A compact reconfigurable rectifying antenna (rectenna) has been proposed for 5.2- and 5.8-GHz microwave power transmission. The proposed rectenna consists of a frequency reconfigurable microstrip ...antenna and a frequency reconfigurable rectifying circuit. Here, the use of the odd-symmetry mode has significantly cut down the antenna size by half. By controlling the switches installed in the antenna and the rectifying circuit, the rectenna is able to switch operation between 5.2 and 5.8 GHz. Simulated conversion efficiencies of 70.5% and 69.4% are achievable at the operating frequencies of 5.2 and 5.8 GHz, respectively, when the rectenna is given with an input power of 16.5 dBm. Experiment has been conducted to verify the design idea. Due to fabrication tolerances and parametric deviation of the actual diode, the resonant frequencies of the rectenna are measured to be 4.9 and 5.9 GHz. When supplied with input powers of 16 and 15 dBm, the measured maximum conversion efficiencies of the proposed rectenna are found to be 65.2% and 64.8% at 4.9 and 5.9 GHz, respectively, which are higher than its contemporary counterparts.
The transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2) is one of the master regulators that control hundreds of genes containing antioxidant response elements (AREs). The ...NRF2-ARE pathway plays a complex role in colorectal cancer (CRC). NRF2 activity is known to be regulated by KEAP1-CUL3 E3 ligase-mediated ubiquitination, indicating the importance of deubiquitination regulation. However, the deubiquitinase (DUB) of NRF2 remains unknown. Here, by screening a DUB library, we identified DUB3 as a DUB that remarkably stabilized NRF2. Further experiments demonstrated that DUB3 promoted NRF2 stability and transcriptional activity by decreasing the K48-linked ubiquitination of NRF2. Coimmunoprecipitation studies revealed interactions between NRF2 and DUB3, as well as between KEAP1 and DUB3, indicating that NRF2, DUB3, and KEAP1 formed a large functional complex. Importantly, ectopic expression of DUB3 caused NRF2-dependent chemotherapy resistance in colon cancer cell lines. Thus, to the best of our knowledge, our findings are the first to identify DUB3 as a NRF2 DUB and may provide a new strategy against chemotherapy resistance in CRC and other NRF2-related diseases.
Background and Aim
Polypoid lesions of the gallbladder may be neoplastic or non‐neoplastic. Correct diagnosis would help reduce unnecessary cholecystectomies. This study aimed to determine the ...predictive value of individual ultrasound characteristics for diagnosis of neoplastic polyps and to build a scoring system based on these characteristics.
Methods
A total of 109 patients with gallbladder polyps ≥ 6 mm underwent conventional ultrasound examination and received finally diagnosis by pathological examination. All images were analyzed to determine characteristics of the lesions. Univariate and multivariate analyses were used to identify the predictors of neoplastic polyps, and a scoring system was built based on multivariate analysis.
Results
Maximum diameter, height/width ratio, base width, presence of hyper‐echoic spots, and intralesional blood flow were statistically significant (P = 0.011, P = 0.016, P = 0.003, P = 0.031, and P = 0.022, respectively) predictors of neoplastic lesions. The total score = (Maximum diameter, ≥ 13.9 mm = 1, < 13.9 = 0) + (Base width, ≥ 3.5 mm = 1, < 3.4 = 0) + (Height/width ratio, ≤ 1.05 = 1, > 1.05 = 0) + (Hyper‐echoic spots, presence = 0, absence = 1) + (Blood flow, presence = 1, absence = 0). Receiver operating characteristic curve showed that the sensitivity, specificity, and accuracy for the risk of neoplastic polyps with scores of 3 or higher were 81.6%, 86.7%, and 84.4%, respectively.
Conclusion
This ultrasound‐based scoring system could be a useful means for differentiating between neoplastic and non‐neoplastic gallbladder polyps in the clinic.
We explore the tripartite entropic uncertainty and genuine tripartite quantumness of Dirac fields in the background of the Garfinkle–Horowitz–Strominger (GHS) dilation space-time. It is interesting ...to note that Hawking radiation leads to the decay of quantum nonlocality in the physically accessible region while preserving its total coherence. More importantly, it demonstrates an intrinsic trade-off relationship between the coherences of physically accessible and inaccessible regions. Moreover, we examine the effect of Hawking radiation on entropy-based measured uncertainty and find that stronger Hawking radiation causes the uncertainty in physically accessible regions to increase while decreasing the uncertainty in physically inaccessible regions. Therefore, our investigations may be beneficial to a better understanding of the system’s quantumness in a curved space-time. Combining relativity theory with quantum information science offers new avenues for comprehending the information paradoxes involving black holes.
Tea trees originated in southwest China 60 million or 70 million years ago. Written records show that Chinese ancestors had begun drinking tea over 3000 years ago. Nowadays, with the aging of ...populations worldwide and more people suffering from non-communicable diseases or poor health, tea beverages have become an inexpensive and fine complementary and alternative medicine (CAM) therapy. At present, there are 3 billion people who like to drink tea in the world, but few of them actually understand tea, especially on its development process and the spiritual and cultural connotations.
We searched PubMed, Google Scholar, Web of Science, CNKI, and other relevant platforms with the key word "tea", and reviewed and analyzed tea-related literatures and pictures in the past 40 years about tea's history, culture, customs, experimental studies, and markets.
