Summary This is a case report of a child with chronic hyponatremia due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) as a paraneoplastic manifestation of olfactory ...neuroblastoma (OFN). We hereby report a clinical presentation as well as a pragmatic approach to one of the most common electrolytic disorders in the pediatric population and have emphasized the necessity of involving the sinonasal area in the diagnostic procedure while evaluating possible causes of SIADH. This report indicates that the chronicity of the process along with the gradual onset of hyponatremia occurrence is responsible for the lack of neurological symptoms at the moment of disease presentation. Learning points Hyponatremia is not infrequently attributed to SIADH. Paraneoplastic syndromes are uncommon but they should be considered in the differential diagnosis of pediatric SIADH. Chronic insidious hyponatremia may not be associated with clear neurological symptoms despite its severity.
Dojenački ili infantilni hemangiomi (IH) su najčešći tumori u djece. Karakterizira ih brzi rast u prvoj godini života, iza kojeg slijedi polagana regresija koja obično završava sa 7 do 10 godina. ...Jedinstvena sposobnost involucije često navodi liječnika primarne zdravstvene zaštite do zaključka da nema potrebe za intervencijom. Neki IH su, međutim, povezani s komplikacijama koje mogu vitalno ugroziti dijete ili uzrokovati funkcionalna oštećenja s trajnim posljedicama. Stoga je važno procijeniti koji IH zahtijevaju ranu konzultaciju sa specijalistom. Cilj ovog preglednog rada je upoznavanje pedijatrijske zajednice s najnovijim saznanjima o epidemiologiji, patogenezi, kliničkim značajkama, komplikacijama i terapijskom pristupu IH.
Renal cell carcinoma is the most malignant urological tumour and the incidence in the Czech Republic is currently highest in the world. Kidney cancer is associated with seven different genes and is ...characterized nowadays as metabolic disease. Authors present some current facts about advances in diagnosis and new treatment methods. Different findings required individual approach. Diagnosis improved with more sophisticated ultrasonography, computed tomography, magnetic resonance imaging and positron emission tomography etc. Apart from standard surgery new alternative methods of minimally invasive procedures also assert (laparoscopy, robotic surgery, radiofrequency ablation, kryoablation) and are incorporated in current complex treatment strategies. Systemic therapy with new targeted antiangiogenics drugs is a new standard of treatment for metastatic kidney cancer Complex care with integration of local treatment (surgery, radiotherapy, selective embolization, radiosurgery, cementoplasty, vetrebroplasty etc.) and systemic medication with best supportive care is optimal for a metastatic kidney cancer. More accurate diagnostic methods and complex interdisciplinary approach with integration of systemic therapy with new targeted drugs and new minimally invasive procedures represent new possibilities for patients with kidney cancer.
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