We provide a coherent, uniform measurement of the evolution of the logarithmic star formation rate (SFR)-stellar mass (M*) relation, called the main sequence (MS) of star-forming galaxies , for ...star-forming and all galaxies out to . We measure the MS using mean stacks of 3 GHz radio-continuum images to derive average SFRs for ∼ 200,000 mass-selected galaxies at z > 0.3 in the COSMOS field. We describe the MS relation by adopting a new model that incorporates a linear relation at low stellar mass (log(M*/M ) < 10) and a flattening at high stellar mass that becomes more prominent at low redshift (z < 1.5). We find that the SFR density peaks at 1.5 < z < 2, and at each epoch there is a characteristic stellar mass (M* = 1-4 × 1010M ) that contributes the most to the overall SFR density. This characteristic mass increases with redshift, at least to z ∼ 2.5. We find no significant evidence for variations in the MS relation for galaxies in different environments traced by the galaxy number density at 0.3 < z < 3, nor for galaxies in X-ray groups at z ∼ 0.75. We confirm that massive bulge-dominated galaxies have lower SFRs than disk-dominated galaxies at a fixed stellar mass at z < 1.2. As a consequence, the increase in bulge-dominated galaxies in the local star-forming population leads to a flattening of the MS at high stellar masses. This indicates that "mass quenching" is linked with changes in the morphological composition of galaxies at a fixed stellar mass.
ABSTRACT
We have entered a new era where integral-field spectroscopic surveys of galaxies are sufficiently large to adequately sample large-scale structure over a cosmologically significant volume. ...This was the primary design goal of the SAMI Galaxy Survey. Here, in Data Release 3, we release data for the full sample of 3068 unique galaxies observed. This includes the SAMI cluster sample of 888 unique galaxies for the first time. For each galaxy, there are two primary spectral cubes covering the blue (370–570 nm) and red (630–740 nm) optical wavelength ranges at spectral resolving power of R = 1808 and 4304, respectively. For each primary cube, we also provide three spatially binned spectral cubes and a set of standardized aperture spectra. For each galaxy, we include complete 2D maps from parametrized fitting to the emission-line and absorption-line spectral data. These maps provide information on the gas ionization and kinematics, stellar kinematics and populations, and more. All data are available online through Australian Astronomical Optics Data Central.
ABSTRACT Recent cosmological hydrodynamical simulations suggest that integral field spectroscopy can connect the high-order stellar kinematic moments h3 (∼skewness) and h4 (∼kurtosis) in galaxies to ...their cosmological assembly history. Here, we assess these results by measuring the stellar kinematics on a sample of 315 galaxies, without a morphological selection, using two-dimensional integral field data from the SAMI Galaxy Survey. Proxies for the spin parameter ( ) and ellipticity ( ) are used to separate fast and slow rotators; there exists a good correspondence to regular and non-regular rotators, respectively, as also seen in earlier studies. We confirm that regular rotators show a strong h3 versus anti-correlation, whereas quasi-regular and non-regular rotators show a more vertical relation in h3 and . Motivated by recent cosmological simulations, we develop an alternative approach to kinematically classify galaxies from their individual h3 versus signatures. Within the SAMI Galaxy Survey, we identify five classes of high-order stellar kinematic signatures using Gaussian mixture models. Class 1 corresponds to slow rotators, whereas Classes 2-5 correspond to fast rotators. We find that galaxies with similar values can show distinctly different signatures. Class 5 objects are previously unidentified fast rotators that show a weak h3 versus anti-correlation. From simulations, these objects are predicted to be disk-less galaxies formed by gas-poor mergers. From morphological examination, however, there is evidence for large stellar disks. Instead, Class 5 objects are more likely disturbed galaxies, have counter-rotating bulges, or bars in edge-on galaxies. Finally, we interpret the strong anti-correlation in h3 versus as evidence for disks in most fast rotators, suggesting a dearth of gas-poor mergers among fast rotators.
Abstract
We investigate the relationship between environment, morphology, and the star formation rate (SFR)–stellar mass relation derived from a sample of star-forming (SF) galaxies (commonly ...referred to as the “star formation main sequence”, SFMS) in the COSMOS field from 0 <
z
< 3.5. We constructed and fit the far-UV–far-IR spectral energy distributions of our stellar-mass-selected sample of 111,537 galaxies with stellar and dust emission models using the public packages
MAGPHYS
and
SED3FIT
. From the best-fit parameter estimates, we construct the SFR–stellar mass relation as a function of redshift, local environment, NUVrJ color diagnostics, and morphology. We find that the shape of the main sequence derived from our color–color and specific-star-formation-rate-selected SF galaxy population, including the turnover at high stellar mass, does not exhibit an environmental dependence at any redshift from 0 <
z
< 3.5. We investigate the role of morphology in the high-mass end of the SFMS to determine whether bulge growth is driving the high-mass turnover. We find that SF galaxies experience this turnover independent of bulge-to-total ratio, strengthening the case that the turnover is due to the disk component’s specific SFR evolving with stellar mass rather than bulge growth.
