ABSTRACT We present high-resolution (0 16) 870 m Atacama Large Millimeter/submillimeter Array (ALMA) imaging of 16 luminous ( ) submillimeter galaxies (SMGs) from the ALESS survey of the Extended ...Chandra Deep Field South. This dust imaging traces the dust-obscured star formation in these galaxies on ∼1.3 kpc scales. The emission has a median effective radius of Re = 0 24 0 02, corresponding to a typical physical size of 1.8 0.2 kpc. We derive a median Sérsic index of n = 0.9 0.2, implying that the dust emission is remarkably disk-like at the current resolution and sensitivity. We use different weighting schemes with the visibilities to search for clumps on 0 12 (∼1.0 kpc) scales, but we find no significant evidence for clumping in the majority of cases. Indeed, we demonstrate using simulations that the observed morphologies are generally consistent with smooth exponential disks, suggesting that caution should be exercised when identifying candidate clumps in even moderate signal-to-noise ratio interferometric data. We compare our maps to comparable-resolution Hubble Space Telescope -band images, finding that the stellar morphologies appear significantly more extended and disturbed, and suggesting that major mergers may be responsible for driving the formation of the compact dust disks we observe. The stark contrast between the obscured and unobscured morphologies may also have implications for SED fitting routines that assume the dust is co-located with the optical/near-IR continuum emission. Finally, we discuss the potential of the current bursts of star formation to transform the observed galaxy sizes and light profiles, showing that the descendants of these SMGs are expected to have stellar masses, effective radii, and gas surface densities consistent with the most compact massive ( 1-2 × 1011 ) early-type galaxies observed locally.
We present subkiloparsec-scale mapping of the 870 m ALMA continuum emission in six luminous (LIR ∼ 5 × 1012 L ) submillimeter galaxies (SMGs) from the ALESS survey of the Extended Chandra Deep Field ...South. Our high-fidelity 0 07-resolution imaging (∼500 pc) reveals robust evidence for structures with deconvolved sizes of 0.5-1 kpc embedded within (dominant) exponential dust disks. The large-scale morphologies of the structures within some of the galaxies show clear curvature and/or clump-like structures bracketing elongated nuclear emission, suggestive of bars, star-forming rings, and spiral arms. In this interpretation, the ratio of the "ring" and "bar" radii (1.9 0.3) agrees with that measured for such features in local galaxies. These potential spiral/ring/bar structures would be consistent with the idea of tidal disturbances, with their detailed properties implying flat inner rotation curves and Toomre-unstable disks (Q < 1). The inferred one-dimensional velocity dispersions ( r 70-160 km s−1) are marginally consistent with the limits implied if the sizes of the largest structures are comparable to the Jeans length. We create maps of the star formation rate density ( SFR) on ∼500 pc scales and show that the SMGs are able to sustain a given (galaxy-averaged) SFR over much larger physical scales than local (ultra)luminous infrared galaxies. However, on 500 pc scales, they do not exceed the Eddington limit set by radiation pressure on dust. If confirmed by kinematics, the potential presence of nonaxisymmetric structures would provide a means for net angular momentum loss and efficient star formation, helping to explain the very high star formation rates measured in SMGs.
