Područje poplavnih šuma crne johe (Alnus glutinosa (L.) Gaertn.) u Sloveniji čini samo 0,4 % (približno 4708 ha) ukupne površine šumskog zemljišta (Čater i sur., 2001.). Veći kompleks takvih ...sastojina u Sloveniji su Črni i Polanski Log, a istraživanje je provedeno na području potonjeg (slika 1). Kako čiste sastojine johe odlikuju brojne specifičnosti, potrebno im je prilagoditi šumskouzgojne postupke.
Da bi se utvrdio odgovarajući intenzitet prorjede takvih sastojina, 1967. godine u Polanskom Logu postavljene su pokusne plohe. Od tada do 2018. godine na plohama je izvršeno pet do sedam mjerenja. Sva stabla na plohama su bila obrojčana. Izvršeno je mjerenje prsnih promjera i procjena sljedećih elemenata na stablima: pripadnost etaži, vitalnost, uzgojna perspektiva, uzgojna uloga, duljina krošnje i kvaliteta (tablica 3). Svaka ploha bila je podijeljena u tri polja (40 x 50 m) s različitim metodama rada: bez intervencije, umjereno i intenzivno prorjeđivanje. Uzgojni postupci koji su poduzeti tijekom praćenja pokusa prikazani su u tablici 2. Danas su te sastojine u zreloj fazi razvoja, stoga smo u ovom radu analizirali reakcije crne johe na različite intenzitete prorjeđivanja i dobivene rezultate usporedili s preporukama autora tradicionalnih uzgojnih modela i modela koji se temelje na situacijskoj njezi šuma.
Ustanovili smo da se na plohama s intenzivnim prorjeđivanjem gustoća sastojine koja je u dobi između 50 i 70 godina i na kraju je ophodnje kreće od 295 do 690 kom/ha (slika 3), dok se na plohama bez intervencije ova vrijednost kreće u rasponu od 370 do 790 kom/ha. Drvne zalihe u istom su se razdoblju kretale u rasponu od 277 do 458 m3/ha na plohama s intenzivnim prorjeđivanjem, dok su na plohama bez intervencije bile veće, u rasponu od 309 do 516 m3/ha (slika 4). U to su se doba temeljnice nalazile u rasponu između 23 i 41 m2/ha na plohama s intenzivnim prorjeđivanjem, a na plohama bez intervencije u rasponu od 26 do čak 51 m2/ha (slika 5). Tijekom cijelog razdoblja praćenja ploha, stabla su, bez obzira na metodu rada, narasla za tri do četiri debljinska stupnja (slika 2). Na plohama s umjerenim prorjeđivanjem i onima bez intervencije, debljinski prirast stabala bio je skoro jednak (0,33 cm godišnje) (slika 6). Statistički je značajan veći debljinski prirast stabala na plohama s jako intenzivnim prorjeđivanjem (0,37 cm godišnje). Debljinski prirast dominantnih stabala bio je nešto veći, od 0,46 cm godišnje na plohama bez intervencije do 0,50 cm godišnje na plohama s jako intenzivnim prorjeđivanjem, ali statistički značajne razlike između metoda rada nisu utvrđene (slika 6). Međutim, otkrili smo da kod dominantnih stabala ne postoje statistički značajne razlike s obzirom na njihovu slojevitost, vitalnost, tendenciju, dužinu krošnje i kvalitete s obzirom na korištenu metodu rada.
U usporedbi s uzgojnim modelima koji su se koristili za manji broj odabranih stabla, gustoća i temeljnica ispitivanih sastojina je znatno veća, a debljinski prirast manji. Autori tradicionalnih i modela s manjim brojem odabranih stabala zagovaraju rano prorjeđivanje takvih sastojina (tablica 1). Veće razlike nastaju u konačnom broju stabala po hektaru i u intenzitetu intervencije. Razlog malog debljinskog prirasta i razlike između metoda rada na našim plohama pripisali smo nedovoljnom intenzitetu i djelomično nedosljednoj provedbi postupka prorjeđivanja. Ipak, ukazala se potreba za intenzivnim prorjeđivanjem i pospješivanjem rasta stabala najvećeg prsnog promjera, vitalnosti i tendencije, lijepo oblikovane i duge krošnje (slika 7, slika 8).
