After clarifying the relationship between the closely related concepts of ecology and epidemiology as they are used in plant virology, this article provides a historical perspective on the subject ...before discussing recent progress and future prospects. Ecology focuses on virus populations interacting with host populations within a variable environment, while epidemiology focuses on the complex association between virus and host plant, and factors that influence spread. The evolution and growth of plant virus ecology and epidemiology since its inception to the present day, and the major milestones in its development, are illustrated by examples from influential historical reviews published in the Annals of Applied Biology over the last 100 years. Original research papers published in the journal are used to illustrate important ecological and epidemiological principles and new developments in both fields. Both areas are multifaceted with many factors influencing host plants, and virus and vector behaviour. The highly diverse scenarios that arise from this process influence the virus population and the spatiotemporal dynamics of virus distribution and spread. The review then describes exciting progress in research in the areas of molecular epidemiology and ecology, and understanding virus–vector interactions. Application of new molecular techniques has greatly accelerated the rate of progress in understanding virus populations and the way changes in these populations influence epidemics. Viruses cause direct and plant‐mediated indirect effects on insect vectors by modifying their life cycles, fitness and behaviour, and one of the most fascinating recent fields of research concerns plant‐mediated indirect virus manipulation of insect vector behaviour that encourages virus spread. Next, the review describes the current state of knowledge about spread of plant viruses at the critical agro‐ecological interface between managed and natural vegetation. There is an urgent need to understand how viruses move in both directions between the two and be able to anticipate these kinds of events. To obtain an understanding of, and ability to foresee, such events will require a major research effort into the future. The review finishes by discussing the implications of climate change and rapid technological innovation for the types of research needed to avoid virus threats to future world food supplies and plant biodiversity. There has been lamentably little focus on research to determine the magnitude of the threat from diseases caused in diverse plant virus pathosystems under different climate change scenarios. Increasing technological innovation offers many opportunities to help ensure this situation is addressed, and provide plant virus ecology and epidemiology with a very exciting future.
Abstract
Type Ia supernovae (SNe Ia) are more precise standardizable candles when measured in the near-infrared (NIR) than in the optical. With this motivation, from 2012 to 2017 we embarked on the ...RAISIN program with the Hubble Space Telescope (HST) to obtain rest-frame NIR light curves for a cosmologically distant sample of 37 SNe Ia (0.2 ≲
z
≲ 0.6) discovered by Pan-STARRS and the Dark Energy Survey. By comparing higher-
z
HST data with 42 SNe Ia at
z
< 0.1 observed in the NIR by the Carnegie Supernova Project, we construct a Hubble diagram from NIR observations (with only time of maximum light and some selection cuts from optical photometry) to pursue a unique avenue to constrain the dark energy equation-of-state parameter,
w
. We analyze the dependence of the full set of Hubble residuals on the SN Ia host galaxy mass and find Hubble residual steps of size ∼0.06-0.1 mag with 1.5
σ
−2.5
σ
significance depending on the method and step location used. Combining our NIR sample with cosmic microwave background constraints, we find 1 +
w
= −0.17 ± 0.12 (statistical + systematic errors). The largest systematic errors are the redshift-dependent SN selection biases and the properties of the NIR mass step. We also use these data to measure
H
0
= 75.9 ± 2.2 km s
−1
Mpc
−1
from stars with geometric distance calibration in the hosts of eight SNe Ia observed in the NIR versus
H
0
= 71.2 ± 3.8 km s
−1
Mpc
−1
using an inverse distance ladder approach tied to Planck. Using optical data, we find 1 +
w
= −0.10 ± 0.09, and with optical and NIR data combined, we find 1 +
w
= −0.06 ± 0.07; these shifts of up to ∼0.11 in
w
could point to inconsistency in the optical versus NIR SN models. There will be many opportunities to improve this NIR measurement and better understand systematic uncertainties through larger low-
z
samples, new light-curve models, calibration improvements, and eventually by building high-
z
samples from the Roman Space Telescope.
