Background and Objectives
ABO isoagglutinin titre is important for evaluating and monitoring ABO‐incompatible (ABOi) stem cells or solid organ transplantations. There are several methods to measure ...the titre level, including the tube haemagglutination method, micro‐column agglutination and erythrocyte‐magnetized technology (EMT). However, few studies have reported isoagglutinin measured by EMT. Here, we compared the isoagglutinin titre of normal individuals obtained by an automated instrument with that obtained by conventional manual methods to evaluate the feasibility of replacing the manual method with the automated instrument.
Materials and Methods
The ABO isoagglutinin titre was measured on residual samples of healthy individuals who visited the health promotion centre of the National Cancer Center, Korea, from April to October 2015. Samples from 120 patients were collected, which included 20 males and 20 females for each blood group (A, B and O). IgM and IgG ABO isoagglutinin titres of each blood group were measured by the tube haemagglutination, micro‐column agglutination and EMT techniques. The median (minimum‐maximum) titres were compared, and the concordance between two methods was evaluated with the rate of results showing within one titre difference.
Results
The median ABO IgM and IgG titres of all blood groups obtained by the EMT method were higher than that obtained by the conventional tube haemagglutination and micro‐column agglutination.
Conclusion
The agreement between the two methods was comparable in case of IgM but low in IgG.
•A process of packaging and drum generation of radioactive waste was implemented using Matlab/Simulink.•An algorithm was designed to optimize the repackaging of radioactive waste.•6 scenarios were ...constructed and analyzed according to the confidence interval, the optimization algorithm and repackaging methods.•The amount of radioactive waste was predicted by repackaging simulation.
This study implemented a packaging and drum generation process for radioactive waste using Matlab/Simulink. The simulation was based on the regulations of field work, and aimed to derive the optimal repackaging method by adjusting the constraints. We analyzed the radioactive waste nuclide concentration, weight, and small package amount as constraints and also analyzed the number of drums for each radioactive level generated according to the scenarios. The radioactive waste repackaging process simulation was designed to analyze cases according to the confidence interval, and the optimization algorithm to reduce the number of radioactive waste drums was analyzed while checking the change in the number of drums according to the repackaging scenario. Simulation analysis can be used for radioactive waste management and analysis, decision-making, and generation prediction, and through systematic management, the safety and economic efficiency of radioactive waste management can be expected.
A Radioactive Waste Information Management System (RAWINGS) currently in operation mainly manages the inventory and history of the operating waste. The system has the disadvantages of the entered ...information needing to be transferred manually from the site to the system, information getting incorrectly entered during the process or information going missing. Recently, the Nuclear Safety and Security Commission (NSSC) and Korea Radioactive Waste Agency (KORAD) called for the development of a digital system that can show information transparently in real-time regarding the preliminary inspections of RAdioactive Waste (RAW) and the assessment of its suitability for disposal before the radioactive waste is delivered to the disposal site. A Digital Twin (DT)system is being developed for the safety management of radioactive waste to address the problems that these systems have and meet the needs of disposal operators. This paper introduces the DT technology that uses Augmented Reality (AR) technology enabling users to check the contents of small-packaged wastes in radioactive waste drums without opening them, Internet of Things (IoT) sensor technology that checks the status of the drums in the radioactive waste storage and the RAWINGS system. Based on the performance of a prototype Digital Twin consisting of three modules (AR, IoT and RAWINGS), the augmented reality enables users to see the shape information and filling rate of small-packaged wastes in the radioactive waste drums and includes Quick Response (QR) code management. The basic data of the radioactive waste used in the augmented reality, as well as small packaged wastes and repackaged drums, were processed in conjunction with RAWINGS. In addition, real-time monitoring of radioactive waste drums loaded in the designated space (Y zone: an area where combustible waste is loaded within radioactive waste storage and TEST area: a section where drums scheduled to be transported to the disposal site are loaded) of the radioactive waste storage was possible by transmitting IoT sensor signals attached to the drum to the digital twin. Currently, augmented reality has an important role in enhancing the visibility and intuitiveness of radioactive waste information for radioactive waste managers and workers by overlapping digital information about radioactive waste storage. Due to the nature of radioactive waste, it is difficult to know what waste is inside the enclosed drum. However, the results of this study confirmed that waste contained in radioactive waste drums can be identified in real time in the Digital Twin rather than in the radioactive waste storage.
This technology will be useful in determining the conformity of the radioactive waste acceptance criteria required by KORAD before the delivery of radioactive waste drums to disposal sites.
AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male ...C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD.
•An outlier and correlation analysis were carried out for 32 generation facilities.•A outlier concentrations were determined in radioactive waste.•There was a significant interaction in Cs-137 and ...Tc-99 according to the facility.•Analyzing radionuclide data is an important factor for radwaste management.