Pure black alder stands are specific and require adapted silvicultural models. To determine the best intensity of selective thinning in such stands, research plots were established in Polanski Log in 1967. Three thinning intensities were selected: control, moderate and high. These stands are presently in a mature phase. In 1967, 1973, 1979, 1983, 1993, 1998 and 2018 diameter at breast height was measured and social status, vitality, tendency, silvicultural role, crown length and overall quality were estimated. The differences in black alder responses to thinning intensities were analysed and the results were compared with recommendations for selective high thinning and newer crop tree situational thinning models. Diameter increments were lower than expected regardless of thinning intensity. In moderately thinned plots and control plots diameter increment was the same (0.33 cm/year); high intensity thinning plots showed higher increment (0.37 cm/year). Dominant trees had slightly higher increment regardless of thinning model. Compared to thinning models with a lower number of crop trees, density and basal area of studied stands were significantly higher and diameter increments lower. We attribute the small diameter increments and small differences among thinning models to insufficient intensity and partially to inconsistent thinning. The results indicate that thinning must be of higher intensity and the largest-diameter trees which display the best vigour, quality, tendency, and which have well formed, long crowns, must be promoted from the beginning.
Područje poplavnih šuma crne johe (Alnus glutinosa (L.) Gaertn.) u Sloveniji čini samo 0,4 % (približno 4708 ha) ukupne površine šumskog zemljišta (Čater i sur., 2001.). Veći kompleks takvih ...sastojina u Sloveniji su Črni i Polanski Log, a istraživanje je provedeno na području potonjeg (slika 1). Kako čiste sastojine johe odlikuju brojne specifičnosti, potrebno im je prilagoditi šumskouzgojne postupke. Da bi se utvrdio odgovarajući intenzitet prorjede takvih sastojina, 1967. godine u Polanskom Logu postavljene su pokusne plohe. Od tada do 2018. godine na plohama je izvršeno pet do sedam mjerenja. Sva stabla na plohama su bila obrojčana. Izvršeno je mjerenje prsnih promjera i procjena sljedećih elemenata na stablima: pripadnost etaži, vitalnost, uzgojna perspektiva, uzgojna uloga, duljina krošnje i kvaliteta (tablica 3). Svaka ploha bila je podijeljena u tri polja (40 x 50 m) s različitim metodama rada: bez intervencije, umjereno i intenzivno prorjeđivanje. Uzgojni postupci koji su poduzeti tijekom praćenja pokusa prikazani su u tablici 2. Danas su te sastojine u zreloj fazi razvoja, stoga smo u ovom radu analizirali reakcije crne johe na različite intenzitete prorjeđivanja i dobivene rezultate usporedili s preporukama autora tradicionalnih uzgojnih modela i modela koji se temelje na situacijskoj njezi šuma.Ustanovili smo da se na plohama s intenzivnim prorjeđivanjem gustoća sastojine koja je u dobi između 50 i 70 godina i na kraju je ophodnje kreće od 295 do 690 kom/ha (slika 3), dok se na plohama bez intervencije ova vrijednost kreće u rasponu od 370 do 790 kom/ha. Drvne zalihe u istom su se razdoblju kretale u rasponu od 277 do 458 m3/ha na plohama s intenzivnim prorjeđivanjem, dok su na plohama bez intervencije bile veće, u rasponu od 309 do 516 m3/ha (slika 4). U to su se doba temeljnice nalazile u rasponu između 23 i 41 m2/ha na plohama s intenzivnim prorjeđivanjem, a na plohama bez intervencije u rasponu od 26 do čak 51 m2/ha (slika 5). Tijekom cijelog razdoblja praćenja ploha, stabla su, bez obzira na metodu rada, narasla za tri do četiri debljinska stupnja (slika 2). Na plohama s umjerenim prorjeđivanjem i onima bez intervencije, debljinski prirast stabala bio je skoro jednak (0,33 cm godišnje) (slika 6). Statistički je značajan veći debljinski prirast stabala na plohama s jako intenzivnim prorjeđivanjem (0,37 cm godišnje). Debljinski prirast dominantnih stabala bio je nešto veći, od 0,46 cm godišnje na plohama bez intervencije do 0,50 cm godišnje na plohama s jako intenzivnim prorjeđivanjem, ali statistički značajne razlike između metoda rada nisu utvrđene (slika 6). Međutim, otkrili smo da kod dominantnih stabala ne postoje statistički značajne razlike s obzirom na njihovu slojevitost, vitalnost, tendenciju, dužinu krošnje i kvalitete s obzirom na korištenu metodu rada.U usporedbi s uzgojnim modelima koji su se koristili za manji broj odabranih stabla, gustoća i temeljnica ispitivanih sastojina je znatno veća, a debljinski prirast manji. Autori tradicionalnih i modela s manjim brojem odabranih stabala zagovaraju rano prorjeđivanje takvih sastojina (tablica 1). Veće razlike nastaju u konačnom broju stabala po hektaru i u intenzitetu intervencije. Razlog malog debljinskog prirasta i razlike između metoda rada na našim plohama pripisali smo nedovoljnom intenzitetu i djelomično nedosljednoj provedbi postupka prorjeđivanja. Ipak, ukazala se potreba za intenzivnim prorjeđivanjem i pospješivanjem rasta stabala najvećeg prsnog promjera, vitalnosti i tendencije, lijepo oblikovane i duge krošnje (slika 7, slika 8).