Abstract
We present the ∼800 star formation rate maps for the Sydney-AAO Multi-object Integral field spectrograph (SAMI) Galaxy Survey based on H α emission maps, corrected for dust attenuation via ...the Balmer decrement, that are included in the SAMI Public Data Release 1. We mask out spaxels contaminated by non-stellar emission using the O iii/H β, N ii/H α, S ii/H α, and O i/H α line ratios. Using these maps, we examine the global and resolved star-forming main sequences of SAMI galaxies as a function of morphology, environmental density, and stellar mass. Galaxies further below the star-forming main sequence are more likely to have flatter star formation profiles. Early-type galaxies split into two populations with similar stellar masses and central stellar mass surface densities. The main-sequence population has centrally concentrated star formation similar to late-type galaxies, while galaxies >3σ below the main sequence show significantly reduced star formation most strikingly in the nuclear regions. The split populations support a two-step quenching mechanism, wherein halo mass first cuts off the gas supply and remaining gas continues to form stars until the local stellar mass surface density can stabilize the reduced remaining fuel against further star formation. Across all morphologies, galaxies in denser environments show a decreased specific star formation rate from the outside in, supporting an environmental cause for quenching, such as ram-pressure stripping or galaxy interactions.
Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by ...2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.
We estimated costs of managing different forms of tuberculosis (TB) across Canada by conducting a retrospective chart review and cost assessment of patients treated for TB infection, drug-susceptible ...TB (DS TB), isoniazid-resistant TB, or multidrug-resistant TB (MDR TB) at 3 treatment centers. We included 90 patients each with TB infection and DS TB, 71 with isoniazid-resistant TB, and 62 with MDR TB. Median per-patient costs for TB infection (in 2020 Canadian dollars) were $804 (interquartile range IQR $587-$1,205), for DS TB $12,148 (IQR $4,388-$24,842), for isoniazid-resistant TB $19,319 (IQR $7,117-$41,318), and for MDR TB $119,014 (IQR $80,642-$164,015). Compared with costs for managing DS TB, costs were 11.1 (95% CI 9.1-14.3) times lower for TB infection, 1.7 (95% CI 1.3-2.1) times higher for isoniazid-resistant TB, and 8.1 (95% CI 6.1-10.6) times higher for MDR TB. Broadened TB infection treatment could avert high costs associated with managing TB disease.
Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the granuloma. In some granulomas, immune activity promotes bacterial clearance, but in others, bacteria ...persist and grow. We identified correlates of bacterial control in cynomolgus macaque lung granulomas by co-registering longitudinal positron emission tomography and computed tomography imaging, single-cell RNA sequencing, and measures of bacterial clearance. Bacterial persistence occurred in granulomas enriched for mast, endothelial, fibroblast, and plasma cells, signaling amongst themselves via type 2 immunity and wound-healing pathways. Granulomas that drove bacterial control were characterized by cellular ecosystems enriched for type 1-type 17, stem-like, and cytotoxic T cells engaged in pro-inflammatory signaling networks involving diverse cell populations. Granulomas that arose later in infection displayed functional characteristics of restrictive granulomas and were more capable of killing Mtb. Our results define the complex multicellular ecosystems underlying (lack of) granuloma resolution and highlight host immune targets that can be leveraged to develop new vaccine and therapeutic strategies for TB.
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•Timing of granuloma formation influences local microenvironment and bacterial burden•Mast cells, type 2 immunity, and tissue remodeling underlie early, high-burden granulomas•Type1-type17 and cytotoxic T cells associate with late-forming, low-burden granulomas•Distinct interaction circuits across granuloma phenotypes nominate therapeutic targets
Tuberculosis granulomas exhibit independent trajectories even within a single individual: some granulomas permit high bacterial growth, whereas others successfully resolve. Gideon et al. leveraged longitudinal PET-CT, bacterial burden assays, and scRNA-seq in cynomolgus macaques to define dynamic cellular phenotypes and circuits underlying granuloma persistence and immune control. Uncovered cell states and interactions may represent targets for host-directed therapies and vaccines.
T cell activation, a key early event in the adaptive immune response, is subject to elaborate transcriptional control. In the present study, we examined how the activities of eight major ...transcription factor (TF) families are integrated to shape the epigenome of naive and activated CD4 and CD8 T cells. By leveraging extensive polymorphisms in evolutionarily divergent mice, we identified the 'heavy lifters' positively influencing chromatin accessibility. Members of Ets, Runx and TCF/Lef TF families occupied the vast majority of accessible chromatin regions, acting as 'housekeepers', 'universal amplifiers' and 'placeholders', respectively, at sites that maintained or gained accessibility upon T cell activation. In addition, a small subset of strongly induced immune response genes displayed a noncanonical TF recruitment pattern. Our study provides a key resource and foundation for the understanding of transcriptional and epigenetic regulation in T cells and offers a new perspective on the hierarchical interactions between critical TFs.
Cellular immunity is critical for controlling intracellular pathogens, but individual cellular dynamics and cell-cell cooperativity in evolving human immune responses remain poorly understood. ...Single-cell RNA-sequencing (scRNA-seq) represents a powerful tool for dissecting complex multicellular behaviors in health and disease
and nominating testable therapeutic targets
. Its application to longitudinal samples could afford an opportunity to uncover cellular factors associated with the evolution of disease progression without potentially confounding inter-individual variability
. Here, we present an experimental and computational methodology that uses scRNA-seq to characterize dynamic cellular programs and their molecular drivers, and apply it to HIV infection. By performing scRNA-seq on peripheral blood mononuclear cells from four untreated individuals before and longitudinally during acute infection
, we were powered within each to discover gene response modules that vary by time and cell subset. Beyond previously unappreciated individual- and cell-type-specific interferon-stimulated gene upregulation, we describe temporally aligned gene expression responses obscured in bulk analyses, including those involved in proinflammatory T cell differentiation, prolonged monocyte major histocompatibility complex II upregulation and persistent natural killer (NK) cell cytolytic killing. We further identify response features arising in the first weeks of infection, for example proliferating natural killer cells, which potentially may associate with future viral control. Overall, our approach provides a unified framework for characterizing multiple dynamic cellular responses and their coordination.
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