In this paper, we collected the analysis data of radionuclide concentrations and performed verification analysis on the data integrity and outliers in radioactive waste. These analysis results investigated the correlation between the radionuclide concentration data. As a result of analyzing the characteristics and outliers of the radioactive waste radionuclide data by using the collected original and repackaged drum information, the several generation facilities with high average radionuclide concentrations were identified. As a result of discriminating radioactive concentration outliers by standardizing the values for each nuclide, it was confirmed that the I-129(2.45), Mn-54(2.31) and Nb-94(2.31) nuclides had outliers. Also, it was found that there was a significant interaction of concentration in the middle class of Cs-137 and Tc-99 according to the waste generation facility and middle-class classification. We expect to be able to efficiently manage and dispose the radioactive waste inventory through analyzing the radionuclide related data.
The smart management of radioactive waste by deep learning technology is becoming of great concern, as it could decrease the workload and errors of workers in categorizing radioactive waste, thereby ...reducing the waste volume. In this paper, we try to maximize the efficiency of categorization for new or temporary workers instead of skilled workers by training the categorization using deep learning technology. The waste recognition system based on the deep learning technology was trained with a total of 86,084 images for 50 epochs with a subdivision of 8 and a batch of 128, which were extracted from video data that were taken in a waste sorting site. The image recognition was applied for four typical radioactive wastes (vinyl, rubber, cotton, and paper) with no object with hands (no object) and without hands (empty). The waste recognition was tested with a total of 21,521 images to evaluate the accuracy. It was determined that the accuracy of the image recognition with a deep neural network was 99.67%.
Display omitted
•Dataset for deep learning was extracted from video taken during manual categorization work.•The accuracy of the ResNet model increased as the layer increased.•Regularization by the random removal was applied to the last layer to solve the overfitting problem in the model training.•Trained model performed parallel processing using GPU to accelerate the detection.
Patients with colorectal cancer (CRC) often fail to complete full-course chemotherapy with a standard dose due to various reasons. This study aimed to determine whether body composition affects ...chemotherapy adherence in patients with CRC. The medical records of 107 patients with stage III CRC who underwent adjuvant folinic acid, fluorouracil and oxaliplatin (FOLFOX) chemotherapy at a single center between 2014 and 2018 were analyzed retrospectively. Blood test results for selected immunonutritional markers were analyzed and body composition was measured through computed tomography. Univariate and multivariate analyses were performed on low and high relative dose intensity (RDI) groups, based on an RDI of 0.85. In the univariate analysis, a higher skeletal muscle index was correlated with a higher RDI (
= 0.020). Psoas muscle index was also higher in patients with high RDI than in those with low RDI (
= 0.026). Fat indices were independent of RDI. Multivariate analysis was performed for the aforementioned factors and results showed that age (
= 0.028), white blood cell count (
= 0.024), and skeletal muscle index (
= 0.025) affected RDI. In patients with stage III CRC treated with adjuvant FOLFOX chemotherapy, a decrease in RDI was related to age, white blood cell count, and skeletal muscle index. Therefore, if we adjust the drug dosage in consideration of these factors, we can expect an increased treatment efficiency in patients by increasing chemotherapy compliance.
Pelvic actinomycosis in women most commonly occurs during ascending infections, usually associated with intrauterine devices (IUDs). However, secondary hepatic actinomycosis is very rare. A ...47-year-old woman using IUDs for 18 years was referred under the impression of ovarian cancer. Further investigation revealed a hepatic tumor diagnosed as an inflammatory pseudotumor by fine needle aspiration biopsy, and a pelvic mass diagnosed as pelvic actinomycosis by sulfur granules in bilateral adnexa gained by an explorative laparotomy. Long-term therapy with high-dose intravenous penicillin and oral amoxicillin resulted in clinical and radiological improvement. The management of pelvic actinomycosis is based on a medical approach, although it sometimes requires surgical intervention. However, the necessity for surgical treatment is controversial in cases of secondary hepatic actinomycosis.
NUMERICAL ANALYSIS OF FENCE TYPE SUPPORT OF APPLE TREES Kang, Il-Min; Shin, Kyung-Jae; Lee, Young-Ju ...
Proceedings of International Structural Engineering and Construction,
11/2015, Letnik:
2, Številka:
1
Journal Article
Damages to apple trees caused by typhoons have been repeated every year in Korea. Many types of support of apple trees such as single support, fence-type, matrix-type have been used; however, there ...is no standard type designed or specified by a code or manual. Most of the support is set up by farmers based on their experience, which results in frequent damage by typhoon. In this study, a prototype support for apple tree suggested by 'Rural Development Administration' is modelled for structural analysis. The previous test results of other trees for wind tunnel test is used as an input of numerical modeling, and the turnover test result of an apple tree is used to assess the strength of the support system. Numerical analysis is conducted for an assumed wind speed based on the test results to estimate the safety of the support. The appropriate steel-pile sizes of fence-type support are suggested based on the analysis result, which might be used as the standard type of support. Analysis results are also used for new design of the support with respect to a different wind speed by using the analysis model.
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