Growth trajectories of young animals are intimately connected to their fitness prospects, but we have little knowledge of growth regulation mechanisms, particularly in the wild. Insulin-like growth ...factor 1 (IGF-1) is a central hormone in regulating resource allocation, with higher IGF-1 levels resulting in more growth. IGF-1 levels generally increase in conjunction with nutritional state, but whether IGF-1 levels are adjusted in response to current nutrient availability or to the nutrient availability integrated over a longer term is not well known. We tested for such effects by supplementary feeding the jackdaw (
Corvus monedula
) nestlings in experimentally reduced or enlarged broods with either water (control) or a food solution; these manipulations have long- and short-term effects on the nutritional state, respectively. Baseline plasma IGF-1 levels were higher in reduced broods. Food supplementation induced an increase in plasma IGF-1 levels measured one hour later, and this effect was significantly more substantial in nestlings in reduced broods. Changes in plasma IGF-1 levels increased with increased retention of the supplementary food, which was higher in reduced broods, explaining the stronger IGF-1 response. Thus, IGF-1 levels respond to short-term variations in the nutritional state, but this effect is amplified by longer-term variations in the nutritional state. We discuss our findings using a graphical model that integrates the results of the two treatments.
Effective cancer prevention is based on accurate molecular diagnosis and results of genetic family screening, genotype-informed risk assessment, and tailored strategies for early diagnosis. The ...expanding etiology for hereditary pheochromocytomas and paragangliomas has recently included SDHA, TMEM127, MAX, and SDHAF2 as susceptibility genes. Clinical management guidelines for patients with germline mutations in these 4 newly included genes are lacking.
To study the clinical spectra and age-related penetrance of individuals with mutations in the SDHA, TMEM127, MAX, and SDHAF2 genes.
This study analyzed the prospective, longitudinally followed up European-American-Asian Pheochromocytoma-Paraganglioma Registry for prevalence of SDHA, TMEM127, MAX, and SDHAF2 germline mutation carriers from 1993 to 2016. Genetic predictive testing and clinical investigation by imaging from neck to pelvis was offered to mutation-positive registrants and their relatives to clinically characterize the pheochromocytoma/paraganglioma diseases associated with mutations of the 4 new genes.
Prevalence and spectra of germline mutations in the SDHA, TMEM127, MAX, and SDHAF2 genes were assessed. The clinical features of SDHA, TMEM127, MAX, and SDHAF2 disease were characterized.
Of 972 unrelated registrants without mutations in the classic pheochromocytoma- and paraganglioma-associated genes (632 female 65.0% and 340 male 35.0%; age range, 8-80; mean SD age, 41.0 13.3 years), 58 (6.0%) carried germline mutations of interest, including 29 SDHA, 20 TMEM127, 8 MAX, and 1 SDHAF2. Fifty-three of 58 patients (91%) had familial, multiple, extra-adrenal, and/or malignant tumors and/or were younger than 40 years. Newly uncovered are 7 of 63 (11%) malignant pheochromocytomas and paragangliomas in SDHA and TMEM127 disease. SDHA disease occurred as early as 8 years of age. Extra-adrenal tumors occurred in 28 mutation carriers (48%) and in 23 of 29 SDHA mutation carriers (79%), particularly with head and neck paraganglioma. MAX disease occurred almost exclusively in the adrenal glands with frequently bilateral tumors. Penetrance in the largest subset, SDHA carriers, was 39% at 40 years of age and is statistically different in index patients (45%) vs mutation-carrying relatives (13%; P < .001).