Real-world prescription pathways leading to triple therapy (TT) (inhaled corticosteroid ICS plus long-acting β2-agonist bronchodilator LABA plus long-acting muscarinic antagonist) differ from Global ...initiative for chronic Obstructive Lung Disease GOLD and National Institute for Health and Care Excellence treatment recommendations. This study sets out to identify COPD patients without asthma receiving TT, and determine the pathways taken from diagnosis to the first prescription of TT.
This was a historical analysis of COPD patients without asthma from the Optimum Patient Care Research Database (387 primary-care practices across the UK) from 2002 to 2010. Patient disease severity was classified using GOLD 2013 criteria. Data were analyzed to determine prescribing of TT before, at, and after COPD diagnosis; the average time taken to receive TT; and the impact of lung function grade, modified Medical Research Council dyspnea score, and exacerbation history on the pathway to TT.
During the study period, 32% of patients received TT. Of these, 19%, 28%, 37%, and 46% of patients classified as GOLD A, B, C, and D, respectively, progressed to TT after diagnosis (P<0.001). Of all patients prescribed TT, 25% were prescribed TT within 1 year of diagnosis, irrespective of GOLD classification (P=0.065). The most common prescription pathway to TT was LABA plus ICS. It was observed that exacerbation history did influence the pathway of LABA plus ICS to TT.
Real life UK prescription data demonstrates the inappropriate prescribing of TT and confirms that starting patients on ICS plus LABA results in the inevitable drift to overuse of TT. This study highlights the need for dissemination and implementation of COPD guidelines to physicians, ensuring that patients receive the recommended therapy.
Aims. The DustPedia project is capitalising on the legacy of the Herschel Space Observatory, using cutting-edge modelling techniques to study dust in the 875 DustPedia galaxies – representing the ...vast majority of extended galaxies within 3000 km s-1 that were observed by Herschel. This work requires a database of multiwavelength imagery and photometry that greatly exceeds the scope (in terms of wavelength coverage and number of galaxies) of any previous local-Universe survey. Methods. We constructed a database containing our own custom Herschel reductions, along with standardised archival observations from GALEX, SDSS, DSS, 2MASS, WISE, Spitzer, and Planck. Using these data, we performed consistent aperture-matched photometry, which we combined with external supplementary photometry from IRAS and Planck. Results. We present our multiwavelength imagery and photometry across 42 UV-microwave bands for the 875 DustPedia galaxies. Our aperture-matched photometry, combined with the external supplementary photometry, represents a total of 21 857 photometric measurements. A typical DustPedia galaxy has multiwavelength photometry spanning 25 bands. We also present the Comprehensive & Adaptable Aperture Photometry Routine (CAAPR), the pipeline we developed to carry out our aperture-matched photometry. CAAPR is designed to produce consistent photometry for the enormous range of galaxy and observation types in our data. In particular, CAAPR is able to determine robust cross-compatible uncertainties, thanks to a novel method for reliably extrapolating the aperture noise for observations that cover a very limited amount of background. Our rich database of imagery and photometry is being made available to the community.
It is unclear whether diet affects glycaemic control in type 2 diabetes (T2D), over and above its effects on bodyweight. We aimed to assess whether changes in dietary patterns altered glycaemic ...control independently of effects on bodyweight in newly diagnosed T2D.
We used data from 4-day food diaries, HbA1c and potential confounders in participants of the Early-ACTivity-In-Diabetes trial measured at 0, 6 and 12 months. At baseline, a 'carb/fat balance' dietary pattern and an 'obesogenic' dietary pattern were derived using reduced-rank regression, based on hypothesised nutrient-mediated mechanisms linking dietary intake to glycaemia directly or via obesity. Relationships between 0 and 6 month change in dietary pattern scores and baseline-adjusted HbA1c at 6 months (n = 242; primary outcome) were assessed using multivariable linear regression. Models were repeated for periods 6-12 months and 0-12 months (n = 194 and n = 214 respectively; secondary outcomes).
