Two layered-pillared Cd(II)-containing coordination polymers, Cd
2
(BTC)(bpdh)
2
(HCOO)(H
2
O)·H
2
O
n
(1) and CdNa(BTC)(bpdh)(H
2
O)
2
·H
2
O
n
(2) (H
3
BTC = 1,3,5-benzenetricarboxylic acid, bpdh = ...2,5-bis-(3-pyrazinyl)-3,4-diaza-2,4-hexadiene) have been controlly synthesized under hydrothermal condition. In both complexes, the BTC
3−
ligands bridge metal ions to build 2D layers, and the linear bpdh ligands link the layers into 3D motifs. Compared with our earlier reports, it showed that the Cd
2+
ion with larger radius can effectively reduce the steric overcrowding, which is very favorable for the construction of layered-pillared structure. Furthermore, the solid state luminescent properties of 1 and 2 have also been investigated.
This study sought to investigate the clinical efficacy and safety of combined oral therapy with sildenafil and doxazosin GITS compared to sildenafil monotherapy in treating Chinese patients with ...erectile dysfunction （ED） and lower urinary tract symptoms secondary to benign prostatic hyperplasia （BPH/LUTS）. The trial was conducted in hospitals in Beijing, Shanghai, Changsha, Wuhan and Guangzhou, five major cities in China. A total of 250 patients diagnosed with ED and BPH/LUTS aged 50-75 years, and who had International Index of Erection Function-5 （IIEF-5） scores ≤ 21 and International Prostate Symptom Score （IPSS） ≥ 10 points, were enrolled and randomly divided into Group A （168 cases; doxazosin GITS 4 mg once daily plus sildenafi125-100 mg on demand） and Group B （82 cases; sildenafi125-100 mg on demand）. Efficacies were evaluated by IIEF-5 and IPSS scores and a quality of life （QoL） questionnaire, and adverse effects were evaluated during the treatment period. There were no statistically significant differences in mean age, and IIEF-5, IPSS and QoL scores pre-treatment between the two groups. After treatment, IIEF-5, IPSS and QoL scores were significantly improved in Group A, while only IIEF-5 scores were significantly improved in Group B compared with pre-treatment. There were no significant differences in side effects between the two groups. The results indicated that combined therapy with sildenafil and doxazosin GITS for the treatment of ED and BPH/LUTS is safe and effective compared to sildenafil monotherapy.
There are four different types of molecules of hydroxyl groups of the natural attapulgite. The band at 3614 cm(-1) was attributed to the stretching modes of hydroxyls coordinated with the magnesium. ...The band at 3415 cm(-1) is associated with the hydroxyl stretching vibrations of absorbed water. The bands at 3581 and 3552 cm(-1) were attributed to the symmetric and antisymmetric stretching modes of molecular water coordinated with the magnesium at the edges of the channels. The band at 1653 cm(-1) is associated with the hydroxyl stretching vibrations of zeolitic water. The structures of the natural palygorskite and its products dried at different temperatures for 30 min were analysed by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The absorbed, zeolitic and co-ordinated water decreased during the drying process at the same time. The absorbed water was completely-dehydrated firstly, then the zeolitic water, and lastly the co-ordinated water. And the hydroxyl groups remained until
Acetylcholinesterase (AChE) inhibitors played an important role in developing a cure for Alzheimer’ s disease. In order to study on the influence of modifications at different groups and side chains ...on the AChE inhibitory ability and the active sites of 7
H
-thiazolo3,2-
b
1,2,4triazin-7-one derivatives, fourteen 3,6-diaryl-7
H
-thiazolo3,2-
b
1,2,4triazin-7-one derivatives were designed and synthesized. The study of AChE inhibitory activity was carried out using the Ellman colorimetric assay with huperzine-A as the positive control drug. Most of the target compounds exhibited more than 50% inhibition at 10 μM. Some target compounds showed strong inhibition against AChE. The molecular fields analysis and preliminary structureactivity relationships are discussed.
