Due to the existence of multiple stakeholders with conflicting goals and policies, alterations to the existing Internet architecture are now limited to simple incremental updates; deployment of any ...new, radically different technology is next to impossible. To fend off this ossification,
network virtualization has been propounded as a diversifying attribute of the future inter-networking paradigm. By introducing a plurality of heterogeneous network architectures cohabiting on a shared physical substrate, network virtualization promotes innovations and diversified applications. In this paper, we survey the existing technologies and a wide array of past and state-of-the-art projects on network virtualization followed by a discussion of major challenges in this area.
Hydrogels based on cellulose comprising many organic biopolymers including cellulose, chitin, and chitosan are the hydrophilic material, which can absorb and retain a huge proportion of water in the ...interstitial sites of their structures. These polymers feature many amazing properties such as responsiveness to pH, time, temperature, chemical species and biological conditions besides a very high-water absorption capacity. Biopolymer hydrogels can be manipulated and crafted for numerous applications leading to a tremendous boom in research during recent times in scientific communities. With the growing environmental concerns and an emergent demand, researchers throughout the globe are concentrating particularly on naturally derived hydrogels due to their biocompatibility, biodegradability and abundance. Cellulose-based hydrogels are considered as useful biocompatible materials to be used in medical devices to treat, augment or replace any tissue, organ, or help function of the body. These hydrogels also hold a great promise for applications in agricultural activity, as smart materials and some other useful industrial purposes. This review offers an overview of the recent and contemporary research regarding physiochemical properties of cellulose-based hydrogels along with their applications in multidisciplinary areas including biomedical fields such as drug delivery, tissue engineering and wound healing, healthcare and hygienic products as well as in agriculture, textiles and industrial applications as smart materials.
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A mathematical model is developed to examine the effects of the Stefan blowing, second order velocity slip, thermal slip and microorganism species slip on nonlinear bioconvection boundary layer flow ...of a nanofluid over a horizontal plate embedded in a porous medium with the presence of passively controlled boundary condition. Scaling group transformations are used to find similarity equations of such nanobioconvection flows. The similarity equations are numerically solved with a Chebyshev collocation method. Validation of solutions is conducted with a Nakamura tri-diagonal finite difference algorithm. The effects of nanofluid characteristics and boundary properties such as the slips, Stefan blowing, Brownian motion and Grashof number on the dimensionless fluid velocity, temperature, nanoparticle volume fraction, motile microorganism, skin friction, the rate of heat transfer and the rate of motile microorganism transfer are investigated. This work is relevant to bio-inspired nanofluid-enhanced fuel cells and nano-materials fabrication processes.
Alzheimer’s disease (AD) is a progressive neurodegenerative disease involving aggregation of misfolded proteins inside the neuron causing prolonged cellular stress. The neuropathological hallmarks of ...AD include the formation of senile plaques and neurofibrillary tangles in specific brain regions that lead to synaptic loss and neuronal death. The exact mechanism of neuron dysfunction in AD remains obscure. In recent years, endoplasmic reticulum (ER) dysfunction has been implicated in neuronal degeneration seen in AD. Apart from AD, many other diseases also involve misfolded proteins aggregations in the ER, a condition referred to as ER stress. The response of the cell to ER stress is to activate a group of signaling pathways called unfolded protein response (UPR) that stimulates a particular transcriptional program to restore ER function and ensure cell survival. ER stress also involves the generation of reactive oxygen species (ROS) that, together with mitochondrial ROS and decreased effectiveness of antioxidant mechanisms, producing a condition of chronic oxidative stress. The unfolded proteins may not always produce a response that leads to the restoration of cellular functions, but they may also lead to inflammation by a set of different pathways with deleterious consequences. In this review, we extensively discuss the role of ER stress and how to target it using different pharmacological approaches in AD development and onset.
