HapMap samples using available genotyping data.
Expression of the CHI3L1 transcript is under the control of potently acting cis-variation in lymphoblasts. Polymorphisms in the promoter region of CHI3L1 were significantly associated with this allelic imbalance. In the single postmortem brain tissue investigated, only moderate allelic imbalance was detected and was restricted to a small number of individuals.
CHI3L1 contains common cis-acting regulatory variants that affect gene expression in lymphoblasts. A previously identified schizophrenia susceptibility variant was significantly associated with allelic imbalance in lymphoblasts. These findings do not support the notion that the schizophrenia-associated CHI3L1 variants influence gene expression in BA46 of the adult brain. We confirm that CHI3L1 contains cis-acting variation but is subject to tissue-specific regulation.
The Second International Workshop on CMV & Immunosenescence was held in Cambridge, UK, 2-4th December, 2010. The presentations covered four separate sessions: cytomegalovirus and T cell phenotypes; T ...cell memory frequency, inflation and immunosenescence; cytomegalovirus in aging, mortality and disease states; and the immunobiology of cytomegalovirus-specific T cells and effects of the virus on vaccination. This commentary summarizes the major findings of these presentations and references subsequently published work from the presenter laboratory where appropriate and draws together major themes that were subsequently discussed along with new areas of interest that were highlighted by this discussion.
Dynamic 3D ultrasound and MR image registration of the beating heart Huang, Xishi; Hill, Nicholas A; Ren, Jing ...
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention,
2005, Letnik:
8, Številka:
Pt 2
Journal Article, Book Chapter
Recenzirano
Odprti dostop
Real-time three-dimensional ultrasound (RT3D US) is an ideal imaging modality for the diagnosis of cardiac disease. RT3D US is a flexible, inexpensive, non-invasive tool that provides important ...diagnostic information related to cardiac function. Unfortunately, RT3D US suffers from inherent shortcomings, such as low signal-to-noise ratio and limited field of view, producing images that are difficult to interpret. Multi-modal dynamic cardiac image registration is a well-recognized approach that compensates for these deficiencies while retaining the advantages of RT3D US imaging. The clinical application of multi-modal image registration methods is difficult, and there are a number of implementation issues to be resolved. In this work, we present a method for the rapid registration of RT3D US images of the beating heart to high-resolution magnetic resonance (MR) images. This method was validated using a volunteer image set. Validation results demonstrate that this approach can achieve rapid registration of images of the beating heart with fiducial landmark and registration errors of 1.25 +/- 0.63 and 1.76 mm respectively. This technique can potentially be used to improve the diagnosis of cardiac disease by augmenting RT3D US images with high-resolution MR images and to facilitate intra-operative image fusion for minimally invasive cardio-thoracic surgical navigation.
We combine archival ALMA data targeting the Hubble Ultra Deep Field (HUDF) to produce the deepest currently attainable 1-mm maps of this key region. Our deepest map covers 4.2arcmin^2, with a ...beamsize of 1.49''x1.07'' at an effective frequency of 243GHz (1.23mm). It reaches an rms of 4.6uJy/beam, with 1.5arcmin^2 below 9.0uJy/beam, an improvement of >5% (and up to 50% in some regions) over the best previous map. We also make a wider, shallower map, covering 25.4arcmin^2. We detect 45 galaxies in the deep map down to 3.6sigma, 10 more than previously detected, and 39 of these galaxies have JWST counterparts. A stacking analysis on the positions of ALMA-undetected JWST galaxies with z<4 and stellar masses from 10^8.4 to 10^10.4 M_sun yields 10% more signal compared to previous stacking analyses, and we find that detected sources plus stacking contribute (10.0+/-0.5)Jy/deg^2 to the cosmic infrared background (CIB) at 1.23mm. Although this is short of the (uncertain) background level of about 20Jy/deg^2, we show that our measurement is consistent with the background if the HUDF is a mild (~2sigma) negative CIB fluctuation, and that the contribution from faint undetected objects is small and converging. In particular, we predict that the field contains about 60 additional 15uJy galaxies, and over 300 galaxies at the few uJy level. This suggests that JWST has detected essentially all of the galaxies that contribute to the CIB, as anticipated from the strong correlation between galaxy stellar mass and obscured star formation.
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