Exercise facilitates weight control, partly through effects on appetite regulation. Single bouts of exercise induce a short-term energy deficit without stimulating compensatory effects on appetite, ...whilst limited evidence suggests that exercise training may modify subjective and homeostatic mediators of appetite in directions associated with enhanced meal-induced satiety. However, a large variability in responses exists between individuals. This article reviews the evidence relating to how adiposity, sex, and habitual physical activity modulate exercise-induced appetite, energy intake, and appetite-related hormone responses. The balance of evidence suggests that adiposity and sex do not modify appetite or energy intake responses to acute or chronic exercise interventions, but individuals with higher habitual physical activity levels may better adjust energy intake in response to energy balance perturbations. The effect of these individual characteristics and behaviours on appetite-related hormone responses to exercise remains equivocal. These findings support the continued promotion of exercise as a strategy for inducing short-term energy deficits irrespective of adiposity and sex, as well as the ability of exercise to positively influence energy balance over the longer term. Future well-controlled studies are required to further ascertain the potential mediators of appetite responses to exercise.
Recently, there has been a growing interest in deploying smart materials as sensing components of structural health monitoring systems. In this arena, piezoelectric materials offer great promise for ...researchers to rapidly expand their many potential applications. The main goal of this study is to review the state-of-the-art piezoelectric-based sensing techniques that are currently used in the structural health monitoring area. These techniques range from piezoelectric electromechanical impedance and ultrasonic Lamb wave methods to a class of cutting-edge self-powered sensing systems. We present the principle of the piezoelectric effect and the underlying mechanisms used by the piezoelectric sensing methods to detect the structural response. Furthermore, the pros and cons of the current methodologies are discussed. In the end, we envision a role of the piezoelectric-based techniques in developing the next-generation self-monitoring and self-powering health monitoring systems.
With recent advancements in technology, energy storage for gadgets and sensors has become a challenging task. Among several alternatives, the triboelectric nanogenerators (TENG) have been recognized ...as one of the most reliable methods to cure conventional battery innovation’s inadequacies. A TENG transfers mechanical energy from the surrounding environment into power. Natural energy resources can empower TENGs to create a clean and conveyed energy network, which can finally facilitate the development of different remote gadgets. In this review paper, TENGs targeting various environmental energy resources are systematically summarized. First, a brief introduction is given to the ocean waves’ principles, as well as the conventional energy harvesting devices. Next, different TENG systems are discussed in details. Furthermore, hybridization of TENGs with other energy innovations such as solar cells, electromagnetic generators, piezoelectric nanogenerators and magnetic intensity are investigated as an efficient technique to improve their performance. Advantages and disadvantages of different TENG structures are explored. A high level overview is provided on the connection of TENGs with structural health monitoring, artificial intelligence and the path forward.
Research into
discourse synthesis
examines the ways in which writers make use of, and transform, multiple other texts in writing their own. It is intertextual research that has blurred boundaries of ...various kinds, not only the boundary between the processes of reading and writing but also boundaries across disciplines as well as regions of the world. Guided by a cognitive constructivist perspective, this research into discourse synthesis drew at its origin—and continues to draw now—from multidisciplinary theoretical and empirical work. This article, which establishes the foundations for this research and traces its development, attends to writers’ transformations of multiple source texts resulting from operations of organizing, selecting, and connecting. Studies into synthesis writing for varying academic tasks have shown that, by applying these operations to multiple textual sources, writers produce discourses that function as new texts in new contexts. Following a discussion of historical background, attention in this article goes to three major issues: the variation in synthesis associated with different academic genres; the kinds of insights into product and process that come from different research approaches; and the nature of new instructional approaches that emphasize elements of discourse synthesis. All facets of this research reveal continuity as well as change, the latter occurring, in large part, through contact and convergence of discourse synthesis research with related bodies of work. The conclusion, which centers on the notion of transformation, summarizes research conducted thus far and points to future directions.
Acute pancreatitis is a common disease with significant associated morbidity and mortality. We performed a systematic review and meta-analysis of population-based studies to explore the changing ...temporal trends of acute pancreatitis incidence globally.
We performed a systematic literature search to identify population-based studies reporting the annual incidence of acute pancreatitis. Abstracts were assessed independently to identify applicable articles for full-text review and data extraction. Joinpoint temporal trend analyses were performed to calculate the average annual percent change (AAPC) with 95% confidence intervals (CIs). The AAPCs were pooled in a meta-analysis to capture the overall and regional trends in acute pancreatitis incidence over time. Temporal data were summarized in a static map and an interactive, web-based map.
