A new capacitive‐type humidity sensor is proposed using novel materials and fabrication process for practical applications in sensitive environments and cost‐effective functional devices that require ...ultrasensing performances. Metal halide perovskites (CsPbBr3 and CsPb2Br5) combined with diverse ceramics (Al2O3, TiO2, and BaTiO3) are selected as sensing materials for the first time, and nanocomposite powders are deposited by aerosol deposition (AD) process. A state‐of‐the‐art CsPb2Br5/BaTiO3 nanocomposite humidity sensor prepared by AD process exhibits a significant increase in humidity sensing compared with CsPbBr3/Al2O3 and CsPbBr3/TiO2 sensors. An outstanding humidity sensitivity (21426 pF RH%−1) with superior linearity (0.991), fast response/recovery time (5 s), low hysteresis of 1.7%, and excellent stability in a wide range of relative humidity is obtained owing to a highly porous structure, effective charge separation, and water‐resistant characteristics of CsPb2Br5. Notably, this unprecedented result is obtained via a simple one‐step AD process within a few minutes at room temperature without any auxiliary treatment. The synergetic combination of AD technique and perovskite‐based nanocomposite can be potentially applied toward the development of multifunctional sensing devices.
An ultrasensitive and highly stable humidity sensor is fabricated through perovskite/ceramic nanocomposite layers using a simple and cost‐effective aerosol deposition process. The porous perovskite in the device plays an important role in the resultant massive polarization effect under low humidity, resulting in high sensitivity in the dynamic humidity range. This model can be widely implemented in various industrial fields.
A wearable interactive device that can synchronously detect and visualize pressure, stimuli will supplement easily identifiable in situ signals with conventional sensing that outputs only electronic ...signals. Currently, most interactive devices are composed of physically connected separate pressure sensors and display elements, which do not conform to the development of miniaturization and high integration. The realization of combining these two functions in one device with a simplified configuration is still only beginning to be explored. Inspired by the two‐in‐one response of the octopus, which can both sense and visualize stimuli, an integrated hybrid device based on ionic sensing and electrochromic display is proposed for interactive pressure perception. By efficiently reusing the electrodes and ionic gel, the device enables quantitative sensing and direct color changing in response to pressure. Benefiting from its excellent comprehensive performance, the applications are explored and verified, including the interactive perception of pressure information, hiding and display of visual information under pressure regulation, and repeated writing and erasing on flexible boards. Notably, multiple customized systems with improved design flexibility are implemented to provide remote monitoring and visual warning of behavioral states and physiological parameters. This study diversifies solutions to realize a direct link between pressure detection and visualization.
Inspired by the two‐in‐one response of the octopus, which can both sense and visualize stimuli, an integrated hybrid device based on ionic sensing and electrochromic display is proposed for interactive pressure perception. By efficiently reusing the electrodes and ionic gel, the device enables quantitative sensing and direct color‐changing in response to pressure. Multiple customized systems with improved design flexibility are implemented to provide remote monitoring and visual warning of behavioral states and physiological parameters.
The purpose of this study was to identify the types and contents of non-pharmacological delirium prevention interventions applied to inpatients in general wards, and to verified the effectiveness of ...the interventions on the incidence of delirium. We performed an extensive search of bibliographic databases and registries (CENTRAL, MEDLINE, EMBASE, CINAHL, ClinicalTrials.gov and WHO International Clinical Trials Registry Platform, PubMed and Google Scholar, and Korean DB such as RISS, DBpia, KISS, NDSL and KCI) using terms to identify delirium, prevention, and non-pharmacological. We searched all databases from their inception to January 2021 and imposed restriction on language of publication in English and Korean. We included studies if they were conducted as all types of randomized controlled trials (RCT), involving adult patients aged 19 years or more who were admitted to a general ward. We included trials comparing non-pharmacological intervention versus usual care. The entire process of data selection and extraction, assessment of risk of bias with ROB2.O was independently performed by three researchers. The estimated effect size was an odds ratio (OR) and 95% confidence interval. The fixed effects model and general inverse variance estimation method were adopted. The type of non-pharmacological delirium prevention interventions for inpatients in general ward was mainly multi-component intervention to correct delirium risk factors. The content and intensity of non-pharmacological interventions varied greatly depending on the characteristics of the patient and the clinical situation. As a result of the meta-analysis, non-pharmacological multi-component intervention was effective in reducing the incidence of delirium, and it was confirmed that it was effective in reducing the incidence of delirium in both the internal and surgical wards. It was confirmed by quantitative evidence that non-pharmacological interventions, especially multi-component interventions, were effective in preventing delirium in general ward inpatients.
Activated macrophages have the potential to be ideal targets for imaging inflammation. However, probe selectivity over non-activated macrophages and probe delivery to target tissue have been ...challenging. Here, we report a small molecule probe specific for activated macrophages, called CDg16, and demonstrate its application to visualizing inflammatory atherosclerotic plaques in vivo. Through a systematic transporter screen using a CRISPR activation library, we identify the orphan transporter Slc18b1/SLC18B1 as the gating target of CDg16.
