Concerns over fake news have triggered a renewed interest in various forms of media literacy. Prevailing expectations posit that literacy interventions help audiences to be “inoculated” against any ...harmful effects of misleading information. This study empirically investigates such assumptions by assessing whether individuals with greater literacy (media, information, news, and digital literacies) are better at recognizing fake news, and which of these literacies are most relevant. The results reveal that information literacy—but not other literacies—significantly increases the likelihood of identifying fake news stories. Interpreting the results, we provide both conceptual and methodological explanations. Particularly, we raise questions about the self-reported competencies that are commonly used in literacy scales.
Although the actual effect of fake news online on voters’ decisions is still unknown, concerns over the perceived effect of fake news online have prevailed in the US and other countries. Based on an ...analysis of survey responses from national samples (n = 1299) in the US, we found a strong tendency of the third-person perception. That is, individuals believed that fake news would have greater effects on out-group members than themselves or in-group members. Additionally, we proposed a theoretical path model, identifying the antecedents and consequences of the third-person perception. The results showed that partisan identity, social undesirability of content, and external political efficacy were positive predictors of the third-person perception. Interestingly, our findings revealed that third-person perception led to different ways of combating fake news online. Those with a greater level of third-person perception were more likely to support the media literacy approach but less likely to support the media regulation approach.
•Individuals showed third-person perception concerning the influence of fake news.•Social undesirability, partisan identity, and efficacy were positive predictors of third-person perception.•Third-person perception leads to support for media literacy intervention to combat fake news.•Third-person perception leads to rejection of media regulation approach.
Researchers have used surveys and experiments to better understand communication dynamics, but confront consistent distortion from self‐report data. But now both digital exposure and resulting ...expressive behaviors (such as tweets) are potentially accessible for direct analysis with important ramifications for the formulation of communication theory. We utilize “big data” to explore attention and framing in the traditional and social media for 29 political issues during 2012. We find agenda setting for these issues is not a one‐way pattern from traditional media to a mass audience, but rather a complex and dynamic interaction. Although the attentional dynamics of traditional and social media are correlated, evidence suggests that the rhythms of attention in each respond to a significant degree to different drummers.
In this study, we tested our hypothesis regarding mechanistic cross-talk between gastrointestinal inflammation and memory loss in a mouse model. Intrarectal injection of the colitis inducer ...2,4,6-trinitrobenzenesulfonic acid (TNBS) in mice caused colitis via activation of nuclear factor (NF)-κB and increase in membrane permeability. TNBS treatment increased fecal and blood levels of lipopolysaccharide (LPS) and the number of Enterobacteriaceae, particularly Escherichia coli (EC), in the gut microbiota composition, but significantly reduced the number of Lactobacillus johnsonii (LJ). Indeed, we observed that the mice treated with TNBS displayed impaired memory, as assessed using the Y-maze and passive avoidance tasks. Furthermore, treatment with EC, which was isolated from the feces of mice with TNBS-induced colitis, caused memory impairment and colitis, and increased the absorption of orally administered LPS into the blood. Treatment with TNBS or EC induced NF-κB activation and tumor necrosis factor-α expression in the hippocampus of mice, as well as suppressed brain-derived neurotrophic factor expression. However, treatment with LJ restored the disturbed gut microbiota composition, lowered gut microbiota, and blood LPS levels, and attenuated both TNBS- and EC-induced memory impairment and colitis. These results suggest that the gut microbiota disturbance by extrinsic stresses can cause gastrointestinal inflammation, resulting in memory impairment.
The corticospinal tract, a major neural tract in the human brain for motor function, is concerned mainly with movement of the distal extremities. Preservation or recovery of the corticospinal tract ...is essential for good recovery of impaired motor function in patients with brain injury. Therefore, thorough and precise knowledge of the corticospinal tract is necessary for successful brain rehabilitation. Many studies have reviewed the corticospinal tract; however, review articles from the rehabilitative viewpoint are lacking. Therefore, the aim of this paper was to review the corticospinal tract from the rehabilitative viewpoint with regard to classification, cerebral origin, collaterals and development.
Aim
We isolated Lactobacillus brevis G‐101 from kimchi lactic acid bacteria (LAB) strains, which induced IL‐10 expression in lipopolysaccharide (LPS)‐stimulated peritoneal macrophages. To evaluate ...the inflammatory effect of G‐101, we examined its inhibitory effect in 2,4,6‐trinitrobenzene sulfonic acid (TNBS)‐induced colitic mice.
