Shaping the Future of Probiotics and Prebiotics Cunningham, Marla; Azcarate-Peril, M. Andrea; Barnard, Alan ...
Trends in microbiology (Regular ed.),
08/2021, Letnik:
29, Številka:
8
Journal Article
Recenzirano
Odprti dostop
Recent and ongoing developments in microbiome science are enabling new frontiers of research for probiotics and prebiotics. Novel types, mechanisms, and applications currently under study have the ...potential to change scientific understanding as well as nutritional and healthcare applications of these interventions. The expansion of related fields of microbiome-targeted interventions, and an evolving landscape for implementation across regulatory, policy, prescriber, and consumer spheres, portends an era of significant change. In this review we examine recent, emerging, and anticipated trends in probiotic and prebiotic science, and create a vision for broad areas of developing influence in the field.
An expanding range of candidate probiotic species and prebiotic substrates is emerging to address newly elucidated data-driven microbial niches and host targets.Overlapping with, and adjacent to, the probiotic and prebiotic fields, new variants of microbiome-modulating interventions are developing, including synbiotics, postbiotics, microbial consortia, live biotherapeutic products, and genetically modified organisms, with renewed interest in polyphenols, fibres, and fermented foods.Personalised nutrition and precision medicine are beginning to influence the application of probiotics and prebiotics, with growing interest in modulation of microbial signatures of health and disease.Demand for probiotics and prebiotics across divergent product formats is driving innovation in quality assurance techniques to measure dose, viability, and structural and functional integrity.
The integrity of peer review is essential for modern science. Numerous studies have therefore focused on identifying, quantifying, and mitigating biases in peer review. One of these better-known ...biases is prestige bias, where the recognition of a famous author or affiliation leads reviewers to subconsciously treat their submissions preferentially. A common mitigation approach for prestige bias is double-blind reviewing, where the identify of authors is hidden from reviewers. However, studies on the effectivness of this mitigation are mixed and are rarely directly comparable to each other, leading to difficulty in generalization of their results. In this paper, we explore the design space for such studies in an attempt to reach common ground. Using an observational approach with a large dataset of peer-reviewed papers in computer systems, we systematically evaluate the effects of different prestige metrics, aggregation methods, control variables, and outlier treatments. We show that depending on these choices, the data can lead to contradictory conclusions with high statistical significance. For example, authors with higher h-index often preferred to publish in competitive conferences which are also typically double-blind, whereas authors with higher paper counts often preferred the single-blind conferences. The main practical implication of our analyses is that a narrow evaluation may lead to unreliable results. A thorough evaluation of prestige bias requires a careful inventory of assumptions, metrics, and methodology, often requiring a more detailed sensitivity analysis than is normally undertaken. Importantly, two of the most commonly used metrics for prestige evaluation, past publication count and h-index, are not independent from the choice of publishing venue, which must be accounted for when comparing authors prestige across conferences.
Fostering nature connection may promote psychological well-being and enhance proenvironmental attitudes. However, there is limited understanding of what factors influence a person’s nature ...connection. Using survey responses from 1,000 residents of a large Australian city, we describe the relationship between nature connection and nature experiences at different stages in life, that is, past nature experiences that occurred during childhood, and current, everyday nature experiences. Both past childhood nature experiences and duration of current nature experiences significantly predicted nature connection. The positive relationship between duration of current nature experiences and nature connection was not significantly moderated by past childhood nature experiences. Hence, current nature experiences are associated with high levels of nature connection, even among those lacking childhood nature experiences. This research empirically demonstrates the positive relationship between nature connection and nature experiences, and suggests that it may be equally important to promote nature experiences at any life stage if increasing nature connection is the goal.
Environmental challenges are often marked by an intergroup dimension. Political conservatives and progressives are divided on their beliefs about climate change, farmers come into conflict with ...scientists and environmentalists over water allocation or species protection, and communities oppose big business and mining companies that threaten their local environment. These intergroup tensions are reminders of the powerful influence social contexts and group memberships can have on attitudes, beliefs, and actions relating to climate change and the environment more broadly. In this paper, we use social identity theory to help describe and explain these processes. We review literature showing, how conceiving of oneself in terms of a particular social identity influences our environmental attitudes and behaviors, how relations between groups can impact on environmental outcomes, and how the content of social identities can direct group members to act in more or less pro-environmental ways. We discuss the similarities and differences between the social identity approach to these phenomena and related theories, such as cultural cognition theory, the theory of planned behavior, and value-belief-norm theory. Importantly, we also advance social-identity based strategies to foster more sustainable environmental attitudes and behaviors. Although this theoretical approach can provide important insights and potential solutions, more research is needed to build the empirical base, especially in relation to testing social identity solutions.
