Nonsteroidal antiinflammatory drugs (NSAIDs) are recognized for inhibiting growth of colon tumors in animal models, and for reducing the risk of colon cancer in humans. The mechanisms involved have ...not been established, but are thought to be related to reduced prostaglandin biosynthesis. The present study investigates the effect of COX-inhibiting and non-COX-inhibiting enantiomers of flurbiprofen on rat colonocyte proliferation. Intestinal ulceration was used as a surrogate indicator of COX inhibition. Sprague Dawley rats were treated orally with 6.3 mg/kg of R- or s-flurbiprofen or vehicle. Colonocyte labeling index and small bowel ulcer index were measured. R-flurbiprofen and S-flurbiprofen significantly reduced colonocyte labeling index, by 34% and 23% respectively, compared with vehicle. R-flurbiprofen caused minimal ulcer formation (4.48 mm2) compared with S-flurbiprofen (94.4 mm2). These findings suggest that R-flurbiprofen-mediated control of colonocyte proliferation is independent of prostaglandin biosynthesis.
Sve o mrkvi Kantoci, Darko
Glasnik Zaštite Bilja,
12/2014, Letnik:
37, Številka:
6
Journal Article
Odprti dostop
Mrkva je porijeklom s područja Mediterana. Danas se uzgaja po cijelome svijetu i jedna je od deset najvažnijih povrtnih vrsta. Mrkva se uzgaja zbog zadebljanog korijena koji je hranjiv i ljekovit. ...Korijen mrkve osobito je bogat A vitaminom. Sjetva se obavlja u rano proljeće ili u svibnju i lipnju za zimsku potrošnju. Visoki prinosi i dobra kvaliteta korijenja postižu se uzgojem na prikladnom tlu i uz navodnjavanje.
Racionalnim korištenjem poljoprivrednih površina moguće je ostvariti veće prinose, a tu se uklapa postrni uzgoj povrća. Naime, nakon ubiranja kulture s poljoprivredne površine, ona u većini slučajeva ...ostaje prazna. Nakon berbe prve kulture moguć je uzgoj druge što osigurava veće prihode. Međutim, za postrni uzgoj povrća važno je navodnjavanje jer se druga kultura uglavnom uzgaja u ljetnim mjesecima kada ima malo oborina.
Ljetnice su jednogodišnje cvjetne vrste koje u istoj godini izrastu, procvatu, donesu sjeme i ugibaju. Upotreba ljetnica je raznolika, možemo ih koristiti za sadnju u posude i uzgoj na prozorima, ...balkonima i terasama. Također se mogu saditi u vrtu, na cvjetnoj gredici. Sadnice ljetnica možemo kupiti u vrtnom centru ili ih možemo uzgojiti sami.
Growth factors are endogenous proteins capable of stimulating new bone formation, but their clinical benefit for systemic stimulation of bone mass has not been demonstrated. The critical challenge is ...to deliver a significant dose of the proteins to bone after intravenous injection. This challenge may be overcome by derivatizing proteins with ligands that exhibit a high bone affinity (e.g., bisphosphonates). To demonstrate the feasibility of this approach, 1‐amino‐1,1‐diphosphonate methane (aminoBP) was conjugated to a model protein, albumin. The conjugation was performed by (1) converting the amino group of aminoBP to a thiol group using 2‐iminothiolane, (2) derivatizing the albumin amino groups with a thiol‐reactive sulfosuccinimidyl‐4‐(N‐maleimidomethyl)‐1‐cyclohexane carboxylate, and (3) reacting the derivatized albumin with thiolated aminoBP. Typically, 1–4 aminoBP molecules per albumin were obtained. The conjugated albumin exhibited a high affinity to hydroxyapatite that was proportional to the extent of conjugation. The conjugates were shown to exhibit a high affinity to bone matrix in vitro in a serum‐containing medium. Once bound to bone matrix, the conjugates were found to desorb more slowly than the unmodified albumin, especially from bone whose organic matrix was removed by ashing. In conclusion, conjugation of bisphosphonates to albumin was shown to impart a high bone affinity to the protein, and such conjugates can be potentially targeted to bone.
A New Endogenous Natriuretic Factor: LLU-α Wechter, William J.; Kantoci, Darko; Murray, E. David ...
Proceedings of the National Academy of Sciences - PNAS,
06/1996, Letnik:
93, Številka:
12
Journal Article
Recenzirano
Odprti dostop
For over three decades, renal physiology has sought a putative natriuretic hormone (third factor) that might control the body's pool of extracellular fluid, an important determinant in hypertension, ...congestive heart failure, and cirrhosis. In our search for this hormone, we have isolated several pure natriuretic factors from human uremic urine that would appear, alone or in combination, to mark a cluster of phenomena previously presumed to be that of a single ``natriuretic hormone.'' This paper reports the purification, chemical structure, and total synthesis of the first of these compounds, LLU-α , which proved to be 2,7,8-trimethyl-2-(β -carboxyethyl)-6-hydroxychroman, presumably a metabolite of γ -tocopherol. Both natural LLU-α and synthetic material are identical (except for optical activity) with respect to structure and biological activity. It appears that the natriuretic activity of LLU-α is mediated by inhibition of the 70 pS K+ channel in the apical membrane of the thick ascending limb of the kidney.
Božićni i novogodišnji blagdani ne mogu se zamisliti bez božićnog drvca. Nezaobilazno je i sobno bilje, prije svega božićna zvijezda i božićni kaktus. Stambeni prostor u ove dane ukrašavamo i drugim ...biljkama: božikovinom i imelom.
A non-linear algorithm, ACE (Algorithm for Cross-Evaluation), was developed to correlate the activity of anti-cancer drugs against human cell lines. ACE evaluates the relationships among compounds ...and cell lines and displays the resulting clusters on a 3-D surface plot This plot along with a frequency plot and rank graph provides clear information regarding the sensitivity of groups of cell lines to particular compounds. The program was tested on published anti-cancer data sets and found associations useful in the selection and design of chemotherapy drugs for pre-clinical trials. ACE may be applied to other situations where details of groupings and relationships need to be extracted from large sets of data.
Gnojenje voćaka važna je agrotehnička mjera kojom se održava potrebna razina hraniva u tlu. Tlo u voćnjaku potrebno je gnojiti kako bi se voćke dobro razvijale i kako bi se održala njihova rodnost. ...Najvažniji elementi u ishrani biljaka su dušik, kalij i fosfor. Tlo u voćnjaku gnoji se mineralnim gnojivima, ali i organskim, stajskim gnojem i/ili kompostom. Gnojenje voćaka dijeli se na osnovnu gnojidbu, ranu proljetnu gnojidbu i prihranjivanje. Unos gnojiva u tlo provodi se istovremeno s obradom tla.
Ljetnice su jednogodišnje biljke koje u jednoj godini izrastu, procvatu i nakon toga uvenu. Uzgajamo ih zbog dekorativnih cvjetova na različitim mjestima: balkonima, terasama ili na cvjetnim ...gredicama u vrtu. Izbor ljetnica je velik i svatko može naći biljku koja mu najviše odgovara.
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