We present the latest results of the use of soluble materials such as organic semiconductors (OSCs) or gate-dielectrics for simplified processing of organic thin-film transistors (OTFTs). In this ...paper, we described our fabrication of a solution-processed OTFT with 6,13-bis(triisopropylsilylethynyl) pentacene (TIPS-pentacene) as the OSC and siloxane-based spin-on glass (SOG) as the inorganic gate-dielectric. Also, synthesized TIPS-pentacene and SOG were examined for use as the OSC and gate-dielectric in an OTFT. From electrical measurements, we obtained device performance characteristics such as charge carrier mobility, threshold voltage, current ON/OFF ratio, and subthreshold swing, which were 6.48 times 10 -3 cm 2 /V ldr s, -13 V, ~100, and 1.83 V/dec, respectively.
Image inpainting is a field that has been traditionally attempted in the field of computer vision. After the development of deep learning, image inpainting has been advancing endlessly together with ...convolutional neural networks and generative adversarial networks. Thereafter, it has been expanded to various fields such as image filing through guiding and image inpainting using various masking. Furthermore, the field termed image out‐painting has also been pioneered. Meanwhile, after the recent announcement of the vision transformer, various computer vision problems have been attempted using the vision transformer. In this paper, we are trying to solve the problem of image generalization painting using the vision transformer. This is an attempt to fill images with painting no matter whether the areas where painting is missing are in or out of the images, and without guiding. To that end, the painting problem was defined as a problem to drop images in patch units for easy use in the vision transformer. And we solved the problem with a simple network structure created by slightly modifying the vision transformer to fit the problem. We named this network PIPformers. PIPformers achieved better values than other papers compared to PSNR, RMSE and SSIM.
In this paper, we addressed the problem of image generalization in painting using the Vision Transformer. Our method aims to fill in missing areas of paintings, regardless of where these gaps are located. Our model reconstructs images by adding patch‐wise noise to the original image. For this purpose, we used the Vision Transformer with the following parameters: an original image size of 256, a patch size of 16, an embedding size of 768, 8 attention heads, and 6 layers.
A hallmark of Parkinson's disease (PD) is the preferential loss of substantia nigra dopamine neurons. Here, we identify a new
parkin
interacting
substrate, PARIS (ZNF746), whose levels are regulated ...by the ubiquitin proteasome system via binding to and ubiquitination by the E3 ubiquitin ligase, parkin. PARIS is a KRAB and zinc finger protein that accumulates in models of parkin inactivation and in human PD brain. PARIS represses the expression of the transcriptional coactivator, PGC-1α and the PGC-1α target gene, NRF-1 by binding to insulin response sequences in the PGC-1α promoter. Conditional knockout of parkin in adult animals leads to progressive loss of dopamine (DA) neurons in a PARIS-dependent manner. Moreover, overexpression of PARIS leads to the selective loss of DA neurons in the substantia nigra, and this is reversed by either parkin or PGC-1α coexpression. The identification of PARIS provides a molecular mechanism for neurodegeneration due to parkin inactivation.
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► PARIS (ZNF746) is a substrate of the E3 ubiquitin ligase parkin ► PARIS accumulates in parkin inactivation models and in human Parkinson's disease brain ► PARIS transcriptionally represses PGC-1α by binding to insulin responsive sequences ► Degeneration of dopamine neurons in conditional parkin knockouts depends on PARIS
The mitochondrial protein apoptosis-inducing factor (AIF) plays a pivotal role in poly(ADP-ribose) polymerase-1 (PARP-1)-mediated cell death (parthanatos), during which it is released from the ...mitochondria and translocates to the nucleus. We show that AIF is a high-affinity poly(ADP-ribose) (PAR)-binding protein and that PAR binding to AIF is required for parthanatos both in vitro and in vivo. AIF bound PAR at a site distinct from AIF's DNA binding site, and this interaction triggered AIF release from the cytosolic side of the mitochondrial outer membrane. Mutation of the PAR binding site in AIF did not affect its NADH (reduced form of nicotinamide adenine dinucleotide) oxidase activity, its ability to bind FAD (flavin adenine dinucleotide) or DNA, or its ability to induce nuclear condensation. However, this AIF mutant was not released from mitochondria and did not translocate to the nucleus or mediate cell death after PARP-1 activation. These results suggest a mechanism for PARP-1 to initiate AIF-mediated cell death and indicate that AIF's bioenergetic cell survival-promoting functions are separate from its effects as a mitochondrially derived death effector. Interference with the PAR-AIF interaction or PAR signaling may provide notable opportunities for preventing cell death after activation of PARP-1.
In this study, we have developed high performance TFT (thin film transistor) and a 7.4-inch high resolution LCD (liquid crystal display) panel of full color WSXGA (1600×RGB×1024, 257ppi, 43% aperture ...ratio) format using ‘sequential lateral solidification (SLS)’ laser crystallization process Y.J. Kim et al., Grain boundary effect on the characteristics of the high-performance poly-Si TFTs crystallized by SLS Technique, AM-LCD (2005) 249–251. The gate and data driver circuits were integrated on panel and the integrated drivers comprise a sequential analog sampling data driver and a dual logic gate scanner for redundancy.