An update of the systematic review of evidence on the association between amount of sugars intake and dental caries, as well as on the effect of restricting sugars intake to <10% and <5% energy (E) ...on caries, was conducted, almost 10 y since the review that informed the World Health Organization (WHO) Guideline on Sugars. The aim was to systematically review epidemiological data published from 2011 to 2020 on the amount of sugars consumption and levels of caries and to report the findings for adults and children. Data sources included MEDLINE, EMBASE, Cochrane Database, Cochrane Central Register of Controlled Trials, Latin American and Caribbean Health Sciences, China National Knowledge Infrastructure, Scopus, and Google Scholar. Eligible studies reported the amount of sugars and caries, measured as prevalence, incidence, or severity. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Risk of bias was assessed using the Office of Health Assessment and Translation tool. Vote counting and harvest plots provided the basis for evidence synthesis. From 488 new papers identified, 23 studies were eligible: 4 cohort, 1 case-controlled, 12 cross-sectional, and 6 ecological. Eleven of 15 studies in children and 6 of 8 studies in adults reported at least 1 positive association between sugars and caries. Six of 7 studies in children and 4 of 4 studies in adults, with data enabling comparison of caries levels with sugars intakes >10%E and <10%E, showed lower caries when sugars intake was <10%E. Amalgamating with original studies yielded 64 of 78 studies showing at least 1 positive association, 20 of 78 a null association, and 3 of 78 a negative association between sugars and caries. GRADE profiles of new and original cohort data confirmed “moderate-quality” evidence that caries is lower when sugars intake is <10%E. Furthermore, new cohort data upgraded the quality of evidence (from “very low” to “low”) for lower caries when free sugars are <5%E. The findings support and strengthen original evidence underpinning the WHO recommendations for sugars.
Although numerous studies have investigated changes in soil microbial communities across space, questions about the temporal variability in these communities and how this variability compares across ...soils have received far less attention. We collected soils on a monthly basis (May to November) from replicated plots representing three land-use types (conventional and reduced-input row crop agricultural plots and early successional grasslands) maintained at a research site in Michigan, USA. Using barcoded pyrosequencing of the 16S rRNA gene, we found that the agricultural and early successional land uses harbored unique soil bacterial communities that exhibited distinct temporal patterns. α-Diversity, the numbers of taxa or lineages, was significantly influenced by the sampling month with the temporal variability in α-diversity exceeding the variability between land-use types. In contrast, differences in community composition across land-use types were reasonably constant across the 7-month period, suggesting that the time of sampling is less important when assessing β-diversity patterns. Communities in the agricultural soils were most variable over time and the changes were significantly correlated with soil moisture and temperature. Temporal shifts in bacterial community composition within the successional grassland plots were less predictable and are likely a product of complex interactions between the soil environment and the more diverse plant community. Temporal variability needs to be carefully assessed when comparing microbial diversity across soil types and the temporal patterns in microbial community structure can not necessarily be generalized across land uses, even if those soils are exposed to the same climatic conditions.
Tourism in protected areas not only plays an essential role in terms of contributing to the financial sustainability of protected areas but through effective and efficient benefit-sharing can ...positively impact numerous stakeholders within and beyond the protected area. This paper provides a brief analysis of the evolution of benefit-sharing from protected area tourism, discussing tangible and intangible benefits and highlighting that revenue-sharing is only one way of sharing benefits from tourism and protected areas. The paper highlights the complexity of benefit-sharing, the importance of identifying all relevant stakeholders, the challenges of ensuring equity and sustainability and the critical importance of good governance. The evolution of benefit-sharing mechanisms over time emphasises a continuing need to evolve and adapt to each unique situation, as much evidence indicates that little has changed for those living on the edge. Although this paper focuses on benefit-sharing from protected area tourism, it is essential to acknowledge that along with these benefits are costs associated with tourism, including possible increased local prices, loss of access to land, human-wildlife conflict, and other related costs. Recommendations for future research are included to encourage an ongoing evolution and improvement in benefit-sharing mechanisms.
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