Reductions over 0-6 months were observed in mean bodyweight (- 2.3 (95% CI: - 2.7, - 1.8) kg), body mass index (- 0.8 (- 0.9, - 0.6) kg/m
), energy intake (- 788 (- 953, - 624) kJ/day), and HbA1c (- 1.6 (- 2.6, -0.6) mmol/mol). Weight loss strongly associated with lower HbA1c at 0-6 months (β = - 0.70 95% CI - 0.95, - 0.45 mmol/mol/kg lost). Average fat and carbohydrate intakes changed to be more in-line with UK healthy eating guidelines between 0 and 6 months. Dietary patterns shifting carbohydrate intakes higher and fat intakes lower were characterised by greater consumption of fresh fruit, low-fat milk and boiled/baked potatoes and eating less of higher-fat processed meats, butter/animal fats and red meat. Increases in standardised 'carb/fat balance' dietary pattern score associated with improvements in HbA1c at 6 months independent of weight loss (β = - 1.54 - 2.96, - 0.13 mmol/mol/SD). No evidence of association with HbA1c was found for this dietary pattern at other time-periods. Decreases in 'obesogenic' dietary pattern score were associated with weight loss (β = - 0.77 - 1.31, - 0.23 kg/SD) but not independently with HbA1c during any period.
Promoting weight loss should remain the primary nutritional strategy for improving glycaemic control in early T2D. However, improving dietary patterns to bring carbohydrate and fat intakes closer to UK guidelines may provide small, additional improvements in glycaemic control.
ISRCTN92162869 . Retrospectively registered on 25 July 2005.
Abstract
In outburst, neutron star X-ray binaries produce less powerful jets than black holes at a given X-ray luminosity. This has made them more difficult to study as they fade towards quiescence. ...To explore whether neutron stars power jets at low accretion rates (L
X ≲ 1036 erg s−1), we investigate the radio and X-ray properties of three accreting millisecond X-ray pulsars (IGR J17511−3057, SAX J1808.4−3658 and IGR J00291+5934) during their outbursts in 2015, and of the non-pulsing neutron star Cen X−4 in quiescence (2015) and in outburst (1979). We did not detect the radio counterpart of IGR J17511−3057 in outburst or of Cen X−4 in quiescence, but did detect IGR J00291+5934 and SAX J1808.4−3658, showing that at least some neutron stars launch jets at low accretion rates. While the radio and X-ray emission in IGR J00291+5934 seem to be tightly correlated, the relationship in SAX J1808.4−3658 is more complicated. We find that SAX J1808.4−3658 produces jets during the reflaring tail, and we explore a toy model to ascertain whether the radio emission could be attributed to the onset of a strong propeller. The lack of a universal radio/X-ray correlation, with different behaviours in different neutron star systems (with various radio/X-ray correlations; some being radio faint and others not), points at distinct disc–jet interactions in individual sources, while always being fainter in the radio band than black holes at the same X-ray luminosity.
We describe the spectroscopic target selection for the Galaxy And Mass Assembly (GAMA) survey. The input catalogue is drawn from the Sloan Digital Sky Survey (SDSS) and UKIRT Infrared Deep Sky Survey ...(UKIDSS). The initial aim is to measure redshifts for galaxies in three 4°× 12° regions at 9, 12 and 14.5 h, on the celestial equator, with magnitude selections r < 19.4, z < 18.2 and KAB < 17.6 over all three regions, and r < 19.8 in the 12-h region. The target density is 1080 deg−2 in the 12-h region and 720 deg−2 in the other regions. The average GAMA target density and area are compared with completed and ongoing galaxy redshift surveys. The GAMA survey implements a highly complete star–galaxy separation that jointly uses an intensity-profile separator (Δsg=rpsf−rmodel as per the SDSS) and a colour separator. The colour separator is defined as Δsg,jk=J−K−f(g−i), where f(g−i) is a quadratic fit to the J−K colour of the stellar locus over the range 0.3 < g−i < 2.3. All galaxy populations investigated are well separated with Δsg,jk > 0.2. From 2 yr out of a 3-yr AAOmega program on the Anglo-Australian Telescope, we have obtained 79 599 unique galaxy redshifts. Previously known redshifts in the GAMA region bring the total up to 98 497. The median galaxy redshift is 0.2 with 99 per cent at z < 0.5. We present some of the global statistical properties of the survey, including K-band galaxy counts, colour–redshift relations and preliminary n(z).
