Jupiter's tenuous dust ring system is embedded in the planet's inner magnetosphere, and—among other structures—contains a very tenuous protrusion called the Thebe extension. In an attempt to explain ...the existence of this swath of particles beyond Thebe's orbit, Hamilton and Krüger (2008), https://doi.org/10.1038/nature06886 proposed that the dust particle motion is driven by a shadow resonance caused by variable dust charging on the day and night side of Jupiter. However, the model by Divine and Garrett (1983), https://doi.org/10.1029/ja088ia09p06889 together with recent observations by the Juno spacecraft indicates a warm and rather dense inner magnetosphere of Jupiter which implies that the mechanism of the shadow resonance does not work. Instead, we argue that dust grains ejected from Thebe due to micrometeoroid bombardment become the source of dust in the Thebe extension. We show that large (grain radii of a few micrometers up to multi‐micrometers) charged dust grains having significant initial velocities oscillate in the Thebe extension. Smaller charged grains (with sub‐micrometer radii) ejected from Thebe do not spend much time in the Thebe extension and migrate into the Thebe ring. At the same time, if such grains are ejected from larger dust grains in the Thebe extension due to fragmentation, they continue to oscillate within the Thebe extension for years. We argue that fragmentation of large dust grains in the Thebe extensions could be the main source of sub‐micrometer grains detected in the Thebe extension.
Key Points
In Jupiter's warm and dense inner magnetosphere dust grains acquire high negative electric charges
Dust particles ejected from Thebe with sufficient speeds contribute to the formation of the Thebe extension
Instead of shadow resonances as suggested earlier an alternative mechanism is suggested for the formation of the Thebe extension
Before Rosetta, the space missions Giotto and Stardust shaped our view on cometary dust, supported by plentiful data from Earth based observations and interplanetary dust particles collected in the ...Earth’s atmosphere. The Rosetta mission at comet 67P/Churyumov-Gerasimenko was equipped with a multitude of instruments designed to study cometary dust. While an abundant amount of data was presented in several individual papers, many focused on a dedicated measurement or topic. Different instruments, methods, and data sources provide different measurement parameters and potentially introduce different biases. This can be an advantage if the complementary aspect of such a complex data set can be exploited. However, it also poses a challenge in the comparison of results in the first place. The aim of this work therefore is to summarize dust results from Rosetta and before. We establish a simple classification as a common framework for intercomparison. This classification is based on the dust particle structure, porosity, and strength and also on its size. Depending on the instrumentation, these are not direct measurement parameters, but we chose them because they were the most reliable for deriving our model. The proposed classification has proved helpful in the Rosetta dust community, and we offer it here also for a broader context. In this manner, we hope to better identify synergies between different instruments and methods in the future.
Rodent-borne hantaviruses are emerging human pathogens that cause severe human disease. The underlying mechanisms are not well understood, as hantaviruses replicate in endothelial and epithelial ...cells without causing any cytopathic effect. We demonstrate that hantaviruses strongly stimulated neutrophils to release neutrophil extracellular traps (NETs). Hantavirus infection induced high systemic levels of circulating NETs in patients and this systemic NET overflow was accompanied by production of autoantibodies to nuclear antigens. Analysis of the responsible mechanism using neutrophils from β2 null mice identified β2 integrin receptors as a master switch for NET induction. Further experiments suggested that β2 integrin receptors such as complement receptor 3 (CR3) and 4 (CR4) may act as novel hantavirus entry receptors. Using adenoviruses, we confirmed that viral interaction with β2 integrin induced strong NET formation. Collectively, β2 integrin-mediated systemic NET overflow is a novel viral mechanism of immunopathology that may be responsible for characteristic aspects of hantavirus-associated disease such as kidney and lung damage.
