To investigate whether the presence of the CCR5Delta32 allele was associated with atopy or asthma.
A total of 118 children with asthma, 145 children with non-asthmatic, but allergic phenotype, and ...303 children without allergic or asthmatic disorders were studied.
There were no significant differences in the frequency of CCR5Delta32, or in the distributions of genotypes between the groups. The relative eosinophil blood count was slightly lower in patients with heterozygous genotype, than in patients with wild type genotype.
No association was found between the susceptibility of allergy or asthma and the functional deficient CCR5Delta32 allele.
Aims: To investigate whether the presence of the CCR5Δ32 allele was associated with atopy or asthma. Methods: A total of 118 children with asthma, 145 children with non-asthmatic, but allergic ...phenotype, and 303 children without allergic or asthmatic disorders were studied. Results: There were no significant differences in the frequency of CCR5Δ32, or in the distributions of genotypes between the groups. The relative eosinophil blood count was slightly lower in patients with heterozygous genotype, than in patients with wild type genotype. Conclusion: No association was found between the susceptibility of allergy or asthma and the functional deficient CCR5Δ32 allele.
Human natural killer (NK) cells express low-affinity Fc immunoglobulin G (IgG) receptor (FcgammaRIIIA/CD16). The binding of monomeric IgG (mIgG) and F(ab')(2) fragments of 3G8 anti-CD16 monoclonal ...antibody (mAb) to FcgammaRIIIA was investigated by flow cytometry. Over 90% of NK cells bound endogenous IgG, and during incubation at 37 degrees C, the FcgammaRIIIA occupancy decreased slowly. Approximately 90% of NK cells bind mIgG or F(ab')(2) fragments of 3G8 anti-CD16 mAb. The calculated half-time (T(1/2)) of in vitro mIgG dissociation from FcgammaRIIIA was 130 min. By cross-linking the mIgG ligand with F(ab')(2) fragments of anti-human IgG antibody, the T(1/2) decreases to 85 min. In kinetics study, it has been shown that (125)I-mIgG bound to FcgammaRIIIA is slowly released in the culture supernatant, maybe eluted at acid pH, or partially internalized and degraded. The binding of IgG to FcgammaRIIIA was increased by 53.8% on cells cultured in the presence of RU36156, a matrix metalloproteinase (MMP) inhibitor. Furthermore, an increase in phosphorylation of Lyn tyrosine kinase, after cross-linking of mIgG-FcgammaRIIIA complex, was observed on NK cells treated with RU36156. When the FcgammaRIIIA was occupied by mIgG, the capacity of NK cells to kill K562 target cells was decreased by RU36156, because the MMP inhibitor protects CD16 from proteolysis. Our data demonstrate that binding of mIgG to human NK cells is followed by ligand dissociation and/or internalization, enzymatic degradation and exocytosis. The RU36156 MMP inhibitor protects FcgammaRIIIA from cleavage, augments NK-cell activation and may interfere in their killing capacity.
The short tandem repeat systems (STRs) HumCD4 (CD4), HumTH01 (TH01) and HumFIBRA (FGA) were amplified by the polymerase chain reaction (PCR) on blood samples from 100 unrelated Yemenians and 100 ...unrelated Egyptians. PCR products were separated on native horizontal discontinuous gel electrophoresis followed by silver staining. The distribution of observed phenotypes did not deviate from Hardy-Weinberg equilibrium. While significant differences between both Arab populations and an European population from Austria were found at all loci, differences between the Egyptian and the Yemenian samples were found only for CD4. In a number of verified Austrian families (TH01: 426 meioses, CD4: 275 meioses, FGA: 144 meioses) no mutations were found. The observation of a TH01 allele consisting of 4 repeats was confirmed by sequencing. Moreover we report the structure of a TH01 allele 6.3 observed in a Hungarian Caucasian population.
Inscripția: Pe fila de gardă de la început: Friedenfels. Câteva sublinieri în text, linii de-a lunugl paragrafelor etc, de ex. linie la p. 185 din primul calup, NB la p. 53 din calupul al doilea de ...pagini ș.a.
Cartea cuprinde articole dietale transilvănene din intervalul 1744-1792, dar și Dreptul Municipal Săsec din Transilvania, precum și indexuri mari la ambele opere legislative, îngrijite de Halmágy István și Matthias Fronius. Acest exemplar a mai făcut parte din biblitoteca unui Friedenfels.
Ștampila veche cu Br. Brukenthal´sches Museum in Hermannstadt și cu cota veche pe pagina de titlu. Ștampila cu nr. de inventar la ultima filă cu text din volum.
HARMADIK KÖNYV. NOVELLARIS ARTICULUSOK. ADLIG. INDEX NOVELLARIUM ARTICULORUM, DIÆTALIUM. Ab Anno 1744. usque Annum 1792. Conditorum elaboratus Operâ et Studio STEPHANI HALMÁGY de Étfalva Secretarii in Transylvania Gubernialis Actualis Intimi. Annô Domini 1816. CLAUDIOPOLI. Typis Lycei Regii 1816. ADLIG. STATUTA JURIUM MUNICIPALIUM SAXONUM IN TRANSYLVANIA: Opera MATTHIÆ FRONII revisa, locupletata and edita denuo ad exemplar Coronense Anni 1583. recusa CLAVDIOPOLI Typis Lycei Regii 1815. ADLIG. INDEX STATUTORUM seu JURIUM MUNICIPALIUM SAXONUM IN TRANSYLVANIA. Elaboratus Per STEPHANUM HALMÁGYI de Étfalva Secretarium in Transylvania Gubernialem Actualem Intimum. Annô Domini 1816. CLAUDIOPOLI. Typis Lycei Regii 1816.
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