The objective of this study is to fabricate conductive carbon fiber composites with thermal and electrical properties by degradation carbon-fiber-reinforced plastics (CFRPs) and recycled carbon ...fibers using only supercritical water without any catalyst or oxidant. We focused on a recycling method that is harmless to the human body and environment-friendly, by using supercritical fluid water rather than recycling CFRP by physical or pyrolysis methods. In particular, we recycled carbon fibers (R-CFs) in which up to 99.5% of epoxy resin was removed, by optimizing the conditions of supercritical fluid water (SCF-W) treatment, and we fabricated conductive R-CFs composites with thermal and electrical properties by combining the R-CFs with cyclic butylene terephthalate (CBT), which is a polymerizable low-viscosity thermoplastic resin. The fabricated composites had a thermal conductivity of 1.35 ± 0.05 (W/mK) and an electrical conductivity of 11.23 × 10−6 (S/cm) when the added amount of recycled carbon fibers was 5 wt%.
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In this paper, we propose an approach to realize substrate integrated waveguide (SIW)-based leaky-wave antennas (LWAs) supporting continuous beam scanning from backward to forward above the cutoff ...frequency. First, through phase delay analysis, it was found that SIWs with straight transverse slots support backward and forward radiation of the -1-order mode with an open-stopband (OSB) in between. Subsequently, by introducing additional longitudinal slots as parallel components, the OSB can be suppressed, leading to continuous beam scanning at least from -40° through broadside to 35°. The proposed method only requires a planar structure and obtains less dispersive beam scanning compared with a composite right/left-handed (CRLH) LWA. Both simulations and measurements verify the intended beam scanning operation while verifying the underlying theory.
Developing electronic skins (e‐skins) with extraordinary perception through bionic strategies has far‐reaching significance for the intellectualization of robot skins. Here, an artificial ...intelligence (AI)‐motivated all‐fabric bionic (AFB) e‐skin is proposed, where the overall structure is inspired by the interlocked bionics of the epidermis‐dermis interface inside the skin, while the structural design inspiration of the dielectric layer derives from the branch‐needle structure of conifers. More importantly, AFB e‐skin achieves intuition sensing in proximity mode and tactile sensing in pressure mode based on the fringing and iontronic effects, respectively, and is simulated and verified through COMSOL finite element analysis. The proposed AFB e‐skin in pressure mode exhibits maximum sensitivity of 15.06 kPa−1 (<50 kPa), linear sensitivity of 6.06 kPa−1 (50–200 kPa), and fast response/recovery time of 5.6 ms (40 kPa). By integrating AFB e‐skin with AI algorithm, and with the support of material inference mechanisms based on dielectric constant and softness/hardness, an intelligent material perception system capable of recognizing nine materials with indistinguishable surfaces within one proximity‐pressure cycle is established, demonstrating abilities that surpass human perception.
In this work, a novel all‐fabric bionic (AFB) electronic skin (e‐skin) based on capacitive sensing, achieves intuition and tactile bimodal sensing based on the fringing and iontronic effects. Assisted by the artificial intelligence‐motivated “brain”, the proposed AFB e‐skin can achieve the efficient perception of multiple materials within one proximity‐pressure cycle.
Wearable blood‐pressure sensors have recently attracted attention as healthcare devices for continuous non‐invasive arterial pressure (CNAP) monitoring. However, the accuracy of wearable ...blood‐pressure (BP) monitoring devices has been controversial due to the low signal quality of sensors, the absence of an accurate transfer function to convert the sensor signals into BP values, and the lack of clinical validation regarding measurement precision. Here, a wearable piezoelectric blood‐pressure sensor (WPBPS) is reported, which achieves a high normalized sensitivity (0.062 kPa−1), and fast response time (23 ms) for CNAP monitoring. The transfer function of a linear regression model is designed, offering a simple solution to convert the flexible piezoelectric sensor signals into BP values. In order to verify the measurement accuracy of WPBPS, clinical trials are performed on 35 subjects aged from 20 to 80 s after screening. The mean difference between the WPBPS and a commercial sphygmomanometer of 175 BP data pairs is −0.89 ± 6.19 and −0.32 ± 5.28 mmHg for systolic blood pressure (SBP) and diastolic blood pressure (DBP), respectively. By building a WPBPS‐embedded wristwatch, the potentially promising use of a convenient, portable, continuous BP monitoring system for cardiovascular disease diagnosis is demonstrated.
A wearable piezoelectric blood‐pressure sensor (WPBPS) using an extremely sensitive flexible piezoelectric sensor is demonstrated for continuous and non‐invasive arterial pressure (CNAP) monitoring. Its transfer function is designed by a linear regression model, offering a simple solution to convert the sensor signals into BP values. The high accuracy of WPBPS is confirmed through clinical validation with an oscillometric sphygmomanometer as a reference.
Viral Load Kinetics of MERS Coronavirus Infection Oh, Myoung-Don; Park, Wan Beom; Choe, Pyoeng Gyun ...
New England journal of medicine/The New England journal of medicine,
2016-Sep-29, Letnik:
375, Številka:
13
Journal Article
The rapid and sensitive classification of bacteria is the first step of bacterial community research and the treatment of infection. Herein, a fluorescent probe BacGO is presented, which shows the ...best universal selectivity for Gram‐positive bacteria among known probes with a minimum staining procedure for sample detection and enrichment of the live bacteria. BacGO could also be used to assess of the Gram status in the bacterial community from wastewater sludge. Furthermore, BacGO could sensitively and selectively detect a Gram‐positive bacterial infection, not only in vitro but also using an in vivo keratitis mouse model. BacGO provides an unprecedented research tool for the study of dynamic bacterial communities and for clinical application.
BacGO, a novel Gram‐positive bacterial probe, was developed from a library of fluorescent molecules with a boronic‐acid motif that binds to peptidoglycan on the Gram‐positive bacterial cell wall. BacGO can be used to identify Gram‐positive bacteria in diverse, highly complex samples, and is an attractive alternative to Gram staining.
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