Hepatitis B envelope antigen (HBeAg) seroconversion represents an endpoint of treatment of chronic hepatitis B virus (HBV) infections. We have studied whether levels of serum HBV RNA during ...polymerase inhibitor treatment might be helpful for predicting HBeAg seroconversion. HBV RNA levels were determined in serial serum samples from 62 patients with chronic HBV infection (50 HBeAg positive). Patients received antiviral treatment for a mean duration of 30 ± 15 (range, 4‐64) months. A new rapid amplification of complimentary DNA‐ends‐based real‐time polymerase chain reaction was established for quantitative analysis of polyadenylated full‐length (fl) and truncated (tr) HBV RNA. HBV RNA, HBV DNA, and hepatitis B surface antigen (HBsAg) levels as well as presence of HBeAg and hepatitis B envelope antibody were measured at baseline, month 3, month 6, and subsequent time points. Fifteen patients who achieved HBeAg seroconversion after a mean duration of 19 ± 14 (range, 3‐56) months of antiviral treatment showed a significantly stronger decline in mean HBV flRNA and trRNA levels from baseline to month 3 of 1.0 ± 1.4 (range, −1.6‐3.4) and 2.1 ± 1.4 (range, 0‐3.9) and to month 6 of 1.8 ± 1.4 (range, 0‐4.6) and 3.1 ± 1.7 (range, 0‐5.1) log10 copies/mL, respectively, in comparison to 35 HBeAg‐positive patients without HBeAg seroconversion (P < 0.001 for months 3 and 6). A similar decline in HBV RNA levels was observed in HBeAg‐negative patients. The decline of HBV RNA levels at months 3 and 6 of treatment was to be the strongest predictor of HBeAg seroconversion, when compared to levels of HBV DNA, HBsAg, alanine aminotransferase, and HBV genotype, age, and sex. Conclusion: Serum HBV RNA levels may serve as a novel tool for prediction of serological response during polymerase inhibitor treatment in HBeAg‐positive patients. (Hepatology 2015;61:66–76)
Randomized controlled trials (RCTs) have shown an antidepressant effect of glabellar botulinum toxin (BoNT) injections. In the FDA Adverse Event Reporting System (FAERS) database, BoNT injection is ...associated with reduced incidence rates of depression across various non-psychiatric indications, which confirms the previous findings independently of specific expectations to an antidepressant effect of BoNT. The rationale of using BoNT to treat depression is to interrupt proprioceptive body feedback that may reinforce negative emotions. Negative emotions also occur in other mental disorders, suggesting a transdiagnostic therapeutic potential of BoNT in psychiatry. Here we report an analysis of the FAERS database, in which we found that, compared to alternative treatments, BoNT injections were associated with lower incidence of anxiety symptoms and related disorders. Among seven indications/injection sites, we found this protective effect of BoNT in cosmetic use/facial muscles, migraine/facial and head muscles, spasms and spasticity/upper and lower limbs, torticollis and neck pain/neck muscles, and sialorrhea/parotid and submandibular glands (reporting odds ratios 0.79-0.27). These findings are encouraging for possible future RCTs on the use of BoNT as a treatment for anxiety and related disorders.
Abstract Acute hepatitis E virus (HEV) infection is a self-limiting symptomatic or asymptomatic disease. However, as recently observed, it can manifest itself as chronic hepatitis in patients ...receiving solid organ transplants as well as in patients with HIV infection or severe hematologic disorders. Here, we describe the clinical course of a 73-year-old male patient in whom HEV transmission occurred after receiving a HEV-infected liver from a donor with occult HEV infection, whereby the patient had tested negative for HEV RNA and anti-HEV antibodies shortly before explantation. Anti-HEV IgG, IgM, and HEV RNA were detected in the first tested serum sample of the liver recipient obtained 150 days after liver transplantation and remained positive (earlier samples after OLT were not available). Liver cirrhosis developed within 15 months and the patient died of septic shock. Based on phylogenetic analyses of the donor and recipient’s HEV strains, we were able to prove that the occult HEV infection was transmitted via the graft.