Materials and Results
The colitic mice were prepared by intrarectal injection of TNBS. We measured intestinal mucosal cytokines by enzyme‐linked immunosorbent assay; activation of transcription factors, by immunoblotting; and macrophage polarization markers, by real‐time polymerase chain reaction. Of 200 LAB strains tested, Lact. brevis G‐101 showed most potent activity for induction of IL‐10 expression in LPS‐stimulated peritoneal macrophages. However, it significantly inhibited the expression of TNF‐α, IL‐1β and IL‐6 and the phosphorylation of IRAK1 and AKT, and activated NF‐κB and MAPKs. Treatment with TNBS caused colon shortening; increased myeloperoxidase activity; and increased IL‐1β, IL‐6 and TNF‐α expression in mice. Oral administration of Lact. brevis G‐101 significantly inhibited these activities. Lactobacillus brevis G‐101 inhibited TNBS‐induced IRAK‐1 phosphorylation and NF‐κB activation, as well as the expression of COX‐2 and iNOS. Lactobacillus brevis G‐101 inhibited the expression of M1 macrophage markers, but increased the expression of M2 macrophages in the colons of TNBS‐treated mice.
Conclusions
Lactobacillus brevis G‐101 may improve colitis by inhibiting the IRAK1/NF‐κB, MAPK and AKT pathways and by polarizing M1 macrophages to M2‐like macrophages.
Significance and Impact of the Study
These results suggest that IL‐10 expression‐inducing LAB can ameliorate colitis by inhibiting NF‐κB activation and macrophage polarization.
Although collective efforts are essential to fight COVID-19, public opinion in the United States is sharply divided by partisan attitudes and health beliefs. Addressing the concern that media use ...facilitates polarization, this study investigated whether social and traditional media use for COVID-19 information attenuates or reinforces existing disparities. This article focuses on two important areas where the public is highly polarized: partisan affect and vaccine attitudes. Contradicting the filter bubble claim, our survey (n = 1106) revealed that social media use made people less polarized in both partisan affect and vaccine hesitancy. In contrast, traditional media use made people more polarized in partisan affect. These findings corroborate the growing evidence that social media provide diverse viewpoints and incidental learning.
Upon the growing concern over a massive infodemic and politicization of health issues during the COVID-19 pandemic, this study investigated how individuals' use of partisan media and Trump briefings, ...along with other information sources, predicts risk preventive behaviors. Drawing on the Extended Parallel Process Model (EPPM), our survey analysis (n= 1,106) revealed that those obtaining COVID-19 information from conservative media and Trump briefings were less likely to believe that COVID-19 is a serious threat (perceived threat) and that recommended preventive behaviors are effective and feasible (perceived efficacy). These beliefs, in turn, resulted in their decreased intentions to adopt risk preventative behaviors. In contrast, those who got COVID-19 information from liberal media, health organizations' briefings, and traditional media reported heightened threat and efficacy perception, which, in turn, led to their willingness to take risk preventive actions.
Arthropod-borne viruses (arboviruses) are ecologically distinct from many other pathogens because of the involvement of arthropod vectors and animal reservoirs. Several mosquito-borne arboviruses ...have emerged in various geographic regions during the past few decades. Since the beginning of the 21st century, the emergence of two mosquito-borne arboviruses, chikungunya and Zika, has taken place globally. Millions of infections have not only changed the epidemiology of previously obscure viruses, but also put the world’s public health capability to the test. Newly recognized pathogenic mechanisms and modes of transmission demand the development of new strategies for disease control and treatment. The advancement of vaccine candidates in various phases of clinical trials and the evaluation of vector control strategies in the field provide the promise of new solutions for endemic or emerging diseases. In this review, the emergence of six medically important mosquito-borne arboviruses and new tools for disease control will be discussed.
Hundreds of viruses, designated as arboviruses, are transmitted by arthropod vectors in complex transmission cycles between the virus, vertebrate host, and the vector. With millions of human and ...animal infections per year, it is critical to improve our understanding of the interactions between the biological and environmental factors that play a critical role in pathogenesis, disease outcomes, and transmission of arboviruses. This review focuses on mosquito-borne arboviruses and discusses current knowledge of the factors and underlying mechanisms that influence infection and transmission of arboviruses and discusses critical factors and pathways that can potentially become targets for intervention and therapeutics.
PDF