Forty-four studies reported the temporal incidence of acute pancreatitis (online interactive map: https://kaplan-acute-pancreatitis-ucalgary.hub.arcgis.com/). The incidence of acute pancreatitis has increased from 1961 to 2016 (AAPC, 3.07%; 95% CI, 2.30% to 3.84%; n = 34). Increasing incidence was observed in North America (AAPC, 3.67%; 95% CI, 2.76% to 4.57%; n = 4) and Europe (AAPC, 2.77%; 95% CI, 1.91% to 3.63%; n = 23). The incidence of acute pancreatitis was stable in Asia (AAPC, –0.28%; 95% CI, –5.03% to 4.47%; n = 4).
This meta-analysis provides a comprehensive overview of the global incidence of acute pancreatitis over the last 56 years and demonstrates a steadily rising incidence over time in most countries of the Western world. More studies are needed to better define the changing incidence of acute pancreatitis in Asia, Africa, and Latin America.
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Incidence of acute pancreatitis is increasing in most countries, driven largely by changes in clinical criteria, methodologies in reporting acute pancreatitis, as well as increases in biliary-associated disease.
The organisation of the genome in nuclear space is an important frontier of biology. Chromosome conformation capture methods such as Hi-C and Micro-C produce genome-wide chromatin contact maps that ...provide rich data containing quantitative and qualitative information about genome architecture. Most conventional approaches to genome-wide chromosome conformation capture data are limited to the analysis of pre-defined features, and may therefore miss important biological information. One constraint is that biologically important features can be masked by high levels of technical noise in the data. Here we introduce a replicate-based method for deep learning from chromatin conformation contact maps. Using a Siamese network configuration our approach learns to distinguish technical noise from biological variation and outperforms image similarity metrics across a range of biological systems. The features extracted from Hi-C maps after perturbation of cohesin and CTCF reflect the distinct biological functions of cohesin and CTCF in the formation of domains and boundaries, respectively. The learnt distance metrics are biologically meaningful, as they mirror the density of cohesin and CTCF binding. These properties make our method a powerful tool for the exploration of chromosome conformation capture data, such as Hi-C capture Hi-C, and Micro-C.
Comparative genomics has revealed a class of non-protein-coding genomic sequences that display an extraordinary degree of conservation between two or more organisms, regularly exceeding that found ...within protein-coding exons. These elements, collectively referred to as conserved non-coding elements (CNEs), are non-randomly distributed across chromosomes and tend to cluster in the vicinity of genes with regulatory roles in multicellular development and differentiation. CNEs are organized into functional ensembles called genomic regulatory blocks-dense clusters of elements that collectively coordinate the expression of shared target genes, and whose span in many cases coincides with topologically associated domains. CNEs display sequence properties that set them apart from other sequences under constraint, and have recently been proposed as useful markers for the reconstruction of the evolutionary history of organisms. Disruption of several of these elements is known to contribute to diseases linked with development, and cancer. The emergence, evolutionary dynamics and functions of CNEs still remain poorly understood, and new approaches are required to enable comprehensive CNE identification and characterization. Here, we review current knowledge and identify challenges that need to be tackled to resolve the impasse in understanding extreme non-coding conservation.
DNA methylation variations are prevalent in human obesity but evidence of a causative role in disease pathogenesis is limited. Here, we combine epigenome-wide association and integrative genomics to ...investigate the impact of adipocyte DNA methylation variations in human obesity. We discover extensive DNA methylation changes that are robustly associated with obesity (N = 190 samples, 691 loci in subcutaneous and 173 loci in visceral adipocytes, P < 1 × 10-7). We connect obesity-associated methylation variations to transcriptomic changes at >500 target genes, and identify putative methylation-transcription factor interactions. Through Mendelian Randomisation, we infer causal effects of methylation on obesity and obesity-induced metabolic disturbances at 59 independent loci. Targeted methylation sequencing, CRISPR-activation and gene silencing in adipocytes, further identifies regional methylation variations, underlying regulatory elements and novel cellular metabolic effects. Our results indicate DNA methylation is an important determinant of human obesity and its metabolic complications, and reveal mechanisms through which altered methylation may impact adipocyte functions.
•Hybrid energy harvesters designed in rotational structures;•Combination of piezoelectric, triboelectric and electromagnetic generators;•Energy harvesting under low-frequency excitations such as ...wind.
The rapid development of sensing technology has driven the global energy demand for micro-to-milliwatt continuous power supply and increased the need for energy harvesters. This study reports the hybrid rotational energy harvester (H-REH) comprising piezoelectric, triboelectric, and electromagnetic (EM) generators for energy harvesting from low-wind speeds. The H-REH prototype is fabricated and tested to evaluate the performance of simultaneously generating electrical power through the piezoelectric strips, triboelectric layers, and EM generators. Numerical models are developed to validate the experimental results, and satisfactory agreements are observed. The maximum electrical power is obtained as 121 µW, 191 µW, and 168 nW for the piezoelectric, EM, and triboelectric components at the wind speed of 3.5 m/s, respectively. In the end, we use the H-REH to power 130 LEDs while conducting the field test to display the energy harvesting performance visually. The reported H-REH can be applied for energy harvesting from low-high wind speeds.
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