China is the hometown of tea, tea trees, tea drinking, and tea culture. China has the oldest wild and planted tea trees in the world, fossil of a tea leaf from 35,400,000 years ago, and abundant tea-related literatures and art works. Moreover, tea may be the first Chinese herbal medicine (CHM) used by Chinese people in ancient times. Tea drinking has many benefits to our physical health via its antioxidant, anti-inflammatory, immuno-regulatory, anticancer, cardiovascular-protective, anti-diabetic, and anti-obesity activities. At the moment, COVID-19 is wreaking havoc across the globe and causing severe damages to people's health and lives. Tea has anti-COVID-19 functions via the enhancement of the innate immune response and inhibition of viral growth. Besides, drinking tea can allow people to acquire a peaceful, relaxed, refreshed and cheerful enjoyment, and even longevity. According to the meridian theory of traditional Chinese medicine, different kinds of tea can activate different meridian systems in the human body. At present, black tea (fermented tea) and green tea (non-fermented tea) are the most popular in the world. Black tea accounts for over 90% of all teas sold in western countries. The world's top-grade black teas include Qi Men black in China, Darjeeling and Assam black tea in India, and Uva black tea in Sri Lanka. However, all top ten famous green teas in the world are produced in China, and Xi Hu Long Jing tea is the most famous among all green teas. More than 700 different kinds of components and 27 mineral elements can be found in tea. Tea polyphenols and theaflavin/thearubigins are considered to be the major bioactive components of black tea and green tea, respectively. Overly strong or overheated tea liquid should be avoided when drinking tea.
Today, CAM provides an array of treatment modalities for the health promotion in both developed and developing countries all over the world. Tea drinking, a simple herb-based CAM therapy, has become a popular man-made non-alcoholic beverage widely consumed worldwide, and it can improve the growth of economy as well. Tea can improve our physical and mental health and promote the harmonious development of society through its chemical and cultural elements.
Construction of C(sp
)-C(sp
) bonds
regioselective coupling of C(sp
)-H/C(sp
)-H bonds is challenging due to the low reactivity and regioselectivity of C-H bonds. Here, a novel photoinduced ...Ru/photocatalyst-cocatalyzed regioselective cross-dehydrogenative coupling of dual remote C-H bonds, including inert γ-C(sp
)-H bonds in amides and
-C(sp
)-H bonds in arenes, to construct
-alkylated arenes has been accomplished. This metallaphotoredox-enabled site-selective coupling between remote inert C(sp
)-H bonds and
-C(sp
)-H bonds is characterized by its unique site-selectivity, redox-neutral conditions, broad substrate scope and wide use of late-stage functionalization of bioactive molecules. Moreover, this reaction represents a novel case of regioselective cross-dehydrogenative coupling of unactivated alkanes and arenes
a new catalytic process and provides a new strategy for
-functionalized arenes under mild reaction conditions. Density functional theory (DFT) calculations and control experiments explained the site-selectivity and the detailed mechanism of this reaction.
The violation of Leggett–Garg inequalities tested the quantumness of neutrino oscillations (NOs) across macroscopic distances. The quantumness can be quantified by using the tools of the quantum ...resource theories. Recently, a new genuine tripartite entanglement measure (Xie et al. in Phys Rev Lett 127:040403, 2021), concurrence fill, is defined as the square root of the area of the concurrence triangle satisfying all genuine multipartite entanglement conditions. It has several advantages compared to other existing tripartite measures. Here, we focus on using concurrence fill to quantify the tripartite entanglement in three-flavor NOs. Concurrence fill can reach its maximum 0.89 for the experimentally-observed electron antineutrino oscillations, but it cannot for the muon antineutrino oscillations. In both cases, we compare its performance with other three tripartite entanglement measures, including the generalized geometric measure (GGM), the three-
π
entanglement, and the genuinely multipartite concurrence (GMC), in the neutrino propagation, and accordingly show that concurrence fill contains the most quantum resource. Furthermore, concurrence fill and the three-
π
entanglement are always smooth, while GGM and GMC measures have several sharp peaks. The genuine tripartite quantification of the quantumness of three-flavor NOs represents the first step towards the further potential application of neutrinos on quantum information processing.
Abstract
Stone cells negatively affect fruit quality because of their firm and lignified cell walls, so are targets for reduction in pear breeding programmes. However, there is only limited knowledge ...of the molecular mechanisms underlying the formation of stone cells. Here, we show that PbrMYB169, an R2R3 MYB transcription factor, of Pyrus bretschneideri positively regulates lignification of stone cells in pear fruit. PbrMYB169 was shown to be co-expressed with lignin biosynthesis genes during pear fruit development, and this co-expression pattern was coincident with stone cell formation in the fruit of Pyrus bretschneideri 'Dangshansuli'. The PbrMYB169 expression level was also positively correlated with stone cell content in 36 pear cultivars tested. PbrMYB169 protein significantly activated the promoter of lignin genes C3H1, CCR1, CCOMT2, CAD, 4CL1, 4CL2, HCT2, and LAC18 via binding to AC elements ACC(T/A)ACC in these promoters. Furthermore, overexpression of PbrMYB169 in transgenic Arabidopsis plants enhanced the expression of lignin genes, and increased lignin deposition and cell wall thickness of vessel elements, but did not change the ratio of syringyl and guaiacyl lignin monomers. In conclusion, PbrMYB169 appears to be a transcriptional activator of lignin biosynthesis and regulates secondary wall formation in fruit stone cells. This study advances the understanding of the regulation of lignin biosynthesis and provides valuable molecular genetic information for reducing stone cell content in pear fruit.
PbrMYB169 has been shown to positively regulate lignification of stone cells in pear fruit via activating the promoter of lignin genes C3H1, CCR1, CCOMT2, CAD, 4CL1, 4CL2, HCT2, and LAC18.
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