In addition, we have improved key process for fine image quality. Metal lines used Cu/MoX (5000Å/300Å) for uniform data transfer and array on BM (black matrix) structure for lager aperture ratio was adopted.
Flows in a ramjet inlet is simulated for the study of the rocket-ramjet transition. The flow is unsteady, two-dimensional axisymmetric, compressible and turbulent. Double time marching method is used ...for the unsteady calculation and HLLC method is used as a higher order MUSCL method. As for turbulent calculation, k -- ω SST model is used for more accurate viscous calculations. Sinusoidal pressure perturbation is given at the exit and the flow fields at the inlet is studied. The cruise condition as well as the ground test condition are considered. The pressure level for the ground test condition is relatively low and the effect of the pressure perturbation at the combustion chamber is small. The normal shock at the cruise condition is very sensitive to the pressure perturbation and can be easily detached from the cowl when the exit pressure is relatively high. The sudden decrease in the mass flux is observed when the inlet flow becomes subcriticai, which can make the inlet incapable. The amplitude of travelling pressure waves becomes larger as the downstream pressure increases, and the wavelength becomes shorter as Mach number increases. The phase difference of the travelling perturbed pressure wave in space is 180 degree.PUBLICATION ABSTRACT
Objective
The transcricothyroid (CT) membrane approach is a good option for office‐based vocal fold injection (VFI). However, because the needle tip is invisible during injection using the CT ...approach, precise localization requires a high level of experience, and mastering this approach involves a steep learning curve. To overcome current limitations, we conceptualized a novel technique: real‐time light‐guided VFI (RL‐VFI), which enables simultaneous VFI under direct visualization of the lighted needle tip. Herein, we aimed to verify the feasibility of RL‐VFI in cadaveric canine model, simulating the setting of office‐based VFI, as well as to explore its clinical usefulness.
Study Design
Animal study.
Methods
A customized prototype device was developed. It consisted of three parts: light source, controller, and injector. Light source comprised laser diodes of two wavelengths (635 nanometers nm, red; 532 nm, green). Four types of injector were developed using 40‐mm needles of 23‐ and 25‐gauge and optic fibers of 50 and 100 μm. ex vivo canine larynx was prepared for the experiment. Flexible laryngoscopy system was used to examine canine vocal folds.
Results
Various routes from three insertion points (3 mm, 10 mm, and 17 mm from the midline) were validated using the device. Regardless of the injection routes, the location of the needle tip was accurately indicated by light. RL‐VFI was feasible under light guidance without difficulties. Moreover, precise and simultaneous re‐injection could be performed at the intended point using the device.
Conclusion
We introduced RL‐VFI using our customized prototype device in an ex vivo canine larynx, simulating the setting of office‐based VFI. Clinical application of RL‐VFI will improve safety and precision of CT approach, as well as expand its applications in laryngology.
Level of Evidence
NA. Laryngoscope, 129:935–942, 2019
In this paper, we describe our fabrication of a solution-processed organic thin-film transistor (OTFT) with 6,13-bis(triisopropylsilylethynyl)pentacene (TIPS-pentacene) as the organic semiconductor ...(OSC) and methyl-siloxane-based spin-on glass (SOG) as the inorganic gate dielectric. Also, we compare these results with OTFTs using different substrates such as a silicon wafer or a polyethersulfone (PES) substrate. From electrical measurements, we observed exemplary
I–
V characteristics for these TFTs. We calculated the field effect mobility to be 0.007
cm
2/V
s for an OTFT fabricated on a wafer and 0.004
cm
2/V
s for an OTFT fabricated on a PES substrate.
Flows in a ramjet inlet is simulated for the study of the rocket-ramjet transition. The flow is unsteady, two-dimensional axisymmetric, compressible and turbulent. Double time marching method is used ...for the unsteady calculation and HLLC method is used as a higher order MUSCL method. As for turbulent calculation, $\kappa-\omega$ SST model is used for more accurate viscous calculations. Sinusoidal pressure perturbation is given at the exit and the flow fields at the inlet is studied. The cruise condition as well as the ground test condition are considered. The pressure level for the ground test condition is relatively low and the effect of the pressure perturbation at the combustion chamber is small. The normal shock at the cruise condition is very sensitive to the pressure perturbation and can be easily detached from the cowl when the exit pressure is relatively high. The sudden decrease in the mass flux is observed when the inlet flow becomes subcritical, which can make the inlet incapable. The amplitude of travelling pressure waves becomes larger as the downstream pressure increases, and the wavelength becomes shorter as Mach number increases. The phase difference of the travelling perturbed pressure wave in space is 180 degree.
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