We exploit Atacama Large Millimeter Array (ALMA) 870 μm observations of sub-millimetre sources in the Extended Chandra Deep Field South to investigate the far-infrared properties of high-redshift ...sub-millimetre galaxies (SMGs). Using the precisely located 870 μm ALMA positions of 99 SMGs, together with 24μm and radio imaging, we deblend the Herschel/SPIRE imaging to extract their far-infrared fluxes and colours. The median redshifts for ALMA LESS (ALESS) SMGs which are detected in at least two SPIRE bands increases with wavelength of the peak in their spectral energy distributions (SEDs), with z = 2.3 ± 0.2, 2.5 ± 0.3 and 3.5 ± 0.5 for the 250, 350 and 500 μm peakers, respectively. 34 ALESS SMGs do not have a >3σ counterpart at 250, 350 or 500 μm. These galaxies have a median photometric redshift derived from the rest-frame UV–mid-infrared SEDs of z = 3.3 ± 0.5, which is higher than the full ALESS SMG sample; z = 2.5 ± 0.2. We estimate the far-infrared luminosities and characteristic dust temperature of each SMG, deriving L
IR = (3.0 ± 0.3) × 1012 L⊙ (SFR = 300 ± 30 M⊙ yr−1) and T
d = 32 ± 1 K. The characteristic dust temperature of these high-redshift SMGs is ΔT
d = 3–5 K lower than comparably luminous galaxies at z = 0, reflecting the more extended star formation in these systems. We show that the contribution of S
870 μm ≥ 1 mJy SMGs to the cosmic star formation budget is 20 per cent of the total over the redshift range z ∼ 1–4. Adopting an appropriate gas-to-dust ratio, we estimate a typical molecular mass of the ALESS SMGs of
$M_{\rm H_2}$
= (4.2 ± 0.4) × 1010 M⊙. Finally, we show that SMGs with S
870 μm > 1 mJy (L
IR ≳ 1012 L⊙) contain ∼ 10 per cent of the z ∼ 2 volume-averaged H2 mass density.
The majority of estrogen receptor (ER)-positive breast cancers are treated with endocrine therapy. While this is effective, acquired resistance to therapies targeted against ER is a major clinical ...challenge. Here, model systems of ER-positive breast cancers with differential susceptibility to endocrine therapy were employed to define common nodes for new therapeutic interventions. These analyses revealed that cell cycle progression is effectively uncoupled from the activity and functional state of ER in these models. In this context, cyclin D1 expression and retinoblastoma tumor suppressor protein (RB) phosphorylation are maintained even with efficient ablation of ER with pure antagonists. These therapy-resistant models recapitulate a key feature of deregulated RB/E2F transcriptional control. Correspondingly, a gene expression signature of RB-dysfunction is associated with luminal B breast cancer, which exhibits a relatively poor response to endocrine therapy. These collective findings suggest that suppression of cyclin D-supported kinase activity and restoration of RB-mediated transcriptional repression could represent a viable therapeutic option in tumors that fail to respond to hormone-based therapies. Consistent with this hypothesis, a highly selective CDK4/6 inhibitor, PD-0332991, was effective at suppressing the proliferation of all hormone refractory models analyzed. Importantly, PD-0332991 led to a stable cell cycle arrest that was fundamentally distinct from those elicited by ER antagonists, and was capable of inducing aspects of cellular senescence in hormone therapy refractory cell populations. These findings underscore the clinical utility of downstream cytostatic therapies in treating tumors that have experienced failure of endocrine therapy.
Abstract
We present the first results from the Mapping Obscuration to Reionization with ALMA (MORA) survey, the largest Atacama Large Millimeter/submillimeter Array (ALMA) blank-field contiguous ...survey to date (184 arcmin
2
) and the only at 2 mm to search for dusty star-forming galaxies (DSFGs). We use the 13 sources detected above 5
σ
to estimate the first ALMA galaxy number counts at this wavelength. These number counts are then combined with the state-of-the-art galaxy number counts at 1.2 and 3 mm and with a backward evolution model to place constraints on the evolution of the IR luminosity function and dust-obscured star formation in the past 13 billion years. Our results suggest a steep redshift evolution on the space density of DSFGs and confirm the flattening of the IR luminosity function at faint luminosities, with a slope of
. We conclude that the dust-obscured component, which peaks at
z
≈ 2–2.5, has dominated the cosmic history of star formation for the past ∼12 billion years, back to
z
∼ 4. At
z
= 5, the dust-obscured star formation is estimated to be ∼35% of the total star formation rate density and decreases to 25%–20% at
z
= 6–7, implying a minor contribution of dust-enshrouded star formation in the first billion years of the universe. With the dust-obscured star formation history constrained up to the end of the epoch of reionization, our results provide a benchmark to test galaxy formation models, to study the galaxy mass assembly history, and to understand the dust and metal enrichment of the universe at early times.