The nucleocapsid (N) protein of hantaviruses represents an impressive example of a viral multifunctional protein. It encompasses properties as diverse as genome packaging, RNA chaperoning, ...intracellular protein transport, DNA degradation, intervention in host translation, and restricting host immune responses. These functions all rely on the capability of N to interact with RNA and other viral and cellular proteins. We have compiled data on the N protein of different hantavirus species together with information of the recently published three-dimensional structural data of the protein. The array of diverse functional activities accommodated in the hantaviral N protein goes far beyond to be a static structural protein and makes it an interesting target in the development of antiviral therapeutics.
Aims. Based on measurements by the Ulysses spacecraft and high-resolution modelling of the motion of interstellar dust (ISD) through the heliosphere we predict the ISD flow in the inner planetary ...system and on to the Earth. This is the third paper in a series of three about the flow and filtering of the ISD. Methods. Micrometer- and sub-micrometer-sized dust particles are subject to solar gravity and radiation pressure as well as to interactions with the interplanetary magnetic field that result in a complex size-dependent flow pattern of ISD in the planetary system. With high-resolution dynamical modelling we study the time-resolved flux and mass distribution of ISD and assess the necessary requirements for detection of ISD near the Earth. Results. Along the Earth orbit the density, speed, and flow direction of ISD depend strongly on the Earth’s position and the size of the interstellar grains. A broad maximum of the ISD flux (~2 × 10−4 m−2 s−1 of particles with radii ≳0.3 μm) occurs in March when the Earth moves against the ISD flow. During this time period the relative speed with respect to the Earth is highest (~60 km s-1), whereas in September when the Earth moves with the ISD flow, both the flux and the speed are lowest (≲10 km s-1). The mean ISD mass flow on to the Earth is approximately 100 kg yr-1 with the highest flux of ~3.5 kg day-1 occurring for about 2 weeks close to the end of the year when the Earth passes near the narrow gravitational focus region of the incoming ISD flow, downstream from the Sun. The phase of the 22-year solar wind cycle has a strong effect on the number density and flow of sub-micrometer-sized ISD particles. During the years of maximum electromagnetic focussing (year 2031 +/− 3) there is a chance that ISD particles with sizes even below 0.1 μm can reach the Earth. Conclusions. We demonstrate that ISD can be effectively detected, analysed, and even collected by space probes at 1 AU distance from the Sun.
Inhibiting the facial expression of negative emotions via botulinum toxin A (BTX) has been shown to mitigate symptoms of clinical depression in randomized controlled trials. This retrospective case ...study sought to reproduce the beneficial effects of BTX in a naturalistic setting for major depressive disorder and collect casuistic data on its effect on other mental disorders. Moreover, we describe symptom development across multiple treatment cycles with BTX, and assess the implementation of additional injection targets in the lower face region. Participants were
= 51 adult psychiatric outpatients mainly seeking treatment for depression. Over 50% suffered from comorbid psychiatric conditions, predominantly generalized anxiety disorder (GAD) or borderline personality disorder (BPD). A pre-post case series design was adapted. All participants received BTX-injections in the glabellar region on at least one occasion. Some received additional injections in the mouth region and over multiple treatment cycles. Treatment response was followed up by self-rated scales at varying time intervals post treatment. The results showed that BTX may yield favorable outcomes across multiple and comorbid mental disorders, especially, however, for patients suffering from depression. It potentially prevents the recurrence of clinical symptoms if applied regularly. Adding additional regions of the face does not seem to be superior over applying it to the glabellar region alone. The results add to the growing evidence that BTX therapy is effective in alleviating symptoms of depression. Positive effects can be sustained and reinstated, when applied over multiple treatment cycles. Observed symptom reduction in other psychiatric disorders was less pronounced. Further research is needed to understand the mechanisms by which BTX therapy reduces psychiatric symptoms.
We report molecular evidence of Tula virus infection in an immunocompetent patient from Germany who had typical signs of hantavirus disease. Accumulating evidence indicates that Tula virus infection, ...although often considered nonpathogenic, represents a threat to human health.
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