Human antimalignin antibody (AMA) appears to have clinical significance because in actuarial studies its concentration relates quantitatively to survival (Bogoch et al. Protides Biol Fluids 1984; ...31:739-747). Therefore isolation, characterization, and production in vitro of AMA were undertaken. Serum AMA concentrations are elevated in cancer, regardless of cell type, as demonstrated by earlier blind studies of 1,026 (Bogoch et al. J. Med 1982; 13:49-69) and 501 (Bogoch and Bogoch. Protides Biol Fluids 1983; 30:337-352) and independently confirmed by others on 354 (Bogoch et al. Protides Biol Fluids 1984; 31: 739-747) cancer patients and controls. Mouse monoclonal AMA was produced earlier (Bogoch et al. Lancet 1981; 2:141-142). To validate the identity of the natural substrate AMA in the serum determination (AMAS test) and to prepare for human imaging and therapeutic trials, human AMA has now been produced in vitro from human lymphocytes and has been shown to be increased when primed with its specific 10,000-dalton peptide antigen malignin. This synthesized human AMA adsorbs specifically to its immobilized antigen in vitro and resembles in cancer cell staining and in other properties human AMA isolated from sera of cancer patients and mouse monoclonal AMA. All are predominantly IgM, as shown by reduction to heavy and light chains followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
High-precision experiments have been done to test the Pauli exclusion principle (PEP) for electrons by searching for anomalous \(K\)-series X-rays from a Cu target supplied with electric current. ...With the highest sensitivity, the VIP (VIolation of Pauli Exclusion Principle) experiment set an upper limit at the level of \(10^{-29}\) for the probability that an external electron captured by a Cu atom can make the transition from the 2\(p\) state to a 1\(s\) state already occupied by two electrons. In a follow-up experiment at Gran Sasso, we aim to increase the sensitivity by two orders of magnitude. We show proofs that the proposed improvement factor is realistic based on the results from recent performance tests of the detectors we did at Laboratori Nazionali di Frascati (LNF).
One of the fundamental rules of nature and a pillar in the foundation of quantum theory and thus of modern physics is represented by the Pauli Exclusion Principle. We know that this principle is ...extremely well fulfilled due to many observations. Numerous experiments were performed to search for tiny violation of this rule in various systems. The experiment VIP at the Gran Sasso underground laboratory is searching for possible small violations of the Pauli Exclusion Principle for electrons leading to forbidden X-ray transitions in copper atoms. VIP is aiming at a test of the Pauli Exclusion Principle for electrons with high accuracy, down to the level of 10\(^{-29}\) - 10\(^{-30}\), thus improving the previous limit by 3-4 orders of magnitude. The experimental method, results obtained so far and new developments within VIP2 (follow-up experiment at Gran Sasso, in preparation) to further increase the precision by 2 orders of magnitude will be presented.
The AMADEUS experiment aims to perform dedicated precision studies in the sector of low-energy kaon-nuclei interaction at the DA\Phi NE collider at LNF-INFN. In particular the experiment plans to ...perform measurements of the debated deeply bound kaonic nuclear states (by stopping kaons in cryogenic gaseous targets 3He and 4He) to explore the nature of the \Lambda(1405) in nuclear environment and to measure the cross section of K- on light nuclei, for K- momentum lower than 100 MeV/c. The AMADEUS dedicated setup will be installed in the central region of the KLOE detector.
The X-ray transition yields of kaonic atoms produced in Kapton polyimide (C22H10N2O5) were measured for the first time in the SIDDHARTA experiment. X-ray yields of the kaonic atoms with low atomic ...numbers (Z = 6, 7, and 8) and transitions with high principal quantum numbers (n = 5-8) were determined. The relative yield ratios of the successive transitions and those of carbon-to-nitrogen (C:N) and carbon-to-oxygen (C:O) were also determined. These X-ray yields provide important information for understanding the capture ratios and cascade mechanisms of kaonic atoms produced in a compound material, such as Kapton.
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