Abstract
We present a new exploration of the cosmic star formation history and dust obscuration in massive galaxies at redshifts 0.5 < z < 6. We utilize the deepest 450- and 850-μm imaging from ...SCUBA-2 CLS, covering 230 arcmin2 in the AEGIS, COSMOS and UDS fields, together with 100–250 μm imaging from Herschel. We demonstrate the capability of the t-phot deconfusion code to reach below the confusion limit, using multiwavelength prior catalogues from CANDELS/3D-HST. By combining IR and UV data, we measure the relationship between total star formation rate (SFR) and stellar mass up to z ∼ 5, indicating that UV-derived dust corrections underestimate the SFR in massive galaxies. We investigate the relationship between obscuration and the UV slope (the IRX–β relation) in our sample, which is similar to that of low-redshift starburst galaxies, although it deviates at high stellar masses. Our data provide new measurements of the total SFR density (SFRD) in $M_{\ast }>10^{10}\,\textrm{M}_{\odot }$ galaxies at 0.5 < z < 6. This is dominated by obscured star formation by a factor of >10. One third of this is accounted for by 450-μm-detected sources, while one-fifth is attributed to UV-luminous sources (brighter than $L_{\rm UV}^\ast$), although even these are largely obscured. By extrapolating our results to include all stellar masses, we estimate a total SFRD that is in good agreement with previous results from IR and UV data at z ≲ 3, and from UV-only data at z ∼ 5. The cosmic star formation history undergoes a transition at z ∼ 3–4, as predominantly unobscured growth in the early Universe is overtaken by obscured star formation, driven by the build-up of the most massive galaxies during the peak of cosmic assembly.
ABSTRACT
We report the discovery of an intrinsically faint, quintuply-imaged, dusty galaxy MACS0600-z6 at a redshift z = 6.07 viewed through the cluster MACSJ0600.1–2008 (z = 0.46). A ≃ 4σ dust ...detection is seen at 1.2mm as part of the ALMA Lensing Cluster Survey (ALCS), an on-going ALMA Large programme, and the redshift is secured via C ii 158 μm emission described in a companion paper. In addition, spectroscopic follow-up with GMOS/Gemini-North shows a break in the galaxy’s spectrum, consistent with the Lyman break at that redshift. We use a detailed mass model of the cluster and infer a magnification μ ≳ 30 for the most magnified image of this galaxy, which provides an unprecedented opportunity to probe the physical properties of a sub-luminous galaxy at the end of cosmic reionization. Based on the spectral energy distribution, we infer lensing-corrected stellar and dust masses of $\rm {2.9^{+11.5}_{-2.3}\times 10^9}$ and $\rm {4.8^{+4.5}_{-3.4}\times 10^6}$$\rm {M_{\odot }}$, respectively, a star formation rate of $\rm {9.7^{+22.0}_{-6.6} \, M_{\odot } \, yr^{-1}}$, an intrinsic size of $\rm {0.54^{+0.26}_{-0.14}}$ kpc, and a luminosity-weighted age of 200 ± 100 Myr. Strikingly, the dust production rate in this relatively young galaxy appears to be larger than that observed for equivalent, lower redshift sources. We discuss if this implies that early supernovae are more efficient dust producers and the consequences for using dust mass as a probe of earlier star formation.