The SDHA, TMEM127, MAX, and SDHAF2 genes may contribute to hereditary pheochromocytoma and paraganglioma. Genetic testing is recommended in patients at clinically high risk if the classic genes are mutation negative. Gene-specific prevention and/or early detection requires regular, systematic whole-body investigation.
To estimate the comparative efficacy of ciltacabtagene autoleucel (cilta-cel) versus idecabtagene vicleucel (ide-cel) in patients with relapsed/refractory multiple myeloma (RRMM) treated with 2-4 ...prior lines of therapy.OBJECTIVETo estimate the comparative efficacy of ciltacabtagene autoleucel (cilta-cel) versus idecabtagene vicleucel (ide-cel) in patients with relapsed/refractory multiple myeloma (RRMM) treated with 2-4 prior lines of therapy.Matching adjusted indirect comparison (MAICs) were performed using individual patient-level data (IPD) for cilta-cel from CARTITUDE-1 and CARTITUDE-4 and published aggregated data for ide-cel from KarMMa-3. Cilta-cel patients who met inclusion criteria from KarMMa-3 were selected, and outcomes were compared against data for ide-cel using simulated IPD derived from aggregate-level data from KarMMa-3. Patient characteristics were adjusted by reweighting cilta-cel IPD to match the distribution of prognostic factors in KarMMa-3. Comparative efficacy was estimated for response outcomes using a weighted logistic regression analysis and for progression-free survival using a weighted Cox proportional hazards model.METHODSMatching adjusted indirect comparison (MAICs) were performed using individual patient-level data (IPD) for cilta-cel from CARTITUDE-1 and CARTITUDE-4 and published aggregated data for ide-cel from KarMMa-3. Cilta-cel patients who met inclusion criteria from KarMMa-3 were selected, and outcomes were compared against data for ide-cel using simulated IPD derived from aggregate-level data from KarMMa-3. Patient characteristics were adjusted by reweighting cilta-cel IPD to match the distribution of prognostic factors in KarMMa-3. Comparative efficacy was estimated for response outcomes using a weighted logistic regression analysis and for progression-free survival using a weighted Cox proportional hazards model.Patients treated with cilta-cel were 1.2 times more likely to achieve overall response (relative response ratio RR: 1.18 95% confidence interval: 1.03-1.34; p = 0.04), 1.3 times more likely to achieve very good partial response or better (RR: 1.34 1.15-1.57; p = 0.003), and 1.9 times more likely to achieve complete response or better (RR: 1.91 1.54-2.37; p < 0.0001) versus ide-cel patients from KarMMa-3. Cilta-cel was associated with a significant 49% reduction in risk of disease progression or death versus ide-cel (hazard ratio: 0.51 95% confidence interval: 0.31, 0.84; p = 0.0078).RESULTSPatients treated with cilta-cel were 1.2 times more likely to achieve overall response (relative response ratio RR: 1.18 95% confidence interval: 1.03-1.34; p = 0.04), 1.3 times more likely to achieve very good partial response or better (RR: 1.34 1.15-1.57; p = 0.003), and 1.9 times more likely to achieve complete response or better (RR: 1.91 1.54-2.37; p < 0.0001) versus ide-cel patients from KarMMa-3. Cilta-cel was associated with a significant 49% reduction in risk of disease progression or death versus ide-cel (hazard ratio: 0.51 95% confidence interval: 0.31, 0.84; p = 0.0078).For patients with triple-class exposed RRMM treated with 2-4 prior lines of treatment, cilta-cel was found to provide superior clinical benefit over ide-cel in terms of response and progression-free survival.CONCLUSIONFor patients with triple-class exposed RRMM treated with 2-4 prior lines of treatment, cilta-cel was found to provide superior clinical benefit over ide-cel in terms of response and progression-free survival.
•Myeloma patients progressing on BCMA-targeted therapy can maintain BCMA expression and still respond to different BCMA-targeted therapy.•These observations suggest this patient population could be ...included in ongoing BCMA-targeted therapy trials.
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