Alzheimer's disease (AD) is the leading cause of dementia worldwide. Even though the number of AD patients is rapidly growing, there is no effective treatment for this neurodegenerative disorder. At ...present, implementation of effective treatment approaches for AD is vital to meet clinical needs. In AD research, priorities concern the development of disease-modifying therapeutic agents to be used in the early phases of AD and the optimization of the symptomatic treatments predominantly dedicated to the more advanced AD stages. Until now, available therapeutic agents for AD treatment only provide symptomatic treatment. Since AD pathogenesis is multifactorial, use of a multimodal therapeutic intervention addressing several molecular targets of AD-related pathological processes seems to be the most practical approach to modify the course of AD progression. It has been demonstrated through numerous studies, that the clinical efficacy of combination therapy (CT) is higher than that of monotherapy. In case of AD, CT is more effective, mostly when started early, at slowing the rate of cognitive impairment. In this review, we have covered the major studies regarding CT to combat AD pathogenesis. Moreover, we have also highlighted the safety, tolerability, and efficacy of CT in the treatment of AD.
Contaminants in road dusts can directly pose significant human health risks through oral ingestion, particle inhalation, and dermal contact. Therefore, this study has been designed to analyze heavy ...metal contaminations in 88 street dusts collected from the 22 high traffic sites and industrial areas of the Southeast Asian Megacity: Dhaka (capital of Bangladesh) using energy dispersive X-ray fluorescence (EDXRF) spectroscopy. This study revealed that the maximum Pb, Cd, Zn, Cr, Ni, As, Mn and Cu contents in the street dust samples were 18.9, 11.6, 239.2, 144.3, 37.1, 8.1, 261.5 and 49.6 mg/ kg respectively in which Ni and Pb concentration were 2 times, and Cd concentration was 200 times higher than the background level in soil; and As concentration was slightly higher than soil background level. The spatial distribution of heavy metal concentrations in street dust samples in Dhaka City was revealed that the hot spot areas of Pb, Ni, Cd and As were mainly associated with heavy traffic and industrial activities. The risk assessment strategies were used for this study for identifying the routes of exposure through oral ingestion, inhalation, and dermal contact by the fine particles (~75 μm) of street dust, especially for children based on the US EPA health risk models. Both non-carcinogenic and carcinogenic risks of heavy metals were characterized in street dust samples. Results based on the hazard index (HI), in the case of non-cancer effect, the ingestion of dust particles of children and adults in Dhaka City appeared to be the route of exposure to street dust that results in a higher risk for heavy metals, followed by dermal contact. This study revealed that the inhalation of re-suspended particles through mouth and nose were almost negligible. It was also noticed that children were experiencing the potential health risk due to HI for Cr (1.04), which was slightly higher than the safe level 1, and Cd (0.69) was close to the safe level 1. Reversely, cancer risk for Cr (i.e. 4.27 × 10−6) was fallen within the range of threshold values (10−4 to 10−6) and As (i.e. 9.59 × 10−7) was close to the upper limit of threshold values (10−4 to 10−6).
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•Heavy metal conc in 88 road dust sample of capital city of Bangladesh were examined•Spatial distribution of heavy metal and their source identification are focused•Human health risk assessment for heavy metals are done based on US EPA models•Risk comparison among ingestion, inhalation and dermal adsorption are evaluated
Increasing penetration of photovoltaic (PV), as well as increasing peak load demand, has resulted in poor voltage profile for some residential distribution networks. This paper proposes coordinated ...use of PV and battery energy storage (BES) to address voltage rise and/or dip problems. The reactive capability of PV inverter combined with droop-based BES system is evaluated for rural and urban scenarios (having different \mbi R/X ratios). Results show that reactive compensation from PV inverters alone is sufficient to maintain acceptable voltage profile in an urban scenario (low-resistance feeder), whereas coordinated PV and BES support is required for the rural scenario (high-resistance feeder). Constant, as well as variable, droop-based BES schemes are analyzed. The required BES sizing and associated cost to maintain the acceptable voltage profile under both schemes are presented. Uncertainties in PV generation and load are considered, with probabilistic estimation of PV generation and randomness in load modeled to characterize the effective utilization of BES. Actual PV generation data and distribution system network data are used to verify the efficacy of the proposed method.