Satellite carbon dioxide (CO
2
) retrievals provide important constraints on surface carbon fluxes in regions that are undersampled by global
in situ
networks. In this study, we developed an ...atmospheric inversion system to infer CO
2
sources and sinks from Orbiting Carbon Observatory-2 (OCO-2) column CO
2
retrievals during 2015–2019, and compared our estimates to five other state-of-the-art inversions. By assimilating satellite CO
2
retrievals in the inversion, the global net terrestrial carbon sink (net biome productivity, NBP) was found to be 1.03±0.39 petagrams of carbon per year (PgC yr
−1
); this estimate is lower than the sink estimate of 1.46–2.52 PgC yr
−1
, obtained using surface-based inversions. We estimated a weak northern uptake of 1.30 PgC yr
−1
and weak tropical release of −0.26 PgC yr
−1
, consistent with previous reports. By contrast, the other inversions showed a strong northern uptake (1.44–2.78 PgC yr
−1
), but diverging tropical carbon fluxes, from a sink of 0.77 PgC yr
−1
to a source of −1.26 PgC yr
−1
. During the 2015–2016 El Niño event, the tropical land biosphere was mainly responsible for a higher global CO
2
growth rate. Anomalously high carbon uptake in the northern extratropics, consistent with concurrent extreme Northern Hemisphere greening, partially offset the tropical carbon losses. This anomalously high carbon uptake was not always found in surface-based inversions, resulting in a larger global carbon release in the other inversions. Thus, our satellite constraint refines the current understanding of flux partitioning between northern and tropical terrestrial regions, and suggests that the northern extratropics acted as anomalous high CO
2
sinks in response to the 2015–2016 El Niño event.
A novel sulfonated diamine monomer, 4,6-bis(4-aminophenoxy)-naphthalene-2-sulfonic acid(BAPNS), was synthesized. A series of sulfonated polyimide copolymers was prepared from BAPNS, ...1,4,5,8-naphthalenetetra-carboxylic dianhydride(NTDA) and nonsulfonated diamine 4,4′-diaminodiphenyl ether(ODA). Flexible, transparent, and mechanically strong membranes were obtained. The novel sulfonated polyimide(SPI) membranes show higher conductivity, for example, SPI-100 shows a conductivity of 0.0698 S/cm at 80 °C(SPI-
X
:
X
refers to molar fraction of BAPNS). The membranes exhibit the permeability of methanol from 2.18×10
−7
cm
2
/s to 2.57×10
−7
cm
2
/s, which is much lower than that of Nafion(2.00×10
−6
cm
2
/s). The copolymers were thermally stable up to 330 °C. The sulfonated polyimide copolymers also show reasonable mechanical strength; for example, the maximum tensile strength at break of the sulfonated polyimide copolymer with 100%(molar fraction) BAPNS is 1.35 GPa under high moisture conditions. The optimum concentration of BAPNS was found to be 100%(molar fraction) from the view point of proton conductivity, methanol permeability, and membrane stability.
•There were 143 metabolic gens that differentially expressed in the survival group comparing with the dead group.•SVM classifier based on 21 feature metabolic genes have a good performance in samples ...classifying.•RS prognostic prediction model constructed by 10 metabolic genes have great potential in prognostic prediction.•GSEA showed complement and coagulation cascades, PPAR signaling pathway and hematopoietic cell lineage were activated in high risk group.•High risk group had obviously lower counts of b cell naive and t cell CD4+ memory resting, while higher counts of b cell plasma and macrophage M2.
Our study aimed to reveal the metabolic-related gene signatures for survival prediction and immune cell subtypes associated with IHCC prognosis.
Differentially expressed metabolic genes were identified between survival group and dead group which were divided according to survival at discharge. Recursive feature elimination (RFE) and randomForest (RF) algorithms were applied to optimize the combination of feature metabolic genes, which were used to generate SVM classifier. Performance of SVM classifier was evaluated by receiver operating characteristic (ROC) curves. Gene set enrichment analysis (GSEA) was conducted to uncover the activated pathways in high risk group, and differences in immune cell distributions were revealed.
There were 143 differentially expressed metabolic gens. RFE and RF identified 21 overlapping differentially expressed metabolic genes, and the constructed SVM classifier had excellent accuracy in training and validation dataset. RS survival prediction model was consisted of 10 metabolic genes. RS model had reliable predictive capability in the training and validation dataset. GSEA revealed 15 significant KEGG pathways that were relatively activated in the high risk group. High risk group had obviously lower counts of B cell naive and T cell CD4+ memory resting, while higher counts of B cell plasma and macrophage M2.
Prognostic prediction model of 10 metabolic genes could accurately predict the prognosis of IHCC patients.