We derive photometric redshifts from 17-band optical to mid-infrared photometry of 78 robust radio, 24-μm and Spitzer IRAC counterparts to 72 of the 126 submillimetre galaxies (SMGs) selected at 870 ...μm by LABOCA observations in the Extended Chandra Deep Field-South (ECDF-S). We test the photometric redshifts of the SMGs against the extensive archival spectroscopy in the ECDF-S. The median photometric redshift of identified SMGs is z= 2.2 ± 0.1, the standard deviation is σ
z
= 0.9 and we identify 11 (∼15 per cent) high-redshift (z≥ 3) SMGs. A statistical analysis of sources in the error circles of unidentified SMGs identifies a population of possible counterparts with a redshift distribution peaking at z= 2.5 ± 0.2, which likely comprises ∼60 per cent of the unidentified SMGs. This confirms that the bulk of the undetected SMGs are coeval with those detected in the radio/mid-infrared. We conclude that at most ∼15 per cent of all the SMGs are below the flux limits of our IRAC observations and thus may lie at z≳ 3 and hence at most ∼30 per cent of all SMGs have z≳ 3. We estimate that the full S
870 μm > 4 mJy SMG population has a median redshift of 2.5 ± 0.5. In contrast to previous suggestions, we find no significant correlation between submillimetre flux and redshift. The median stellar mass of the SMGs derived from spectral energy distribution fitting is (9.1 ± 0.5) × 1010 M⊙ although we caution that the uncertainty in the star formation histories results in a factor of ∼5 uncertainty in these stellar masses. Using a single temperature modified blackbody fit with β= 1.5, the median characteristic dust temperature of SMGs is 37.4 ± 1.4 K. The infrared luminosity function shows that SMGs at z= 2-3 typically have higher far-infrared luminosities and luminosity density than those at z= 1-2. This is mirrored in the evolution of the star formation rate density (SFRD) for SMGs which peaks at z∼ 2. The maximum contribution of bright SMGs to the global SFRD (∼5 per cent for SMGs with S
870 μm≳ 4 mJy or ∼50 per cent extrapolated to SMGs with S
870 μm > 1 mJy) also occurs at z∼ 2.
We present radio and infrared (3.6-24 μm) counterparts to submillimetre galaxies (SMGs) detected in the Extended Chandra Deep Field-South with the Large APEX Bolometer Camera (LABOCA) 870-μm ...bolometer camera on the 12-m Atacama Pathfinder Experiment. Using the Very Large Array at 1.4 GHz and Spitzer, we have identified secure counterparts to 79 of the 126 SMGs signal-to-noise ratio (S/N) > 3.7, S
870 > 4.4 mJy in the field, 62 via their radio and/or 24-μm emission, the remainder using a colour-flux cut on Infrared Array Camera 3.6- and 5.8-μm sources chosen to maximize the number of secure, coincident radio and 24-μm counterparts. In constructing our radio catalogue, we have corrected for the effects of 'flux boosting', then used the corrected flux densities to estimate the redshifts of the SMGs based on the radio/submm spectral indices. The effect of the boosting correction is to increase the median redshift by 0.2 resulting in a value of
(1σ errors) for the secure radio counterparts, in agreement with other studies, both spectroscopic and photometric.
MicroRNAs (miRNAs) are small regulatory RNAs that are implicated in cancer pathogenesis and have recently shown promise as blood-based biomarkers for cancer detection. Epithelial ovarian cancer is a ...deadly disease for which improved outcomes could be achieved by successful early detection and enhanced understanding of molecular pathogenesis that leads to improved therapies. A critical step toward these goals is to establish a comprehensive view of miRNAs expressed in epithelial ovarian cancer tissues as well as in normal ovarian surface epithelial cells.
We used massively parallel pyrosequencing (i.e., "454 sequencing") to discover and characterize novel and known miRNAs expressed in primary cultures of normal human ovarian surface epithelium (HOSE) and in tissue from three of the most common histotypes of ovarian cancer. Deep sequencing of small RNA cDNA libraries derived from normal HOSE and ovarian cancer samples yielded a total of 738,710 high-quality sequence reads, generating comprehensive digital profiles of miRNA expression. Expression profiles for 498 previously annotated miRNAs were delineated and we discovered six novel miRNAs and 39 candidate miRNAs. A set of 124 miRNAs was differentially expressed in normal versus cancer samples and 38 miRNAs were differentially expressed across histologic subtypes of ovarian cancer. Taqman qRT-PCR performed on a subset of miRNAs confirmed results of the sequencing-based study.
This report expands the body of miRNAs known to be expressed in epithelial ovarian cancer and provides a useful resource for future studies of the role of miRNAs in the pathogenesis and early detection of ovarian cancer.
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