Therapy directed against oncogenic FLT3 has been shown to induce response in patients with acute myeloid leukemia (AML), but these responses are almost always transient. To address the mechanism of ...FLT3 inhibitor resistance, we generated two resistant AML cell lines by sustained treatment with the FLT3 inhibitor sorafenib. Parental cell lines carry the FLT3-ITD (tandem duplication) mutation and are highly responsive to FLT3 inhibitors, whereas resistant cell lines display resistance to multiple FLT3 inhibitors. Sanger sequencing and protein mass-spectrometry did not identify any acquired mutations in FLT3 in the resistant cells. Moreover, sorafenib treatment effectively blocked FLT3 activation in resistant cells, whereas it was unable to block colony formation or cell survival, suggesting that the resistant cells are no longer FLT3 dependent. Gene expression analysis of sensitive and resistant cell lines, as well as of blasts from patients with sorafenib-resistant AML, suggested an enrichment of the PI3K/mTOR pathway in the resistant phenotype, which was further supported by next-generation sequencing and phospho-specific-antibody array analysis. Furthermore, a selective PI3K/mTOR inhibitor, gedatolisib, efficiently blocked proliferation, colony and tumor formation, and induced apoptosis in resistant cell lines. Gedatolisib significantly extended survival of mice in a sorafenib-resistant AML patient-derived xenograft model. Taken together, our data suggest that aberrant activation of the PI3K/mTOR pathway in FLT3-ITD-dependent AML results in resistance to drugs targeting FLT3.
Histone protein modifications control fate determination during normal development and dedifferentiation during disease. Here, we set out to determine the extent to which dynamic changes to histones ...affect the differentiated phenotype of ordinarily quiescent adult glomerular podocytes. To do this, we examined the consequences of shifting the balance of the repressive histone H3 lysine 27 trimethylation (H3K27me3) mark in podocytes. Adriamycin nephrotoxicity and subtotal nephrectomy (SNx) studies indicated that deletion of the histone methylating enzyme EZH2 from podocytes decreased H3K27me3 levels and sensitized mice to glomerular disease. H3K27me3 was enriched at the promoter region of the Notch ligand Jag1 in podocytes, and derepression of Jag1 by EZH2 inhibition or knockdown facilitated podocyte dedifferentiation. Conversely, inhibition of the Jumonji C domain-containing demethylases Jmjd3 and UTX increased the H3K27me3 content of podocytes and attenuated glomerular disease in adriamycin nephrotoxicity, SNx, and diabetes. Podocytes in glomeruli from humans with focal segmental glomerulosclerosis or diabetic nephropathy exhibited diminished H3K27me3 and heightened UTX content. Analogous to human disease, inhibition of Jmjd3 and UTX abated nephropathy progression in mice with established glomerular injury and reduced H3K27me3 levels. Together, these findings indicate that ostensibly stable chromatin modifications can be dynamically regulated in quiescent cells and that epigenetic reprogramming can improve outcomes in glomerular disease by repressing the reactivation of developmental pathways.
Few studies have examined the associated factors of antepartum depressive and anxiety symptoms (ADS and AAS) in low-income countries, yet the World Health Organization identifies depressive disorders ...as the second leading cause of global disease burden by 2020. There is a paucity of research on mental disorders and their predictors among pregnant women in Bangladesh. This study aims to estimate the prevalence of depressive and anxiety symptoms and explore the associated factors in a cross-section of rural Bangladeshi pregnant women.
The study used cross-sectional data originating from a rural community-based prospective cohort study of 720 randomly selected women in their third trimester of pregnancy from a district of Bangladesh. The validated Bangla version of the Edinburgh Postnatal Depression Scale was used to measure ADS, and a trait anxiety inventory to assess general anxiety symptoms. Background information was collected using a structured questionnaire at the respondents' homes.
Prevalence of ADS was 18% and AAS 29%. Women's literacy (OR 0.59, 95% CI 0.37-0.95), poor partner relationship (OR 2.23, 95% CI 3.37-3.62), forced sex (OR 1.95, 95% CI 1.01-3.75), physical violence by spouse (OR 1.69, 95% CI 1.02-2.80), and previous depression (OR 4.62 95% CI 2.72-7.85) were found to be associated with ADS. The associated factors of AAS were illiteracy, poor household economy, lack of practical support, physical partner violence, violence during pregnancy, and interaction between poor household economy and poor partner relationship.
Depressive and anxiety symptoms are found to occur commonly during pregnancy in Bangladesh, drawing attention to a need to screen for depression and anxiety during antenatal care. Policies aimed at encouraging practical support during pregnancy, reducing gender-based violence, supporting women with poor partner relationships, and identifying previous depression may ameliorate the potentially harmful consequences of antepartum depression and anxiety for the women and their family, particularly children.
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