Creep crack growth (CCG) has been studied in phosphorus-alloyed oxygen-free copper (Cu-OFP) at 22, 75, 175, and 215°C with compact tension (CT) specimens. At 175 and 215°C, the cracks grew about 10mm ...before final instantaneous failure. In contrast, there was no visible crack growth at 22 and 75°C. Strongly deformed grains were observed adjacent to the cracks at 175 and 215°C. Intergranular creep cavities were found around the cracks. At 22 and 75°C, deformed grains and some cavities as well as microcracks were observed close to the crack tip.
A model for crack propagation based on creep damage formation has been formulated to interpret the test results. Rupture criteria based on both creep ductility exhaustion and grain boundary cavitation were taken into account. The contribution from the ductility exhaustion to the creep damage dominated at the lower two test temperatures whereas the contribution from grain boundary cavitation at the higher test temperatures. The model can describe the influence of temperature on the observed creep crack propagation. It can also account for the observed cavitation in a qualitative way.
Objectives
To reveal a radiogenomic correlation between the presence of the T2-fluid-attenuated inversion recovery resection (T2-FLAIR) mismatch sign on MR images and isocitrate dehydrogenase (IDH) ...mutation status in adult patients with lower-grade gliomas (LGGs).
Methods
A web-based systemic search for eligible literature up to April 13, 2021, was conducted on PubMed, Embase, and the Cochrane Library databases by two independent reviewers. This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. We included studies evaluating the accuracy of the T2-FLAIR mismatch sign in diagnosing the IDH mutation in adult patients with LGGs. The T2-FLAIR mismatch sign was defined as a T2-hyperintense lesion that is hypointense on FLAIR except for a hyperintense rim.
Results
Fourteen studies (
n
= 1986) were finally identified. The mean age of patients in the included studies ranged from 38.5 to 56 years. The pooled area under the curve (AUC), sensitivity, and specificity were obtained for each molecular profile: IDHmut-Codel: 0.46 (95% confidence interval CI: 0.42–0.50), 1% (95%CI: 0–7%), and 69% (95%CI: 62–75%), respectively; IDHmut-Noncodel: 0.75 (95%CI: 0.71–0.79), 42% (95%CI: 34–50%), and 99% (95%CI: 96–100%), respectively; IDH-Mutation regardless of 1p/19q codeletion status: 0.77 (95%CI: 0.73–0.80), 29% (95%CI: 21–40%), and 99% (95%CI: 92–100%), respectively.
Conclusions
The T2-FLAIR mismatch sign was an insensitive but highly specific marker for IDHmut-Noncodel and IDH-Mutation LGGs, whereas it was not a useful marker for IDHmut-Codel LGGs. The findings might identify the T2-FLAIR mismatch sign as a non-invasive imaging biomarker for the selection of patients with IDH-mutant LGGs.
Key Points
•
The T2-FLAIR mismatch sign was not a sensitive sign for IDH mutation in LGGs.
•
The T2-FLAIR mismatch sign was related to IDHmut-Noncodel with a specificity of 99%.
•
The pooled specificity (69%) of the T2-FLAIR mismatch sign for IDHmut-Codel was low.
•A non-invertible transform, Randomized Graph-based Hamming Embedding is proposed.•Well preservation of the performance in Hamming with respect to Euclidean space.•Template is revocable due to ...user-specific random projection.•Satisfactory equal error rate (EER) but higher level irreversibility.•Registration-free cancelable fingerprint template.
Biometric technology is likely to provide a new level of security to various applications. Yet if the stored biometric template is compromised, invasion of user privacy is inevitable. Since biometric is irreplaceable and irrevocable, such an invasion implies a permanent loss of identity. In this paper, a fingerprint template protection technique is proposed to secure the fingerprint minutiae. Remarkably, by incorporating Randomized Graph-based Hamming Embedding (RGHE), the generated binary template can be strongly protected against inversion. The proposed method adopts a minutiae descriptor, dubbed as minutiae vicinity decomposition (MVD) to derive a set of randomized geometrical invariant features together with random projection. The discrimination of randomized MVD is then enhanced by User-specific Minutia Vicinities Collection scheme and embedded into a Hamming space by means of Graph-based Hamming Embedding. The resultant binary template enjoys four merits: (1) strong concealment of the minutia vicinity, thus effectively protects the location and orientation of minutiae. (2) Well preservation of the discriminability of MVD in the Hamming space with respect to the Euclidean space without accuracy performance degradation. (3) Template is revocable due to user-specific random projection. (4) Speedy matching attributed to bit-wise operations. Promising experimental results on FVC2002 database vindicate the feasibility of the proposed technique.
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