ABSTRACT
During wound healing of the skin, keratinocytes disassemble hemidesmosomes and reorganize their actin cytoskeletons in order to exert traction forces on and move directionally over the ...dermis. Nonetheless, the transmembrane hemidesmosome component collagen XVII (ColXVII) is found in actin‐rich lamella, situated behind the lamellipodium. A set of actin bundles, along which ColXVII colocalizes with actinin4, is present at each lamella. Knockdown of either ColXVII or actinin4 not only inhibits directed migration of keratinocytes but also relieves constraints on actin bundle retrograde movement at the site of lamella, such that actin bundle movement is enhanced more than 5‐fold. Moreover, whereas control keratinocytes move in a stepwise fashion over a substrate by generating alternating traction forces, of up to 1.4 kPa, at each flank of the lamellipodium, ColXVII knockdown keratinocytes fail to do so. In summary, our data indicate that ColXVII‐actinin4 complexes at the lamella of a moving keratinocyte regulate actin dynamics, thereby determining the direction of cell movement.—Hiroyasu, S., Colburn, Z. T., Jones, J. C. R. A hemidesmosomal protein regulates actin dynamics and traction forces in motile keratinocytes. FASEB J. 30, 2298–2310 (2016). www.fasebj.org
•Rapidly advancing technological innovation is creating a new paradigm for plant virus epidemiology.•Many opportunities to enhance research on plant virus epidemics and their control are becoming ...available.•Research on plant virus epidemics is being transformed radically at both macro and micro levels.•Understanding of plant virus epidemics and how best to control them are advancing rapidly.•Harnessing new technologies to control plant virus epidemics is critical for future food security.
This review focuses on new or improved technologies currently being applied, or likely to be applied in the future, to worldwide research on plant virus epidemiology. Recent technological advances and innovations provide many opportunities to improve understanding of the way diverse types of plant virus epidemics develop and how to manage them. The review starts at the macro level by considering how recent innovations in remote sensing and precision agriculture can provide valuable information about (i) virus epidemics occurring at continental, regional or district scales (via satellites) and within individual crops (mostly via lightweight unmanned aerial vehicles), and (ii) exactly where to target control measures. It then considers recent improvements in information systems and innovations in modelling that improve (i) understanding of virus epidemics and ability to predict them, and (ii) delivery to end-users of critical advice on control measures, such as Internet-based Decision Support Systems. The review goes on to discuss how advances in analysis of spatiotemporal virus spread patterns within crops can help to enhance understanding of how virus epidemics develop and validate potentially useful virus control measures. At the micro level, the review then considers the many insights that advances in molecular epidemiology can provide about genetic variation within plant virus populations involved in epidemics, and how this variation drives what occurs at the macro level. Next, it describes how recent innovations in virus detection technologies are providing many opportunities to collect and analyse new types, and ever increasing amounts, of data about virus epidemics, and the genetic variability of the virus populations involved. Finally, the implications for plant virus epidemiology of technologies likely to be important in the future are considered. To address looming world food insecurity and threats to plant biodiversity resulting from climate change and rapid population growth, it is important that new and improved technologies that help understand and control epidemics of damaging plant viruses are adopted as smoothly and speedily as possible.
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